子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 281 | β-adrenergic receptor agonists | JP2001543495 | 2000-12-06 | JP4703081B2 | 2011-06-15 | ジョン エイチ． グリッフィン，; ソッキ チェ，; エドマンド ジェイ． モーラン， |
| 282 | Synthetic methods and synthesizing apparatus of the array of Dna probe | JP2000532704 | 1999-02-22 | JP4698023B2 | 2011-06-08 | ローランド グリーン; マイケル アール サッスマン; ガッソン サンギート シング; フランチェスコ セリーナ; フレデリック アール ブラットナー |
| The synthesis of arrays of DNA probe sequences, polypeptides and the like is carried out using a patterning process on an active surface of a substrate (12). An image is projected onto the active surface (15) utilizing an image former (11) that includes a light source that provides light to a micromirror device (35) comprising an array of electronically addressable micromirrors (36). The substrate (12) is activated in a defined pattern and bases are coupled at the activated sites, with further repeats until the elements of a two-dimensional array on the substrate have an appropriate base bound thereto. The micromirror array (35) can be controlled in conjunction with a DNA synthesizer to control the sequencing of images presented by the micromirror array (35) in coordination with the reagents provided to the substrate (12). | ||||||
| 283 | Bicyclic pyrazoles as kinase inhibitors, their process for preparing and pharmaceutical compositions containing them | JP2002518217 | 2001-07-25 | JP4555547B2 | 2010-10-06 | バラジ，マリオ; ピツターラ，バレーリア; フアンチエツリ，ダニエーレ |
| 284 | High affinity nucleic acid ligand of complement system protein | JP2010086118 | 2010-04-02 | JP2010187687A | 2010-09-02 | BIESECKER GREGORY; GOLD LARRY |
| <P>PROBLEM TO BE SOLVED: To provide a method for identifying and preparing high-affinity nucleic acid ligands to complement system proteins. <P>SOLUTION: The method is for identifying and preparing high affinity nucleic acid ligands to complement system proteins C1q, C3 and C5, wherein specific RNA ligands for C1q, C3 and C5 identified by the SELEX method are included. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 285 | Oligomer and polymer of cyclic imino carboxylic acid | JP2010019577 | 2010-01-29 | JP2010168383A | 2010-08-05 | GELLMAN SAMUEL H; HUCK BAYARD R; RICHARDS MICHELE R |
| <P>PROBLEM TO BE SOLVED: To provide artificial polypeptide-like molecules, a method for producing combinatorial libraries using the residues, and the combinatorial libraries formed thereby. <P>SOLUTION: The artificial polypeptide-like molecules are oligomers and polymers of cyclic imino carboxylic acids comprising small groups represented by formulae (I). <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 286 | Bicyclo-pyrazole as kinase inhibitor, method for producing the same and pharmaceutical composition comprising the same | JP2009287171 | 2009-12-18 | JP2010111677A | 2010-05-20 | FANCELLI DANIELE; PITTALA VALERIA; VARASI MARIO |
| <P>PROBLEM TO BE SOLVED: To provide a novel compound useful for treating diseases associated with dysregulated protein kinases. <P>SOLUTION: A bicyclo-pyrazole expressed by formula (I) and having kinase inhibition activity, a pharmaceutically accepted salt of the same and a pharmaceutical composition comprising the same are provided. <P>COPYRIGHT: (C)2010,JPO&INPIT | ||||||
| 287 | The combination oligomers and suitable libraries for their preparation, methods, kits, and compositions | JP2002571915 | 2002-03-09 | JP4408628B2 | 2010-02-03 | ジェイムズ エム． クール，; テレサ クリーシー，; マーク ディー． クリストジャンソン，; ジェンス ジェイ． ヒルディッグ−ニールセン，; マーク ジェイ． フィアンダカ， |
| 288 | Detection of the interaction on the probe array | JP2003523685 | 2002-09-02 | JP4308652B2 | 2009-08-05 | エーリヒト、ラルフ; エリンガー、トーマス; エルマントラウト、オイゲン; ヴェー． エンゲルス、ヨアヒム; ホルツァイ、ナンシー; ヤーン−ホフマン、ケルスティン |
