Process for the preparation of 5-hydroxy-l-tryptophan专利检索-色氨酸生物化学专利检索查询-专利查询网

Process for the preparation of 5-hydroxy-l-tryptophan

阅读：554发布：2023-10-29

专利汇可以提供Process for the preparation of 5-hydroxy-l-tryptophan专利检索，专利查询，专利分析的服务。并且A process for the preparation of 5-hydroxy-L-tryptophan, comprising microbiologically hydroxylating a substrate selected from the group consisting of L-tryptophan, D,L-tryptophan and omega -N-acyl-L-tryptophan with a human-nonpathogenic microorganism selected from the group consisting of the families micrococcaceae, pseudomonadaceae, corynebacteriaceae, and bacillaceae, especially the specie Bacillus subtilis ATCC No. 21733.，下面是Process for the preparation of 5-hydroxy-l-tryptophan专利的具体信息内容。

权利要求

2. A process as defined by claim 1, wherein the hydroxylation is conducted in a fermentation broth containing Fe ion.

3. A process as defined by claim 2, wherein the hydroxylation is conducTed in a fermentation broth containing ascorbic acid.

4. A process as defined by claim 1, wherein the hydroxylation is conducted in a fermentation broth containing ascorbic acid.

5. A process according to claim 1, wherein the substrate is added to a fermentation broth toward the end of the main growth period of the microorganism.

6. A process for the preparation of 5-hydroxy-L-tryptophan, comprising microbiologically hydroxylating a substrate selected from the group consisting of L-tryptophan, D,L-tryptophan and omega -N-acyl-L-tryptophan with a microorganism of the species Bacillus subtilis ATCC No. 21733, Sarcina lutea, Micrococcus lysodeikticus, Protaminobacter alboflavus, Pseudomonas facilis, Corynebacterium hoagii, or Escherichia coli, said hydroxylating being conducted in a fermentation broth containing a member selected from the group consisting of Fe ion, ascorbic acid and mixtures thereof.

7. A process as defined by claim 6, wherein the hydroxylation is conducted in a fermentation broth containing Fe ion.

8. A process as defined by claim 7, wherein the hydroxylation is conducted in a fermentation broth containing ascorbic acid.

9. A process as defined by claim 6, wherein the hydroxylation is conducted in a fermentation broth containing ascorbic acid.

10. A process according to claim 6, wherein the substrate is added to a fermentation broth toward the end of the main growth period of the microorganism.

11. A process for the preparation of 5-hydroxy-L-tryptophan, comprising microbiologically hydroxylating a substrate selected from the group consisting of L-tryptophan, D,L-tryptophan and omega -N-acyl-L-tryptophan with a microorganism of the species Bacillus subtilis ATCC No. 21733, Sarcina lutea, Micrococcus lysodeikticus, Protaminobacter alboflavus, Pseudomonas facilis, Corynebacterium hoagii, or Escherichia coli, said substrate being added to a fermentation broth toward the end of the main growth period.

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Process for the preparation of 5-hydroxy-l-tryptophan

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