子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | Loop-Variant Pdz Domains As Biotherapeutics, Diagnostics And Research Reagents | US13415490 | 2012-03-08 | US20120171122A1 | 2012-07-05 | Simon Delagrave |
| The present invention provides polypeptides that contain one or more PDZ loop-variants and are useful in the detection of pathogens and disease-associated molecules. The polypeptides of the invention are also useful in the diagnosis, treatment, and prevention of diseases. Also provided are methods of preparing polypeptides of the invention. | ||||||
| 42 | Acoustically mediated fluid transfer methods and uses thereof | US11964628 | 2007-12-26 | US08137640B2 | 2012-03-20 | Roger O. Williams; Tarlochan S. Jutty; N. Nicolas Mansour; Lawrence Lee, Jr.; Michael J. Forbush |
| Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology. | ||||||
| 43 | MULTI-MODAL ION EXCHANGE CHROMATOGRAPHY RESINS | US12517570 | 2008-01-10 | US20100009867A1 | 2010-01-14 | Enrique Carredano; Bo-Lennart Johansson; Jean-Luc Maloisel |
| The present invention relates to a method of preparing a library of resins which are useful in chromatography, which method comprises creating a diversity of multi-modal ion exchange resins; and providing the diversity in a parallel system in which each resin is presented separated from the other resin(s). | ||||||
| 44 | Long oligonucleotide arrays | US10985372 | 2004-11-09 | US07556919B2 | 2009-07-07 | Alex Chenchik; Alexander Munishkin; Peter Simonenko |
| Long oligonucleotide arrays, as well as methods for their preparation and use in hybridization assays, are provided. The subject arrays are characterized in that at least a portion of the probes of the array, and usually all of the probes of the array, are long oligonucleotides, e.g. oligonucleotides having a length of from about 50 to 120 nt. Each long oligonucleotide probe on the array is preferably chosen to exhibit substantially the same high target binding efficiency and substantially the same low non-specific binding under conditions in which the array is employed. The subject arrays find use in a number of different applications, e.g. differential gene expression analysis. | ||||||
| 45 | Loop-Variant Pdz Domains as Biotherapeutics, Diagnostics and Research Reagents | US12096099 | 2006-12-04 | US20080311042A1 | 2008-12-18 | Simon Delagrave |
| The present invention provides polypeptides that contain one or more PDZ loop-variants and are useful in the detection of pathogens and disease-associated molecules. The polypeptides of the invention are also useful in the diagnosis, treatment, and prevention of diseases. Also provided are methods of preparing polypeptides of the invention. | ||||||
| 46 | Polyanion/polycation multilayer film for DNA immobilization | US09886759 | 2001-06-21 | US06689478B2 | 2004-02-10 | Bruno Laguitton |
| A substrate with a charged surface coated with one or more bilayers of oppositely charged polyelectrolytes. Subsequent optional bilayers of polyelectrolytes must bear alternating opposite charges. The final or top layer may be activated for biomolecular attachment. | ||||||
| 47 | Acoustically mediated fluid transfer methods and uses thereof | US10402664 | 2003-03-28 | US20030186459A1 | 2003-10-02 | Roger O. Williams; Tarlochan Singh; N. Nicolas Mansour; Lawrence Lee JR.; Michael J. Forbush |
| Acoustic waves are used to transfer small amounts of fluid in a non-contact manner. Acoustic waves are propagated through a pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precise automation of a wide variety of procedures including screening and synthesis procedures commonly used in biotechnology. | ||||||
