子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | DNA Methylation Changes Associated with Major Psychosis | US13337394 | 2011-12-27 | US20120220475A1 | 2012-08-30 | Arturas PETRONIS; Jonathan MILL; James FLANAGAN; Sun-Chong WANG |
| The present invention provides a method of identifying one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia, the method comprising a) obtaining a first group of samples comprising genomic DNA from a plurality of bipolar or schizophrenic subjects and a second group of samples comprising genomic DNA from a plurality of control subjects; b) performing DNA methylation analysis to determine methylation differences in one or more DNA regions between the first group and second group of samples, wherein a methylation difference in a DNA region is indicative of an epigenetic marker associated with bipolar disease or schizophrenia. The invention also provides one or more epigenetic markers associated with psychosis-associated diseases such as bipolar disease or schizophrenia. | ||||||
| 22 | High-Throughput Combinatorial Dip-Coating Apparatus and Methodologies | US13160732 | 2011-06-15 | US20120156498A1 | 2012-06-21 | Nikhil D. Kalyankar; Nitin Kumar; Zhi-Wen Sun; Kenneth A. Williams |
| Embodiments of the current invention describe a high performance combinatorial method and apparatus for the combinatorial development of coatings by a dip-coating process. The dip-coating process may be used for multiple applications, including forming coatings from varied sol-gel formulations, coating substrates uniformly with particles to combinatorially test particle removal formulations, and the dipping of substrates into texturing formulations to combinatorially develop the texturing formulations. | ||||||
| 23 | High-Throughput Combinatorial Dip-Coating Apparatus and Methodologies | US12970638 | 2010-12-16 | US20110151105A1 | 2011-06-23 | Nikhil D. Kalyankar; Nitin Kumar; Zhi-Wen Sun; Kenneth A. Williams |
| Embodiments of the current invention describe a high performance combinatorial method and apparatus for the combinatorial development of coatings by a dip-coating process. The dip-coating process may be used for multiple applications, including forming coatings from varied sol-gel formulations, coating substrates uniformly with particles to combinatorially test particle removal formulations, and the dipping of substrates into texturing formulations to combinatorially develop the texturing formulations. | ||||||
| 24 | PATTERNED NANOSUBSTRATES MADE BY DIRECTED SELF ASSEMBLY OF AMPHIPHILIC MOLECULES | US12743441 | 2008-11-21 | US20100311613A1 | 2010-12-09 | Ahmed Busnaina; Joey L. Mead; Carol M.F. Barry; Ming Wei |
| Nanoscale patterns prepared by lithography are used to direct the self-assembly of amphiphilic molecules to form patterned nanosubstrates having a desired distribution of chemical functional moieties. These patterns can be fabricated over a large area and require no special limitations on the chemistry the assembled amphiphiles. Hydrophilic/hydrophobic patterns can be created and used to direct the deposition of a single functional component to specific regions of the surface or to selectively assemble polymer blends to desired sites in a one step fashion with high specificity and selectivity. The selective deposition of functional moieties on a patterned surface can be based on electrostatic forces, hydrogen bonding, or hydrophobic interactions. The methods and patterned nanosubstrates of the invention can be used in the assembly of functional polymer systems, polyelectrolytes, biomolecules, conducting polymers, colloids and nanoparticles, and find wide technological applications in biosensors, biochips, photonics and electronics. | ||||||
| 25 | INTRINSICALLY LABELLED SOLID SUPPORT | US09000125 | 1998-01-21 | US20010007740A1 | 2001-07-12 | BRIAN GEOFFREY MAIN; RICHARD EDEN SHUTE |
| A compound library comprises a plurality of different units each comprising a solid support with which is associated a single member of the compound library, each solid support has a defined chemical composition which acts as an intrinsic label capable of identifying the first reaction choice in the synthesis of the associated member of the compound library. | ||||||
| 26 | METHOD AND ARRAYS FOR USE IN DIAGNOSING EARLY BREAST CANCER | EP15747502.1 | 2015-06-09 | EP3152578A2 | 2017-04-12 | BORREBAECK, Carl Arne Krister; WINGREN, Christer Lars Bertil |
