子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 灌流バイオリアクタ・プラットフォーム | JP2017523433 | 2015-10-29 | JP2017532970A | 2017-11-09 | ロジャー マーティン，グレゴリー; ジーン タナー，アリソン |
| 細胞培養装置は、第1の主面及び反対側の第2の主面を有する1つ以上のプレートを備えている。第1の主面は、複数のウェルを画成する構造化された表面を含む。各ウェルは、上部開口及び底を画成する内面を有し、各ウェルの上部開口は、100マイクロメートル〜2000マイクロメートルの範囲の直径寸法を有する。装置はまた、底面の長さに沿って第1の主面から延びる複数のスペーサも備えている。複数のフローチャネルは、隣接するレール同士の間に画成される。 | ||||||
| 2 | Apparatus for manufacturing an implantable prosthesis, kit and it | JP50390395 | 1994-07-05 | JPH09500298A | 1997-01-14 | ウォロワッツ，ソレル，エリザベス; カーター，アンドルー，ジェームズ; キング，ジョン，ビー．; サール，リチャード，ジョン; キャロライン シェルトン，ジュリア; パーマー，デブラ; マシューズ，ジェーン，ブリジェット |
| (57)【要約】 埋込型プロステーシスは、繊維芽細胞を接種した、生物適合性の合成の実質的に生物同化可能なマトリックス素材からなる。 | ||||||
| 3 | CELL PREPARATION METHOD, CELL CULTIVATION DEVICE, AND KIT | US16320003 | 2017-07-25 | US20190249146A1 | 2019-08-15 | Masahiko HAGIHARA; Shyusei OHYA |
| The present invention relates to a cell preparation method that includes a step in which cells are applied to a polyimide porous film and cultivated, wherein the polyimide porous film is a polyimide porous film with a three-layer structure, having a surface layer A and a surface layer B that have a plurality of holes, and a macrovoid layer that is sandwiched between the surface layer A and the surface layer B, and the polyimide porous film is produced by a method including the following steps: (1) a step in which a poly(amic acid) solution comprising poly(amic acid) and an organic polar solvent is flow cast in a film shape and the result is immersed in or brought into contact with a coagulation medium to create a porous film of poly(amic acid); and (2) a step in which the porous film of poly(amic acid) obtained in step (1) is heat-treated and imidized. | ||||||
| 4 | TEMPERATURE SENSITIVE CELL CULTURE SURFACE AND PREPARATION METHOD THEREOF | US15775695 | 2016-01-29 | US20180327526A1 | 2018-11-15 | Jianhua YUAN; Yong CHEN; Huilun LI; Xiangyuan FANG |
| The invention provides a temperature sensitive cell culture surface and preparation method thereof. The preparation method comprises the following steps: (1) preparing a temperature sensitive primary liquid by adding a temperature sensitive compound and a free radical into a solvent, mixing and dissolving the same, and obtaining the temperature sensitive primary liquid; and (2) distributing the temperature sensitive primary liquid on a cell culture surface, and leaving the cell culture surface at 50-150° C. to react for 5-120 mins. | ||||||
| 5 | GELATIN, CHEMICALLY MODIFIED PRODUCT THEREOF, AQUEOUS COMPOSITION AND MEDICAL LAMINATE CONTAINING SAME, PRODUCTION METHOD FOR MEDICAL LAMINATE, AND CELL SHEET ISOLATION METHOD | US15769362 | 2016-10-18 | US20180312726A1 | 2018-11-01 | Yoshimi OHYABU; Shunji YUNOKI; Hirosuke HATAYAMA; Masataka ODA; Yosuke HIRAOKA |
| A gelatin or a chemically modified product thereof contains 10 to 50% by mass of a high-molecular weight component, and a low-molecular weight component in such an amount that a value obtained by subtracting a low-molecular weight component content from a high-molecular weight component content is greater than or equal to 0% by mass. | ||||||
