子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 221 | Biomarker discovery in complex biological fluid using bead or particle based libraries and diagnostic kits and therapeutics | US13428313 | 2012-03-23 | US09804168B2 | 2017-10-31 | Muralidhar Reddy Moola; Jessica Schilke |
| The present invention is useful in screening for biomarkers associated with any other disease or condition. Such diseases and conditions range from the neurological diseases, autoimmune diseases and cancers identified above as well as any other disease or condition that has a biomarker such as an antibody or other characterizing protein or biomolecule associated with the disease or progression of the disease. The large ligand libraries of the invention can be used directly in biological fluid, under the appropriate experimental conditions and according to the processes recited herein, to screen for such markers and without the need to use fewer support members (e.g. about 100,000 or less) or without the need to transfer such peptoids or ligands to a microarray before screening the biological fluid. In addition, the ligand libraries may also be used to screen for cell based receptors that specifically relate to a particular cell surface marker. | ||||||
| 222 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US15331452 | 2016-10-21 | US09752141B2 | 2017-09-05 | Darren Roy Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 223 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US15331452 | 2016-10-21 | US20170067047A1 | 2017-03-09 | Darren Roy Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 224 | COMPOUND LIBRARY PREPARATION PROCESS | US15242931 | 2016-08-22 | US20170050163A1 | 2017-02-23 | Ludwik LEIBLER; Renaud NICOLAY |
| The present invention relates to the preparation of a compound library comprising the following steps: i. Having available at least two different compounds each comprising at least a dioxaborolane or dioxaborinane ring. In said compounds: the boron of the dioxaborolane or dioxaborinane ring is directly linked to a carbon atom of a hydrocarbon radical; at least one carbon atom of the dioxaborolane or dioxaborinane ring is monosubstituted, the other carbon atoms of the dioxaborolane or dioxaborinane ring being non-substituted or monosubstituted; in at least two compounds, the hydrocarbon radicals linked to the boron are different; in at least two compounds, the substituents carried by at least one of the carbon atoms of the dioxaborolane or dioxaborinane rings are different and/or the size of the boronic ester ring is different; ii. Reacting the compounds of step (i.) and forming, by a boronic ester metathesis reaction, the library comprising at least four different compounds. The present invention also relates to a compound library. | ||||||
| 225 | Agents and methods for treating ischemic and other diseases | US14091076 | 2013-11-26 | US09566284B2 | 2017-02-14 | Xiujun Sun; Michael Tymianski; Jonathan David Garman |
| This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity. | ||||||
| 226 | Dipeptide mimics, libraries combining two dipeptide mimics with a third group, and methods for production thereof | US13418917 | 2012-03-13 | US09562023B2 | 2017-02-07 | Kevin Burgess |
| Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic moiety, and a spacer group. Monovalent compounds may be combined into bivalent and trivalent compounds, some of which may have a labeling tag. Methods of production of bivalent compounds and contemplated uses thereof are disclosed. | ||||||
| 227 | LIGHT-CONTROLLED ELECTROKINETIC ASSEMBLY OF PARTICLES NEAR SURFACES | US15216775 | 2016-07-22 | US20170014794A1 | 2017-01-19 | Michael SEUL |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 228 | Functionalized polydiacetylene sensors | US14157670 | 2014-01-17 | US09523683B2 | 2016-12-20 | Jinsang Kim; Jiseok Lee |
| A microarray includes a solid substrate having a surface, the surface having a plurality of binding spots and a plurality of reaction moieties bound to the binding spots. A reaction moiety includes a plurality of polyacetylene monomers, the polyacetylene monomers having a first coupling region and a second coupling region, the first coupling region having a first functional group operable to bind to the binding spot and the second coupling region comprising a second functional group operable to bind to an accessory molecule; and an accessory molecule having a binding region and an analyte reaction region, the analyte reaction region operable to selectively bind to the target analyte, and the binding region operable to bind to the second coupling region of the polyacetylene monomer. Upon binding a target analyte with the reaction moiety, a color change from the polyacetylene monomer occurs and the reaction moiety produces fluorescence. | ||||||
| 229 | MICROARRAY SYSTEM AND A PROCESS FOR DETECTING TARGET ANALYTES USING THE SYSTEM | US15182626 | 2016-06-15 | US20160291006A1 | 2016-10-06 | Dieter Trau; Wen-Tso Liu; Kian Kok Johnson NG |
