| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions | US09063356 | 1998-04-21 | US06893816B1 | 2005-05-17 | Kenneth L. Beattie |
| An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a second surface thereof such that when a test sample is applied to the substrate, it is capable of penetrating through each such region during the course of said binding reaction. The apparatus is especially useful for sequencing by hybridization of DNA molecules. | ||||||
| 162 | Microarray detector and synthesizer | US10968556 | 2004-10-19 | US20050079603A1 | 2005-04-14 | Perry Sandstrom |
| The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray. | ||||||
| 163 | Preparation and screening of crystalline zeolite and hydrothermally-synthesized materials | US09881036 | 2001-06-13 | US06864201B2 | 2005-03-08 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 164 | Preparation and screening of crystalline inorganic materials | US10772894 | 2004-02-04 | US20040154704A1 | 2004-08-12 | Peter G. Schultz; Xiao-Dong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 165 | Discrete nano-textured structures in biomolecular arrays, and method of use | US10214951 | 2002-08-07 | US20040029303A1 | 2004-02-12 | Mark Whitney Hart; Ho-Cheol Kim; Robert Dennis Miller; Gregory Michael Wallraff |
| A biomolecular array includes a substrate across which is distributed an array of discrete regions of a porous substance. The porous substance is designed to bind chemical targets useful in biotechnology applications, such as gene expression, protein, antibody, and antigen experiments. The regions are preferably optically isolated from each other and may be shaped to enhance detection of optical radiation emanating from the porous substance, e.g., as a result of irradiation of the regions with ultraviolet light. The discrete regions may be configured as microscopic wells within the substrate, or they may reside on top of the substrate in the form of microscopic mesas. | ||||||
| 166 | Polymer arrays from the combinatorial synthesis of novel materials | US10226485 | 2002-08-22 | US20030134089A1 | 2003-07-17 | Peter G. Schultz; Xiao-Dong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 167 | Microarray detector and synthesizer | US09679858 | 2000-10-05 | US06545758B1 | 2003-04-08 | Perry Sandstrom |
| The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray. | ||||||
| 168 | Plasma spray high throughput screening method and system | US09694254 | 2000-10-24 | US06491967B1 | 2002-12-10 | Reed Roeder Corderman; Yuk-Chiu Lau |
| Combinatorial high throughput screening is used to rapidly investigate and screen a multiplicity of complex thermal barrier coating candidates. In the screening method, a solution of thermal barrier coating precursors is formed and injected into a plasma jet of an air plasma spray (APS). The plasma jet is directed toward a substrate to deposit a gradient film formed from the precursors onto the substrate. An APS torch system comprises an APS torch, solution precursor vessels connected to the torch through a mixing zone and injector, a substrate oriented with respect to the torch to receive a plasma spray film formed from solution precursors from the vessels and a controller. The controller is connected to the solution precursor vessels and the torch or substrate to control mixing of the solution precursors and to control orientation of the torch or substrate to deposit a gradient film onto the substrate from the plasma spray. A CHTS array comprises a substrate and a gradient film of candidate TBC materials deposited over the substrate. | ||||||
| 169 | Combinatorial sythesis of organometallic materials | US09127660 | 1998-07-31 | US06420179B1 | 2002-07-16 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 170 | Combinatorial screening of inorganic and organometallic materials | US09122932 | 1998-07-27 | US06410331B1 | 2002-06-25 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 171 | Preparation and screening of crystalline materials | US09881036 | 2001-06-13 | US20010055775A1 | 2001-12-27 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 172 | Combinatorial synthesis of novel materials | US327513 | 1994-10-18 | US5985356A | 1999-11-16 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 173 | Giant magnetoresistive cobalt oxide compounds | US438043 | 1995-05-08 | US5776359A | 1998-07-07 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 174 | SYSTEMS, DEVICES, KITS AND METHODS FOR SEEDING CELLS OR SETS OF MOLECULES IN AN ARRAY ON A SUBSTRATE | EP15869470 | 2015-12-15 | EP3234234A4 | 2018-05-23 | SHEINMAN YEHOSHUA; SHARIVKIN REVITAL; BELENKOVICH MERAV |
| The present disclosure provides systems, devices and methods for seeding cells or sets of molecules on a substrate by utilizing a seeding mesh, to obtain an essentially homogenous patterned seeding of the cells or sets of molecules on the mesh. | ||||||
| 175 | SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS | EP15841893 | 2015-09-16 | EP3194643A4 | 2018-04-25 | ESHOO MARK W; CLEMENS JOHN M; HAYDEN MARK A |
| Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced). | ||||||
| 176 | SEQUENCING BY SYNTHESIS USING PULSE READ OPTICS | EP15841893.9 | 2015-09-16 | EP3194643A1 | 2017-07-26 | ESHOO, Mark W.; CLEMENS, John M.; HAYDEN, Mark A. |
| Provided herein are systems and methods for nucleic acid sequencing by synthesis in a plurality of wells using detectably labeled chain terminating nucleotides with photolabile blocking groups and pulses of photocleaving light. In certain embodiments, the systems and methods provides a plurality of deblock-scan cycles comprising an initial deblock time period followed by a scanning light period, wherein at least one of the following occurs in each deblock-scan cycle: 1) the deblock time period is shorter than the scan time period; 2) the deblock time period is only long enough to deblock the photolabile groups that are part of a primer in less than all of the plurality of wells; or 3) the deblock time period is between 25 and 150 mSec and the scan time is at least 200 mSec. Such shorter deblock time periods help prevent the addition of more than one nucleotide to the primer prior to scanning (e.g., accuracy is enhanced). | ||||||
| 177 | Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors | EP10196179.5 | 2006-06-01 | EP2364774A3 | 2014-06-04 | LINK, Darren, R.; BOITARD, Laurent; BRANCIFORTE, Jeffrey; CHARLES, Yves; FEKE, Gilbert; LU, John, Q.; MARRAN, David; TABATABAI, Ahmadali; WEINER, Michael; HINZ, Wolfgang; ROTHBERG, Jonathan, M. |
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label,; thereby identifying a single compound from a library of compounds.
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| 178 | Microfluidic Devices And Methods Of Use In The Formation And Control Of Nanoreactors | EP10196339.5 | 2006-06-01 | EP2363205A3 | 2014-06-04 | LINK, Darren, R.; BOITARD, Laurent; BRANCIFORTE, Jeffrey; CHARLES, Yves; FEKE, Gilbert; LU, John, Q.; MARRAN, David; TABATABAI, Ahmadali; WEINER, Michael; HINZ, Wolfgang; ROTHBERG, Jonathan, M. |
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label,; thereby identifying a single compound from a library of compounds.
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| 179 | METHODS FOR SCREENING AND ARRAYING MICRORGANISMS SUCH AS VIRUSES USING SUBTRACTIVE CONTACT PRINTING BACKGROUND | EP09786626.3 | 2009-07-16 | EP2329270A1 | 2011-06-08 | COYER, Sean R.; DELAMARCHE, Emmanuel; SOLIS, Daniel, J. |
| Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate. | ||||||
| 180 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | EP06844121.1 | 2006-06-01 | EP1984738A2 | 2008-10-29 | LINK, Darren, R.; BOITARD, Laurent; BRANCIFORTE, Jeffrey; CHARLES, Yves; FEKE, Gilbert; LU, John, Q.; MARRAN, David; TABATABAI, Ahmadali; WEINER, Michael; HINZ, Wolfgang; ROTHBERG, Jonathan, M. |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label,; thereby identifying a single compound from a library of compounds. | ||||||
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