专利检索_ .与两个氧原子结合专利检索_ .与两个氧原子结合专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	源于多氯联苯降解菌的双加氧酶基因及其应用	CN201611186538.1	2016-12-20	CN106854651A	2017-06-16	许育新; 喻曼; 沈阿林
本发明涉及微生物基因工程领域，公开了一种源于多氯联苯降解菌的双加氧酶基因，基因的碱基序列如SEQ ID No.1所示，其编码的蛋白质的氨基酸序列如SEQ ID No.2所示。基因的名称是bphC2基因，其编码阅读框由903bp碱基组成，编码成一个300个氨基酸的蛋白质。还公开了该基因在多氯联苯和联苯类物质降解中的应用，应用的方式包括用于基因工程菌的构建，双加氧酶的制备和获取利用，作为材料用于环境监测。本发明的基因和蛋白可用于制备降解多氯联苯和其它联苯类物质的基因工程菌，有望应用于多氯联苯污染土壤的修复，在环境污染治理和保护人们身体健康方面发挥作用。
2	抗炎性肽及包含其的组合物	CN201380036639.9	2013-05-07	CN104507962A	2015-04-08	金商在; 金京姫; 李圭庸; 高成昊; 朴贤喜; 许成珍; 李宇珍; 金范埈
本发明涉及具有抗炎活性的肽，其中，该肽包含SEQ ID NO:1；该肽与上述序列具有超过80％的氨基酸序列同源性；或该肽为上述肽的片段。本发明还涉及包含上述肽的炎症组合物。根据本发明，包含SEQ ID NO:1序列的肽在抑制炎症及预防性手段方面皆具有优异的功效。因此，包含本发明的肽的组合物可用作抗炎药物组合物或用作化妆品组合物，从而治疗或防止多种不同类型的炎性疾病。
3	Herbicide resistance gene	JP2012225890	2012-10-11	JP2013046624A	2013-03-07	WRIGHT TERRY R; LIRA JUSTIN M; WALSH TERENCE ANTHONY; MERLO DONALD J; JAYAKUMAR PON SAMUEL; LIN GAOFENG
PROBLEM TO BE SOLVED: To provide new plants that are not only resistant to 2,4-D and other phenoxy auxin herbicides but also to an aryloxyphenoxypropionate herbicide.SOLUTION: The subject invention includes plants that produce one or more enzymes of the subject invention alone or "stacked" together with one or more other herbicide-resistant genes, including glyphosate-resistant genes, so as to provide broader and more robust weed control, greater flexibility in treatments, and improvement in herbicide resistance management options. The subject invention also includes transgenic plants containing genes and enzymes called AAD (AryloxyAlkanoate Dioxygenase) genes and proteins.
4	Herbicide resistance gene	JP2008538037	2006-10-27	JP2009513139A	2009-04-02	テレンスアンソニーウォルシュ; ポンサミュエルジャヤクマール; ドナルドジェイ．マーロ; テリーアール．ライト; ジャスティンエム．ライラ; ゴーフェンリン
本発明は、2,4-Dおよび他のフェノキシオーキシン除草剤に対してのみならず、アリールオキシフェノキシプロピオネート除草剤にもまた抵抗性である新規な植物を提供する。従来、これらの有利な特性の両方を有する植物が、単一の遺伝子の導入によって産生することができるという予測または示唆は存在しなかった。本発明はまた、より広くかつより強固な雑草の制御、処理の柔軟性の増加、および除草剤抵抗性管理の選択肢の改善を提供するために、本発明の1種または複数の酵素を、単独で、または別の除草剤抵抗性遺伝子、好ましくは、グリホセート抵抗性遺伝子とともに「重ね合わせて」産生する植物を含む。より具体的には、本発明による使用のための好ましい酵素および遺伝子は、本明細書でAAD（アリールオキシシアルカノエートジオキシゲナーゼ）遺伝子およびタンパク質と呼ばれる。 α-ケトグルタレート依存性ジオキシゲナーゼ酵素は、異なる化学クラスおよび作用の様式の除草剤を分解する能力を有することが以前には報告されていなかった。この非常に新規な発見は、有意な除草剤耐性作物形質の可能性ならびに選択可能なマーカー技術の開発を基礎としている。本発明はまた、雑草を制御する関連方法も含む。本発明は、除草剤の新規な組み合わせが、新規な方法で使用されることを可能にする。さらに、本発明は、グリホセートのような1種または複数の除草剤に対して抵抗性である（または天然により耐性である）雑草の形成を妨害し、かつその雑草を制御する新規な方法を提供する。本発明の使用のための好ましい酵素および遺伝子は、本明細書ではAAD-12（アリールオキシアルカノエートジオキシゲナーゼ（ A ryloxy A lkanoate D ioxygenase））と呼ばれる。この高度に新規な発見は、有意な除草剤耐性作物形質および選択可能なマーカーの可能性の基礎である。
5	Anti-Inflammatory Peptides and Composition Comprising the Same	US15343502	2016-11-04	US20170143806A1	2017-05-25	Sang Jae KIM; Kyung Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating and preventing a variety of different types of inflammatory diseases.