| The invention concerns a method for detecting interactions between probe molecules and target molecules, whereby marking target molecules is not required. The invention further concerns probe arrays and kits suited to such a method, as well as a method for production, quality control and standardization of probe arrays. | ||||||
| 289 | Use as onium salt and its potential acid | JP2002548218 | 2001-11-26 | JP4294317B2 | 2009-07-08 | 真樹 大和; 斉 山戸; 敏景 朝倉; 啓 松本 |
| 290 | Gene expression analysis using a plurality of potential | JP2000187486 | 2000-06-22 | JP4272800B2 | 2009-06-03 | 雅司 小川; 健一 山下; 快彦 牧野; 繁織 竹中; 義彦 阿部; 誠 高木 |
| A method of detecting nucleic acid fragments in plural samples is performed by the steps of: attaching an electroconductive label to nucleic acid fragments in one sample and attaching a different electroconductive label to nucleic acid fragments in another sample; preparing a mixture of these samples; spotting the mixture on an electroconductive microarray having plural electrodes onto which probe molecules complementary to the nucleic acid fragments are fixed, so that hybridization between the nucleic acid fragments and the probe molecules on the electroconductive microarray can proceed to form hybrid structures; applying to the electrode an electric potential corresponding to the oxidation-reduction potential of the former label and detecting on the electrode an electric current; applying to the electrode an electric potential corresponding to the oxidation-reduction potential of the latter label and detecting on the electrode an electric current; and comparing the electric current detected in the former detecting procedure and that detected in the latter detecting procedure. | ||||||
| 291 | Functionalization process of the solid support, functionalized solid support, and use thereof | JP2003513921 | 2002-07-05 | JP4248393B2 | 2009-04-02 | シェヴァリアー，イヴ; ステイランド，エリアン; ドゥガス，ヴィンセント |
| 292 | Molasses crystal composition and its manufacturing method | JP2001560215 | 2001-02-14 | JP4166980B2 | 2008-10-15 | 隆三 上野; 陽二郎 古川; 純哉 本多; 昭彦 田畑; 祥 荒井 |
| 293 | Parallel Cellex | JP51106296 | 1995-09-19 | JP4153030B2 | 2008-09-17 | イートン，ブルース; ゴールド，ラリー |
| 294 | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques | JP2008054175 | 2008-03-04 | JP2008200040A | 2008-09-04 | VAN NESS JEFFREY; TABONE JOHN C; HOWBERT J JEFFRY; MULLIGAN JOHN T |
| <P>PROBLEM TO BE SOLVED: To provide tags and linkers specifically designed for a wide variety of nucleic acid reactions. <P>SOLUTION: A method includes: (a) generating tagged nucleic acid molecules from one or more selected target nucleic acid molecules, wherein a tag is correlative with a particular nucleic acid fragment and detectable by non-fluorescent spectrometry or potentiometry, (b) separating the tagged molecules by size, (c) cleaving the tag from the tagged molecule, and (d) detecting the tag by non-fluorescent spectrometry or potentiometry, and therefrom determining the identity of the nucleic acid molecule. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 295 | Method and composition for determining sequence of nucleic acid molecule | JP2008054176 | 2008-03-04 | JP2008183012A | 2008-08-14 | VAN NESS JEFFREY; TABONE JOHN C; HOWBERT J JEFFRY; MULLIGAN JOHN T |
