| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | DOSAGE COMPENSATING TRANSGENES AND CELLS | US14776672 | 2014-03-14 | US20160143951A1 | 2016-05-26 | Jeanne B. Lawrence; Jun Jiang; Lisa L. Hall |
| Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16. | ||||||
| 2 | COMPOSITIONS AND METHODS FOR GENETIC CONSTRUCTS | US14419215 | 2013-08-02 | US20150299714A1 | 2015-10-22 | Sean Moore |
| In an aspect, the invention relates to compositions and methods for genetic constructs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 3 | SUPER-ENHANCERS AND METHODS OF USE THEREOF | US14063894 | 2013-10-25 | US20140287932A1 | 2014-09-25 | Denes Hnisz; Brian Abraham; Tong Ihn Lee; Richard A. Young |
| The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer). | ||||||
| 4 | ＨＢＶ及び／又はＨＤＶ感受性の細胞、細胞株及び非ヒト動物の開発 | JP2015541181 | 2013-11-12 | JP2015535524A | 2015-12-14 | アーバン，シュテファン; ニ，イ |
| 本発明は、新規なB型肝炎ウイルス(HBV)及び/又はD型肝炎ウイルス(HDV)レセプター、並びにHBV及び/又はHDV感染に感受性であり、免疫学的研究のため、かつ/又は薬物、ポストエントリー抑制因子及びホスト依存性因子のスクリーニングのために使用することができる細胞、細胞株及び非ヒト動物を開発するためのその使用に関する。本発明は、さらに、HBV及び/又はHDV感染の処置に有用な化合物を同定するための該レセプターの使用に関する。 | ||||||
| 5 | STRAIN OF DEFORMED WING VIRUS (DWV) | US14783787 | 2014-04-15 | US20160032252A1 | 2016-02-04 | David J. EVANS; Eugene RYABOV |
| The invention is in the field of virology and relates to the deformed wing virus (DWV). A new strain of deformed wing virus (DWV) has been identified that is predominant in bees infested with Varroa mites. This particular strain of DWV can be used in diagnostics to identify at risk colonies. Also, inhibitors of the particular strain may be used in the treatment and/or prevention of DWV. | ||||||
| 6 | DEVELOPMENT OF HBV-AND/OR HDV-SUSCEPTIBLE CELLS, CELL LINES AND NON-HUMAN ANIMALS | US14442279 | 2013-11-12 | US20150299289A1 | 2015-10-22 | Stephan Urban; Yi Ni |
| The present invention relates to a novel Hepatitis B virus (HBV) and/or Hepatitis D virus (HDV) receptor and its use for the development of cells, cell lines and non-human animals that are susceptible to HBV and/or HDV infection and can be used for immunological studies and/or for the screening of drugs, post-entry restriction factors and host dependency factors. It further relates to the use of the receptor for the identification of compounds useful in the treatment of HBV and/or HDV infection. | ||||||
| 7 | METHODS AND COMPOSITIONS FOR TREATING CANCER | EP13782196.3 | 2013-04-23 | EP2841102B1 | 2018-06-27 | WERTHEIMER, Efrat |
| The present invention generally concerns methods and compositions for treating skin hyperplasia and cancer. | ||||||
| 8 | SALMON GILL POXVIRUS | US15539039 | 2015-12-22 | US20180216080A1 | 2018-08-02 | Mona Cecilie GJESSING; Torstein TENGS |
| The present document is directed to a new poxvirus infecting salmon. The present document further discloses the genomic sequence of this double-stranded DNA virus and the use of this sequence information for detection, diagnosis and/or vaccine development for the virus. | ||||||
| 9 | Dosage compensating transgenes and cells | US14776672 | 2014-03-14 | US10004765B2 | 2018-06-26 | Jeanne B. Lawrence; Jun Jiang; Lisa L. Hall |
| Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16. | ||||||
| 10 | Compositions and methods for genetic constructs | US14419215 | 2013-08-02 | US09605267B2 | 2017-03-28 | Sean Moore |
| In an aspect, the invention relates to compositions and methods for genetic constructs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 11 | Pharmaceutical Composition and Method for the Treatment of Neurodegenerative Diseases, in Particular Amyotrophic Lateral Sclerosis | US14460110 | 2014-08-14 | US20150038559A1 | 2015-02-05 | Rustam R. ATAULLAKHANOV; Maksim M. SHMAROV |
