| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | Process for the preparation of pyridine-2,3-dicarboxylic acids | US332339 | 1989-03-31 | US5166060A | 1992-11-24 | Randall A. Roehl; George W. Matcham; David I. Stirling |
| Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation. | ||||||
| 2 | Production of pyridine-2,3-dicarboxylic acid | JP8474790 | 1990-03-30 | JPH03218358A | 1991-09-25 | RANDAARU EE ROORU; JIYOOJI DABURIYU MATSUCHIYAMU; DEIBITSUDO AI SUTAARINGU |
| PURPOSE: To obtain the subject compound, by treatment of a 2,3- dihydroxybenzoic acid or its salt with 2,3-dihydroxybenzoate-3,4-dioxygenase in a specific liquid medium, followed by the reaction with a source of ammonia or a primary amine. CONSTITUTION: A 2,3-dihydroxybenzoic acid of formula I (R 1 and R 2 are each H, alkyl, alkoxy, halogen, mercapto, phenyl or phenoxy; R 3 is H or alkyl; R 2 and R 3 together form a residue of an aromatic ring fused to the pyridine ring) is treated with 2,3-dihydroxybenzoate-3,4-dioxygenase in a liquid medium which lacks active decarboxylase and which has a pH of 4-9, an ionic strength below about 1 mole, and a low concentration of metal cations and complex anions, thereby to accumulate the 2-hydroxy-3-carboxymuconic acid semialdehyde, which is allowed to react with a source of ammonia or a primary amine to give a pyridine-2,3-dicarboxylic acid of formula II useful as an intermediate for herbicides. COPYRIGHT: (C)1991,JPO | ||||||
| 3 | Process for the preparation of pyridine-2,3-dicarboxylic acids | EP90105892.5 | 1990-03-28 | EP0390102A2 | 1990-10-03 | Roehl, Randall A.; Matcham, George W.; Stirling, David I. |
Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation. |
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| 4 | Process for the preparation of pyridine-2,3-dicarboxylic acids | EP90105892.5 | 1990-03-28 | EP0390102A3 | 1992-02-26 | Roehl, Randall A.; Matcham, George W.; Stirling, David I. |
Pyridine-2,3-dicarboxylic acids are prepared by the action of 2,3-dihydroxybenzoate-3,4-dioxygenase on 2,3-dihydroxybenzoic acids in a liquid medium which lacks active decarboxylase and which has a pH from 4 to 9, an ionic strength below about 1 molar, and a low concentration of metal cations and complex anions. In close temporal proximity, the 2-hydroxy-3-carboxymuconic acid semialdehyde which forms is allowed to react with a source of ammonia or a primary amine, avoiding substantial decarboxylation. |
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