| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 201 | Mass spectrometry methods and apparatus | US14153078 | 2014-01-13 | US09082600B1 | 2015-07-14 | Matthew Paul Greving; Trent R. Northen |
| Methods, apparatus, compositions, systems, and articles of manufacture useful in connection with performing offsite mass spectrometric (MS) analysis of samples are disclosed. In embodiments, library samples are arrayed on MS substrates in a blinded fashion and stability-packaged for transport to an off-site location where the MS substrate is de-packaged and MS analysis is performed, enabling off-site MS analysis without requiring transport of the sample library and without compromising the confidentiality of the library contents. | ||||||
| 202 | Compositions and methods for classifying thyroid nodule disease | US13254571 | 2010-03-03 | US09074258B2 | 2015-07-07 | Elai Davicioni; Sam Michael Wiseman |
| A system for classifying thyroid nodule tissue as malignant or benign is provided that is based on the identification of sets of gene transcripts, which are characterized in that changes in expression of each gene transcript within a set of gene transcripts can be correlated to with either malignant or benign thyroid nodule disease. The thyroid classification system provides for sets of “thyroid classifying” target sequences and further provides for combinations of polynucleotide probes and primers derived there from. These combinations of polynucleotide probes can be provided in solution or as an array. The combination of probes and the arrays can be used for diagnosis. The invention further provides further methods of classifying thyroid nodule tissue. | ||||||
| 203 | Molecular profiling of tumors | US14175800 | 2014-02-07 | US09064045B2 | 2015-06-23 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 204 | Molecular profiling of tumors | US14187008 | 2014-02-21 | US09058418B2 | 2015-06-16 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 205 | Molecular profiling of tumors | US14175728 | 2014-02-07 | US09053224B2 | 2015-06-09 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 206 | Device, Array, And Methods For Disease Detection And Analysis | US14465796 | 2014-08-21 | US20150087543A1 | 2015-03-26 | Rupa S. Rao; Stephen M. Lane; Dennis L. Matthews; Matthew A. Coleman |
| A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions. | ||||||
| 207 | Thermal phase separation simulator | US13399663 | 2012-02-17 | US08888362B2 | 2014-11-18 | Paul R. Hart; Lee E. Nuebling; Robert R. Cleary; Virgil T. Little; Jan H. Beetge |
| A thermal phase separation simulator and method for testing chemicals is disclosed. The simulator comprises a circular block heater carousel mounted for rotation on a stage. The carousel includes a circular array of test wells for receiving a plurality of test bottles, a plurality of heating elements and thermocouples disposed between the wells. Each well has an illumination port and a vertical slit to the outside to allow visual observation or imaging of a vertical swatch of the bottle. An illumination source aligns with the illumination port of each well in response to rotation of the carousel. The method includes adding a mixed phase fluid to a plurality of bottles, adding a chemical agent to each bottle, and simulating a thermal phase separation. Images of the fluid in each bottle are captured and analyzed to determine the performance of the one or more chemical agents. | ||||||
| 208 | Analyte screening and detection systems and methods | US12041660 | 2008-03-03 | US08857279B2 | 2014-10-14 | William P. Hanson; Maureen A. Dyer; Robert E. Hetrick; Jennifer A. Oberholtzer |
| Methods of concentrating an analyte that is in liquid and method of detecting an analyte in a liquid are disclosed. Methods of screening a liquid for the presence of an analyte are also disclosed. Processes comprising continuously collecting a sample of fluid throughout the process and analyzing the sample are disclosed as are processes comprising treating ultrafilter membranes. Devices and systems for concentrating an analyte that is in liquid and for screening a liquid for an analyte are disclosed as well as devices and systems for concentrating an analyte from a continuous sample are disclosed. | ||||||
| 209 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US14226482 | 2014-03-26 | US20140256595A1 | 2014-09-11 | Darren R. Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 210 | Peptides and peptide compositions having osteoinductive activity | US13309734 | 2011-12-02 | US08815807B2 | 2014-08-26 | Shigemi Nagai; Masazumi Nagai; Mindy Sungmin Gil |
| Compositions and kits are provided having a peptide having an amino acid sequence that binds to eukaryotic cells and effects differentiation and support growth of the cells. Peptide-scaffold compositions containing at least one peptide or combinations of peptides are therapeutic agents for stimulating and promoting osteogenic activity and osteoinduction activity for cells. The scaffold is for example apatite, natural cancellous bone, demineralized natural cancellous bone, collagen, calcium phosphate, or hydroxyapatite. | ||||||
