| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Novel radiationnphotosensitive compound and radiationnphotosensitive compositions containing same | JP8246978 | 1978-07-06 | JPS5414974A | 1979-02-03 | KONSUTANCHIN KURISU PETOROPOOR; JIYOOJI AASAA REINORUZU; JIEEMUSU ARUBAATO BANARAN |
| 182 | 신규 히드록시 피라논 화합물, 이의 제조방법 및 이를 포함하는 화장료 조성물 | KR1020150169638 | 2015-12-01 | KR1020170064198A | 2017-06-09 | 노호식; 유재원; 김용진 |
| 본발명은신규한히드록시피라논화합물, 이의제조방법및 이를포함하는화장료조성물에관한것이다. 본발명에따른히드록시피라논화합물은기존의지방세포분화촉진물질대비현저히개선된효과를나타내므로, 피부볼륨또는탄력증진을위한화장료조성물의유효성분으로바람직하게함유된다. | ||||||
| 183 | 광전 변환 소자 및 그것을 사용한 촬상 소자 | KR1020157030634 | 2014-03-28 | KR1020150136511A | 2015-12-07 | 사와키다이고 |
| (과제) 응답속도, 캐리어수송성 (감도), 내열성이양호한유기광전변환소자및 그것을구비한촬상소자를제공한다. (해결수단) 유기광전변환소자 (1) 는, 정공포집전극 (20) 과전자포집전극 (40) 에협지된적어도광전변환층 (32) 을포함하는수광층 (30) 을갖고, 정공포집전극 (20) 과광전변환층 (32) 사이에전자블로킹층 (31) 을구비하고, 광전변환층 (32) 이, n 형유기반도체와 p 형유기반도체의벌크헤테로층인제 1 광전변환층 (32b) 과, 제 1 광전변환층 (32b) 의정공포집전극 (20) 측의표면에접하여형성되어이루어지는제 2 광전변환층 (32a) 으로이루어지고, 제 2 광전변환층 (32a) 의 p 형유기반도체에대한 n 형유기반도체의혼합비율의평균치 (X2) 가, 제 1 광전변환층 (32b) 과제 2 광전변환층 (32a) 으로이루어지는광전변환층의상기평균치 (X1) 보다높아져있다. | ||||||
| 184 | 신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 항균 조성물 | KR1020090068834 | 2009-07-28 | KR1020110011271A | 2011-02-08 | 신계정; 노은주; 정민경; 차현주; 서선희 |
| PURPOSE: A novel 3-phenoxy-4-pyrone, 3-penoxy-4-pyridone or 4-pyridoen derivative and an antibacterial composition are provided to effectively suppress enoyl-ACP reductase(Fabl). CONSTITUTION: A novel 3-penoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative is denoted by chemical formula 1. A method for preparing the novel 3-phenoxy-4-pyrone derivative of chemical formula 1 comprises: a step of performing Ullmann reaction of kojic acid compound of chemical formula 4 to obtain a compound of chemical formula 5; a step of substituting the compound of chemical formula 5 with a chloride group to prepare a compound of chemical formula 6; a step of performing Arbuzov reation of the compound of chemical formula 6 to obtain a compound of chemical formula 7; and a step of performing Horner-Emmons reaction of compound of chemical formula 7 to introduce a double bond structure to prepare a compound of chemical formula 1a. An antibacterial composition contains the novel 3-phenoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative or pharmaceutically acceptable salt thereof as an active ingredient. | ||||||
| 185 | 세린 프로테아제 억제제 | KR1020027016932 | 2001-06-12 | KR100634936B1 | 2006-10-17 | 리에베슈에츠,존,월터; 머레이,크리스토퍼,윌리암; 영,스테판,클린턴; 캠프,니콜라스,폴; 존스,스튜어트,도날드; 윌리,윌리암,알렉산더; 매스터스,존,죠셉; 윌리,마이클,로버트; 쉬한,스코트,마틴; 엔겔,데이비드,비렌바움; 왓슨,브라이언,모간; 구조,피터,로버트; 메이어,마이클,존 |
| A process for the preparation of compounds of formula (I) <CHEM> in which R2, X, Y, Cy, L and Lp(D)n have the meanings given in the specification, which are inhibitors of the serine protease, Factor Xa and are useful in the treatment of cardiovascular disorders, and intermediates useful in the preparation of the compounds. | ||||||
| 186 | 세린 프로테아제 억제제 | KR1020027016932 | 2001-06-12 | KR1020030008154A | 2003-01-24 | 리에베슈에츠,존,월터; 머레이,크리스토퍼,윌리암; 영,스테판,클린턴; 캠프,니콜라스,폴; 존스,스튜어트,도날드; 윌리,윌리암,알렉산더; 매스터스,존,죠셉; 윌리,마이클,로버트; 쉬한,스코트,마틴; 엔겔,데이비드,비렌바움; 왓슨,브라이언,모간; 구조,피터,로버트; 메이어,마이클,존 |
| 하기 화학식 I의 화합물은 세린 프로테아제, 제Xa인자의 억제제이고, 심혈관 장애의 치료에 유용하다. <화학식 I> 상기 식에서, R 2 , X, Y, C y , L 및 L p (D) n 은 본원 명세서에 나타낸 의미를 갖는다. | ||||||
| 187 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | PCT/ZA2016050042 | 2016-10-22 | WO2017070719A3 | 2017-08-03 | GUMEDE NJABULO JOYFULL |
