| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | 5-amino-4-methoxyisoxazoles and 3-amino-4-methoxyisoxazoles | US3706761D | 1970-08-06 | US3706761A | 1972-12-19 | ALBRECHT HARRY ALLEN; PLATI JOHN THOMAS |
| 5-AMINO-4-METHOXY-3-ALKYLISOXAZOLES AND 3-AMINO-4METHOXY-5-ALKYLISOXAZOLES, INTERMEDIATES FOR THE PREPARATION OF ANTIBACTERIAL N1-(4-METHOXY-3-ALKYL-5-ISOXAZOLYL)SULFANILAMIDES AND N1-(4-METHOXY-5-ALKYL-3-ISOXAZOLYL)SULFANILAMIDES, RESPECTIVELY, ARE PREPARED AND DESCRIBED.
|
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| 162 | 3-hydroxyisoxazole derivatives | US3687968D | 1970-03-05 | US3687968A | 1972-08-29 | IWAI ISSEI; KISHIDA YUKICHI; HIRAOKA TETSUO; NAKAMURA NORIO |
| A process for preparing a compound having the formula WHEREIN R represents hydrogen; alkyl; unsubstituted or substituted phenyl; or dialkoxymethyl of from one to five carbon atoms in each alkoxy moiety, which comprises reacting a compound having the formula
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| 163 | Isoxazole fungicidal compositions and methods of use | US3629430D | 1969-02-10 | US3629430A | 1971-12-21 | TAKAHI YUKIYOSHI; TOMITA KAZUO; OKA HIDEHIKO |
| AGRICULTURAL FUNGICIDAL COMPOSITIONS WHICH COMPRISE A FUNGICIDALLY EFFECTIVE AMOUNT OF AN ISOXAZOLE DERIVATIVE HAVING THE FORMULA
3-(R3-COO-),4-R1,5-R2-ISOXAZOLE WHEREIN R1 IS HYDROGEN ATOM, A HALOGEN ATOM OR AN ALKYL GROUP OF 1 TO 3 CARBON ATOMS; R2 IS HYDROGEN ATOM OR AN ALKYL GROUP OF 1 TO 3 CARBON ATOMS; AND R3 IS AN ALKOXY GROUP OF 1 TO 5 CARBON ATOMS OR AN ARYL GROUP WHICH CONTAINS 6 TO 10 CARBON ATOMS, THE HYDROGEN ATOM ON ONE OF MORE RING CARBONS OF WHICH MAY BE SUBSTITUTED WITH ALKYL OF 1 TO 5 CARBON ATOMS, ALKOXY OF 1 TO 3 CARBON ATOMS, NITRO, HALOGEN OR METHYLENEDIOXY, AND AN AGRICULTURALLY-ACCEPTABLE CARRIER. THE PRESENT FUNGICIDAL COMPOSITION CAN BE UTILIZED FOR COMBATTING A WIDE RANGE OF PATHOGENIC FUNGI CAUSING PLANT DISEASES, ESPECIALLY THOSE CAUSED BY VARIOUS PATHOGENIC FUNGI BELONGING TO THE GENERA FUSARIUM, PYTHIUM, RHIZOCTONIA, PHYTOPHTHORA AND THE LIKE. |
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| 164 | Preparation of 3-hydroxyisoxazole compounds | US3607880D | 1970-02-09 | US3607880A | 1971-09-21 | TOMITA KAZUO |
| In a process for preparing a 3-hydroxyisoxazole of the formula
D R A W I N G WHEREIN R is hydrogen or alkyl of 1 to 5 carbon atoms and wherein a compound of the formula R-C C-COOR'' wherein R is as defined and R'' is alkyl of 1 to 5 carbon atoms is reacted with hydroxylamine, the invention proposes that the reaction is conducted in the presence of an alkaline earth metal hydroxide in an amount of 0.5 to 1.5 moles per mole of free hydroxylamine base. |
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| 165 | Certain 5-alkyl-3-hydroxyisoxazoles | US3544584D | 1968-10-01 | US3544584A | 1970-12-01 | IWAI ISSEI; KISHIDA YUKICHI; HIRAOKA TETSUO; NAKAMURA NORIO |
| A process for preparing a compound having the formula WHEREIN R represents hydrogen; alkyl; unsubstituted or substituted phenyl; or dialkoxymethyl of from one to five carbon atoms in each alkoxy moiety, which comprises reacting a compound having the formula R - C 3BOND C - COOR'wherein R is as defined above and R' represents alkyl of from one to five carbon atoms with hydroxylamine in the presence of an alkali metal hydroxide, the alkali metal hydroxide being used in an amount sufficient to maintain the reaction medium at an alkaline pH range. | ||||||
