专利检索_ .与两个氧原子结合专利检索_ .与两个氧原子结合专利检索查询

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
21	Anti-Inflammatory Peptides and Composition Comprising the Same	US15354139	2016-11-17	US20170081376A1	2017-03-23	Sang Jae KIM; Kyung Hee KIM; Kyu-Yong LEE; Seong-Ho KOH; Hyun-Hee PARK; Sung Jin HUH; Woo Jin LEE; Bum Joon KIM
The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, the peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.
22	Anti-inflammatory peptides and composition comprising the same	US14400291	2013-05-07	US09540419B2	2017-01-10	Sang Jae Kim; Kyung Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
A peptide with anti-inflammatory activity, wherein the peptide comprises SEQ ID NO: 1, the peptide has above 80% homology of amino acid with above-mentioned sequence, or the peptide is the fragment of the above-mentioned peptides is described. An anti-inflammatory composition comprising the above mentioned peptides is described. According to the present invention, a peptide comprising a sequence of SEQ ID NO: 1 has outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptide of this invention can be used as anti-inflammatory pharmaceutical composition or as cosmetic composition, in turn, treating a variety of different types of inflammatory diseases.
23	Anti-inflammatory peptides and composition comprising the same	US14400321	2013-03-15	US09527888B2	2016-12-27	Sang Jae Kim; Kyung Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
A peptide with anti-inflammatory activity is described, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising those peptides can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.
24	Anti-Inflammatory Peptides and Composition Comprising the Same	US14400321	2013-03-15	US20150099693A1	2015-04-09	Sang Jae Kim; Kyun Hee Kim; Kyu-Yong Lee; Seong-Ho Koh; Hyun-Hee Park; Sung Jin Huh; Woo Jin Lee; Bum Joon Kim
The present invention relates to a peptide with anti-inflammatory activity, wherein the peptide comprises at least one amino acid sequence among SEQ ID NO: 2 to SEQ ID NO: 179, the peptide has above 80% homology of amino acid sequence with above-mentioned sequences, or the peptide is the fragment of the above-mentioned peptides. The present invention also relates to an inflammatory composition comprising the above mentioned peptides. According to the present invention, the peptides that have at least one amino acid sequence of SEQ ID NO: 2 to SEQ ID NO: 179 shows outstanding efficacy in both suppressing inflammation and in prophylactic means. Therefore, the composition comprising the peptides of this invention can be used as anti-inflammatory pharmaceutical compositions or as cosmetic compositions, in turn, treating and preventing a variety of different types of inflammatory diseases.
25	NOVEL ANTI-INFLAMMATORY METABOLITE DERIVED FROM OMEGA-3-TYPE FATTY ACID	US13817079	2011-08-04	US20130274327A1	2013-10-17	Makoto Arita; Hiroyuki Arai; Yosuke Isobe; Tadafumi Kubota
The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, docosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
26	항염증 활성을 갖는 펩티드 및 이를 포함하는 조성물	KR1020147034320	2013-03-15	KR1020150014483A	2015-02-06	김상재; 김경희; 이규용; 고성호; 박현희; 허성진; 이우진; 김범준
본 발명에서는 서열번호 2 내지 179 중 어느 한 항의 서열을 갖는 펩티드, 상기 서열의 단편인 펩티드 또는 상기 펩티드 서열과 80% 이상의 서열 상동성을 갖는 펩티드 및 이를 유효 성분으로 포함하는 항염 조성물이 개시된다. 본 발명에 따른 서열번호 2 내지 179 중 어느 하나의 서열을 갖는 펩티드 또는 상기 서열과 80%의 상동성을 갖는 펩티드 또는 단편인 펩티드는 우수한 염증 예방 또는 억제 효과를 가진다. 따라서 본 발명의 펩티드를 포함하는 조성물은 항염증 효과를 위한 약학적 조성물 또는 화장료 조성물로서 사용될 수 있어 다양한 염증성 질환의 치료 및 예방에 널리 이용될 수 있다.
27	HERSTELLUNG VON AMINEN UND DIAMINEN AUS EINER CARBONSÄURE ODER DICARBONSÄURE ODER EINES MONOESTERS DAVON	EP13810940.0	2013-12-18	EP2935602A1	2015-10-28	SCHAFFER, Steffen; CORTHALS, Jasmin; WESSEL, Mirja; HENNEMANN, Hans-Georg; HÄGER, Harald; VOLLAND, Michael; ROOS, Martin
The invention relates to a whole-cell catalyst which expresses a recombinant α-dioxygenase or a combination of a recombinant fatty acid reductase and a phosphopanthetheinyl transferase which phosphopanthetheinylates the fatty acid reductase, and which, in addition to the α-dioxygenase and/or the combination of fatty acid reductase and phosphopanthetheinyl transferase, expresses a transaminase, where the phosphopanthetheinyl transferase and/or transaminase is preferably recombinant. The invention also relates to a method for converting a carboxylic acid or dicarboxylic acid or a monoester thereof into an amine or diamine, comprising the steps of contacting the carboxylic acid or dicarboxylic acid or the monoester thereof with a phosphopanthetheinylated fatty acid reductase or an α-dioxygenase and contacting the product with a transaminase.