| A pharmaceutical composition and method for therapy of neurodegenerative diseases including amyotrophic lateral sclerosis, the composition comprising an adenoviral vector, expressing a human angiogenesis factor gene; an effective amount of the adenoviral vector in the form of a non-replicating nanoparticle based on a genome of human adenovirus type 5 with an insertion of a human angiogenin gene which produces the human angiogenesis in a human body; a non-replicating nanoparticle based on the genome of human adenovirus type 5 with an insertion of a human vascular endothelium growth factor gene; and a formulating buffer; wherein the human angiogenin factor gene and the human vascular endothelium growth factor gene are cloned in two expression cassettes within one non-replicating nanoparticle based on the genome of human adenovirus type 5. | ||||||
| 12 | DEVELOPMENT OF HBV- AND/OR HDV-SUSCEPTIBLE CELLS, CELL LINES AND NON-HUMAN ANIMALS | EP13792883.4 | 2013-11-12 | EP2917230B1 | 2018-07-18 | URBAN, Stephan; NI, Yi |
| The present invention relates to a novel Hepatitis B virus (HBV) and/or Hepatitis D virus (HDV) receptor and its use for the development of cells, cell lines and non-human animals that are susceptible to HBV and/or HDV infection and can be used for immunological studies and/or for the screening of drugs, post-entry restriction factors and host dependency factors. It further relates to the use of the receptor for the identification of compounds useful in the treatment of HBV and/or HDV infection. | ||||||
| 13 | SUPER-ENHANCERS AND METHODS OF USE THEREOF | EP13848637.8 | 2013-10-25 | EP2912178A1 | 2015-09-02 | HNISZ, Denes; ABRAHAM, Brian; LEE, Tong, Ihn; YOUNG, Richard, A. |
| The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer). | ||||||
| 14 | METHODS AND COMPOSITIONS FOR TREATING CANCER | EP13782196 | 2013-04-23 | EP2841102A4 | 2015-05-06 | WERTHEIMER EFRAT |
| The present invention generally concerns methods and compositions for treating skin hyperplasia and cancer. | ||||||
| 15 | SUPER-ENHANCERS AND METHODS OF USE THEREOF | EP13848637 | 2013-10-25 | EP2912178A4 | 2016-05-25 | HNISZ DENES; ABRAHAM BRIAN; LEE TONG IHN; YOUNG RICHARD A |
| The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer). | ||||||
| 16 | COMPOSITIONS AND METHODS FOR GENETIC CONSTRUCTS | EP13825974 | 2013-08-02 | EP2880166A4 | 2016-04-20 | MOORE SEAN |
| 17 | DEVELOPMENT OF HBV- AND/OR HDV-SUSCEPTIBLE CELLS, CELL LINES AND NON-HUMAN ANIMALS | EP13792883.4 | 2013-11-12 | EP2917230A1 | 2015-09-16 | URBAN, Stephan; NI, Yi |
| The present invention relates to a novel Hepatitis B virus (HBV) and/or Hepatitis D virus (HDV) receptor and its use for the development of cells, cell lines and non-human animals that are susceptible to HBV and/or HDV infection and can be used for immunological studies and/or for the screening of drugs, post-entry restriction factors and host dependency factors. It further relates to the use of the receptor for the identification of compounds useful in the treatment of HBV and/or HDV infection. | ||||||
| 18 | COMPOSITIONS AND METHODS FOR GENETIC CONSTRUCTS | EP13825974.2 | 2013-08-02 | EP2880166A2 | 2015-06-10 | MOORE, Sean |
| In an aspect, the invention relates to compositions and methods for genetic constructs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. | ||||||
| 19 | METHODS AND COMPOSITIONS FOR TREATING CANCER | EP13782196.3 | 2013-04-23 | EP2841102A1 | 2015-03-04 | WERTHEIMER, Efrat |
| The present invention generally concerns methods and compositions for treating skin hyperplasia and cancer. | ||||||
| 20 | MAMMALIAN GENES AND GENE PRODUCTS INVOLVED IN INFECTION | PCT/US2012048507 | 2012-07-27 | WO2013066442A3 | 2013-07-18 | HODGE THOMAS W; MCDONALD NATALIE J; MURRAY JAMES L; SHAW MICHAEL W; RUBIN DONALD H; SANCHEZ ANTHONY |
| The present disclosure relates to mammalian genes and gene products that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include HIV-1, HIV-2, influenza A, Marburg virus and Ebola virus. The disclosure also relates to methods of identifying agents involved in pathogen infection. | ||||||
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