子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | Their use in the treatment of aryl sulfonamides and analogues thereof, as well as neurodegenerative diseases | JP53621598 | 1998-02-10 | JP2001515470A | 2001-09-18 | ケルデニヒ，イエルク; シユーマツハー，ヨアヒム; シユプライヤー，ペーター; ド・ブリ，ジヤン−マリー−ビクトル; ドレツセル，ユルゲン; フエーリンガー，フエレナ; フランツ，ユルゲン; フリードル，アルノ; ホルフアト，エルフイン; マウラー，フランク; マツケ，ミヒヤエル; ミツテンドルフ，ヨアヒム; モールス，クラウス−ヘルムート; ヨルク，ラインハルト; ラダツ，ジークフリート; ロツク，ミヒヤエル−ハロルト |
| (57)【要約】 本発明は新規なアリールスルホンアミド及びそれらの類似体、それらの製造方法、並びに神経変性疾患の治療、特に神経変性疾患の予防及び治療、とりわけ脳卒中及び頭部外傷の治療におけるそれらの使用に関する。 | ||||||
| 102 | Retroviral protease inhibiting compounds | JP13368490 | 1990-05-23 | JP2963910B2 | 1999-10-18 | DEIRU JEI KENPU; DANIERU DABURYU NOOBETSUKU; JON DABURYU ERIKUSON; HIN REUN SHAMU; RIN EMU KODAKOBI; YAKOBU JEI PURATSUTONAA |
| 103 | Method of manufacturing a tertiary amino alcohol having a hydroxyl group at one end | JP30768191 | 1991-11-22 | JP2941524B2 | 1999-08-25 | SOTODANI KOSHIRO; ABE YUTAKA; FUKUSHIMA TETSURO |
| 104 | Catalytic production of n,n,n-trisubstituted nitrogen-containing compound | JP26699891 | 1991-09-19 | JPH04257549A | 1992-09-11 | SUTEIIBUN UEIN KINGU |
| PURPOSE: To contactually produce N,N,N-trisubstd. nitrogen-contg. compds. useful as solvents, liquid absorbers, polyurethane catalysts, acidic gas scrubbing agents, etc., from carboxylated N,N,N-trisubstd. nitrogen-contg. compds. CONSTITUTION: The N,N,N-trisubstd. nitrogen-contg. compds. are obtd. by bringing the carboxylated N,N,N-trisubstd. nitrogen-contg. compds., more preferably the compds. of formulas I to II (R, R 1, R 2 are the residues of org. compds., R may form a heterocyclic alkyl ring which may have a substituent by crosslinking with each other), for example, methyldiethanolamine carbamate, etc., into contact with multi component metal oxide catalysts contg. preferably group IIA metal oxide and group IIIA or group IIIB metal oxide, more preferably magnesium oxide and aluminum oxide and having a surface area preferably larger than about 50 m 2/gm under conditions effective for forming the N,N,N- trisubstd. nitrogen-contg. compds. COPYRIGHT: (C)1992,JPO | ||||||
| 105 | Preparation of nonionic surfactant | JP27442990 | 1990-10-12 | JPH04150935A | 1992-05-25 | NISHIZAKI KATSUICHI |
| PURPOSE: To prepare a nonionic surfactant even from oils and fats having no active hydrogen by mixing an amine compound having a plurality of active hydrogen atoms with natural oils and fats and reacting the resulting mixture with alkylene oxide. CONSTITUTION: Ammonia and an amine compound having two or more active hydrogen atoms such as a 2-30C oxyalkylamine compound are mixed with natural oils and fats such as palm oil or the like. When alkylene oxide is directly reacted with this mixture, an alkylene oxide adduct of natural oils and fats and an alkylene oxide adduct of the amine compound are simultaneously synthesized to become a liquid derivative having a specific mixed composition. Since the nonionic surfactant thus obtained has excellent characteristics, it is used as an emulsifier or a dispersant. COPYRIGHT: (C)1992,JPO&Japio | ||||||
