子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | Amphiphilic nucleotide cochleate compositions and methods of using the same | US13370158 | 2012-02-09 | US08598138B2 | 2013-12-03 | Ruying Lu; Raphael J. Mannino |
| The present invention is directed to siRNA-cochleate compositions that include a siRNA that is associated with a cochleate and a positively charged amphiphile. The present invention also includes methods for making and using the compositions provided herein. | ||||||
| 82 | Crystal forms of O-desmethylvenlafaxine fumarate | US13074364 | 2011-03-29 | US08569371B2 | 2013-10-29 | Marina Ratkaj; Gustavo Frenkel |
| Provided are crystalline forms of O-desmethylvenlafaxine fumarate, methods for their preparation, and pharmaceutical composition thereof. | ||||||
| 83 | Alkynyl phenyl derivative compounds for treating ophthalmic diseases and disorders | US13197659 | 2011-08-03 | US08389771B2 | 2013-03-05 | Ian Leslie Scott; Vladimir Aleksandrovich Kuksa; Mark W. Orme; Thomas Little; Anna Gall; Jennifer Gage; Feng Hong |
| Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions. | ||||||
| 84 | Autocatalytic polyols | US12207745 | 2008-09-10 | US08367870B2 | 2013-02-05 | Juan Jesus Burdeniuc; Gamini Ananda Vedage |
| The present invention provides polymeric polyol compositions employing polyol compounds having multiple tertiary amine groups. Methods of making these compositions are also disclosed. Polyol formulations containing these polymeric polyol compositions and methods of making polyurethane gel and foam employing such polymeric polyol compositions are also provided. | ||||||
| 85 | Pharmaceutical composition | US10565239 | 2004-07-22 | US08034820B2 | 2011-10-11 | Hiroshi Kase; Minoru Kobayashi; Shizuo Shiozaki; Akihisa Mori; Naoki Seno |
| The present invention provides pharmaceutical compositions, which are useful for treatment of depression and the like, and which comprises a compound having an adenosine A2A receptor antagonistic activity such as (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione or a pharmaceutically acceptable salt thereof and an antidepressant drug (for example, a tricyclic antidepressant, a tetracyclic antidepressant, a selective serotonin reuptake inhibitor, a selective noradrenalin reuptake inhibitor, a dopamine reuptake inhibitor, a serotonin-noradrenalin reuptake inhibitor, a monoamine oxidase inhibitor, a 5-HT2 antagonist or the like), and the like. | ||||||
| 86 | Compounds Which Modulate The CB2 Receptor | US12293484 | 2007-04-02 | US20090275611A1 | 2009-11-05 | Doris Riether; David Smith Thomson; Lifen Wu; Renee M. Zindell |
| Compounds are provided which bind to and are agonist, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R1, R2, R3, X and Ar have the meanings given in the specification, and the preparation and use thereof. The compounds are valuable CB2 receptor modulators, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain. | ||||||
| 87 | Amine-functionalized polyisobutylenes for improved hydrophobizing microemulsions | US10946125 | 2004-09-21 | US07388033B2 | 2008-06-17 | Andras Nagy; Joseph P. Kennody; Lonn L. Swinehart |