28	NOVEL HERBICIDE RESISTANCE GENES	EP06844227.6	2006-10-27	EP1947926B1	2014-11-26	WRIGHT, Terry, R.; LIRA, Justin, M.; WALSH, Terence, Anthony; MERLO, Donald, J.; JAYAKUMAR, Pon, Samuel; LIN, Gaofeng
The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention "stacked" together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase); This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
29	NOVEL ANTI-INFLAMMATORY METABOLITE DERIVED FROM OMEGA-3-TYPE FATTY ACID	EP11817905	2011-08-04	EP2607358A4	2014-01-29	ARITA MAKOTO; ARAI HIROYUKI; ISOBE YOSUKE; KUBOTA TADAFUMI
The purpose is to provide a compound which can overcomes the disadvantages of conventional steroid drugs and NSAID. It is found that specific epoxy monohydroxy forms of eicosapentaenoic acid, d ocosahexaenoic acid and docosapentaenoic acid which are independently represented by formulae [chemical formula 1], [chemical formula 5] and the like have an inhibitory activity on neutrophils. This compound can inhibit the invasion of neutrophils into tissues and the activation of neutrophils which are observed in acute inflammations.
30	Novel Herbicide resistance genes	EP11010162.3	2006-10-27	EP2484767A1	2012-08-08	Wright, Terry; Lira, Justin; Walsh, Terence Anthony; Merlo, Donald; Jayakumar, Pon Samuel; Lin, Gaofeng
The subject invention provides novel plants that are not only resistant to 2,4-D, but also to pyridyloxyacetate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention "stacked" together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-12 (AryloxyAlkanoate Dioxygenase); This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
31	TREATMENT OF CYCLOOXYGENASE-2 MEDIATED DISORDERS USING CONJUGATED FATTY ACID COMPOUNDS	EP00951029.8	2000-06-07	EP1231913A2	2002-08-21	ABBAS, Zaheer; KOBOLDT, Carol
This invention is directed to a process for the prevention or treatment of inflammation or other cyclooxygenase-2 mediated disorders. This process comprises administering a conjugated fatty acid to an organism in an amount effective to prevent or treat the cyclooxygenase-2 mediated disorder by inhibiting cyclooxygenase -2. In one embodiment, the process comprises administering a fatty acid compound having formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; m is from 6 to 11; and the sum of n and m is from 13 to 16. In another embodiment, the process comprises administering a fatty acid compound having formula (VI) or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, hydrocarbyl, or substituted hydrocarbyl; R7 is -OH, -SO¿3?H, -SH, -NH2, -PO3H2, or halogen; v is from 7 to 11; and the sum of v and w is from 11 to 15. This invention is also directed to a process for preparing a fatty acid compound. The process comprises combining a ylide with an aldehyde.
32	抗炎症活性を有するペプチド、及びそれを含む組成物	JP2018108788	2018-06-06	JP2018172395A	2018-11-08	キムサンチェ; キムキョンヘ; リキュ−ヨン; コソン−ホ; パクヒョン−ヘ; フソンチン; リウチン; キムポムチュン
