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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	生物技术2-羟基异丁酸生产	CN201380031378.1	2013-06-14	CN104364373A	2015-02-18	T.哈斯; Y.席曼; D.普里拜尔斯基; T.罗维德尔; R.H.米勒; H.哈姆斯
本发明涉及表达2-羟基异丁酰-辅酶A变位酶的氢氧细菌或产乙酸细菌，用于生产2-羟基异丁酸的方法，包括在水性介质中使氢氧细菌或产乙酸细菌与包含氢气和二氧化碳的混合气体混合物接触，以及氢氧细菌或产乙酸细菌在2-羟基异丁酸生产中的应用。
2	一种大豆TPS类酶及其编码基因与应用	CN201310307108.0	2013-07-19	CN103667229A	2014-03-26	喻德跃; 刘建雨; 王慧
本发明属于植物基因工程领域，涉及一种大豆TPS类酶及其编码基因与应用。本发明大豆TPS类酶GmGES，具有SEQ ID NO.2所示的氨基酸序列。该基因的开放阅读框具有SEQ ID NO.1所示的DNA序列。本发明首次从大豆基因组中克隆得到一种大豆TPS类酶的编码基因GmGES。并验证了该基因的功能。利用植物表达载体，将本发明的GmGES基因导入植物细胞，可获得抗虫转基因植株。过量表达本发明GmGES基因的烟草与空载烟草相比，其抗虫性显著提高，说明GmGES基因在提高植物抗虫性方面起着重要作用。
3	Production of Tetrahydrocannabinolic Acid in Yeast	US16122702	2018-09-05	US20180371507A1	2018-12-27	Jason L. Poulos; Anthony N. Farnia
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
4	BIOCONVERSION OF SHORT-CHAIN HYDROCARBONS TO FUELS AND CHEMICALS	US15562606	2016-03-31	US20180355394A1	2018-12-13	Ramon Gonzales
An engineered microorganism(s) with novel pathways for the conversion of short-chain hydrocarbons to fuels and chemicals (e.g. carboxylic acids, alcohols, hydrocarbons, and their alpha-, beta-, and omega-functionalized derivatives) is described. Key to this approach is the use of hydrocarbon activation enzymes able to overcome the high stability and low reactivity of hydrocarbon compounds through the cleavage of an inert C—H bond. Oxygen-dependent or oxygen-independent activation enzymes can be exploited for this purpose, which when combined with appropriate pathways for the conversion of activated hydrocarbons to key metabolic intermediates, enables the generation of product precursors that can subsequently be converted to desired compounds through established pathways. These novel engineered microorganism(s) provide a route for the production of fuels and chemicals from short chain hydrocarbons such as methane, ethane, propane, butane, and pentane.
5	Production of cannabidiolic acid in yeast	US15815651	2017-11-16	US10093949B2	2018-10-09	Jason L. Poulos; Anthony N. Farnia
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
6	Triterpenoid sapogenin production in plant and microbial cultures	US14400527	2013-05-13	US09994883B2	2018-06-12	Alain Goossens; Tessa Moses; Jacob Pollier; Lorena Almagro Romero
The disclosure relates to a method for enhancing the biosynthesis and/or secretion of sapogenins in the culture medium of plant and microbial cell cultures. Further, the disclosure also relates to the identification of novel genes involved in the biosynthesis of sapogenin intermediates, as well as to novel sapogenin compounds.
