序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
101 Dimethylamino derivatives and their use US135800 1980-03-31 US4324739A 1982-04-13 Helmut Zondler; Roland Moser
(Dimethylaminoalkyl)carboxylic and -carbamic acid esters and (dimethylaminoalkyl) ethers and ureas are compounds which are especially suitable for use as amine curing agents for polyepoxide compounds. They impart longer curing times to the curable mixtures and thus good processing properties, especially when the mixtures are used as adhesives. In addition, the mechanical properties are often improved. Further, these compounds afford advantages when used as curing agents on account of their low volatility.
102 Process for the preparation of organic polyisocyanates containing urea groups US213434 1980-12-05 US4292255A 1981-09-29 Hans J. Hennig; Peter Ziemek; Erhard Schellmann
The present invention relates to a process for the preparation of compounds selected from the group consisting of a polyisocyanate containing urea groups and a polyisocyanate containing biuret groups comprising(a) introducing an organic polyisocyanate into a reaction vessel, and(b) injecting an organic polyamine containing at least two primary amino groups into the organic polyisocyanate in the reaction vessel at a pressure of from about 2 to 1000 bar through a straight jet nozzle having an internal diameter of from about 0.01 to 5 mmwherein(i) the polyisocyanate/polyamine NCO/NH.sub.2 molar ratio is at least about 4:1 and(ii) the temperature in the reaction vessel is between about -20.degree. C. to 250.degree. C.
103 Process for the preparation of organic polyisocyanates containing biuret groups US137676 1980-04-07 US4264519A 1981-04-28 Hans J. Hennig; Peter Ziemek; Erhard Schellmann
The present invention relates to a process for the preparation of compounds selected from the group consisting of a polyisocyanate containing urea groups and a polyisocyanate containing biuret groups comprising(a) introducing an organic polyisocyanate into a reaction vessel, and(b) injecting an organic polyamine containing at least two primary amino groups into the organic polyisocyanate in the reaction vessel at a pressure of from about 2 to 1000 bar through a straight jet nozzle having an internal diameter of from about 0.01 to 5 mmwherein(i) the polyisocyanate/polyamine NCO/NH.sub.2 molar ratio is at least about 4:1 and(ii) the temperature in the reaction vessel is between about -20.degree. C. to 250.degree. C.
104 Urea derivatives to treat anxiety and aggressivity US844618 1977-10-25 US4223041A 1980-09-16 Charles Pigerol; Pierre Eymard; Jean-Claude Vernieres; Madeleine Combet epse Broll; Jean-Yves Lacolle
Urea derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which are the same or different, each represent a straight- or branched-chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms, R.sub.4 and R.sub.5, which are the same or different, each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical having from 1 to 5 carbon atoms, R.sub.1, R.sub.2 and R.sub.3 being such that:(a) only one of these radicals can represent an alkenyl or alkynyl group having an unsaturated bond in the .alpha.,.beta.-position with respect to the methylurea radical, in this case, each of the other two substituents represents an alkyl radical,(b) the sum of their carbon atoms is never inferior to 4.They are useful as anxiolytic and antiagressive agents.
105 Polyether polyureides and resinous compositions therefrom US700640 1976-06-28 US4154724A 1979-05-15 Heinz Schulze
Novel polyether polyureides useful in the manufacture of plastics, sealants, molds, foams and coatings. The novel composition comprises a ureido-terminated polyoxyalkylene prepared by reacting a primary amine-terminated polyoxyalkylene with urea at temperatures in the range from about 120.degree. C. to about 150.degree. C. in a molar ratio of about one mole of urea for each terminal primary amino group.
106 Urea compound having carboxylate radical and method for producing the same US878911 1978-02-17 US4136079A 1979-01-23 Shitomi Katayama; Nobuaki Koyama; Hajime Shimabukuro; Kiyoshi Jin
A urea compound having carboxylate radical is obtained by reaction of aminoaminocarboxylate represented by the formula: ##STR1## (where R.sub.1 l is a hydrocarbon-based radical, and R.sub.2 is ethylene radical or a substituted ethylene radical) with diisocyanate, optionally in the presence of diamine and/or water. The reaction may be achieved by interfacial polymerization, solution polymerization, or solvent-free polymerization.
107 POLYUREA POLYMERS FROM SECONDARY POLYETHER POLYAMINES EP04777285.0 2004-06-30 EP1641746A2 2006-04-05 POSEY, Mark, L.; HILLMAN, Kenneth, M.; WHEWELL, Christopher, J.
Provided herein are polyurea polymers made from an organic isocyanate and a polyamine component, wherein the polyamine component comprises a polyether polyamine in which the nitrogen atoms are secondary. The polyurea polymers of the invention are useful in a wide range of end-use applications and possess superior physical properties over polyurea polymers of the prior art. Methods for producing the polyurea polymers are also disclosed.
108 Process to prepare alkyl-ureas from O,S-dimethyl dithiocarbonate EP03100248.8 2003-02-05 EP1334965B1 2005-12-28 PALLUCCA, Edoardo; DEGANI, Jacopo; SERRI, Anna Maria; FOCHI, Rita; GAZZETTO, Sonia; FENOGLIO, Claudia; ORNATI, Claudio; MIGLIACCIO, Mara; CADAMURO, Silvano; CARVOLI, Gianni
109 Process to prepare alkyl-ureas from O,S-dimethyl dithiocarbonate EP03100248.8 2003-02-05 EP1334965A1 2003-08-13 PALLUCCA, Edoardo; DEGANI, Jacopo; SERRI, Anna Maria; FOCHI, Rita; GAZZETTO, Sonia; FENOGLIO, Claudia; ORNATI, Claudio; MIGLIACCIO, Mara; CADAMURO, Silvano; CARVOLI, Gianni

