| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Thin film hpmp matrix systems and methods for you and to present constitute a ligand | JP51928594 | 1994-02-18 | JPH08507602A | 1996-08-13 | ギーベル，ルッツ・ビィ; キャス，ロバート・ティー; シューメーカー，ケビン・アール; ジョンソン，チャールズ・アール; ツォウ，ペン; ハドソン，デレク; ロス，マイケル・ジェイ |
| (57)【要約】 この発明はつなぎ留められた有機リガンド分子の立体障害のない構成および提示の方法および系に関し、より特定的には、薄膜の実質的に橋かけされていない親水性かつ極性の多官能ポリマー（ＨＰＭＰ）の調製および使用に関するものである。 ＨＰＭＰは、薄膜マトリックス層を形成するよう官能基を導入されたさまざまな基体に固定化され、標識された標的分子（ＴＴＭ）へのリガンド（Ｌ）のアフィニティ結合のため、水溶液と同等の、ユニークかつ高度に水和された誘電性の高い環境を提供する。 | ||||||
| 162 | JPH07501261A - | JP50533093 | 1992-09-03 | JPH07501261A | 1995-02-09 | |
| 163 | Repeated chemical treatment apparatus and method | JP10479989 | 1989-04-26 | JPH0272193A | 1990-03-12 | DEREKU HADOSON; JIYOODAN HOONINGU; RONARUDO EMU KUTSUKU; DAGURASU JIEI NUGU |
| PURPOSE: To provide the subject simple and inexpensive new apparatus composed of a specific constitution and useful for dissolving, distributing and reacting a chemical substance and especially useful for synthesizing peptide. CONSTITUTION: At first, a cartridge 12 storing a chemical substance (substance A) is supplied to a work station by a transfer means and a fluid coupling means 16 is brought into contact with the cartridge 12 in this station to set a fluid passage between the content of the cartridge 12 and the fluid conduit connected to the fluid coupling means. Subsequently, chemical substances (substances B) reacting with the substance A are allowed to flow in the cartridge 12 from sumps R 1-R 6 through fluid conduits by pump means to react both substances A, B and the reacted substance is allowed to flow in a fluid conduit and the cartridge 12 by a pump means. In this objective apparatus thus constituted, reaction is controlled by the automatic operation control means connected to the above-mentioned pumps and a valve controlling the flow in the conduit. COPYRIGHT: (C)1990,JPO | ||||||
| 164 | Methods for the electronic, homogeneous assembly and fabrication of devices | US11401713 | 2006-04-11 | US08630807B2 | 2014-01-14 | Carl F. Edman; Michael J. Heller; Rachel Formosa; Christian Gurtner |
| Methods are provided for the fabrication of microscale, including micron and sub-micron scale, including nanoscale, devices. Electronic transport of movable component devices is utilized through a fluidic medium to effect transport to a desired target location on a substrate or motherboard. Forces include electrophoretic force, electroosmotic force, electrostatic force and/or dielectrophoretic force. In the preferred embodiment, free field electroosmotic forces are utilized either alone, or in conjunction with, other forces. These forces may be used singly or in combination, as well as in conjunction with yet other forces, such as fluidic forces, mechanical forces or thermal convective forces. Transport may be effected through the use of driving electrodes so as to transport the component device to yet other connection electrodes. In certain embodiments, the component devices may be attached to the target device using a solder reflow step. | ||||||
| 165 | COMPOSITIONS AND METHODS FOR FUNCTIONAL GYLCOMICS | US13885916 | 2011-11-22 | US20130331280A1 | 2013-12-12 | Richard D. Cummings; David F. Smith; Xuezheng Song |
| The disclosure relates to labeling glycans and glycosphingolipids from undefined mixtures with chemical moieties that emit light when exposed to electromagnetic radiation and uses of these labeled glycans and glycosphingolipids in microarrays for research and diagnostic purposes. In certain embodiments, the disclosure relates to derivatizing glycosphingolipids with a marker. | ||||||
| 166 | PATTERNED DEVICES AND METHODS FOR DETECTING ANALYTES | US13746455 | 2013-01-22 | US20130196880A1 | 2013-08-01 | Stacey Stanislaw; Heather Lewis; Lei Tang; Lizhen Pang; Hong Ni |
| Disclosed herein are devices for the detection of target molecules and methods for their use and production. The disclosed devices may include optically decipherable patterns that facilitate an understanding of binding events between a target molecule and a detection molecule. In one example, a device includes a macroscopic pattern constructed using microscopic elements that can be chromogenically developed to memorialize a binding event. In another example, a device includes characters that can be chromogenically developed using an automated slide staining instrument to memorialize a binding event. | ||||||
| 167 | Method for the electronic analysis of a sample oligonucleotide sequence | US09358788 | 1999-07-22 | US08389212B1 | 2013-03-05 | Michael J. Heller; Eugene Tu |
| A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated. | ||||||