7	Production of Cannabidiolic Acid in Yeast	US15815651	2017-11-16	US20180073043A1	2018-03-15	Jason L. Poulos; Anthony N. Farnia
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
8	PRODUCTION OF CANNABINOIDS IN YEAST	US14795816	2015-07-09	US20160010126A1	2016-01-14	JASON L. POULOS; ANTHONY N. FARNIA
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
9	酸化ストレス、およびＤＮＡに対する損傷によって引き起こされる疾患を処置するための、ＧＳＥ２４．２に由来するペプチド	JP2016549641	2014-10-24	JP2016534752A	2016-11-10	アベロン，ロザリオペローナ; ガルソン，レアンドロサストレ; ベルニンチェス，ローラピンタド; ガルシア，ハイメカルリーリョ; パチョン，アントニオモリーナ; シルバ，ローライラディクシオ; ガルシア，クリスティーナマンガン
本発明は、ペプチドGSE24.2(配列番号1)の断片(配列番号2)を含んでおり、フリーラジカルの生成および/または細胞のDNAの構造に対する損傷を低減させ得るポリペプチドに関し、当該ポリペプチドは必要に応じて核局在化配列を含んでいる。本発明はまた、上記ポリペプチドをコードしている配列を含んでいるポリヌクレオチドおよびベクター、ならびに上記ポリペプチド、ポリヌクレオチドおよび/またはベクターを含んでいる薬学的組成物に関する。本発明はさらに、上記ポリペプチドの用途(例えば、細胞内DNAに対する酸化ストレスおよび/または損傷の増大によって引き起こされる疾患(例えば、血管拡張性運動失調症または先天性角化不全症)を処置するか、および/または予防するための、上記ポリペプチドの使用、または細胞の生存度を向上させるための、組織工学および細胞培養における上記ポリペプチドの使用)に関する。
10	PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA	EP14856578	2014-10-24	EP3061815A4	2017-03-29	PERONA ABELLÓN ROSARIO; SASTRE GARZÓN LEANDRO; PINTADO BERNINCHES LAURA; CARRILLO GARCÍA JAIME; MOLINA PACHÓN ANTONIO; IRRADICCIO SILVA LAURA; MANGUAN GARCÍA CRISTINA
The invention relates to a polypeptide which comprises the fragment SEQ ID No.: 2 of the peptide GSE 24.2 (SEQ ID No.:1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide, such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
11	PRODUCTION METHOD FOR POLYISOPRENOID, VECTOR, TRANSGENIC PLANT, PRODUCTION METHOD FOR PNEUMATIC TIRE, AND PRODUCTION METHOD FOR RUBBER PRODUCT	US15579434	2016-06-28	US20180171364A1	2018-06-21	Haruhiko YAMAGUCHI; Yukino INOUE; Kazuhisa FUSHIHARA; Seiji TAKAHASHI; Satoshi YAMASHITA; Toru NAKAYAMA
The present invention provides a method for producing a polyisoprenoid with which it is possible to enhance the rubber synthesis activity of rubber particles to increase natural rubber production. The present invention relates to a method for producing a polyisoprenoid in vitro, which involves the use of a gene coding for a cis-prenyltransferase (CPT) family protein and a gene coding for a Nogo-B receptor (NgBR) family protein, and further involves the use of rubber particles bound to proteins encoded by these genes; or a method for producing a polyisoprenoid, which includes introducing into a plant a vector in which a promoter having a promoter activity that drives laticifer-specific gene expression is linked to a gene coding for a CPT family protein and a gene coding for a NgBR family protein, to express proteins encoded by the genes specifically in laticifers.
12	Production of cannabinoids in yeast	US14795816	2015-07-09	US09822384B2	2017-11-21	Jason L. Poulos; Anthony N. Farnia
Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
13	PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA	US15031530	2014-10-24	US20160340656A1	2016-11-24	Rosario PERONA ABELLÓN; Leandro SASTRE GARZÓN; Laura PINTADO BERNINCHES; Jaime CARRILLO GARCÍA; Antonio MOLINA PACHÓN; Laura IRRADICCIO SILVA; Cristina MANGUAN GARCÍA
This invention relates to a polypeptide which comprises the fragment SEQ ID No. 2 of peptide GSE24.2 (SEQ ID No. 1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
14	BIOTECHNOLOGICAL 2-HYDROXYISOBUTYRIC ACID PRODUCTION	US14405050	2013-06-14	US20150267231A1	2015-09-24	Thomas Haas; Yvonne Schiemann; Denise Przybylski; Thore Rohwerder; Roland H. Mueller; Hauke Harms
The present invention relates to a knallgas bacterium or acetogenic bacterium expressing a 2-hydroxyisobutyryl-coenzyme A mutase, a method for the production of 2-hydroxyisobutyric acid, comprising contacting in an aqueous medium the knallgas bacterium or acetogenic with a gas mixture comprising hydrogen and carbon dioxide and the use of the knallgas bacterium or acetogenic bacterium for the production of 2-hydroxyisobutyric acid.
15	TRITERPENOID SAPOGENIN PRODUCTION IN PLANT AND MICROBIAL CULTURES	US14400527	2013-05-13	US20150141633A1	2015-05-21	Alain Goossens; Tessa Moses; Jacob Pollier; Lorena Almagro Romero
The disclosure relates to a method for enhancing the biosynthesis and/or secretion of sapogenins in the culture medium of plant and microbial cell cultures. Further, the disclosure also relates to the identification of novel genes involved in the biosynthesis of sapogenin intermediates, as well as to novel sapogenin compounds.