| In one embodiment, the present invention relates to amine-functionalized polyisobutylenes. Methods for preparing the amine-functionalized polyisobutylenes are also described. Furthermore, the invention relates to microemulsion coating compositions comprising the amine-functionalized polyisobutylenes which can be applied to various surfaces, especially metallic vehicle surfaces, wherein the compositions form a protective barrier on the surface and improve the drying rate, protection and shine of the surface. The coating compositions have a long service life and withstand numerous washing cycles. Moreover, the coating compositions when applied to surfaces, hydrophobize the same and allow for easy removal of water by increasing the contact angle of water droplets and thus reducing the “footprint” thereof. | ||||||
| 88 | Fluorochemical urethane composition for treatment of fibrous substrates | US10352613 | 2003-01-28 | US20040147188A1 | 2004-07-29 | Mitchell T. Johnson; Larry A. Lien |
| The compositions comprise one or more fluorochemical urethane compounds and one or more silsesquioxane compounds. This fluorochemical urethane compound(s) comprises the reaction product of (a) one or more polyfunctional isocyanate compounds; (b) one or more fluorochemical monofunctional compounds; and optionally (c) one or more hydrophilic polyoxyalkylene compounds; and/or (d) one or more silane compounds. | ||||||
| 89 | Cationic polyurethane compositions, quaternary ammonium salts and methods for their preparation | US729046 | 1996-10-10 | US5696291A | 1997-12-09 | Ibrahim Bechara; Thomas R. Baranowski |
| The preparation and use of quarternized bis hydroxy alkyl amines by the reaction of a tertiary amine and an alkylene oxide in a strong acid system are disclosed. Cationic polyurethane compositions containing pendent hydroxy alkyl groups and methods for their preparation are also disclosed. | ||||||
| 90 | Process for the preparation of ortho-amides | US916922 | 1992-07-20 | US5326911A | 1994-07-05 | Heinz-Ulrich Blank; Helmut Kraus; Gerhard Marzolph; Nikolaus Muller |
| Ortho-amides of the formula ##STR1## can be prepared by reacting salts of the formula ##STR2## with alcoholates of the formulaM.sup.1 OR.sup.1 (III)where the radicals R.sup.1 to R.sup.4, M.sup.1 and X.sup..crclbar. have the meaning given in the description. The alcoholates are employed in highly active form with an effective content of 98-100% M.sup.1 OR.sup.1. | ||||||
| 91 | 4-substituted cyclohexylamine derivatives, fungicides containing these and a method of controlling fungi | US90761 | 1987-08-28 | US5032616A | 1991-07-16 | Hubert Sauter; Matthias Zipplies; Norbert Goetz; Eberhard Ammermann; Ernst-Heinrich Pommer |
| 4-trans-substituted cyclohexylamine derivatives of the formula ##STR1## where R.sup.1 is the group CR.sup.5 R.sup.6 R.sup.7, in which R.sup.5, R.sup.6 and R.sup.7 are hydrogen, unsubstituted or substituted alkyl, alkoxy, alkylthio or cycloalkyl, with the proviso that not more than one of the substituents R.sup.5, R.sup.6 and R.sup.7 may by hydrogen, or in which R.sup.6 and R.sup.7 together with the included carbon atom form a three-membered to six-membered carbocyclic aliphatic ring,R.sup.2 and R.sup.3 are hydrogen, alkyl, alkenyl or alkynyl or cycloalkyl or cycloalkenyl, which in turn may be substituted, with the proviso that the sum of the carbon atoms and hetero atoms (O, S and halogen) of R.sup.2 and R.sup.3 together is not less than 8,R.sup.4 is hydrogen, alkyl, cycloalkyl or alkoxy, and m is 1 to 4, and the bond is a single or a double bond,salts thereof, and their use as fungicides. | ||||||