The present invention relates to the preparation of alkyl-ureas, starting from O,S-dimethyl dithiocarbonate, which provides the following steps:

  • A) causing the O,S-dimethyl dithiocarbonate to react with a primary amine of general formula R1NH2 in order to obtain an O-methyl thiocarbamate;
  • B) isomerising the O-methyl thiocarbamate in order to obtain an S-methyl thiocarbamate;
  • C) causing the S-methyl thiocarbamate with a compound of general formula R'R"NH, wherein R' and R" may be equal or different one in respect of the other and of R1 and may be H, R2 or R3, in order to obtain one of the alkyl-ureas of formula (4), (5) or (6).

110 Substituted benzylurea derivatives and medicine containing the same EP97118069.0 1997-10-17 EP0839803B1 2002-04-03 Kanamaru, Yoshihiko; Hirota, Hiroyuki; Shibata, Akihiro; Komoto, Teruo; Naito, Hiroyuki; Tachibana, Koichi; Ohtsuka, Mari; Ishii, Fumio; Sato, Susumu
111 BENZOCYCLOALKENE COMPOUNDS WITH MELATONINE RECEPTOR BINDING AFFINITY, THEIR PRODUCTION AND USE EP96925086.9 1996-07-25 EP0848699B1 2001-10-24 OHKAWA, Shigenori; UCHIKAWA, Osamu; FUKATSU, Kohji; MIYAMOTO, Masaomi
A compound of formula (I) wherein R<1> and R<2> independently represent H or an optionally substituted hydrocarbon group; R<3> represents an optionally substituted hydrocarbon group: R<4> represents H or a hydrocarbon group; ring A represents a substituted benzene ring; X represents a C2-4 alkylene group etc.; and Y represents a bond or a lower alkylene group, or salts thereof is useful as prophylactic or therapeutic agents of diseases related with melatonin activity.
112 Carbodiimide und Verfahren zu deren Herstellung EP99104113.8 1999-03-02 EP0940389A3 2001-01-24 Kokel, Nicolas Dr.; Häberle, Karl Dr.; Kraus, Rupert Dr.

Bei einer Temperatur von 25°C feste Carbodiimide enthaltend Carbodiimidstrukturen sowie Urethan- und/oder Harnstoffstrukturen, wobei die Carbodiimidstrukturen an nicht-aromatische Kohlenwasserstoffatome gebunden sind.

113 ARYLOXYUREAS, PROCESS FOR THEIR PREPARATION, AND THEIR USE EP87903426.2 1987-05-26 EP0270683B1 1992-09-09 HASHIMOTO, Isao; ISHIDA, Tatsuyoshi; TSURU, Kazutaka; YAMADA, Yuji; MIYAZAWA, Takeshige; NAKAMURA, Yasuo
Novel aryloxyureas, process for their preparation, and herbicides containing them as effective ingredients. The aryloxyureas exhibit an excellent herbicidal effect when applied to weed over a wide range of stages of, for example, preemergence to growing. The aryloxyureas have an advantage that they exhibit the herbicidal effect with high safety for crops and crop plants.
114 Method of preparation of optically active alpha-amino-acids EP88105584.2 1988-04-08 EP0288795A3 1989-09-06 Di Gioacchino, Sandro; Paolinelli, Antonio; Re, Luciano

A new process of synthesis of optically active α-amino acids is described through nitrosation in a non-aqueous, aprotic system, of the corresponding N-carbamyl derivatives followed by decomposition of the thus obtained N-nitroso derivatives in aqueous acidic medium. The process, which is of a general applicabili­ty, leads to a remarkable increase in the reaction yields, due to the suppression of the main side reaction leading to the corresponding α-hydroxy-acid. Some N-nitroso intermediates, which can be recovered from the process of the invention, are also described.