| 106 | Retroviral protease inhibitor | JP13368490 | 1990-05-23 | JPH03128335A | 1991-05-31 | DEIRU JIEI KENPU; DANIERU DABURIYU NOOBETSUKU; JIYON DABURIYU ERIKUSON; HIN REUN SHIYAMU; RIN EMU KODAKOBI; YAKOBU JIEI PURATSUTONAA |
| NEW MATERIAL: A compound of formula I [X is CO, NOR 1, SO, SO 2, BOR 1, formulae II-XII (R 1 and R 2 are each H, lower alkyl, hydroxyalkyl or alkoxyalkyl), etc.; A and B are each substd. amino, substd. carbonyl, functionalized imino, functionalized alkyl, functionalized acyl, functionalized heterocycle or functionalized (heterocyclic) alkyl], or its salt, ester or prodrug. EXAMPLE: 2,4-Di-(N-((2-pyridinyl)methoxycarbonyl)-valinylamino)-1,5-diphenyl-3- hydroxypentane. USE: Useful for treatment of retroviral infection, especially HIV infection. PROCESS: For example, N-((2-pyridiny)methoxycarbonyl)-valine is coupled with 2,4-diamino-1,5-diphenyl-3-hydroxypentane to give the exemplified compound. COPYRIGHT: (C)1991,JPO | ||||||
| 107 | JPH034535B2 - | JP29611085 | 1985-12-25 | JPH034535B2 | 1991-01-23 | YOKOTA YUKINAGA; HASHIBA IKIZO; KAWAKAMI TAKAHIRO; TANIGUCHI HIDEKI |
| 108 | JPH0260661B2 - | JP9813281 | 1981-06-24 | JPH0260661B2 | 1990-12-17 | ANRI SEBAGU; GYUI BANRURUBURUGU |
| 109 | Production of aminoacetaldehyde dialkyl acetal | JP3015886 | 1986-02-13 | JPS62190151A | 1987-08-20 | TAISHIYA AKIRA; KAWABATA TAKEO; KAKIMOTO TAKEHIKO; HIRATA KAZUMASA |
| PURPOSE: The reaction of a halogenacetaldehyde dialkyl acetal with ammonia is carried out in an aqueous medium in the presence of an alkali metal hydroxide to readily obtain the titled compound which is used as an intermediate of medicines with reduced consumption of the starting materials without anxiety of facility corrosion. CONSTITUTION: The reaction of a halogenacetaldehyde dialkyl acetal with ammonia or an alkylamine is carried out in an aqueous medium in the presence of an alkalie or alkaline earth metal hydroxide, preferably sodium hydroxide, preferably using 4W20mol of ammonia or an alkylamine and 1.0W1.5mol of the alkali or alkaline earth metal hydroxide and 200W1,000ml of the aqueous medium per mole of the starting material to give the objective compound. The distillation is effected using an arbitrary column and the remaining ammonia or amine are removed before the distillation. COPYRIGHT: (C)1987,JPO&Japio | ||||||
| 110 | JPS6228776B2 - | JP8657977 | 1977-07-19 | JPS6228776B2 | 1987-06-23 | FURANSOWA MORUNARU; SEZANNU SUZABOO; PEETORU RADONO SUTATOKOFU |
| 111 | Surface active and statistically arranged novel oligomer | JP8866979 | 1979-07-12 | JPS5515477A | 1980-02-02 | GUI BANRURUBARUGU; ANRI SUBAGU |
| 112 | Phenoxy compound and its composition | JP8657977 | 1977-07-19 | JPS5312828A | 1978-02-04 | FURANSOWA MORUNARU; SEZANNU SUZABOO; PEETORU RADONOU SUTATOKOFU |
| 113 | PROCESSES AND COMPOUNDS | US17430248 | 2020-02-11 | US20220162233A1 | 2022-05-26 | Michael MARKEY |
| Useful processes of preparation and intermediates useful for the preparation of Compound 1, a selective estrogen receptor alpha (ERα) modulator/degrader (SERM/SERD), having utility for the treatment of ER+ cancers including breast cancer are described. | ||||||