| The present invention provides a method for diagnosing breast cancer comprising or consisting of the steps of (a) providing a sample to be tested; and (b) determining a biomarker signature of the test sample by measuring the presence and/or amount in the test sample of one or more biomarker selected from the group defined in Table A(i) and/or Table A(ii); wherein the presence and/or amount in the test sample of the one or more biomarker selected from the group defined in Table A(i) and/or Table A(ii) is indicative of the presence of breast cancer cells in the individual, corresponding uses, methods of treating breast cancer, together with arrays and kits for use in the same. | ||||||
| 27 | METHODE DE SELECTION DANS DES CONDITIONS PHYSICO-CHIMIQUES NON STANDARD DE PROTEINES STABLES | EP06743634.5 | 2006-04-04 | EP1894014B1 | 2016-12-21 | DELCOURT, Marc |
| 28 | EXPANDED RADIX FOR POLYMERIC TAGS | EP12795266.1 | 2012-11-19 | EP2788499A2 | 2014-10-15 | WEINER, Michael P. |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 29 | GENOME-WIDE CONSTRUCTION OF SCHIZOSACCHAROMYCES POMBE HETEROZYGOUS DELETION MUTANTS CONTAINING GENE-SPECIFIC BARCODES BY THE METHODS OF 4-ROUND SERIAL OR BLOCK PCR, OR TOTAL GENE SYNTHESIS THEREOF | EP08793534 | 2008-08-27 | EP2268808A4 | 2011-09-14 | HOE KWANG LAE; KIM DONG UK; WON MI SUN; YOO HYANG SOOK; KIM DONG SUP; PARK HAN OH; CHUNG KYUNG SOOK; JANG YOUNG JOO; NAM MI YOUNG; HAN SANG JO; CHOI SHIN JUNG; BAEK SEUNG TAE; KIM HYONG BAI; HEO KYUNG SUN; LEE HYE MI; LEE MIN HO; PARK JO YOUNG |
| A method comprising transforming Schizosaccharomyces pombe with a deletion cassette, constructed by four-round serial PCR, block PCR or total gene synthesis, containing a homologous recombination site is provided for preparing gene-targeted heterozygous deletion Schizosaccharomyces pombe. Also provided are gene-targeted hetero2ygous deletion Schizosaccharomyces pombe mutants prepared by the method, and a library of gene-targeted heterozygous deletion Schizosaccharomyces pombe mutants. Further, the library is useful in constructing a method and a kit for screening a drug's modes of action. | ||||||
| 30 | GENOME-WIDE CONSTRUCTION OF SCHIZOSACCHAROMYCES POMBE HETEROZYGOUS DELETION MUTANTS CONTAINING GENE-SPECIFIC BARCODES BY THE METHODS OF 4-ROUND SERIAL OR BLOCK PCR, OR TOTAL GENE SYNTHESIS THEREOF | EP08793534.2 | 2008-08-27 | EP2268808A1 | 2011-01-05 | HOE, Kwang Lae; KIM, Dong Uk; WON, Mi Sun; YOO, Hyang Sook; KIM, Dong Sup; PARK, Han Oh; CHUNG, Kyung Sook; JANG, Young Joo; NAM, Mi Young; HAN, Sang Jo; CHOI, Shin Jung; BAEK, Seung Tae; KIM, Hyong Bai; HEO, Kyung Sun; LEE, Hye Mi; LEE, Min Ho; PARK, Jo Young |
| A method comprising transforming Schizosaccharomyces pombe with a deletion cassette, constructed by four-round serial PCR, block PCR or total gene synthesis, containing a homologous recombination site is provided for preparing gene-targeted heterozygous deletion Schizosaccharomyces pombe. Also provided are gene-targeted hetero2ygous deletion Schizosaccharomyces pombe mutants prepared by the method, and a library of gene-targeted heterozygous deletion Schizosaccharomyces pombe mutants. Further, the library is useful in constructing a method and a kit for screening a drug's modes of action. | ||||||
| 31 | INTRINSICALLY LABELLED SOLID SUPPORT | EP96924089.0 | 1996-07-17 | EP0843656A1 | 1998-05-27 | MAIN, Brian, Geoffrey; SHUTE, Richard, Eden |
| A compound library comprises a plurality of different units each comprising a solid support with which is associated a single member of the compound library, each solid support has a defined chemical composition which acts as an intrinsic label capable of identifying the first reaction choice in the synthesis of the associated member of the compound library. | ||||||
| 32 | Method and kit for determining the genome integrity and/or the quality of a library of dna sequences obtained by deterministic restriction site whole genome amplification | EP13195770.6 | 2013-12-04 | EP2881739B1 | 2017-05-17 | Klein, Christoph Andreas; Polzer, Bernhard Michael; Manaresi, Nicolò |
