| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELL | US14323512 | 2014-07-03 | US20140314727A1 | 2014-10-23 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 22 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cell | US14027727 | 2013-09-16 | US08778644B2 | 2014-07-15 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 23 | Optimization of Lipid Synthesis and Accretion | US13806332 | 2011-07-01 | US20130149754A1 | 2013-06-13 | Thierry Dulermo; Jean-Marc Nicaud |
| The present invention relates to a novel mutant strain of yeast, particularly a strain of Yarrowia lipolytica, which is capable of accumulating a large quantity of lipids. Said strain is deficient in the beta-oxidation of fatty acids and overexpresses the GPD1 gene. Preferably, the mutant strains, which do not express the GUT2 gene and which are deficient for the beta-oxidation of fatty acids, do not express the POX2 to POX5 genes, very preferably the POX2 to 6 genes. The invention also relates to a method for obtaining the strains of yeast according to the invention and to the use of said strains in the production of lipids. | ||||||
| 24 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | US13311240 | 2011-12-05 | US20120083615A1 | 2012-04-05 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichois; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 25 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | US13093252 | 2011-04-25 | US08071341B2 | 2011-12-06 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 26 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | US12945708 | 2010-11-12 | US20110054198A1 | 2011-03-03 | SURINDER PAL SINGH; STANLEY SURESH ROBERT; PETER DAVID NICHOLS; SUSAN IRENE ELLIS BLACKBURN; XUE-RONG ZHOU; JAMES ROBERTSON PETRIE; ALLAN GRAHAM GREEN |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 27 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | US11587092 | 2005-04-22 | US07834250B2 | 2010-11-16 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 28 | Synthesis of Long-Chain Polyunsaturated Fatty Acids by Recombinant Cells | US11587092 | 2005-04-22 | US20080268539A1 | 2008-10-30 | Surinder Pal Singh; Stanley Suresh Robert; Peter David Nichols; Susan Irene Ellis Blackburn; Xue-Rong Zhou; James Robertson Petrie; Allan Graham Green |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 29 | NOVEL FATTY ACID DESATURASES AND ELONGASES AND USES THEREOF | EP10732374.3 | 2010-07-15 | EP2454278A1 | 2012-05-23 | BAUER, Jörg; NAPIER, Johnathan, A.; SAYANOVA, Olga |
| The invention provides isolated nucleic acid molecules which encode novel fatty acid desaturases and elongases from the organism Emiliana huxleyi. The invention also provides recombinant expression vectors containing desaturase or elongase nucleic acid molecules, host cells into which the expression vectors have been introduced, and methods for large-scale production of long chain polyunsaturated fatty acids (LCPUFAs), e.g. arachidonic acid (ARA), eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA). | ||||||
| 30 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155266.7 | 2005-04-22 | EP2363492A3 | 2012-03-14 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 31 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155282.4 | 2005-04-22 | EP2357243A2 | 2011-08-17 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 32 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells | EP11155282.4 | 2005-04-22 | EP2357243B1 | 2018-12-12 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 33 | OPTIMISATION DE LA SYNTHESE ET DE L'ACCUMULATION DE LIPIDES | EP11729114.6 | 2011-07-01 | EP2588599B1 | 2016-11-30 | DULERMO, Thierry; NICAUD, Jean-Marc |
| 34 | OPTIMISATION DE LA SYNTHESE ET DE L'ACCUMULATION DE LIPIDES | EP11729114.6 | 2011-07-01 | EP2588599A1 | 2013-05-08 | DULERMO, Thierry; NICAUD, Jean-Marc |
| The invention relates to a novel mutant yeast strain, in particular a strain of Yarrowia lipolytica, which is capable of accreting a large quantity of lipids. Said strain is deficient in the beta-oxidation of fatty acids, and overexpresses the GPD1 gene. Preferably, the mutant strains, which do not express the GUT2 gene and which are deficient only in the beta-oxidation of fatty acids, do not express the POX2 to POX5 genes, more preferably the genes POX1 to 6. The invention also relates to a method for obtaining strains according to the invention, and to the use of said strains in the production of lipids. | ||||||
| 35 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155364.0 | 2005-04-22 | EP2357244A3 | 2011-11-23 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 36 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155282.4 | 2005-04-22 | EP2357243A3 | 2011-11-23 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 37 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155266.7 | 2005-04-22 | EP2363492A2 | 2011-09-07 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 38 | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells. | EP11155364.0 | 2005-04-22 | EP2357244A2 | 2011-08-17 | Singh, Surinder Pal; Robert, Stanley Suresh; Nichols, Peter David; Blackburn, Susan Irene Ellis; Zhou, Xue-Rong; Petrie, James Robertson; Green, Allan Graham |
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. |
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| 39 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | EP05733657 | 2005-04-22 | EP1756280A4 | 2008-04-30 | SINGH SURINDER PAL; ROBERT STANLEY SURESH; BLACKBURN SUSAN IRENE ELLIS; ZHOU XUE-RONG; PETRIE JAMES ROBERTSON; GREEN ALLAN GRAHAM |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
| 40 | SYNTHESIS OF LONG-CHAIN POLYUNSATURATED FATTY ACIDS BY RECOMBINANT CELLS | PCT/AU2005000571 | 2005-04-22 | WO2005103253A8 | 2006-01-05 | SINGH SURINDER PAL; ROBERT STANLEY SURESH; NICHOLS PETER DAVID; BLACKBURN SUSAN IRENE ELLIS; ZHOU XUE-RONG; PETRIE JAMES ROBERTSON; GREEN ALLAN GRAHAM |
| The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desatorase or elongase activity that can be used in methods of synthesizing long-chain polyunsaturated fatty acids. | ||||||
