子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | FACILE LABORATORY METHOD FOR LOCALISING BIOMOLECULES TO THE SURFACE OF CELLS AND VIRUSES | PCT/NZ2012000156 | 2012-08-31 | WO2013081471A3 | 2014-05-08 | BOVIN NIKOLAI VLADIMIROVICH; HENRY STEPHEN MICHEAL; RODIONOV IGOR LEONIDOVICH |
| A facile method of localising sulfhydryl (-SH) group containing biomolecules, in particular peptides, to the membranes of living cells and enveloped viruses and a kit for use in a biological laboratory in accordance with the method. | ||||||
| 182 | A NOVEL STEREOSPECIFIC SYNTHESIS OF (-) (2S,3S)-1-DIMETHYLAMINO-3-(3-METHOXYPHENYL)-2-METHYL PENTAN-3-OL | PCT/IN2011/000054 | 2011-01-27 | WO2012101649A1 | 2012-08-02 | MOHAN RAO, Dodda; KRISHNA REDDY, Pingili; RAMCHANDRA REDDY, Pingili; HARITHA, KIrla; SRINIVAS, Kolluru |
The present invention relates to a novel stereospecific synthesis of (-) (2S,3S)-1-dimethylamino-3-(3-methoxyphenyl)-2-methyl pentan-3-ol an intermediate in the synthesis of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol. |
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| 183 | ALKYLAMINO ALKYLOXY (ALCOHOL) MONOALKYL ETHER FOR ACID GAS SCRUBBING PROCESS | PCT/US2006028686 | 2006-07-21 | WO2007021462A3 | 2007-04-12 | SISKIN MICHAEL; MOZELESKI EDMUND JOHN; FEDICH ROBERT BASIL; WANG FRANK CHENG-YU |
| An acid gas absorbent comprising an alkylamino alkyloxy (alcohol) monoalkyl ether and a process for the selective removal Of H2S from gaseous mixtures containing H2S and CO2 using an absorbent solution comprising an alkylamino alkyloxy alcohol monoalkyl ether. | ||||||
| 184 | ALKOXYLATED AMINE AND PROCESS THEREFOR | PCT/US2005/003123 | 2005-01-18 | WO2005070873A2 | 2005-08-04 | COATES, John, S.; LENGES, Christian, Peter |
A composition that can be used as a component in auto clear coat and primer is disclosed. The composition comprises or is an alkoxylated amine having the formula of (A)[N(R1H)2]p including an isomer or mixture of isomers thereof. Also disclosed is a process, which comprises contacting an amine with an epoxide under a condition sufficient to produce an alkoxylated amine. Further disclosed is a composition that can be used as coating composition and primer, which comprises an alkoxylated amine and an organic polyisocyanate. |
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| 185 | AMINO-PROPANOL DERIVATIVES | PCT/EP2004/006318 | 2004-06-11 | WO2004110979A2 | 2004-12-23 | EHRHARDT, Claus; HINTERDING, Klaus |
Compounds of formula (I) wherein A, R1, R2, R3, R4 and R5 as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them. |
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| 186 | MEDICINAL COMPOUNDS | PCT/EP2003/012038 | 2003-10-24 | WO2004037768A2 | 2004-05-06 | BOX, Philip, Charles |
The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases. |
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| 187 | NOVEL ANGIOTENSIN RECEPTOR MODULATORS AND THEIR USES | PCT/US9911805 | 1999-06-07 | WO9963930A8 | 2001-03-08 | MARQUESS DANIEL; THOMAS G ROGER; GRIFFIN JOHN H |
| This invention relates to novel multibinding compounds that bind to angiotensin (AT) receptors and modulate their activity. The compounds of this invention comprise 2-10 AT receptor ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of AT receptors. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to AT receptors. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by AT receptors. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention. | ||||||
| 188 | MULTIVALENT AGONISTS, PARTIAL AGONISTS, INVERSE AGONISTS AND ANTAGONISTS OF THE 5HT2 RECEPTORS | PCT/US9912782 | 1999-06-07 | WO9963996A8 | 2001-02-22 | HORGER BRIAN A; GRIFFIN JOHN H; NATARAJAN MAYA |
| Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists or antagonists of the 5HT2 receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist or antagonist of the 5HT2 receptors. The multibinding compounds of this invention are useful for the prophylaxis and treatment of various neurological disorders such as depression, anxiety, epilepsy, psychosis, schizophrenia, Alzheimer's disease, drug addiction, sleep and eating disorders, migraine and pain. | ||||||
| 189 | METHODS AND COMPOUNDS FOR TREATING DEPRESSION | PCT/US9915857 | 1999-07-12 | WO0002551A3 | 2000-09-21 | MUELLER ALAN; MOE SCOTT; BALANDRIN MANUEL |
| The present invention features compounds active at both the serotonin euptake site and the N-methyl-D-aspartate (NMDA) receptor and the use of such compounds for treating different disorders. Compounds having activity at the serotonin reuptake site and the NMDA receptor ("multi-active compounds") can be used to treat different types of disorders such as depression, obsessive-compulsive disorders (OCD), sleep disorders, sexual dysfunction, and eating disorders. Preferably, the multi-active compounds are used to treat depression. | ||||||
| 190 | NOVEL THERAPEUTIC AGENTS THAT MODULATE ENDOTHELIN RECEPTORS | PCT/US9912770 | 1999-06-08 | WO9963936A9 | 2000-08-10 | AXT SABINE; GRIFFIN JOHN H; MAMMEN MATHAI |
| Novel multi-binding compounds (agents) which bind endothelin receptors are used to treat disorders affecting the cardiovascular, renal, endocrine and nervous systems in mammals that are mediated by the endothelin receptors, such as congestive heart failure, pulmonary hypertension, cerebral vasospasm following subarachnoid hemorrhage, essential hypertension, myocardial infarction, myocardial ischemia, unstable angina, restenosis, renal failure of ischemic origin, portal hypertension, cardiac hypertrophy, atherosclerosis, eclampsia, cerebrovascular disease, vascular disease, migraines, and auto-immune diseases, such as Morbus Wegener and Morbus Raynaud, to name a few. The compounds of this invention comprise a plurality of ligands each of which can bind to such receptors thereby modulating the biological processes/functions thereof. Each of the ligands, which may be the same or different, is covalently attached to a linker or linkers which may be the same or different to provide for the multi-binding compound. The linker is selected such that the multi-binding compound so constructed demonstrates increased modulation of the biological processes mediated by the endothelin receptor than that provided by the ligands in monomeric form. The invention is also directed to pharmaceutical compositions comprising the multi-binding compounds, methods of inhibiting and treating the disorders mediated by endothelin receptors, and methods of preparing multi-binding compounds of the invention. | ||||||
| 191 | beta 2-ADRENERGIC RECEPTOR AGONISTS | PCT/US9911803 | 1999-06-07 | WO9964034A9 | 2000-06-29 | GRIFFIN JOHN H; MORAN EDMUND J; CHOI SEOK-KI |
| The present invention is directed to multibinding compounds which are beta 2 adrenergic receptor agonists and are therefore useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis, and the like. They are also useful in the treatment of nervous system injury and premature labor. | ||||||
| 192 | NOVEL ANALGESIC AGENTS | PCT/US9912673 | 1999-06-07 | WO9964038A9 | 2000-05-04 | JENKINS THOMAS E; NATARAJAN MAYA; GRIFFIN JOHN H |
| Novel multibinding compounds are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to an nAChR receptor, thereby modulating the biological processes/functions thereof. | ||||||
| 193 | MULTIVALENT AGONISTS, PARTIAL AGONISTS AND ANTAGONISTS OF THE GABA RECEPTORS | PCT/US9912730 | 1999-06-07 | WO9963933A9 | 2000-04-27 | BEATTIE DAVID T; GRIFFIN JOHN H; MORAN EDMUND J |
| Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists, partial inverse agonist or antagonists of the GABA receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist, partial inverse agonist or antagonist of the GABA receptors. The multibinding compounds of this invention are useful in the treatment of neurological disorders such as anxiety, depression, sleep and seizure disorders, emesis and overdoses of benzodiazepine-type drugs, and producing sedation, hypnosis, retrograde amnesia, and enhancing alertness and the like. | ||||||
| 194 | beta 3-ADRENERGIC RECEPTOR AGONISTS | PCT/US1999/012907 | 1999-06-08 | WO99064053A1 | 1999-12-16 | |
| The present invention is directed to multibinding compounds which are beta 3-adrenergic receptor agonists and are therefore useful in the treatment and prevention of metabolic disorders such as obesity, diabetes, and the like. | ||||||
| 195 | MULTIVALENT AGONISTS, PARTIAL AGONISTS AND ANTAGONISTS OF THE GABA RECEPTORS | PCT/US9912730 | 1999-06-07 | WO9963933A2 | 1999-12-16 | BEATTIE DAVID T; GRIFFIN JOHN H; MORAN EDMUND J |
| Disclosed are multibinding compounds which are agonists, partial agonists, inverse agonists, partial inverse agonist or antagonists of the GABA receptors, which are involved in neurological disorders. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is an agonist, partial agonist, inverse agonist, partial inverse agonist or antagonist of the GABA receptors. The multibinding compounds of this invention are useful in the treatment of neurological disorders such as anxiety, depression, sleep and seizure disorders, emesis and overdoses of benzodiazepine-type drugs, and producing sedation, hypnosis, retrograde amnesia, and enhancing alertness and the like. | ||||||
| 196 | NOVEL ANGIOTENSIN RECEPTOR MODULATORS AND THEIR USES | PCT/US9911805 | 1999-06-07 | WO9963930A2 | 1999-12-16 | MARQUESS DANIEL; THOMAS G ROGER; GRIFFIN JOHN H |
| This invention relates to novel multibinding compounds that bind to angiotensin (AT) receptors and modulate their activity. The compounds of this invention comprise 2-10 AT receptor ligands covalently connected by a linker or linkers, wherein the ligands in their monovalent (i.e., unlinked) state bind to one or more types of AT receptors. The manner of linking the ligands together is such that the multibinding agents thus formed demonstrate an increased biologic and/or therapeutic effect as compared to the same number of unlinked ligands made available for binding to AT receptors. The invention also relates to methods of using such compounds and to methods of preparing them. The compounds of this invention are particularly useful for treating diseases and conditions of mammals that are mediated by AT receptors. Accordingly, this invention also relates to pharmaceutical compositions comprising a pharmaceutically acceptable excipient and an effective amount of a compound of this invention. | ||||||
| 197 | HERBICIDAL FORMULATIONS COMPRISING GLYPHOSATE AND COTE-BASED ADJUVANTS | EP19729320.2 | 2019-06-13 | EP3806636A1 | 2021-04-21 | BEVINAKATTI, Hanamanthsa; ISLAM, Mojahedul |
| 198 | CATIONIC SURFACTANTS COMPRISING AN ETHER LINK | EP19731844.7 | 2019-05-30 | EP3802727A1 | 2021-04-14 | LALGUDI, Ramanathan S.; CAIN, Robert J.; VALLURI, Manoj Kumar |
| 199 | CYCLOBUTANE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED POTASSIUM CHANNELS | EP17748893.9 | 2017-07-28 | EP3490977A1 | 2019-06-05 | ALVARO, Giuseppe; MARASCO, Agostino; MARCONI, Guido |
| 200 | BLOWING CATALYST | EP11784707.9 | 2011-11-22 | EP2646489B1 | 2018-07-04 | GASPAR, Zsolt; HUMBERT, Heiko, Heinrich; FELBER, Gabor; GASPAR, Attila; GRIGSBY, Robert, Allison, Jr.; KORDAS, Imre; VANDERSTRAETEN, Petra, Emma |
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