| 48 | LONG OLIGONUCLEOTIDE ARRAYS | US09440829 | 1999-11-15 | US20020160360A1 | 2002-10-31 | ALEX CHENCHIK; ALEXANDER MUNISHKIN; PETER SIMONENKO |
| Long oligonucleotide arrays, as well as methods for their preparation and use in hybridization assays, are provided. The subject arrays are characterized in that at least a portion of the probes of the array, and usually all of the probes of the array, are long oligonucleotides, e.g. oligonucleotides having a length of from about 50 to 120 nt. Each long oligonucleotide probe on the array is preferably chosen to exhibit substantially the same high target binding efficiency and substantially the same low non-specific binding under conditions in which the array is employed. The subject arrays find use in a number of different applications, e.g. differential gene expression analysis. | ||||||
| 49 | Fluorous reaction and separation systems | US80274 | 1998-05-15 | US6156896A | 2000-12-05 | Dennis P. Curran; Sabine Hadida Ruah; Masahide Hoshino; Armido Studer; Peter Wipf; Patrick Jeger; Sun-Young Kim; Rafael Ferritto |
| The present invention provides several methods of synthesis and separation in which organic/fluorous phase separation techniques are used to effect separations. The present invention also provides novel compositions of matter comprising fluorous Si, Sn and Ge compounds. | ||||||
| 50 | 마이크로 어레이 기판 제조 방법 및 마이크로 어레이 기판 제조 장치 | KR1020140157051 | 2014-11-12 | KR1020160056590A | 2016-05-20 | 윤영수; 지승현; 김선태 |
| 본발명은표면개질물질의증기를이용함으로써신뢰성과양산성이향상된마이크로어레이기판제조방법에관한것으로, 본발명에따른마이크로어레이기판제조방법은베이스기판을세척하는단계; 상기베이스기판이제공되는용기내부에표면개질물질의증기를공급하는단계; 및상기표면개질물질의증기가상기베이스기판의표면에결합하여자기조립단층을형성하는단계를포함한다. | ||||||
| 51 | 드 노보 합성된 유전자 라이브러리 | KR1020167005273 | 2014-08-05 | KR1020160041046A | 2016-04-15 | 반야이윌리엄; 펙빌제임스; 페르난데즈안드레스; 첸시유안; 인더물피에르 |
| 핵산의드 노보(De novo) 합성된큰 라이브러리가낮은오류율로본원에서제공된다. 추가로, 고품질빌딩블록, 예컨대, 올리고뉴클레오티드의제조를위한디바이스가본원에기재되어있다. 마이크로플루이딕조립체(microfluidic assemblies)를이용하여보다더 긴핵산들을동시에합성할수 있다. 추가로, 본원의방법은긴 고품질유전자들의큰 라이브러리의신속한구축을가능하게한다. 긴고품질핵산들의큰 라이브러리의제조를위한디바이스도본원에기재되어있다. | ||||||
| 52 | 4차 연속 피씨알, 4차 블록 피씨알, 또는 유전자 합성방법을 이용한 균주 특이적 바코드를 포함하는 유전자 적중 이형접합체 분열효모 균주의 제조방법 | KR1020080037420 | 2008-04-22 | KR1020090111695A | 2009-10-27 | 허광래; 김동욱; 원미선; 유향숙; 김동섭; 박한오; 정경숙; 장영주; 남미영; 한상조; 최신정; 백승태; 김형배; 허경선; 이혜미; 이민호; 박조영 |
| PURPOSE: A method for producing gene targeting heterozygote fission yeast strain is provided to detect drug active point at the genetic level. CONSTITUTION: A method for producing gene targeting heterozygote fission yeast strain containing a strain-specific bar code comprises gene synthesis, 4-round serial PCR, and 4-round block PCR. In the method, a selection marker gene, gene-specific microarray bar code sequence, and gene targeting deletion cassette. | ||||||
| 53 | MODIFIED 3' REGION EXTRACTION AND DEEP SEQUENCING OF POLYDENYLATION SITES AND POLY(A) TAIL LENGTH ANALYSIS | US15853055 | 2017-12-22 | US20180265912A1 | 2018-09-20 | Bin Tian; Dinghai Zheng |
| The present invention relates to modified 3′ region extraction and deep sequencing of polyadenylated RNA to identify a poly(A) site in a reference, as well as to calculate poly(A) tail length. | ||||||
| 54 | TEXTURED SURFACES FOR POLYNUCLEOTIDE SYNTHESIS | US15835342 | 2017-12-07 | US20180104664A1 | 2018-04-19 | Andres FERNANDEZ; Pierre INDERMUHLE; Eugene P. MARSH; William BANYAI; Bill James PECK |