| The present invention relates to a method for determining the integrity of the genome of a sample and/or the quality of a library of DNA sequences obtained by deterministic restriction site whole genome amplification (DRS-WGA) of the genome of the sample comprising the steps of: (a) providing the library of DNA sequences; (b) amplifying the library of DNA sequences by PCR using at least one first primer pair which hybridises to a DNA sequence of the library having a length from 1000 bp to 5000 bp and corresponding to a sequence of the genome located on a first chromosome arm, the step of amplifying giving rise to a first PCR product from 50 to 1000 bp; (c) detecting the first PCR product; (d) correlating the presence of the first PCR product with the integrity of the genome and/or the quality of the library of DNA sequences. The present invention further relates to a related kit and uses thereof. | ||||||
| 33 | EXPANDED RADIX FOR POLYMERIC TAGS | EP12795266.1 | 2012-11-19 | EP2788499B1 | 2016-01-13 | WEINER, Michael P. |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
| 34 | Polymorphisms predictive of anthracycline-induced cardiotoxicity | EP12180869.5 | 2007-11-15 | EP2527501A1 | 2012-11-28 | Carleton, Bruce; Hayden, Michael; Ross, Colin |
Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of cardiotoxicity in response to receiving one or more anthracycline compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of cardiotoxicity. |
||||||
| 35 | POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPLEX-INDUCED OTOTOXICITY | EP07845537 | 2007-11-15 | EP2102393A4 | 2011-01-05 | HAYDEN MICHAEL; CARLETON BRUCE; ROSS COLIN |
| Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of ototoxicity in response to receiving one or more platinum-coordinating compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of ototoxicity. | ||||||
| 36 | POLYMORPHISMS PREDICTIVE OF PLATINUM-COORDINATING COMPLEX-INDUCED OTOTOXICITY | EP07845537.5 | 2007-11-15 | EP2102393A1 | 2009-09-23 | HAYDEN, Michael; CARLETON, Bruce; ROSS, Colin |
| Provided are methods, nucleic acids, and arrays for assessing the susceptibility of a subject to the development of ototoxicity in response to receiving one or more platinum-coordinating compounds, the method including determining the presence or absence of one or more polymorphisms, wherein the presence or absence of one or more such polymorphisms is indicative of susceptibility to the development of ototoxicity. | ||||||
| 37 | METHODE DE SELECTION DANS DES CONDITIONS PHYSICO-CHIMIQUES NON STANDARD DE PROTEINES STABLES | EP06743634.5 | 2006-04-04 | EP1894014A1 | 2008-03-05 | DELCOURT, Marc |
| The invention relates to a method for selecting stable proteins in non-standard physicochemical conditions (temperature, pressure, pH, osmolarity, salinity, solvent, ....), comprising the expression, in an extremophile micro-organism, of variants of the protein of interest in the form of a fusion protein, with a reporter protein which is stable in extreme conditions and acts as a selection marker. | ||||||
| 38 | Methods and Kits for Detecting Contamination and Sample Misidentification | US16277757 | 2019-02-15 | US20190249334A1 | 2019-08-15 | Shannon Piehl; Josh Kinman |
| The disclosed methods and kits are useful in processing and analyzing a multiplicity of samples in molecular biology workflows where there is an increased chance for sample cross-contamination or misidentification. Some embodiments of the methods and kits utilize at least one spike in control and at least one barcode per sample. | ||||||
| 39 | Reimmunization and antibody design | US14493488 | 2014-09-23 | US09938337B2 | 2018-04-10 | Janus Beierholm Larsen |
| The present invention relates to methods for harvesting of antibodies from an antibody library. The antibodies are harvested by utilizing a certain epitope that is analogous to the epitope of the antigen used for immunization but that may differ in global physical and biochemical properties allowing the production of antibodies against antigens that normally cannot be utilized as immunizing agents. The present invention furthermore relate to fields of use for harvested antigens in industry, agriculture and healthcare. | ||||||
| 40 | Expanded radix for polymeric tags | US14921977 | 2015-10-23 | US09909121B2 | 2018-03-06 | Michael P. Weiner |
| A method having steps of (a) providing nucleic acids having a tag sequence (N1)n(N2)n . . . (Nx)n, wherein N1, N2 and Nx are nucleotides that complement different nucleotides, respectively, wherein n is an integer that can differ for N1, N2 and Nx; (b) detecting the nucleic acids individually and under conditions to distinguish signal intensities for (N1)n sequences having different values for n, (N2)n sequences having different values for n and. (Nx)n sequences having different values for n; and (c) distinguishing the tags based on the signal intensities. | ||||||
QQ群二维码
意见反馈
意见反馈