| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions | US11280266 | 2005-11-17 | US20060084106A1 | 2006-04-20 | Kenneth Beattie |
| An improved microfabricated apparatus for conducting a multiplicity of individual and simultaneous binding reactions is described. The apparatus comprises a substrate on which are located discrete and isolated sites for binding reactions. The apparatus is characterized by discrete and isolated regions that extend through said substrate and terminate on a second surface thereof such that when a test sample is allowed to the substrate, it is capable of penetrating through each such region during the course of said binding reaction. The apparatus is especially useful for sequencing by hybridization of DNA molecules. | ||||||
| 122 | Polymer arrays from the combinatorial synthesis of novel materials | US10226485 | 2002-08-22 | US06794052B2 | 2004-09-21 | Peter G. Schultz; Xiao-Dong Xiang; Isy Goldwasser; Gabriel Briceño; Xiao-Dong Sun |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 123 | Combinatorial synthesis of novel materials | US10350703 | 2003-01-23 | US20040014077A1 | 2004-01-22 | Peter G. Schultz; Xiao-Dong Xiang; Isy Goldwasser; Gabriel Briceno; Xiao-Dong Sun; Kai-An Wang |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 124 | Microarray detector and synthesizer | US10408870 | 2003-04-08 | US20030174324A1 | 2003-09-18 | Perry Sandstrom |
| The present invention relates to novel systems, devices, and methods comprising spatial light modulators for use in the reading and synthesis of microarrays. For example, the present invention provides micromirror systems for synthesizing and acquiring data from nucleic acid microarrays and systems for collecting, processing, and analyzing data obtained from a microarray. | ||||||
| 125 | Methods for immobilizing molecules to a solid phase and uses thereof | US10209849 | 2002-07-31 | US20030096273A1 | 2003-05-22 | Claude Gagna |
| Various methodologies for the immobilization of molecules such, as multistranded nucleic acid molecules, are described. The methodologies include activation of solid supports, as well as treatment of, e.g. termini of nucleic acid molecules to render them more receptive to immobilization on surfaces. | ||||||
| 126 | Combinatorial synthesis of novel materials | US10074745 | 2002-02-11 | US20020119243A1 | 2002-08-29 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 127 | Combinatorial synthesis and screening of organometallic compounds and catalysts | US09337048 | 1999-06-21 | US06440745B1 | 2002-08-27 | W. Henry Weinberg; Eric W. McFarland; Isy Goldwasser; Thomas Boussie; Howard Turner; Johannes A. M. van Beek; Vince Murphy; Tim Powers |
| The present invention relates, inter alia, to methodologies for the synthesis, screening and characterization of organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention provide for the combinatorial synthesis, screening and characterization of libraries of supported and unsupported organometallic compounds and catalysts (e.g., homogeneous catalysts). The methods of the present invention can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (e.g., homogeneous catalysts), but also as additives and therapeutic agents. | ||||||
| 128 | Combinatorial synthesis of novel materials | US09127195 | 1998-07-31 | US06346290B1 | 2002-02-12 | Peter G. Schultz; Xiaodong Xiang; Isy Goldwasser |
| Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, non-biological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc. Once prepared, these materials can be screened for useful properties including, for example, electrical, thermal, mechanical, morphological, optical, magnetic, chemical, or other properties. Thus, the present invention provides methods for the parallel synthesis and analysis of novel materials having useful properties. | ||||||
| 129 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US15694108 | 2017-09-01 | US20180080020A1 | 2018-03-22 | Darren Roy Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 130 | CONTINUOUS DIRECTED EVOLUTION | US15188627 | 2016-06-21 | US20170009224A1 | 2017-01-12 | David R. Liu; Kevin Michael Esvelt; Jacob Charles Carlson |
| The invention provides systems, methods, reagents, apparatuses, vectors, and host cells for the continuous evolution of nucleic acids. For example, a lagoon is provided in which a population of viral vectors comprising a gene of interest replicates in a stream of host cells, wherein the viral vectors lack a gene encoding a protein required for the generation of infectious viral particles, and wherein that gene is expressed in the host cells under the control of a conditional promoter, the activity of which depends on a function of the gene of interest to be evolved. Some aspects of this invention provide evolved products obtained from continuous evolution procedures described herein. Kits containing materials for continuous evolution are also provided. | ||||||
| 131 | Microfluidic devices and methods of use in the formation and control of nanoreactors | US14248991 | 2014-04-09 | US09534216B2 | 2017-01-03 | Darren R. Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. The invention provides for aqueous based emulsions containing uniquely labeled cells, enzymes, nucleic acids, etc., wherein the emulsions further comprise primers, labels, probes, and other reactants. An oil based carrier-fluid envelopes the emulsion library on a microfluidic device, such that a continuous channel provides for flow of the immiscible fluids, to accomplish pooling, coalescing, mixing, sorting, detection, etc., of the emulsion library. | ||||||
| 132 | Dielectric doping using high productivity combinatorial methods | US13680701 | 2012-11-19 | US09040465B2 | 2015-05-26 | Prashant B Phatak; Venkat Ananthan; Wayne R French |
| A combination of deposition processes can be used to evaluate layer properties using a combinatorial workflow. The processes can include a base ALD process and another process, such as a PVD process. The high productivity combinatorial technique can provide an evaluation of the material properties for given ALD base layer and PVD additional elements. An ALD process can then be developed to provide the desired layers, replacing the ALD and PVD combination. | ||||||