6	ENHANCED HETEROLOGOUS PRODUCTION OF LIPOXYGENASES	US15211438	2016-07-15	US20160312192A1	2016-10-27	Gaofeng Liu; Min-ju Chang; Averell L. Gnatt; Tian Ye
The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.
7	Herbicide-resistant proteins, encoding genes, and uses thereof	US14139897	2013-12-24	US09462805B2	2016-10-11	Yechun Wu; Qing Tao; Derong Ding; Chengwei Zhang; Dengyuan Wang; Jincun Huang; Na Wang; Yanxun Li; Xiaoyan Liu; Xiaoming Bao
Some embodiments of the present invention can include herbicide-resistant proteins, coding genes, and uses thereof. Certain herbicide-resistant proteins can comprises: (a) a protein consisting of an amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence at least 90% identical to that set forth in SEQ ID NO: 2. Other herbicide-resistant proteins of this disclosure can be suitable for expression in plants, can have resistance to herbicides (e.g., to phenoxy auxinherbicides), or both.
8	Enhanced heterologous production of lipoxygenases	US14263105	2014-04-28	US09404095B2	2016-08-02	Gaofeng Liu; Min-ju Chang; Averell L. Gnatt; Tian Ye
The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.
9	Anti-inflammatory metabolite derived from omega-3-type fatty acid	US13817079	2011-08-04	US09238634B2	2016-01-19	Makoto Arita; Hiroyuki Arai; Yosuke Isobe; Tadafumi Kubota
The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
10	Anti-Inflammatory Peptides and Composition Comprising the Same	US14400291	2013-05-07	US20150099692A1	2015-04-09	Sang Jae Kim; Kyung Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid sequence with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating and preventing a variety of different types of inflammatory diseases.
11	Enhanced Heterologous Production of Lipoxygenases	US14263105	2014-04-28	US20140322388A1	2014-10-30	Gaofeng Liu; Min-Ju Chang; Averell L. Gnatt; Tian Ye
The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.
12	CAR T CELL THERAPIES WITH ENHANCED EFFICACY	US15760519	2016-09-16	US20180258149A1	2018-09-13	Gregory Motz; Frederic Dixon Bushman; Joseph A. Fraietta; Carl H. June; Jan J. Melenhorst; Christopher Loren Nobles; Regina M. Young
The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.
13	Anti-inflammatory peptides and composition comprising the same	US15343502	2016-11-04	US10039811B2	2018-08-07	Sang Jae Kim; Kyung Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating a variety of different types of inflammatory diseases.
14	DETERGENT COMPOSITION	US15590032	2017-05-09	US20170321160A1	2017-11-09	Neil Joseph LANT; Jean-Luc Philippe BETTIOL; Denis Alfred GONZALES
A detergent composition including an oleic acid-transforming enzyme and a surfactant system. Furthermore, a method of manually washing articles including the steps of: delivering a composition including an oleic acid-transforming enzyme and a surfactant system to a volume of water to form a wash liquor and immersing the soiled articles, in the liquor.
15	PRODUCING AMINES AND DIAMINES FROM A CARBOXYLIC ACID OR DICARBOXYLIC ACID OR A MONOESTER THEREOF	US14649414	2013-12-18	US20150307906A1	2015-10-29	Steffen SCHAFFER; Jasmin CORTHALS; Mirja WESSEL; Hans-Georg HENNEMANN; Harald HAEGER; Michael VOLLAND; Martin ROOS
The invention relates to a whole-cell catalyst which expresses a recombinant α-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase which phosphopantetheinylates the fatty acid reductase, and which expresses, in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase, a transaminase, wherein the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and also to a process for converting a carboxylic acid or dicarboxylic acid or a monoester thereof to an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopantetheinylated fatty acid reductase or an α-dioxygenase and contacting the product with a transaminase.