| A process for identifying one or more target analytes present in a sample includes contacting a microarray with the sample. The microarray has at least two microbead subpopulations with randomly distributed spatial positions, each of the subpopulations comprising microbeads having a known active agent capable of binding with a respective target analyte. After contacting the microarray with the sample, the spatial positions of the microbeads which have undergone a change that is indicative of a respective one of the active agents being bound to a corresponding one of the target analytes are determined. At least one of the microbead subpopulations which has undergone the change is identified by comparing the determined spatial positions to recorded spatial positions of the microbeads of the microbead subpopulations stored in an encoding/decoding data table. The target analytes are identified based on the known active agents belonging to the at least one identified microbead subpopulation. | ||||||
| 230 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US14226482 | 2014-03-26 | US09410151B2 | 2016-08-09 | Darren R. Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 231 | Fluorochromes for organelle tracing and multi-color imaging | US12231988 | 2008-09-08 | US09334281B2 | 2016-05-10 | Wayne Forrest Patton; Praveen Pande; Yuejun Xiang; Zaiguo Li; James J. Donegan; Elazar Rabbani |
| Provided are compounds, methods and kits for identifying in cells of interest organelles including nuclei and a wide variety of organelles other than nuclei (non-nuclear organelles), as well as cell regions or cell domains. These compounds and methods can be used with other conventional detection reagents for identifying the location or position or quantity of organelles and even for distinguishing between organelles in cells of interest. | ||||||
| 232 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US13759660 | 2013-02-05 | US09328344B2 | 2016-05-03 | Darren Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | ||||||
| 233 | Versatile and stereospecific synthesis of γ,δ-unsaturated amino acids by Wittig reaction | US14241561 | 2012-08-28 | US09242925B2 | 2016-01-26 | Sylvain Juge; Jerome Bayardon; Emmanuelle Remond; Marie-Joelle Ondel-Eymin |
| The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry. | ||||||
| 234 | Materials and Methods Useful to Induce Vacuolization, Cell Death, or a Combination Thereof | US14246558 | 2014-04-07 | US09023871B2 | 2015-05-05 | William A. Maltese; Paul W. Erhardt; Christopher Trabbic; Jean H. Overmeyer |
| The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism, to induce vacuolization without cell death, or to induce cell death without vacuolization. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein. | ||||||
| 235 | Zwitterionic lipids | US13816882 | 2011-08-15 | US08956646B2 | 2015-02-17 | Francis C. Szoka, Jr.; Colin Walsh; Vincent Venditto; Juliane Nguyen; Emily Perttu |
| In various embodiments, the present invention provides zwitterionic lipids, encapsulants incorporating these zwitterionic lipids and such encapsulants encapsulating one or more bioactive agent. An exemplary bioactive agent is a nucleic acid. Also provided are pharmaceutical formulations of the encapsulants and methods of using such formulations to deliver a bioactive agent to a subject in treating or diagnosing disease in that subject. | ||||||
| 236 | ITERATIVE REACTIVE DISTILLATION OF DYNAMIC ESTER MIXTURES | US14308117 | 2014-06-18 | US20150027873A1 | 2015-01-29 | Ognjen Miljanic; Qing Ji |
| An iterative method of performing a reactive distillation of dynamic ester libraries containing n×m (m≦n) components, to reduce such mixtures to n pure ester species. The distillation occurs under anhydrous conditions, using metal alkoxide catalysts. Vacuum distillation of the mixture then isolates the most volatile ester at the expense of other (2n−2) compounds. The volatile ester is removed, and the process repeated with progressively less volatile ester species, yielding high purities and greater than 70% yields. | ||||||
| 237 | VERSATILE AND STEREOSPECIFIC SYNTHESIS OF GAMMA,DELTA -UNSATURATED AMINO ACIDS BY WITTIG REACTION | US14241561 | 2012-08-28 | US20140364339A1 | 2014-12-11 | Sylvain Jugé; Jérôme Bayardon; Emmanuelle Remond; Marie-Joëlle Ondel-Eymin |
| The γ,δ-unsaturated α-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry. | ||||||
| 238 | Materials and Methods Useful to Induce Cell Death via Methuosis | US14001313 | 2012-02-24 | US20140322128A1 | 2014-10-30 | William A. Maltese; Paul W. Erhardt; Michael W. Robinson; Jean H. Overmeyer |
| The present invention provides materials and methods to induce cell death by methuosis, a non-apoptotic cell death mechanism. Small molecules herein are useful for treating cell proliferation disorders or anomalies, particularly, but not exclusively, cancer. Methods related to the research and pharmaceutical use of the small molecules are also provided herein. | ||||||
| 239 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US14226482 | 2014-03-26 | US20140256595A1 | 2014-09-11 | Darren R. Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 240 | AGENTS AND METHODS FOR TREATING ISCHEMIC AND OTHER DISEASES | US14091076 | 2013-11-26 | US20140235619A1 | 2014-08-21 | Xiujun Sun; Michael Tymianski; David Garman |
| This invention relates to methods of screening for modulators of mammalian cell injury cause by TRPM7 gene and protein activity, compounds that modulate TRPM7 gene and protein activity and methods of treatment of mammalian cell injury using modulators of TRPM7 gene and protein activity. | ||||||
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