专利检索_ .其他碳 - 氧裂解酶专利检索_ .其他碳 - 氧裂解酶专利检索查询_ .其他碳

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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
1	Methods and compositions for Pcr	JP2010523109	2008-08-27	JP2010537637A	2010-12-09	ラリーエル．シー，; アレキサンダーエー．ノビコフ，; デニスイー．プロセン，
熱安定性ＰｏｌＢＤＮＡポリメラーゼと式Ｉの改変因子試薬の、基本的に水性条件下における反応によって産生された、改変熱安定性ＰｏｌＢＤＮＡポリメラーゼ、ここでその反応は、熱安定性ＰｏｌＢＤＮＡポリメラーゼ活性および３'−５'エキソヌクレアーゼ活性の熱的に可逆的な不活性化をもたらし、そのポリメラーゼはホットスタートＰＣＲに適当である。改変の方法、ポリ核酸増幅方法、およびＰＣＲ反応混合物および改変熱安定性ＰｏｌＢＤＮＡポリメラーゼを含むキットも開示される。
2	METHODS AND COMPOSITIONS FOR PCR	EP08798774	2008-08-27	EP2183380A4	2011-11-30	XI LARRY L; PROSEN DENNIS E; NOVIKOV ALEXANDER A
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
3	Microbial production of muconic acid and salicylic acid	US15370755	2016-12-06	US09719113B2	2017-08-01	Yajun Yan; Yuheng Lin
The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
4	MICROBIAL PRODUCTION OF MUCONIC ACID AND SALICYLIC ACID	US15370755	2016-12-06	US20170145447A1	2017-05-25	Yajun Yan; Yuheng Lin
The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
5	MICROBIAL PRODUCTION OF MUCONIC ACID AND SALICYLIC ACID	US14622155	2015-02-13	US20150225751A1	2015-08-13	YAJUN YAN; YUHENG LIN
The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
6	Methods and Compositions for PCR	US12198962	2008-08-27	US20090263869A1	2009-10-22	Lei Xi; Dennis E. Prosen; Alexander A. Novikov
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula I wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3′-5′ exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
7	Methods And Compositions For PCR	US15821651	2017-11-22	US20180094250A1	2018-04-05	Lei (Larry) XI; Dennis PROSEN; Alexander NOVIKOV
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula I wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3′-5′ exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
8	Microbial production of muconic acid and salicylic acid	US14622155	2015-02-13	US09546387B2	2017-01-17	Yajun Yan; Yuheng Lin
The invention provides a recombinant microorganism that has been genetically engineered to contain metabolic pathway for the production of muconic acid from a salicylic acid intermediate. The genetically engineered metabolic pathway comprises both biosynthetic and biodegradative elements.
9	Methods and Compositions for PCR	US14882343	2015-10-13	US20160032262A1	2016-02-04	Lei (Larry) XI; Dennis Prosen; Alexander Novikov
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula I wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3′-5′ exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
10	Method for producing L-cysteine	US13431104	2012-03-27	US09234223B2	2016-01-12	Shunsuke Yamazaki; Gen Nonaka; Kazuhiro Takumi
A method for producing L-cysteine and the like is provided by developing a novel technique for improving bacterial L-cysteine-producing ability. The method includes the steps of culturing a bacterium belonging to the genus Escherichia which has L-cysteine-producing ability, and in which expression of a gene involved in sulfite reduction is enhanced, in a medium containing thiosulfate, and collecting L-cysteine, a related substance thereof, or a mixture thereof which accumulate in the medium.
11	METHOD FOR PRODUCING L-CYSTEINE	US13431104	2012-03-27	US20120252076A1	2012-10-04	Shunsuke Yamazaki; Gen Nonaka; Kazuhiro Takumi
A method for producing L-cysteine and the like is provided by developing a novel technique for improving bacterial L-cysteine-producing ability. The method includes the steps of culturing a bacterium belonging to the genus Escherichia which has L-cysteine-producing ability, and in which expression of a gene involved in sulfite reduction is enhanced, in a medium containing thiosulfate, and collecting L-cysteine, a related substance thereof, or a mixture thereof which accumulate in the medium.
12	Methods and compositions for PCR	EP14194397.7	2008-08-27	EP2913398A1	2015-09-02	Xi, Larry L.; Prosen, Dennis E.; Novikov, Alexander A.
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
13	METHODS AND COMPOSITIONS FOR PCR	EP08798774.9	2008-08-27	EP2183380A2	2010-05-12	XI, Larry, L.; PROSEN, Dennis, E.; NOVIKOV, Alexander, A.
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
14	Methods for PCR	EP14194397.7	2008-08-27	EP2913398B1	2017-07-12	Xi, Larry L.; Prosen, Dennis E.; Novikov, Alexander A.
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
15	METHODS AND COMPOSITIONS FOR PCR	EP08798774.9	2008-08-27	EP2183380B1	2014-11-26	XI, Larry, L.; PROSEN, Dennis, E.; NOVIKOV, Alexander, A.
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.
16	METHODS AND COMPOSITIONS FOR PCR	PCT/US2008074432	2008-08-27	WO2009029648A3	2009-04-30	XI LARRY L; PROSEN DENNIS E; NOVIKOV ALEXANDER A
A modified thermostable Pol B DNA polymerase, produced by a reaction, under essentially aqueous conditions, of a thermostable Pol B DNA polymerase and a modifier reagent of Formula (I) wherein the reaction results in a thermally reversible inactivation of the thermostable Pol B DNA polymerase activity and the 3'-5' exonuclease activity, which polymerase is suitable for hot-start PCR. Also disclosed are the method for the modification, a polynucleic acid amplification method and PCR reaction mixture and kit comprising the modified thermostable Pol B DNA polymerase.

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