| <P>PROBLEM TO BE SOLVED: To provide a novel composition and a method that has largely increased speed and sensitivity in comparison with the conventional methods and can be used for determining the sequence of a nucleic acid molecule. <P>SOLUTION: This is a method for determining the sequence of nucleic acid molecules and comprises following steps: step (a) wherein the tagged nucleic acid fragments that are complementary to the selected target nucleic acid molecule, wherein the tag correlates to a specific nucleotide and can be detectable with non-fluorescence spectral analysis or potentiometry; step (b) wherein the tagged fragment is cut off from the tagged fragment according to length; step (c) wherein the tags are cut off from the tagged fragment, and step (d) wherein the tags are detected with the fluorescence spectral analysis or the potentiometry and the sequence of the nucleic acid molecule is determined therefrom. <P>COPYRIGHT: (C)2008,JPO&INPIT | ||||||
| 296 | Substituted triazine as a prion protein ligand, and, the use of the substituted triazine to detect or remove the prion | JP2007523149 | 2005-07-25 | JP2008508245A | 2008-03-21 | グーゲル、パトリック、バスコンセロス; タットン、ヘレン、ローズマリー; ピアソン、ジェームス、クリストファー |
| プリオン蛋白質を親和性結合させるための式（Ｉ）の化合物の使用であり、式中、Ｒ 1及びＲ 2は同じであっても異なっていてもよく、各々置換されていてもよいアルキル基、置換されていてもよいシクロアルキル基、置換されていてもよいアリール基又は置換されていてもよいヘテロアリール基であり；Ｒ 3は水素又はアリール基の置換基であるか、又はＲ 3はスペーサー分子を介して任意に結合した固体支持体であり；Ｚは酸素原子、硫黄原子又はＮＲ 4を表し；Ｙは酸素原子、硫黄原子又はＮＲ 5を表し；ここで、Ｒ 4及びＲ 5は同じであっても異なっていてもよく、水素、１〜６個の炭素原子を有する、置換されていてもよいアルキル、置換されていてもよいフェニル又は置換されていてもよいβ−フェニルエチルを表し；Ｘ 1及びＸ 2の一方は窒素原子を表し、Ｘ 1及びＸ 2の他方は窒素原子又はＣＲ 6を表し、ここで、Ｒ 6は水素又はアリール基の置換基を表す化合物はプリオン蛋白質の親和性結合に有用である。 | ||||||
| 297 | Pdz- domain interaction inhibiting small molecule | JP2007520394 | 2005-06-30 | JP2008505183A | 2008-02-21 | ロドニー キプリン ガイ; デービッド エム． ジャブロンズ; リャン ヨウ; 直明 藤井 |
| PDZドメインの相互作用、特にMAGI中のPDZドメインの発癌性(腫瘍抑制因子)タンパク質PTENとの相互作用、およびディシュベルド(Dvl)タンパク質のPDZドメインのフリッツルド(Fz)タンパク質のような、他のタンパク質との相互作用を阻害する上で有効であることがわかった新規化合物は、一般式(I)または(III)を有する。 本発明はまた、そのような化合物の使用するタンパク質のスクリーニングおよび試験のためのコンビナトリアルライブラリー、アレイおよび方法を含む。 本発明の化合物は、Wntシグナル伝達を阻害するディシュベルドタンパク質(Dvl)を過剰発現するある種の細胞株においてアポトーシスを生じる。
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| 298 | Electrokinetic assembly was light control of particle proximity surface | JP53836897 | 1997-04-24 | JP4034351B2 | 2008-01-16 | セウル，マイケル |
| 299 | Nucleic acid ligands | JP2007075062 | 2007-03-22 | JP2007195559A | 2007-08-09 | GOLD LARRY; TUERK CRAIG |
| <P>PROBLEM TO BE SOLVED: To provide a novel method for obtaining a ligand capable of specifically binding to a target molecule. <P>SOLUTION: Disclosed is a method comprising a specific in vitro binding of a nucleic acid ligand to a target molecule except binding between nucleic acids, wherein when the target molecule is a protein, the target molecule is a protein not to bind to a nucleic acid as a part of the biological functions. The nucleic acid ligand is also identified by a method comprising the following steps of: (a) contacting a nucleic acid mixture with the target under an advantageous condition for binding; (b) separating non-binding nucleic acids from the nucleic acid binding to the target; (c) dissociating the nucleic acid-target pair; (d) amplifying the nucleic acid dissociated from the nucleic acid-target pair to yield a ligand-enriched mixture; and (e) repeating the steps of binding, separating, dissociating and amplifying as necessary, thereby obtaining a ligand capable of specifically binding to the target molecule. <P>COPYRIGHT: (C)2007,JPO&INPIT | ||||||
| 300 | Fixing method to the carrier of biomolecules | JP2002242456 | 2002-08-22 | JP3888947B2 | 2007-03-07 | 竜一 小田; 直紀 木村 |
| Fixing a biomolecule to a synthetic or natural resin-made carrier, comprising spotting a solution of biomolecules onto the carrier and irradiation with ultra-violet rays, is new. An independent claim is also included for producing a biomolecule-immobilized carrier by application of the above method. | ||||||
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