16	HERBICIDE-RESISTANT PROTEINS, ENCODING GENES, AND USES THEREOF	US14139897	2013-12-24	US20140194292A1	2014-07-10	Yechun WU; Qing TAO; Derong DING; Chengwei ZHANG; Dengyuan WANG; Jincun HUANG; Na WANG; Yanxun LI; Xiaoyan LIU; Xiaoming BAO
Some embodiments of the present invention can include herbicide-resistant proteins, coding genes, and uses thereof. Certain herbicide-resistant proteins can comprises: (a) a protein consisting of an amino acid sequence shown in SEQ ID NO: 2; or (b) a protein consisting of an amino acid sequence at least 90% identical to that set forth in SEQ ID NO: 2. Other herbicide-resistant proteins of this disclosure can be suitable for expression in plants, can have resistance to herbicides (e.g., to phenoxy auxinherbicides), or both.
17	Wheat with reduced lipoxygenase activity	US15185579	2016-06-17	US10087455B2	2018-10-02	Ann Slade; Michelle Noval; Dayna Loeffler; Jessica Mullenberg; Aaron Holm
A series of independent human-induced non-transgenic mutations found at one or more of the Lpx genes of wheat; wheat plants having these mutations in one or more of their Lpx genes; and a method of creating and finding similar and/or additional mutations of Lpx by screening pooled and/or individual wheat plants. The wheat plants disclosed herein exhibit decreased lipoxygenase activity without having the inclusion of foreign nucleic acids in their genomes. Additionally, products produced from the wheat plants disclosed herein display increased oxidative stability and increased shelf life without having the inclusion of foreign nucleic acids in their genomes.
18	Wheat with Reduced Lipoxygenase Activity	US15994062	2018-05-31	US20180265884A1	2018-09-20	Ann Slade; Michelle Noval; Dayna Loeffler; Jessica Mullenberg; Aaron Holm
A series of independent human-induced non-transgenic mutations found at one or more of the Lpx genes of wheat; wheat plants having these mutations in one or more of their Lpx genes; and a method of creating and finding similar and/or additional mutations of Lpx by screening pooled and/or individual wheat plants. The wheat plants disclosed herein exhibit decreased lipoxygenase activity without having the inclusion of foreign nucleic acids in their genomes. Additionally, products produced from the wheat plants disclosed herein display increased oxidative stability and increased shelf life without having the inclusion of foreign nucleic acids in their genomes.
19	PROCESS FOR THE PREPARATION OF 2,4- OR 2,5-PYRIDINEDICARBOXYLIC ACID AND COPOLYMERS DERIVED THEREFROM	US15580254	2016-06-15	US20180148752A1	2018-05-31	Paul Law; Paul Mines; Timothy Bugg
The present invention relates to processes for the formation of pyridinedicarboxylic acid (PDCA), in particular, 2,4-pyridinedicarboxylic acid (2,4-PDCA) and 2,5-pyridinedicarboxylic acid (2,5-PDCA), and mono- and diester derivatives thereof, from 3,4-dihydroxybenzoic acid, via a biocatalytic reaction using, for example, a protocatechuate dioxygenase such as protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase, and a nitrogen source. The invention also relates to copolymers that comprise the pyridinedicarboxylic acid monomers and derivatives thereof, processes for the formation of the copolymers and uses for the copolymers.
20	Producing amines and diamines from a carboxylic acid or dicarboxylic acid or a monoester thereof	US14649414	2013-12-18	US09725746B2	2017-08-08	Steffen Schaffer; Jasmin Corthals; Mirja Wessel; Hans-Georg Hennemann; Harald Haeger; Michael Volland; Martin Roos
The invention relates to a whole-cell catalyst which expresses a recombinant α-dioxygenase or the combination of a recombinant fatty acid reductase and a phosphopantetheinyl transferase which phosphopantetheinylates the fatty acid reductase, and which expresses, in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopantetheinyl transferase, a transaminase, wherein the phosphopantetheinyl transferase and/or transaminase is preferably recombinant; and also to a process for converting a carboxylic acid or dicarboxylic acid or a monoester thereof to an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopantetheinylated fatty acid reductase or an α-dioxygenase and contacting the product with a transaminase.

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