115 Method of preparation of optically active alpha-amino-acids EP88105584.2 1988-04-08 EP0288795A2 1988-11-02 Di Gioacchino, Sandro; Paolinelli, Antonio; Re, Luciano

A new process of synthesis of optically active α-amino acids is described through nitrosation in a non-aqueous, aprotic system, of the corresponding N-carbamyl derivatives followed by decomposition of the thus obtained N-nitroso derivatives in aqueous acidic medium. The process, which is of a general applicabili­ty, leads to a remarkable increase in the reaction yields, due to the suppression of the main side reaction leading to the corresponding α-hydroxy-acid. Some N-nitroso intermediates, which can be recovered from the process of the invention, are also described.

116 Urées substituées, leur procédé de préparation et leur application notamment dans l'ennoblissement des fibres cellulosiques EP88400686.7 1988-03-22 EP0285500A1 1988-10-05 Wilhelm, Didier; Gelabert, Antonio; Blanc, Alain

Elles répondent à la formule : où R₁ et R₂ identiques représentent -CH₂R où R = H ou un alkyle en C₁-C₄, soit R₁ et R₂ forment ensemble un grou­pement -CH₂(CR₄R₄)n où n = 0 ou 1, R₄ = H ou -CH₃, R₃ = H ou -CH₂R₅ où R₅ = H ou un alkyle en C₁-C₄, soit A et A₁ identiques représentent H, soit A et A₁ forment en semble un radical éthylène, triméthylène, -CH(OCH₂R₆)- où R₆ = H ou un alkyle en C₁-C₄ ou, lorsque R₃ = H, un groupement dihydroxy-1,2-éthylène.

Leur procédé d'obtention consiste faire réagir un éthanal disubstitué avec une urée ANH-CO-NHA₁, réaction suivie éventuelle­ment d'une éthérification avec un alcool R₅CH₂OH.

117 Method for preparing formamidines US14433985 2013-10-11 US09663452B2 2017-05-30 Thibault Cantat; Jacky Pouessel; Olivier Jacquet
A method for preparing formamidines of formula (I) in a single step by reducing ureas of formula (II) using silanes of formula (III), according to reaction (II)+(III)+(I) is provided. The present invention also provides a method for preparing insecticides, pesticides, fungicides, pharmaceutical products and catalysts, including a step of preparing formamidines of formula (I) according to the invention.
118 Use of substituted ureas or urethanes for improvement of the use properties of mineral and synthetic nonaqueous industrial fluids US13783708 2013-03-04 US09458401B2 2016-10-04 Jan Strittmatter; Karl Haeberle; Wolfgang Grabarse; Ivette Garcia Castro; Markus Hansch; Irene Troetsch-Schaller; Stephan Schenk; Michael Schroers; Bernhard Lange
The use of substituted diureas, polyureas, bisurethanes or polyurethanes of the formula R1X—CO—NR3R4 in which X is R2N or O and R1 to R4 are each independently hydrogen, alkyl radicals, alkenyl radicals, cycloalkyl radicals, aryl radicals or arylalkyl radicals, where at least one variable must be a radical having at least 4 carbon atoms and where the urea or urethane functionality must be replicated via bridging members, for improvement of the use properties of mineral and synthetic nonaqueous industrial fluids.
119 Ionic liquids having uronium cations and a process for making same US13590655 2012-08-21 US08859813B2 2014-10-14 Nikolai (Myloka) Ignatyev; Urs Welz-Biermann; German Bissky; Helge Willner; Andriy Kucheryna
The present invention relates to salts having uronium cations and to a process for preparing same comprising alkylating urea C(O)(NR2)2 using an ester ARo.
120 Illudin Analogs Useful as Anticancer Agents US11997432 2006-08-03 US20080306147A1 2008-12-11 Trevor C. McMorris; Michael J. Kelner
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents.
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