| Methods, devices and systems are provided herein for surfaces for de novo polynucleotide synthesis that provide for increased polynucleotide yield. Surfaces described herein comprise a texture that increases surface area provide for increased polynucleotide yield compared to non-textured surfaces. In addition, the patterned placement of nucleoside coupling reagent spanning such surfaces provides for improved synthesis yield, representation, and a reduction in contamination on the surface between different polynucleotide species. | ||||||
| 55 | DE NOVO SYNTHESIZED GENE LIBRARIES | US15603013 | 2017-05-23 | US20170362589A1 | 2017-12-21 | William BANYAI; Bill James PECK; Andres FERNANDEZ; Siyuan CHEN; Pierre INDERMUHLE |
| De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein | ||||||
| 56 | METHOD FOR MASS HUMANIZATION OF NON-HUMAN ANTIBODIES | US15130843 | 2016-04-15 | US20170066844A1 | 2017-03-09 | Jacob GLANVILLE |
| The present invention relates to a method for producing a population of nucleic acids encoding at least one protein comprising at least one immunoglobulin variable domain having a non-human-derived CDR3 amino acid sequence embedded in essentially human framework sequences, as well as to a population of nucleic acids and a population of proteins relates thereto and uses thereof. | ||||||
| 57 | DE NOVO SYNTHESIZED GENE LIBRARIES | US15245054 | 2016-08-23 | US20160354752A1 | 2016-12-08 | William BANYAI; Bill James PECK; Andres FERNANDEZ; Siyuan CHEN; Pierre INDERMUHLE |
| De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein. | ||||||
| 58 | DE NOVO SYNTHESIZED GENE LIBRARIES | US15187714 | 2016-06-20 | US20160339409A1 | 2016-11-24 | William BANYAI; Bill James PECK; Andres FERNANDEZ; Siyuan CHEN; Pierre INDERMUHLE |
| De novo synthesized large libraries of nucleic acids are provided herein with low error rates. Further, devices for the manufacturing of high-quality building blocks, such as oligonucleotides, are described herein. Longer nucleic acids can be synthesized in parallel using microfluidic assemblies. Further, methods herein allow for the fast construction of large libraries of long, high-quality genes. Devices for the manufacturing of large libraries of long and high-quality nucleic acids are further described herein. | ||||||
| 59 | MICRODEVICE ARRAYS FORMED BY MAGNETIC ASSEMBLY | US14875514 | 2015-10-05 | US20160023179A1 | 2016-01-28 | Christopher D. Herold; David Rothwarf; Bao Nguyen |
| Microdevices containing a predetermined preferential axis of magnetization are disposed in an array having discreet regions. Under influence of a magnetic field, the microdevices can have at least twelve discrete orientations, and can advantageously be flipped upside down in place. Microdevices can be coded in a manner that supports a coding space of at least 102, 103, 106 or even 1010 or more choices, and can include one or more chemically reactive sites. The regions can be defined by long and short bars, in which microdevices span gaps between the longer bars, and the shorter bars measure less than 60% of such gaps. Preferred embodiments are also provided to produce microfabricated microdevices for magnetic assembly-based arraying. | ||||||
| 60 | Multi-modal ion exchange chromatography resins | US12517570 | 2008-01-10 | US08092683B2 | 2012-01-10 | Enrique Carredano; Bo-Lennart Johansson; Jean-Luc Maloisel |
| The present invention relates to a method of preparing a library of resins which are useful in chromatography, which method comprises creating a diversity of multi-modal ion exchange resins; and providing the diversity in a parallel system in which each resin is presented separated from the other resin(s). | ||||||
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