| The invention provides pharmacophores for use in the design, screening and identification of inhibitors of CYP17A1 and CYP19A1 enzymes. A preferred pharmacophore has a spatial arrangement of atoms as shown in the accompanying Figure 1, wherein: • A represents hydrogen bond acceptors; • D represents hydrogen bond donors; and • R represents aromatic rings. Compounds conforming to the preferred pharmacophore are provided for use as medicaments in the treatment of cancer, especially prostate cancer and breast cancer. By way of example, these compounds include N-(4-ethylphenyl)-5-(2-hydroxy-5-methoxybenzoyl)-2-imino-2H-pyran-3-carboxamide and 2-(4-sulfamoylphenoxy) ethyl 2-amino-3-methylbenzoate. Also provided are methods for the treatment of prostate cancer and breast cancer using the compounds of the invention as well as their salts, solvates, hydrates, primary metabolites and prodrugs. Methods of inhibiting CYP17A1 and CYP19A1, and hence of inhibiting androgen activity in a subject, are disclosed. The invention also provides processes for designing, screening and identifying compounds which can inhibit CYP17A1 and CYP19A1. | ||||||
| 188 | PHARMACOPHORES, COMPOUNDS AND METHODS HAVING APPLICATION IN THE TREATMENT OF CANCER THROUGH INHIBITION OF CYP17A1 AND CYP19A1 | PCT/ZA2016050041 | 2016-10-22 | WO2017070718A4 | 2017-06-15 | GUMEDE NJABULO JOYFULL |
| The invention provides compounds for use as medicaments, which act by inhibiting CYP17A1 and CYP19A1 enzymes. The compounds have particular application in the treatment of cancer especially prostate cancer and breast cancer. The compounds have the formula: [Chem. 1] wherein: R is independently selected from the group consisting of optionally substituted arylamide; optionally substituted alkylarylamide; optionally substituted aryl carboxamide; optionally substituted cyanopiperidine; optionally substituted oxopiperidine; optionally substituted N-(pyridin-3-yl); optionally substituted pyridin-3-yl; optionally substituted pyrazole-4-carboxamide; optionally substituted pyrimidin-4-ylcarboxamide; optionally substituted pyrimidin-4-ylcarboxamide; optionally substituted 1H-pyrrol-2-ylcarboxamide; optionally substituted morpholin carboxamide; optionally substituted 1H-indazol-3-ylcarboxamide; optionally substituted 5-cyanopiperidin-3-ylcarboxamide; optionally substituted quinolin-7-yl; optionally substituted pyrazin-2-ylcarboxamide; optionally substituted 1H-1,3-benzodiazole-6-carboxamide; and optionally substituted 3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-ylcarboxamide; Each R1, R2, R3, R4, R5 is independently selected from the group consisting of H; OH; a halogen atom; OCH3; and NH2; and X is independently selected from the group consisting of O, H and OH. Some of the compounds are claimed per se and the invention also encompasses pharmaceutically acceptable salts, solvates, hydrates, primary metabolites and prodrugs thereof. | ||||||
| 189 | NOVEL 3-PHENOXY-4-PYRONE, 3-PHENOXY-4-PYRIDONE, OR 4-PYRIDONE DERIVATIVES, METHOD FOR PREPARING SAME, AND ANTIMICROBIAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT | PCT/KR2010004966 | 2010-07-28 | WO2011014008A2 | 2011-02-03 | SHIN KYE JUNG; ROH EUN JOO; CHUNG MIN KYUNG; CHA HYUN JU; SEO SEON HEE |
| The present invention relates to novel 3-phenoxy-4-pyrone, 3-phenoxy-4-pyridone, or 4-pyridone derivatives, or to pharmaceutically acceptable salts thereof, to a method for preparing same, and to an antibacterial composition containing same as an active ingredient. The composition containing the novel 3-phenoxy-4-pyrone, 3-phenoxy-4-pyridone, or 4-pyridone derivatives according to the present invention effectively inhibits enoyl-ACP reductase (RabI), which serves as a bacterial fatty acid biosynthesis enzyme, and thus can be effectively used as an antibacterial agent. | ||||||
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