| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 利用代谢工程消除阿卡波糖生产菌株产生组分C的方法 | CN201610962770.3 | 2016-10-28 | CN106566797A | 2017-04-19 | 白林泉; 赵芹芹 |
| 一种利用代谢工程消除阿卡波糖生产菌Actinoplanes spp.产生组分C的方法，是通过缺失阿卡波糖生产菌Actinoplanes spp.中编码麦芽寡聚糖基海藻糖合成酶(TreY)的treY(ACPL_6622)基因，消除该类菌株发酵过程中副产物组分C的积累。本发明所获得的工程菌株QQ‑2不积累组分C，同时阿卡波糖产量提高10.7％。 | ||||||
| 2 | Maltooligosyl trehalose synthase mutant and its application | US15820487 | 2017-11-22 | US10100298B1 | 2018-10-16 | Jing Wu; Lingqia Su; Kailin Yao |
| The present invention relates to the field of genetic engineering and enzyme engineering, and more particularly relates to a maltooligosyl trehalose synthase mutant and its application. The present invention provides a series of maltooligosyl trehalose synthase mutants with improved enzyme activity. | ||||||
| 3 | Bacteria with increased trehalose production and method for using the same in bioremediation | US12762023 | 2010-04-16 | US08481026B1 | 2013-07-09 | Peter J. Woodruff; Tamlyn M. Frederick |
| Bacteria with improved survival under toxic and oxidative stress and methods of using the same for bioremediation are described. Many bacteria such as Escherichia coli have been found to naturally reduce toxic pollutants into a less toxic form, such as by reducing Chromium (VI) to Chromium (III). Reducing such toxins generates damaging reactive oxygen species, so it is important to find a defense for these bacteria against the associated oxidative stress. Trehalose is a small biomolecule that has been shown to protect bacteria from various types of stress by accumulating within the cells. The present invention is directed to bacteria genetically modified to overexpress trehalose biosynthesis genes. The bacteria demonstrate improved viability when challenged with toxins and oxidative stress. The present invention provides inexpensive and beneficial bacteria and methods for environmental remediation. | ||||||
| 4 | 설폴로버스 하코네시스로부터 분리된 트레할로스 합성관여 유전자 및 이들의 단백질 | KR1020010028420 | 2001-05-23 | KR1020020089548A | 2002-11-29 | 최양도; 김정호; 서주석 |
| PURPOSE: The genes associated with synthesis of trehalose isolated from Sulfolobus hakonesis and proteins encoded thereby are provided. Therefore, the trehalose can be more effectively produced because it has improved heat resistance and high trehalose production yield. CONSTITUTION: A ShMTH (maltooligosyltrehalose hydrolase) gene isolated from Sulfolobus hakonesis having the nucleotide sequence of SEQ ID NO: 1 is provided. A recombinant vector pRBShMTH(KCTC 1006BP) contains the ShMTH gene of SEQ ID NO: 1. A ShMTH protein having the amino acid sequence of SEQ ID NO: 2 is provided. A transformant produced by transforming a host cell with the recombinant vector pRBShMTH(KCTC 1006BP) is provided. A ShMTS(maltooligosyltrehalose synthase) gene isolated from Sulfolobus hakonesis having the nucleotide sequence of SEQ ID NO: 3 is provided. A recombinant vector pRBShMTS(KCTC 1007BP) contains the ShMTS gene of SEQ ID NO: 3. A ShMTS protein having the amino acid sequence of SEQ ID NO: 4 is provided. A transformant produced by transforming a host cell with the recombinant vector pRBShMTS(KCTC 1007BP) is provided. | ||||||
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