16	Method for Preparing Fertility-Lowered Plant	US14362900	2012-11-14	US20150020237A1	2015-01-15	Xiaoquan Qi; Zheyong Xue; Yingchun Zhang; Xia Xu; Dan Liu
The present invention relates to a method for preparing fertility-lowered plant. The present invention provides an RNA interference vector and a method for obtaining a transgenic plant by introducing said RNA interference vector into a target plant; said transgenic plant is the following 1) or 2): 1) Sterile transgenic plant or 2) The fertility of said transgenic plant is lower than said target plant; the present invention also provides a method for cultivating a target plant to a sterile mutant or fertility-lowered mutant by sodium azide mutagenesis. The experiments of the present invention proved that the present invention provides various methods for preparing sterile lines or fertility-lowered lines; including RNA interference or TILLING (Targeting Induced Local Lesions IN Genomes) technology selection; sterile lines prepared by the methods of the present invention establish the basis of rice heterosis and crossbreeding.
17	Polypeptides, nucleic acid molecules, and methods for synthesis of triterpenes	US13458668	2012-04-27	US08822187B1	2014-09-02	Joe Chappell; Thomas D. Niehaus; Shigeru Okada; Timothy P. Devarenne; David S. Watt
This application relates to the polypeptides, nucleic acid molecules, vectors, transfected cells, and methods for synthesis of triterpenes, including botryococcene.
18	생명공학적 2-히드록시이소부티르산 제조	KR1020147034928	2013-06-14	KR1020150018813A	2015-02-24	하스,토마스; 쉬만,이폰네; 프르치빌스키,데니제; 뢰베르더,토레; 뮐러,롤란트에이치.; 하름스하우케
본 발명은 2-히드록시이소부티릴-조효소 A 뮤타제를 발현하는 크날가스 박테리아 또는 아세트산생성 박테리아, 수성 배지 중에서 크날가스 박테리아 또는 아세트산생성 박테리아를 수소 및 이산화탄소를 포함하는 기체 혼합물과 접촉시키는 단계를 포함하는, 2-히드록시이소부티르산의 제조 방법, 및 2-히드록시이소부티르산의 제조를 위한 크날가스 박테리아 또는 아세트산생성 박테리아의 용도에 관한 것이다.
19	PEPTIDES DERIVED FROM GSE 24.2 FOR TREATING DISEASES CAUSED BY OXIDATIVE STRESS AND DAMAGE TO DNA	EP14856578.1	2014-10-24	EP3061815A9	2016-10-12	PERONA ABELLÓN, Rosario; SASTRE GARZÓN, Leandro; PINTADO BERNINCHES, Laura; CARRILLO GARCÍA, Jaime; MOLINA PACHÓN, Antonio; IRRADICCIO SILVA, Laura; MANGUAN GARCÍA, Cristina
The invention relates to a polypeptide which comprises the fragment SEQ ID No.: 2 of the peptide GSE 24.2 (SEQ ID No.:1) and can reduce the production of free radicals and/or damage to the DNA structure of a cell, optionally comprising nuclear localisation sequences. The invention also relates to a polynucleotide and to a vector, which comprise sequences coding for said polypeptide, and to a pharmaceutical composition comprising said polypeptide, polynucleotide and/or vector. The invention further relates to the applications of the polypeptide, such as the use thereof for treating and/or preventing diseases caused by an increase in oxidative stress and/or damage to cellular DNA, such as ataxia-telangiectasia or dyskeratosis congenita, or the use thereof in tissue engineering and cell culture for increasing the viability of same.
20	BIOTECHNOLOGICAL 2-HYDROXYISOBUTYRIC ACID PRODUCTION	EP13728753.8	2013-06-14	EP2861730A1	2015-04-22	HAAS, Thomas; SCHIEMANN, Yvonne; PRZYBYLSKI, Denise; ROHWERDER, Thore; MÜLLER, Roland H.; HARMS, Hauke
The present invention relates to a knallgas bacterium or acetogenic bacterium expressing a 2- hydroxyisobutyryl-coenzyme A mutase, a method for the production of 2-hydroxyisobutyric acid, comprising contacting in an aqueous medium the knallgas bacterium or acetogenic with a gas mixture comprising hydrogen and carbon dioxide and the use of the knallgas bacterium or acetogenic bacterium for the production of 2-hydroxyisobutyric acid.

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