| 92 | Insecticidal 5-pyrimidine carbonitriles | US41163 | 1987-04-22 | US4783468A | 1988-11-08 | Haukur Kristinsson; Odd Kristiansen |
| The invention relates to novel substituted 2,4-diamino-5-cyano-pyrimidines of formula ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.2 -C.sub.6 alkynyl,R.sub.2 is hydrogen, C.sub.1 -C.sub.10 alkyl or C.sub.3 -C.sub.6 cycloalkyl, orR.sub.1 and R.sub.2, when taken together, are a radical selected from the group consisting of--(CH.sub.2).sub.3 --,--(CH.sub.2).sub.4 and--(CH.sub.2).sub.5,R.sub.5 is hydrogen or a radical--CO--R.sub.5 or--SO.sub.2 --R.sub.6,R.sub.4 is a radical selected from the group consisting of --NH.sub.2,--NH--CO--R.sub.5,--NH--SO.sub.2 --R.sub.6, ##STR2## or --NH--CH.dbd.N--R.sub.10 ; R.sub.5 is hydrogen, C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.1 -C.sub.6 alkoxy, perhalogenated C.sub.1 -C.sub.3 alkyl or the radical ##STR3## R.sub.6 is C.sub.1 -C.sub.6 alkyl, R.sub.7 is hydrogen or C.sub.1 -C.sub.6 alkyl,R.sub.8 and R.sub.9 are each independently of the other hydrogen or C.sub.1 -C.sub.6 alkyl or, when taken together, are a radical selected from the group consisting of--(CH.sub.2).sub.3 --,--(CH.sub.2).sub.4 --and--(CH.sub.2).sub.5,R.sub.10 is a radical--SO.sub.2 --R.sub.13 or ##STR4## R.sub.11 and R.sub.12 are each independently of the other hydrogen or C.sub.1 -C.sub.6 -alkyl or, when taken together, are a radical selected from the group consisting of--(CH.sub.2).sub.3 --,--(CH.sub.2).sub.4 --and--(CH.sub.2).sub.5,R.sub.13 is C.sub.1 -C.sub.10 alkyl, C.sub.1 -C.sub.10 alkyl which is substituted by up to 10 halogen atoms, or is C.sub.3 -C.sub.6 cycloalkylR.sub.14 and R.sub.15 are each independently of the other C.sub.1 -C.sub.10 alkyl; andX and Y are each independently of the other oxygen or sulfur, and salts thereof, to the preparation and intermediates for the preparation thereof, and to compositions containing these compounds for controlling insects and representatives of the order Acarina, in particular plant-destructive feeding insects and ectoparasites that attack animals. | ||||||
| 93 | Method for producing high purity quaternary ammonium hydroxides | US884505 | 1986-07-11 | US4714530A | 1987-12-22 | Cecil H. Hale; Alan R. Tanner; Bryan M. Hale |
| A process is described for improving the purity of quaternary ammonium hydroxides. In one embodiment, the process of the present invention comprises the steps of(a) charging an aqueous solution containing the quaternary ammonium hydroxide to the anolyte compartment of an electrolysis cell which comprises an anolyte compartment and a catholyte compartment containing water separated from each other by a cation-exchange membrane,(b) passing a direct current through the electrolysis cell to produce a high purity quaternary ammonium hydroxide in the catholyte compartment, and(c) recovering the high purity quaternary ammonium hydroxide from the catholyte compartment.In a preferred embodiment, the aqueous solution containing the quaternary ammonium hydroxide charged to the anolyte compartment is heated to an elevated temperature for a given period of time prior to subjecting the quaternary ammonium hydroxide to the electrolytic process of the present invention.The process of the present invention results in the formation of quaternary ammonium hydroxide solutions containing significantly reduced amounts of halogen (both ionic and latent), carbonates and/or metals, and the solutions also are characterized by improved color. | ||||||