| 168 | Method and system for the detection of cardiac risk factors | US10427744 | 2003-04-28 | US08257967B2 | 2012-09-04 | John T. McDevitt; Eric V. Anslyn; Jason B. Shear; Dean P. Neikirk; Nick J. Christodoulides |
| A system for the rapid characterization of multi-cardiovascular risk factor analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member, in which a plurality of cavities may be formed. A series of chemically sensitive particles, in one embodiment, are positioned within the cavities. The particles may produce a signal when a receptor, coupled to the particle, interacts with the cardiovascular risk factor analyte and the particle-analyte complex is visualized using a visualization reagent. Using pattern recognition techniques, the analytes within a multi-analyte fluid may be characterized. In an embodiment, each cavity of the plurality of cavities is designed to capture and contain a specific size particle. Flexible projections may be positioned over each of the cavities to provide retention of the particles in the cavities. | ||||||
| 169 | IDENTIFICATION AND CHARACTERISATION OF RECOMBINANT VIRAL GENE THERAPY VECTORS | US13063441 | 2009-09-21 | US20110275529A1 | 2011-11-10 | Regine Heilbronn |
| The present invention refers to a method for identifying or characterising a recombinant viral vector, particularly a recombinant adeno-associated virus (AAV) vector. | ||||||
| 170 | Fluidic methods for devices for parallel chemical reactions | US12572230 | 2009-10-01 | US20110251109A1 | 2011-10-13 | Xiaochuan Zhou; Tiecheng Zhou; David Sun |
| Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps, and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosaccharides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities, identifying intermolecular complex formations, and determining structural features of molecular complexes. | ||||||
| 171 | Prostate cancer glycan markers and autoantibody signatures | US12421964 | 2009-04-10 | US07981625B2 | 2011-07-19 | Denong Wang; Leonore A. Herzenberg; Donna M. Peehl; Leonard A. Herzenberg |
| Disclosed are methods for probing the immunogenic sugar moieties of prostate cancer cells. The methods detect a number of glyco-epitopes that are highly and differentially expressed among prostate cancers of various Gleason grades. The glyco-epitopes exist on the surfaces of prostate cells. The methods also comprise the detection of autoantibodies in prostate cancer subjects. The antibodies bound to a glyco-motif of N-glycans that is normally “cryptic.” This target is highly expressed in prostate cancers. Lectins and antibodies that detect these glyco-epitopes that expressed in prostate cancer tissues include Euonymus europaeus lectin (EEL); Psophocarpus Tetragonolobus Lectin-I (PTL-I); Griffonia Simplicifolia Lectin-I-A4 (GSL-I-A4); Griffonia Simplicifolia Lectin-I-B4 (GSL-I-B4); Sambucus nigra I agglutinin (SNA-I; Phaseolus vulgaris-L (PHA-L; Galanthus nivalis agglutinin (GNA); Narcissus pseudonarcissus agglutinin (NPA); Artocarpus integrifolia agglutinin (Jacalin); and mAb TM10 (IgM). | ||||||
| 172 | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics | US11702353 | 2007-02-05 | US07947486B2 | 2011-05-24 | Michael J. Heller; Eugene Tu; Glen A. Evans; Ronald G. Sosnowski |
| A method for analyzing nucleic acid obtained from a cell sample on a platform is described. A platform having a cell selector, a nucleic acid selector, and an array of microlocations, wherein at least one microlocation has an associated capture sequence, is provided. The cell selector is contacted with a cell sample, wherein a portion of the cells remain associated with the cell selector. At least a portion of cells associated with the cell selector are lysed to release a nucleic acid sample. The nucleic acid selector is then contacted with the nucleic acid sample, such that a portion of the nucleic acid sample remains associated with the nucleic acid selector. The associated nucleic acid sample is then released from the nucleic acid selector and then is contacted with the array of microlocations, such that at least a portion of the released nucleic acid sample hybridizes with the capture sequence. | ||||||
| 173 | Disaccharides for drug discovery | US10513286 | 2003-04-24 | US07875707B2 | 2011-01-25 | Wim Meutermans; Michael West; George Adamson; Giang Thanh Le; Nicholas B. Drinnan; Giovanni Abbenante; Bernd Becker; Matthias Grathwohl; Premraj Rajaratnam; Gerald Tometzki |