【課題】抗炎症活性を有するペプチド、及びそれを含む組成物の提供。【解決手段】(a)ヒトテロメラーゼに由来する配列から選択される特定のアミノ酸配列を有するペプチド、又は、(b)(a)において規定されたアミノ酸配列と少なくとも80%の配列同一性を有するアミノ酸配列、又は、(c)(a)もしくは(b)で規定されたアミノ酸配列の断片を含む、抗炎症活性を有するペプチド、並びに当該ペプチドを含む組成物。【選択図】図1
33	有効性が増強されたCAR T細胞療法	JP2018514456	2016-09-16	JP2018527008A	2018-09-20	グレゴリー・モッツ; フレデリック・ディクソン・ブッシュマン; ジョセフ・エイ・フライエッタ; カール・エイチ・ジューン; ジャン・ジェイ・メレンホースト; クリストファー・ローレン・ノーブルズ; レジーナ・エム・ヤング
本発明は、CAR T細胞療法を改善する組成物および方法を提供する。特に、本発明は、Tet、例えば、Tet2機能または発現を低減させた細胞およびその使用方法を提供する。本発明は、さらにCAR T細胞と関連させたTet2阻害剤およびその使用方法を提供する。
34	リポキシゲナーゼ活性を減退させたコムギ	JP2017565827	2016-06-17	JP2018518184A	2018-07-12	スレイドアン; ノヴァルミシェル; レフラーデイナ; ミューレンバーグジェシカ; ホームアーロン
コムギのLpx遺伝子の1つ以上に見出される一連の独立したヒト誘導非トランスジェニック変異;そのLpx遺伝子の1つ以上にこれらの変異を有するコムギ植物体;及びプールしたコムギ植物体及び/又は個々のコムギ植物体をスクリーニングすることによってLpxの類似の変異及び/又は追加の変異を作出及び発見する方法。本明細書に開示するコムギ植物体は、それらのゲノムに外来核酸を加えることなくリポキシゲナーゼ活性の低下を示す。加えて、本明細書に開示するコムギ植物体から製造される製品は、それらのゲノムに外来核酸を加えることなく酸化安定性の増強及び保存寿命の延長を示す。
35	抗炎症活性を有するペプチド、及びそれを含む組成物	JP2015510786	2013-05-07	JP6294306B2	2018-03-14	キムサンチェ; キムキョンヘ; リキュ−ヨン; コソン−ホ; パクヒョン−ヘ; フソンチン; リウチン; キムポムチュン

36	抗炎症活性を有するペプチド、及びそれを含む組成物	JP2015510686	2013-03-15	JP2015523323A	2015-08-13	サンチェキム; キョンヘキム; キュ−ヨンリ; ソン−ホコ; ヒョン−ヘパク; ソンチンフ; ウチンリ; ポムチュンキム
配列番号2〜179のうちいずれか1つのアミノ酸配列を有するペプチド、該配列の断片であるペプチド、または該ペプチド配列と80%以上の配列相同性を有するペプチド、及びそれを有効成分として含む抗炎組成物に係り、該配列番号2〜179のうちいずれか1つの配列を有するペプチド、または該配列と80%の相同性を有するペプチドまたは断片であるペプチドは、優秀な炎症の予防効果または抑制効果を有し、従って、該ペプチドを含む組成物は、抗炎症効果のための医薬組成物または化粧品組成物として使用され、多様な炎症性疾患の治療及び予防に広く利用される。
37	抗炎症活性を有するペプチド、及びそれを含む組成物	JP2017174211	2017-09-11	JP2018039806A	2018-03-15	キムサンチェ; キムキョンヘ; リキュ−ヨン; コソン−ホ; パクヒョン−ヘ; フソンチン; リウチン; キムポムチュン
【課題】抗炎症活性を有するペプチド、及びそれを含む組成物の提供。特にアルツハイマー病を含む中枢又は末梢神経系関連炎症性疾患の治療又は予防のための医薬組成物の提供。【解決手段】特定のアミノ酸配列を含むペプチド、前記特定のアミノ酸配列と80%以上の配列相同性を有するペプチド、又はその断片であるペプチド、及びそれを有効成分として含む抗炎症組成物。前記ペプチドはヒトテロメラーゼに由来する抗炎症組成物。【選択図】図8
38	オメガ3系脂肪酸由来の新規抗炎症性代謝物	JP2012529482	2011-08-04	JP5909183B2	2016-04-26	有田誠; 新井洋由; 磯部洋輔; 久保田唯史

39	カルボン酸又はジカルボン酸又はそれらのモノエステルからのアミン及びジアミンの製造	JP2015548476	2013-12-18	JP2016501031A	2016-01-18	シャファーシュテフェン; コーサルズヤスミン; ヴェセルミリヤ; ヘネマンハンス−ゲオルク; ハラルト　ヘーガー; ヘーガーハラルト; フォラントミヒャエル; マーティン　ロース; ロースマーティン
本発明は、組換えα−ジオキシゲナーゼ又は組換え脂肪酸レダクターゼとこの脂肪酸レダクターゼをホスホパンテテイニル化するホスホパンテテイニルトランスフェラーゼとの組み合わせを発現し、かつこのα−ジオキシゲナーゼ及び/又は脂肪酸レダクターゼとホスホパンテテイニルトランスフェラーゼとの組み合わせに加えて更にトランスアミナーゼを発現し、このホスホパンテテイニルトランスフェラーゼ及び/又はトランスアミナーゼは好ましくは組み換えられている全細胞触媒;並びにカルボン酸又はジカルボン酸又はそれらのモノエステルをホスホパンテテイニル化された脂肪酸レダクターゼ又はα−ジオキシゲナーゼと接触させかつ生成物をトランスアミナーゼと接触させる工程を有する、カルボン酸又はジカルボン酸又はそれらのモノエステルをアミン又はジアミンに変換する方法に関する。
40	抗炎症活性を有するペプチド、及びそれを含む組成物	JP2015510786	2013-05-07	JP2015521039A	2015-07-27	サンチェキム; キョンヘキム; キュ−ヨンリ; ソン−ホコ; ヒョン−ヘパク; ソンチンフ; ウチンリ; ポムチュンキム
配列番号1のアミノ酸配列を含むペプチド、配列番号1の配列と80%以上の配列相同性を有するペプチド、またはその断片であるペプチド、及びそれを有効成分として含む抗炎組成物に係り、該ペプチド、及びそれを含む抗炎組成物は、優秀な炎症の予防または抑制の効果を有する。これにより、該ペプチドを含む組成物は、抗炎症効果のための医薬組成物または化粧品組成物として使用され、多様な炎症性疾患の治療及び予防に広く利用される。

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