Complexes of tetracycline antibiotics and preparation of same
阅读：154发布：2022-10-12
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1. A COMPLEX OF A TETRACYCLINE ANTIBIOTIC SELECTED FROM THE GROUP CONSISTING OF CHLORTETRACYCLINE, OXYTETRACYCLINE, AND TETRACYCLINE; ALUMINUM; A CATION SELECTED FROM THE GROUP CONSISTING OF THE CATIONS OF HYDROGEN, ANTIMONY, CADMIUM, CALCIUM, CHROMIUM, COBALT, COPPER GOLD, IRON MANGANESES, NICKEL, SELENIUM, SILVER, STRONTIUM, TIN AND ZINC AND A NON-TOXIC ALPHA-HYDROXY CARBOXYLIC ACID SELECTED FROM THE GROUP CONSISTING OF CITRIC ACID, GLUCONIC AND TARTARIC ACID IN THE RATIO OF THE ANTIBIOTIC TO ALUMINUM TO ACID OF NOT LESS THAN 1:1:1 AND NOT GREATER THAN 1:8:24.
5. THE COMPLEX CHLORTETRACYCLINE ALUMINUM LACTOBIONATE.
7. A PROCESS OF PREPARING IN AQUEOUS SOLUTION A COMPLEX OF A TETRACYCLINE ANTIBIOTIC SELECTED FROM THE GROUP CONSISTING OF CHLORTETRACYCLINE, OXYTETRACYCLINE, AND TETRACYCLINE; ALUMINUM; A CATION SELECTED FROM THE GROUP CONSISTING OF THE CATIONS OF HYDROGEN, ANTIMONY, CADMIUM, CALCIUM, CHROMIUM, COBALT, COPPER, GOLD, IRON, MANGANESE, NICKEL, SELENIUM SILVER, STRONTIUM, TIN, AND ZINC; AND A NON-TOXIC ALPHA-HYDROXY CARBOXYLIC ACID SELECTED FROM THE GROUP CONSISTING OF CITRIC ACID GLUCONIC ACID, GLYCOLLIC ACID, LACTIC ACID, LACTOBIONIC ACID, MALIC ACID AND TARTARIC ACID IN THE RATIO OF NOT LESS THAN 1:1:1:1 AND NOT GREATER THAN 1:8:10:24, AND THE MOLAR RATIO OF SAID ACID TO ALUMINUM IS GREATER THAN 1:1; COMPRISING REACTING THE ALUMINUM SALT OF THE CORRESPONDING NON-TOXIC ALPHA-HYDROXY CARBOXYLIC ACID, THE CORRESPONDING TETRACYCLINE ANTIBIOTIC SELECTED FROM THE GROUP CONSISTING OF THE FREE BASE AND THE WATER SOLUBLE NON-TOXIC SALTS THEREOF, AND WHERE THE CATION IS NOT HYDROGEN, A MEMBER OF THE GROUP CONSISTING OF THE WATER SOLUBLE NON-TOXIC SALTS CORRESPONDING TO SAID CATION, AND THE HYDROXIDES THEREOF; WITHIN THE NAMED MOLAR RATIOS; THEREBY FORMING SAID COMPLEX.
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