| Methods are described for the preparation of combinatorial libraries of potentially biologically active disaccharide compounds. These compounds are variously functionalized, with a view to varying lipid solubility size, function an other properties, with the particular aim of discovering novel drug or drug-like compounds, or compounds with useful properties. The invention provides intermediates, processes and synthetic strategies for the solution or solid phase synthesis of disaccharides, variously functionalized about the sugar ring, including the addition of aromaticity and charge, and the placement of pharmaceutically useful groups and isosteres. | ||||||
| 174 | Circuits for the control of output current in an electronic device for performing active biological operations | US11775724 | 2007-07-10 | US07858034B2 | 2010-12-28 | Donald E. Ackley; Scott O. Graham |
| A circuit for control of an output current in a multiple unit cell array includes an array of unit cells arranged in rows and columns. Each unit cell includes a column select transistor being adapted for control by a column selector and a row select transistor being adapted for control by a row selector. The column select transistor and the row select transistor are connected together in series to each other and between an output node and a first supply. A return electrode is provided to complete the circuit. | ||||||
| 175 | Photocleavable Protecting Groups | US12797559 | 2010-06-09 | US20100324266A1 | 2010-12-23 | Anthony D. Barone; Glenn H. McGall |
| Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally photolabile and comprise protecting groups which can be removed by photolysis to unmask a reactive group. The protecting group has the general formula Y, wherein Y is a chemical structure as shown in FIG. 1. Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above. | ||||||
| 176 | MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME | US12760379 | 2010-04-14 | US20100260984A1 | 2010-10-14 | Lei WU; Xiaobo Wang; Guoliang Tao; Junquan Xu; Jing Cheng; Mingxian Huang; Baoquan Sun; Wei Shao; Litian Liu; Depu Chen; David M. Rothwarf; Weiping Yang |
| This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | ||||||
| 177 | Microarray devices having controllable reaction volume | US10546226 | 2003-03-28 | US07767438B2 | 2010-08-03 | Wanli Xing; Fei Jun Xian; Xianhua Wang; Jing Cheng |
| This invention relates generally to the field of microarray reaction devices and uses thereof. In particular, the invention provides a microarray reaction device wherein a plurality of reaction spaces are formed between a first and second plurality of projections, the heights of said plurality of reaction spaces being substantially identical and controllable by a supporting structure, and the relative positions between the first and second plurality of projections being controllable by a positioning structure. Articles of manufacture comprising the microarray reaction device and methods for assaying an analyte using the microarray reaction device are also provided. | ||||||
| 178 | CLINICALLY INTELLIGENT DIAGNOSTIC DEVICES AND METHODS | US12614895 | 2009-11-09 | US20100173797A1 | 2010-07-08 | Alice A. Jacobs; Vineet Gupta; Boris Nikolic |
| The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders. | ||||||
| 179 | AUTOMATED SOLUTION-PHASE ITERATIVE SYNTHESIS | US11767098 | 2007-06-22 | US20100159604A1 | 2010-06-24 | Nicola Lucia Pohl; Gisun Park |
| The first method for iterative solution-phase biomolecule synthesis is described. The method requires only 3 or fewer equivalents of building block at each coupling cycle, and incorporates a FSPE step at the end of each coupling/deprotection sequence to eliminate most byproducts. | ||||||
| 180 | Methods, apparatus and computer program products for formulating culture media | US09359260 | 1999-07-22 | US07742877B1 | 2010-06-22 | Robert L. Campbell; Perry D. Haaland; Douglas B. Sherman; Walter William Stewart, II; Sheila A. Lloyd |
| Methods, apparatus and computer program products are provided for identifying a component of culture medium based on the parameters (e.g., physical, chemical, biological and/or topological characteristics) of compounds from within a compound library. In preferred embodiments, the compound library is a peptide library. Also provided are methods of selecting a compound library from a larger compound space based on whole molecule (i.e., global) parameters of the compounds. Preferably, this method is practiced in conjunction with a method of identifying a component of a culture medium. Further provided are methods of predicting a biological activity of a peptide based on at least one whole molecule parameter of the peptide. This method finds use in methods of drug discovery, identifying components of culture medium, and identifying and/or designing peptides with particular pharmacological or therapeutic activities. | ||||||
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