Dosage compensating transgenes and cells |
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| 申请号 | US14776672 | 申请日 | 2014-03-14 | 公开(公告)号 | US10004765B2 | 公开(公告)日 | 2018-06-26 |
| 申请人 | University of Massachusetts; | 发明人 | Jeanne B. Lawrence; Jun Jiang; Lisa L. Hall; | ||||
| 摘要 | Methods and compositions for reducing expression of genes on Chromosome 21 (“Chr 21”) by targeting an XIST transgene to the Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) gene or a Regulator of calcineurin 1 (RCAN1) gene, and cells and transgenic animals comprising an XIST transgene inserted into a DYRK1A or RCAN1 allele, e.g., cells and animals trisomic for human Chr 21 and mouse Chr 16. | ||||||
| 权利要求 | |||||||
| 说明书全文 | |||||||
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