| 133 | DNA microarray having hairpin probes tethered to nanostructured metal surface | US12265047 | 2008-11-05 | US08957002B2 | 2015-02-17 | Benjamin L. Miller; Todd D. Krauss; Lewis J. Rothberg; Hsin-I Peng |
| A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specifically to a target nucleic acid molecule, the first nucleic acid molecule having first and second ends, which first end is tethered to the metal nanoparticle film; and a first fluorophore bound to the second end of the first nucleic molecule. When the first nucleic acid molecule is in the hairpin conformation, the metal nanoparticle film substantially quenches fluorescent emissions by the first fluorophore, and when the first nucleic acid molecule is in a non-hairpin conformation fluorescent emissions by the first fluorophore are surface plasmon-enhanced. | ||||||
| 134 | Methods for screening and arraying microrganisms such as viruses using subtractive contact printing background | US12195577 | 2008-08-21 | US08680023B2 | 2014-03-25 | Sean R. Coyer; Emmanuel Delamarche; Daniel J. Solis |
| Methods for screening and arranging microorganisms such as viruses in an array using subtractive contact printing are provided. In one embodiment, a method for forming an array of receptors for microorganisms comprises: patterning an array of structures on a first substrate to form a template on a surface of the first substrate; applying a receptor material to a face of a second substrate; and contacting the face of the second substrate with the template to remove a portion of the receptor material from the second substrate, thereby forming an array of receptors on the second substrate. | ||||||
| 135 | Stamp usage to enhance surface layer functionalization and selectivity | US12405218 | 2009-03-16 | US08580344B2 | 2013-11-12 | Nikhil D. Kalyankar; Zachary Fresco; Chi-I Lang |
| This disclosure provides methods, devices and systems for using a stamp to enhance selectivity between surface layers of a substrate, and to facilitate functionalizing selected layers. An array of flat stamps may be used to concurrently stamp multiple regions of a substrate to transfer one or more substances to the topmost layer or layers of the substrate. If desired, the affected regions of the substrate may be isolated from each other through the use of a reactor plate that, when clamped to the substrate's surface, forms reaction wells in the area of stamping. The stamp area can, if desired, be configured for stamping the substrate after the reactor plate has been fitted, with the individual stamps sized and arranged in a manner that permits stamping within each reaction well. If applied in a combinatorial process, a robotic process may be used to transfer multiple combinations of contact substances and processing chemicals to each reaction well to perform many concurrent processes upon a single substrate (e.g., a single coupon). The methods, devices and systems provided facilitate semiconductor design, optimization and qualification, and may be adapted to production manufacturing. | ||||||
| 136 | MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS | US13759660 | 2013-02-05 | US20130217583A1 | 2013-08-22 | Darren Link; Laurent Boitard; Jeffrey Branciforte; Yves Charles; Gilbert Feke; John Q. Lu; David Marran; Ahmadali Tabatabai; Michael Weiner; Wolfgang Hinz; Jonathan M. Rothberg |
| The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds. | ||||||
| 137 | Multiplexed Assay Using Spectrally-Encoded Solid Support Matrices | US13708778 | 2012-12-07 | US20130090260A1 | 2013-04-11 | Michael P. Nova; Andrew E. Senyei |
| In a multiplexed assay, each molecule of a plurality of molecules is attached to a support matrix particle with a substrate adapted for attachment and/or synthesis of molecules. A spectrally-encoded identifier embodied in a photochemical medium is embedded or encased within the substrate to uniquely identify the molecule attached to the substrate. The molecules are exposed to one or more processing conditions, and then placed within the path of an optical detector adapted to read the spectrally-encoded identifier and measure biochemical activity on each support matrix particle. The measured biochemical activity is associated with the unique identity of the support matrix particle and, hence, with the molecule attached to the particle. | ||||||
| 138 | MICROFLUIDIC ARRAYS AND METHODS FOR THEIR PREPARATION AND USE | US13567801 | 2012-09-10 | US20130035257A1 | 2013-02-07 | Linfen YU; Karen C. CHEUNG |
| Methods of isolating at least one cell of interest, methods of making fixed arrays, arrays comprising a glass substrate bonded to a patterned siloxane structure having inlets, outlets and microchannels, array kits, and methods of making microfluidic apparati are provided in the present application. | ||||||
| 139 | Microfluidic device and methods of using same | US12859176 | 2010-08-18 | US08343442B2 | 2013-01-01 | Lincoln McBride; Michael Lucero; Marc Unger; Hany Ramez Nassef; Geoffrey Facer |
| A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include reaction sites located at the end of blind channels at which reagents have been previously deposited during manufacture. The reagents become suspended once sample is introduced into the reaction site. The devices can be utilized with a variety of heating devices and thus can be used in a variety of analyses requiring temperature control, including thermocycling applications such as nucleic acid amplification reactions, genotyping and gene expression analyses. | ||||||
| 140 | LASER MODIFICATION AND FUNCTIONALIZATION OF SUBSTRATES | US13073655 | 2011-03-28 | US20110287980A1 | 2011-11-24 | Matthew ASPLUND; Matthew LINFORD; Guilin JIANG |
| Assay devices comprising substrates functionalized to comprise probe species on multiple separate regions are provided. Ten thousand to a hundred thousand separate regions can be provided in a substrate of one square centimeter. The separate regions can comprise separate probe species, or in another embodiment, multiple different probe species can be present on each single functionalized region. The probe species are selected to be specific for binding to target species of interest in a sample. Methods and systems for making these devices are also provided. The devices are useful, for example for assaying molecules in a human sample that are reactive to a large number of different allergens placed on the substrate. | ||||||
QQ群二维码
意见反馈
意见反馈