| 114 | Hydroxy aliphatic substituted phenyl aminoalkyl ether derivatives | US14654661 | 2013-12-20 | US09624158B2 | 2017-04-18 | Josep R. Prous; Neus Serradell; Ramon Flores; Noemi Garcia-Delgado; Marcel-li Carbo Banus |
| New hydroxy aliphatic substituted phenyl aminoalkyi ether compounds of formula (I), compositions thereof and their use as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or mental disorders associated with cognitive deficits. | ||||||
| 115 | Cyclic compounds and methods of making and using the same | US14365148 | 2012-12-10 | US09469616B2 | 2016-10-18 | Yan Li; Hitesh Thaker; Gregory N. Tew; Dahui Liu; Wenxi Pan; Richard W Scott; Xiaodong Fan |
| The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative. | ||||||
| 116 | HYDROXY ALIPHATIC SUBSTITUTED PHENYL AMINOALKYL ETHER DERIVATIVES | US14654661 | 2013-12-20 | US20150344408A1 | 2015-12-03 | Josep R. PROUS; Neus SERRADELL; Ramon FLORES; Noemi GARCIA-DELGADO; Marcel-li CARBO BANUS |
| New hydroxy aliphatic substituted phenyl aminoalkyl ether compounds of formula (I), compositions thereof and their use as a medicament in the treatment of nervous system diseases and/or the treatment of developmental, behavioral and/or mental disorders associated with cognitive deficits. | ||||||
| 117 | Amine suitable as PU-catalyst | US14401953 | 2013-04-23 | US20150152213A1 | 2015-06-04 | Eugene P Wiltz, Jr.; Robert Allison Grigsby, Jr.; Jennifer Price; Jingjun Zhou |
| An amine according to the invention has a formula (CH3)2NCH2CH2OCH2CH2CH2N(R1)(R2) wherein R1 is selected from (CH3)2NCH2CH2OCH2CH2CH2— and R2 is selected from the group consisting of H—, CH3(CnH2n)—, HO(CmH2m)— and (CH3)2NCH2CH2OCH2CH2CH2—, n being an integer in the range of 0 to 5, m being an integer in the range of 2 to 4. | ||||||
| 118 | CYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | US14365148 | 2012-12-10 | US20150031738A1 | 2015-01-29 | Yan Li; Hitest Thaker; Gregory N. Tew; Dahui Liu; Wenxi Pan |
| The present invention provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative. | ||||||
| 119 | Plant activator | US13402947 | 2012-02-23 | US08741807B2 | 2014-06-03 | Tadao Asami; Masashi Hikosaka; Masaki Mori; Satoru Maeda; Fumio Matsuda; Kazuki Saito |
| A compound useful as a plant activator for activating an endogenous defense system of a plant to control disease damage is provided. A compound represented by the formula: (R3)NH—(CH2)4—N(R1)—(CH2)3—NH(R2) (one of R1 and R2 represents a linear C6-18 alkanoyl group or alkenoyl group, the other represents hydrogen atom or a protective group of amino group; and R3 represents hydrogen atom or a protective group of amino group). | ||||||
| 120 | ELECTROLYTE SOLUTION AND ELECTRIC ENERGY STORING DEVICE USING ELECTROLYTE SOLUTION | US13616387 | 2012-09-14 | US20130003259A1 | 2013-01-03 | Masaaki SASA; Tamotsu YAMAMOTO; Tsutomu TANAKA; Kensuke YOSHIDA |
| To provide an electrolyte solution, which contains an electrolyte compound, a molecular structure of which contains a molecular chain containing a repeating unit of alkylene oxide, and contains quaternary ammonium cations at both terminals of the molecular chain. | ||||||
QQ群二维码
意见反馈
意见反馈