| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Modified Heterocyclase | US15524219 | 2015-11-04 | US20180245061A1 | 2018-08-30 | James NAISMITH; Jesko KOEHNKE; Andrew BENT; Nicholas WESTWOOD; Greg Mann; Wael HOUSSEN IBRAHIM; Marcel JASPARS; Ying GE |
| This invention relates to an engineered leader-independent heterocyclase (also known as a cyclodehydratase) comprising a defined cyanobactin leader sequence which drives the efficient conversion of heterocyclisable amino acids, such as Ser, Thr and Cys, within a peptide substrate lacking a leader sequence into heterocycles produce a homogenous heterocycle-containing product. This may be useful in biotechnology and chemical synthesis. | ||||||
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