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Pharmaceutical method and compositions employing substituted chromanone oximes and chromanone oxime ethers

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专利汇可以提供Pharmaceutical method and compositions employing substituted chromanone oximes and chromanone oxime ethers专利检索,专利查询,专利分析的服务。并且This disclosure teaches the preparation of chromanone oximes, such as, 7,8-dichloro-4-chormanone oxime and their use as diuretics in warm-blooded mammals.,下面是Pharmaceutical method and compositions employing substituted chromanone oximes and chromanone oxime ethers专利的具体信息内容。

  • 2. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of a compound of the formula where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen; and X is bromine or chlorine.
  • 3. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of a compound of the formula where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine and chlorine, with the limitation that at last one of R1 and R2 must be hydrogen.
  • 4. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of a compound of the formula where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine, and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen.
  • 5. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of 7-chloro-6-fluoro-4-chromanone oxime.
  • 6. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of 7-chloro-6-fluoro-4-chromanone oxime methyl ether.
  • 7. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of 7-chloro-8-fluoro-4-chromanone oxime.
  • 8. A method of producing a diuretic effect in mammals comprising administering to said mammal a diuretically effective amount of 7-chloro-8-fluoro-4-chromanone oxime methyl ether.
  • 9. A pharmaceutical composition containing from 1 percent to 99.98 percent by weight of a pharmaceutical carrier in combination with from 0.02 percent to 99 percent by weight of a diuretic compound of the formula where R is hydrogen or methyl; R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen; and X is bromine or chlorine.
  • 10. The pharmaceutical composition of claim 9 in which the active ingredient is a compound of the formula: where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen; and X is bromine or chlorine.
  • 11. The pharmaceutical composition of claim 9 in which the active ingredient is a compound of the formula: where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen.
  • 12. The pharmaceutical composition of claim 9 in which the active ingredient is a compound of the formula: where R1 and R2 can be the same or different and are each selected from the group consisting of hydrogen, bromine, fluorine, and chlorine, with the limitation that at least one of R1 and R2 must be hydrogen.
  • 13. The pharmaceutical composition of claim 9 in which the active ingredient is 7-chloro-6-fluoro-4-chromanone oxime.
  • 14. The pharmaceutical composition of claim 9 in which the active ingredient is 7-chloro-6-fluoro-4-chromanone oxime methyl ether.
  • 15. The pharmaceutical composition of claim 9 in which the active ingredient is 7-chloro-8-fluoro-4-chromanone oxime.
  • 16. The pharmaceutical composition of claim 9 in which the active ingredient is 7-chloro-8-fluoro-4-chromanone oxime methyl ether.
  • 17. The unit pharmaceutical dosage form of the composition of claim q selected from the group consisting of a capsule and a tablet.
  • 18. The unit pharmaceutical dosage form of the composition of claim 9 selected from the group consisting of a syrup and a suspension.
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