| 211 | MOLECULAR PROFILING OF TUMORS | US14249261 | 2014-04-09 | US20140221222A1 | 2014-08-07 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 212 | MOLECULAR PROFILING OF TUMORS | US14175728 | 2014-02-07 | US20140221221A1 | 2014-08-07 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 213 | METHOD FOR HANDLING PRODUCT FLUID FLOWS | US14236994 | 2012-07-30 | US20140174987A1 | 2014-06-26 | Josef Find; Alfred Haas; Armin Brenner |
| The present invention relates to a process for handling product fluid streams which are obtained in the catalytic hydrogenation of liquid feeds in laboratory catalysis apparatuses. The liquid feeds are preferably hydrocarbons comprising sulfur- and nitrogen-comprising compounds as impurities. The hydrogenation serves to convert the impurities into hydrogen sulfide and ammonia which in this form can be readily separated off from the other constituents of the liquid feed. The product fluid streams are contacted with an inert gas stream, with the flow rate of the inert gas being a multiple of the flow rate of the product fluid stream. The formation of deposits in lines of the region on the outlet side of the reaction space can be effectively prevented by means of the process of the invention. | ||||||
| 214 | MOLECULAR PROFILING OF TUMORS | US14187015 | 2014-02-21 | US20140172319A1 | 2014-06-19 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 215 | MOLECULAR PROFILING OF TUMORS | US14175800 | 2014-02-07 | US20140156199A1 | 2014-06-05 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 216 | MOLECULAR PROFILING OF TUMORS | US14175781 | 2014-02-07 | US20140155298A1 | 2014-06-05 | Daniel D. Von Hoff; David M. Loesch; Arlet Alarcon; Robert J. Penny; Alan Wright; Matthew J. McGinniss; Ryan P. Bender; Traci Pawlowski |
| Provided herein are methods and systems of molecular profiling of diseases, such as cancer. In some embodiments, the molecular profiling can be used to identify treatments for a disease, such as treatments that were not initially identified as a treatment for the disease or not expected to be a treatment for a particular disease. | ||||||
| 217 | Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background | US13429929 | 2012-03-26 | US08680024B2 | 2014-03-25 | Sean R. Coyer; Emmanuel Delamarche; Daniel J. Solis |
| Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate. | ||||||
| 218 | Microarray reaction device and method of using the same | US13007750 | 2011-01-17 | US08647591B2 | 2014-02-11 | Won-seok Chung; Myo-yong Lee; Kak Namkoong; Woochang Lee |
| A microarray reaction device includes a fluid container, a reaction chamber, a first channel connected with the fluid container, a second channel connected with the reaction chamber, and a valve. The valve includes a first and second support unit, respectively including a first and second penetration opening unit, extended through a first and second surface thereof. The first and second penetration opening unit is connected to a second end of the first and second channel, respectively. The second support unit includes a third penetration opening unit extended through a second surface thereof. The first and second surfaces contact each other, such that the first support unit and the second support unit are slidably disposed with each other. The microarray reaction device further includes a storing chamber connected with the third penetration opening unit, and a pump connected to the storing chamber and providing pressure to the storing chamber. | ||||||
| 219 | High pressure parallel fixed bed reactor and method | US12447143 | 2007-10-26 | US08592220B2 | 2013-11-26 | H. Sam Bergh; Jason Wells; Victor Wong; John Gallipeo; Lynn Van Erden; Anthony F. Volpe; Jeffrey Maag |
| The present invention discloses an apparatus and method for rapid analysis of members of a combinatorial library. The apparatus includes a plurality of reactor vessels for containing individual library members, a fluid handling system that apportions a test fluid about equally between each of the vessels and a housing for enclosing the reactor vessels, the housing defining a pressure chamber, wherein the housing is configured to sustain a pressure substantially above atmospheric pressure. This allows for simultaneous screening of library members at high pressure by providing a small pressure differential on reactor components. The disclosed apparatus is especially useful for screening library members based on their ability to catalyze the conversion of fluid reactants. | ||||||
| 220 | MICROARRAY ANALYSIS METHOD AND MICROARRAY READING DEVICE | US13981787 | 2011-12-26 | US20130303403A1 | 2013-11-14 | Kumie Ozaki; Hiromichi Sasamoto; Kunihisa Nagino |
| A microarray analysis method, in which a microarray obtained by arranging probes on a substrate surface having an irregular shape is irradiated with excitation light and fluorescence amounts of the probes excited by the excitation light are obtained as numerical data, includes a step (a) of measuring the fluorescence amounts of the probes to acquire fluorescence image data, a step (b) of receiving reflected light and/or scattered light from the substrate surface to acquire the irregular shape of the substrate surface of the microarray as alignment image data based on the light receiving intensities of the light, and a step (c) of determining positions of the probes on the fluorescence image data based on the alignment image data. | ||||||
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