| 166 | Substituted 3, 5-dioxo-isoxazolidines and a process for the manufacture thereof | US82331559 | 1959-06-29 | US3007936A | 1961-11-07 | MAX MATTER; HANNI GERBER |
| 167 | Process for the production of symmetrical and unsymmetrical azo compounds | US69603357 | 1957-11-13 | US2950273A | 1960-08-23 | WILLIBALD PELZ |
| 168 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS | PCT/IN2011000749 | 2011-10-31 | WO2012056478A8 | 2012-06-14 | IRLAPATI NAGESWARA RAO; DESHMUKH GOKUL KERUJI; KARCHE VIJAY PANDURANG; JACHAK SANTOSH MADHUKAR; SINHA NEELIMA; PALLE VENKATA P; KAMBOJ RAJENDER KUMAR |
| The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I). | ||||||
| 169 | COMPOUNDS, COMPOSITIONS AND METHODS FOR MODULATING URIC ACID LEVELS | PCT/US2010035573 | 2010-05-20 | WO2010135530A3 | 2011-05-19 | DE LA ROSA MARTHA; GIRARDET JEAN-LUC |
| Described herein are compounds useful in the reduction of blood uric acid levels, formulations containing them and methods of making and using them. In some embodiments, the compounds described herein are used in the treatment or prevention of disorders related to aberrant levels of uric acid. | ||||||
| 170 | NON-LINEAR OPTICALLY ACTIVE MOLECULES, THEIR SYNTHESIS, AND USE | PCT/US2005014418 | 2005-04-28 | WO2005119315A3 | 2006-09-28 | MCGINNISS VINCENT D; RISSER STEVEN M; DROTLEFF ELIZABETH; JIANG EDWARD; SPAHR KEVIN |
| In one aspect, the present invention provides a hyperpolarizable organic chromophore. The chromophore is a nonlinear optically active compound that includes a p-donor conjugated to a p-acceptor through a p-electron conjugated bridge. In other aspects of the invention, donor structures and acceptor structures are provided. In another aspect of the invention, a chromophore containing polymer is provided. In one embodiment, the chromophore is physically incorporated into the polymer to provide a composite. In another embodiment, the chromophore is covalently bonded to the polymer, either as a side chain polymer or through crosslinking into the polymer. In other aspects, the present invention also provides a method for making the chromophore, a method for making the chromophore-containing polymer, and methods for using the chromophore and chromophore-containing polymer. | ||||||
| 171 | KETONE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | PCT/US0131872 | 2001-10-11 | WO0230860A9 | 2003-02-20 | DASSEUX JEAN-LOUIS H; ONICIU CARMEN DANIELA |
| The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents. | ||||||
| 172 | Arthropodical and fungicidal cyclic amides | PCT/US9712809 | 1997-07-24 | WO9805652A3 | 1998-06-11 | BROWN RICHARD JAMES; CHAN DOMINIC MING-TAK; CLARK DAVID ALAN; DRUMM JOSEPH EUGENE III; KOETHER GERARD MICHAEL; MCCANN STEPHEN FREDERICK; RORER MORRIS PADGETT; SELBY THOMAS PAUL; WALKER MICHAEL PAUL |