| 94 | 포스포디에스테라제 4 억제제 | KR1020037009624 | 2002-01-22 | KR100856622B1 | 2008-09-03 | 호퍼,알렌; 슈마허,리하르트,에이.; 테힘,아쇽; 드비보,마이클; 브루베이커,윌리암,프레데릭,주니어; 리우,루이핑; 헤스,한스-쥐르겐,에른스트; 운터벡,악셀 |
| PDE4 억제는 신규 화합물, 예를 들어 N-치환된 아닐린 및 디페닐아민 유사체에 의해 달성된다. 본 발명의 화합물은 화학식 Ⅰ의 화합물이고, 여기서 R 1 , R 2 , R 3 및 R 4 는 본원에 정의된 바와 같다. <화학식 Ⅰ> 포스포디에스테라제 4, 억제제, 아닐린, 디페닐아민 유사체, cAMP | ||||||
| 95 | 하이드로카빌 폴리옥시알킬렌 아미노알코올 및 이를함유한 연료조성물 | KR1020027006850 | 2000-11-30 | KR100648425B1 | 2006-11-24 | 토마스에프.데로사; 조세프엠.루소; 벤자민제이.카우프만; 제임스,알.캣참; 리차드,브이.케슬러; 프랭크,제이.데블러스 |
| 본 발명은 하기의 일반식으로 표시되는 하이드로카빌 폴리옥시알킬렌 아미노알코올 화합물, 및 이를 함유한 내연 엔진 연료조성물에 관한 것이다: 상기식에서, R 1 은 알킬, 4개 내지 30개의 탄소원자수를 갖는 알리시클릭 또는 알킬알리시클릭 라디칼, 또는 알킬기가 4개 내지 30개의 탄소원자수인 알킬아릴이고; x는 0 내지 5의 정수이고, y는 1 내지 49의 정수이고, z는 1 내지 49의 정수이고, x+y+z의 합이 3 내지 50이고; R 2 및 R 3 은 각각 상이하고, 1개 내지 4개의 탄소원자수를 갖는 알킬기이고, 각각의 옥시알킬렌 라디칼은 옥시알킬렌 유닛이 반복된 어떠한 조합도 가능하여서 불규칙 또는 블록 공중합체를 형성하고; R 4 는 R 2 또는 R 3 과 동일하고; R 5 는 수소 또는 , 여기서 R 7 은 수소 또는 1개 내지 5개의 탄소원자수를 갖는 알킬기이고; 및 R 6 은 수소 또는 1개 내지 5개의 탄소원자수를 갖는 알킬기이다. 하이드로카빌 폴리옥시알킬렌 아미노알코올, 연료 연소 침전 | ||||||
| 96 | 6-(4-페닐부톡시)헥실아민의 신규한 유도체 및 살메테롤의제조방법 | KR1020017003977 | 1999-09-20 | KR100479256B1 | 2005-03-30 | 베싸벨문트호르디; 달마세스바르호안페레; 마르키야스올론드리스프란시스코 |
| 본 발명은 화학식 I의 6-(4-페닐부톡시)헥실아민의 신규한 유도체 및 이의 제조방법에 관한 것이다. 화학식 I 위의 화학식 I에서, R 1 은 CHO 또는 CHOR 3 OR 4 [여기서, R 3 및 R 4 는 독립적으로 C 1 -C 6 알킬 또는 아르알킬이거나, R 3 과 R 4 는 5원 또는 6원 사이클릭 아세탈을 형성한다]이고, R 2 는 H, 벤질 그룹, 알킬옥시카보닐 그룹, 아릴옥시카보닐 그룹, 아르알킬옥시카보닐 그룹 또는 아실 그룹이다. 본 발명은 또한, 화학식 13의 유기 금속성 화합물을 저온에서 불활성 용매 속에서 R 1 이 CHO이고 R 2 가 알킬옥시카보닐 그룹, 아릴옥시카보닐 그룹, 아르알킬옥시카보닐 그룹 또는 아실 그룹인 화학식 I의 합성 중간체와 반응시킴을 특징으로 하는, 살메테롤 또는 약제학적으로 허용되는 이의 염의 신규한 제조방법에 관한 것이다. | ||||||
| 97 | 하이드로카빌 폴리옥시알킬렌 아미노알코올 및 이를함유한 연료조성물 | KR1020027006850 | 2000-11-30 | KR1020020071871A | 2002-09-13 | 토마스에프.데로사; 조세프엠.루소; 벤자민제이.카우프만; 제임스,알.캣참; 리차드,브이.케슬러; 프랭크,제이.데블러스 |
| 본발명은하기의일반식으로표시되는하이드로카빌폴리옥시알킬렌아미노알코올화합물, 및이를함유한내연엔진연료조성물에관한것이다: 상기식에서, R은알킬, 4개내지 30개의탄소원자수를갖는알리시클릭또는알킬알리시클릭라디칼, 또는알킬기가 4개내지 30개의탄소원자수인알킬아릴이고; x는 0 내지 5의정수이고, y는 1 내지 49의정수이고, z는 1 내지 49의정수이고, x+y+z의합이 3 내지 50이고; R및 R은각각상이하고, 1개내지 4개의탄소원자수를갖는알킬기이고, 각각의옥시알킬렌라디칼은옥시알킬렌유닛이반복된어떠한조합도가능하여서불규칙또는블록공중합체를형성하고; R는 R또는 R과동일하고; R는수소또는, 여기서 R은수소또는 1개내지 5개의탄소원자수를갖는알킬기이고; 및 R은수소또는 1개내지 5개의탄소원자수를갖는알킬기이다. | ||||||
| 98 | 아미노테트랄린 유도체, 이것의 조성물 및 사용방법 | KR1019980706779 | 1997-02-25 | KR1019990087369A | 1999-12-27 | 와라와에드워드존; 미글러버나드 |
| 본 발명은 하기 화학식 I의 화합물 또는 이것의 약학적으로 허용 가능한 산 첨가 염, 이들을 포함하는 약학 조성물 및 운동 장해의 치료 또는 예방에 이들을 사용하는 방법에 관한 것이다. 화학식 I 상기 식중에서, R 1 은 메틸 또는 에틸이고, R 2 는 수소, 할로겐, 저급 알콕시 또는 티오 저급 알킬이며, R 3 은 수소, 할로겐, 저급 알콕시 또는 저급 알킬이고, 및 키랄 중심 * 은 (S)(-) 형태이며, 단 R 2 과 R 3 이 둘다 수소일 때, R 1 은 메틸이어야 함을 조건으로 한다. | ||||||
| 99 | 방향족 디아민화합물 및 그 제조방법 | KR1019900016962 | 1990-10-23 | KR100079849B1 | 1994-11-29 | 야마구찌게이자브로오; 우라가미다쯔히로; 다나베요시미쯔; 야마자기미도리; 다마이쇼오지; 야마야노리마사; 오오다마사히로; 야마구찌아끼히로 |
| 100 | 6-치환된 안드로스타-1,4-디엔-3,17-디온 유도체의 제조 방법 | KR1019860006111 | 1986-07-26 | KR1019870002049A | 1987-03-28 | 프랑코파우스티니; 로베르토드'알레시오; 비토리아빌라; 에리코디살레; 파올로롬바르디 |
| 내용 없음. | ||||||
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