| Compounds of Formula (I), and their N-oxides and agriculturally suitable salts, are disclosed which are useful as fungicides and arthropodicides, wherein A is O; S; N; NR?5; or CR14¿; G is C or N; provided that when G is C, then A is O, S or NR5 and the floating double bond is attached to G; and when G is N, then A is N or CR14 and the floating double bond is attached to A; W is O; S; NH; N(C¿1?-C6alkyl); or NO(C1-C6alkyl); X is OR?1¿; S(O)¿mR?1; or halogen; R1 is C1-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; or C2-C4alkoxycarbonyl; R2 is H; C¿1?-C6alkyl; C1-C6haloalkyl; C2-C6alkenyl; C2-C6haloalkenyl; C2-C6alkynyl; C2-C6haloalkynyl; C3-C6cycloalkyl; C2-C4alkylcarbonyl; C2-C4alkoxycarbonyl; hydroxy; C1-C2alkoxy; or acetyloxy; m is 0, 1 or 2; and E, R?5¿, Y, Z and R14 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling plant diseases caused by fungal plant pathogens which involves applying an effective amount of a compound of Formula (I). Also disclosed are compositions containing the compounds of Formula (I) and a method for controlling arthropods which involves contacting the arthropods or their environment with an effective amount of a compound of formula (I). | ||||||
| 173 | 리신 진지파인의 케톤 억제제 | KR20197010797 | 2017-09-15 | KR102780603B1 | 2025-03-12 | 콘라디, 안드레이 더블유.; 갈렘모, 로버트 에이., 주니어; 도미니, 스티븐 에스.; 린치, 케이시 씨.; 홀싱어, 레슬리 제이. |
| 본발명은본원에기술된바와같은화학식 (I)에따른화합물, 및박테리아포르피로모나스진지발리스로부터의리신진지파인프로테아제(Kgp)을억제하는이들의용도에관한것이다. 또한, 진지파인활성프로브화합물이기술되며, 진지파인활성을검정하는방법또한기재되어있으며, 뿐만아니라알츠하이머병과같은뇌 장애를포함하는 P. 진지발리스감염과관련된장애의치료를위한방법이기술되어있다. | ||||||
| 174 | 살충 유용성을 갖는 분자, 및 그와 관련된 중간체, 조성물 및 방법 | KR20177031723 | 2016-04-07 | KR20180009045A | 2018-01-25 | |
| 본개시내용은절지동물문, 연체동물문및 선형동물문의해충에대해살충유용성을갖는분자, 이러한분자를제조하는방법, 이러한방법에사용되는중간체, 이러한분자를함유하는살충조성물, 및이러한해충에대해이러한살충조성물을사용하는방법의분야에관한것이다. 이살충조성물들은, 예를들어살진드기제(acaricides), 살곤충제(insecticides), 살응애제(miticides), 살연체동물제(molluscicides) 및살선형동물제(nematicides)로서사용될수 있다. 본원은하기화학식 (“”)을갖는분자를개시한다. | ||||||
| 175 | 살충 유용성을 갖는 분자, 및 그와 관련된 중간체, 조성물 및 방법 | KR20177028681 | 2016-04-07 | KR20180008408A | 2018-01-24 | MARTIN TIMOTHY P; ECKELBARGER JOSEPH D; ROSS RONALD; DEKORVER KYLE A; HEEMSTRA RONALD J; KNUEPPEL DANIEL I; VEDNOR PETER; HUNTER RICKY; DEMETER DAVID A; TRULLINGER TONY K; BAUM ERICH W; BENKO ZOLTAN L; CHOY NAKYEN; CROUSE GARY D; DAEUBLE JOHN F; LI FANGZHENG; NISSEN JEFFREY; RIENER MICHELLE; SPARKS THOMAS C; WESSELS FRANK J; YAP MAURICE C |
| 본개시내용은절지동물문, 연체동물문및 선형동물문의해충에대해살충유용성을갖는분자, 이러한분자를제조하는방법, 이러한방법에사용되는중간체, 이러한분자를함유하는살충조성물, 및이러한해충에대해이러한살충조성물을사용하는방법의분야에관한것이다. 이살충조성물들은, 예를들어살진드기제(acaricides), 살곤충제(insecticides), 살응애제(miticides), 살연체동물제(molluscicides) 및살선형동물제(nematicides)로서사용될수 있다. 본원은하기화학식 (“”)을갖는분자를개시한다. | ||||||
| 176 | 皮膚疾患を治療するためのホルミルペプチド受容体2アゴニストの使用 | JP2015561540 | 2014-03-04 | JP6196328B2 | 2017-09-13 | ヴィスワナス ヴィーナ; ベアード リチャード エル; ドネッロ ジョン イー; シア エドワード シー |
| 177 | 眼炎症性疾患の治療のためのホルミルペプチド受容体2のアゴニストの使用 | JP2015561536 | 2014-03-04 | JP6196327B2 | 2017-09-13 | ヴィスワナス ヴィーナ; ベアード リチャード エル; ドネッロ ジョン イー |
| 178 | 新規複素環誘導体およびそれらを含有する医薬組成物 | JP2012528675 | 2011-08-09 | JP6075621B2 | 2017-02-08 | 甲斐 浩幸; 遠藤 毅; 直原 彩枝; 旭 健太郎; 堀口 透 |
| 179 | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 | JP2015246947 | 2015-12-18 | JP2016094453A | 2016-05-26 | メリッサ フルーリー; ローランド ジェンドロン; アダム ディー. ヒューズ; キャメロン スミス |
| 【課題】心血管疾患、下痢、腎疾患等の疾患の治療に有効なネプリライシン酵素阻害剤の提供。 【解決手段】式(I)で表される化合物又は薬学的に許容されるその塩。 【選択図】なし |
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| 180 | ネプリライシン阻害剤としての置換アミノ酪酸誘導体 | JP2015246942 | 2015-12-18 | JP2016094452A | 2016-05-26 | メリッサ フルーリー; ローランド ジェンドロン; アダム ディー. ヒューズ |
| 【課題】高血圧及び心不全等の治療に有用なネプリライシン阻害化合物の提供。 【解決手段】次式(I)で示される化合物又は薬学的に許容されるその塩。前記化合物は、高血圧、心不全、肺高血圧、及び腎疾患等の疾患を処置に使用する。 [R1はアルコキシ基又はアミノ基;R2aはヒドロキシメチル基等;R2bはH又はメチル基等;Zは−CH−又は−N−;Xは−C1〜9ヘテロアリール;R3は存在しないか又はH、ハロゲン、アルキル等;R4は存在しないか又はOH、アルキル基等] 【選択図】なし |
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