| 6 | A METHOD OF CULTURING CELLS | US15759817 | 2015-09-15 | US20180258380A1 | 2018-09-13 | Wayne George KLEINTJES |
| A method of culturing autogenous cells as well as a method of treating a mammalian patient is described. The cells are cultured on a substrate material having a surface treated with a fatty acid ester so as to have a strong hydrophobic surface and autogenous plasma obtained from a blood sample of the patient is used as a growth medium in order to culture the cells. The substrate material is also used as a transfer dressing for transferring the cultured cells to the patient and as a wound cover dressing. The invention also describes a kit as well as a system for culturing autogenous cells using the culture method. | ||||||
| 7 | RESPIRATION DEVICE FOR ANALYSIS OF A RESPONSE TO SHEAR STRESS AND FOREIGN AGENTS ON CELLS | US15563140 | 2016-03-31 | US20180080925A1 | 2018-03-22 | Kambez Hajipouran Benam; Richard Novak; Josiah Sliz; Thomas Charles Ferrante; Donald Elliot Ingber; Youngjae Choe |
| A microfluidic system for determining a response of cells comprises one or more fluid pumps. The one or more fluid pumps move a fluid across cells within a microfluidic device. The microfluidic device includes a microchannel at least partially defined by a surface having cells adhered thereto, a first port at one end of the microchannel, and a second port at an opposing end of the microchannel. The one or more fluid pumps move the fluid across the cells in a first direction toward the second port and then move the fluid across the cells in a second direction toward the first port. | ||||||
| 8 | OPEN-TOP MICROFLUIDIC DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A TISSUE | EP16871655.3 | 2016-12-02 | EP3383992A1 | 2018-10-10 | VARONE, Antonio; WEN, Norman; LEVNER, Daniel; NOVAK, Richard; MCPARTLIN, Lori; INGBER, Donald, E.; CHOE, Youngjae; LENG, Lian; NGUYEN, Justin, K. |
| A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber. | ||||||
| 9 | 組織の機能を模擬するためのオープントップマイクロ流体デバイスおよび方法 | JP2018528976 | 2016-12-02 | JP2018535688A | 2018-12-06 | ヴァローン アントニオ; ウェン ノーマン; レヴナー ダニエル; ノヴァク リチャード; マックパートリン ロリ; イングバー ドナルド イー; チョー ヤンジャエ; レン ライアン; グエン ジャスティン ケー |
| 組織の機能を模擬するためのデバイスは、第1構造部、第2構造部、および薄膜を含む。第1構造部は、第1チャンバを画定する。第1チャンバは、内部に配置されるマトリックスおよび開口領域を含む。第2構造部は第2チャンバを画定する。薄膜は、第1チャンバおよび第2チャンバの間の界面領域に配置される。薄膜は、第1チャンバに向く第1面および第2チャンバに向く第2面を含む。薄膜により第1チャンバは第2チャンバから分離される。 | ||||||
| 10 | 積層化細胞シート組成物を製造する方法、それにより製造される積層化細胞シート組成物及びその製造装置 | JP2016082342 | 2016-10-31 | JPWO2017077985A1 | 2018-08-23 | 清水 達也; 坂口 勝久; 日向 裕人 |
| 本発明は、シート状細胞群の上面に培養細胞移動治具を接触させ、第1細胞シートを前記培養細胞移動治具に付着する工程、第2シート状細胞群の上面、及び/又は、前記培養細胞移動治具に付着した前記第1細胞シートの下面、に細胞接着性物質を塗布する工程、前記培養細胞移動治具に付着した前記第1細胞シートの下面を、前記第2シート状細胞群の上面に接触させ、第2細胞シートを前記第1細胞シートに接着させる工程、を含む、積層化細胞シート組成物を製造する方法を提供する。また、本発明は、その方法により得られる積層化細胞シート組成物を提供する。また、本発明は、積層化細胞シート組成物の製造装置を提供する。 | ||||||
| 11 | 培養容器、計測装置、培養方法、及び培養装置 | JP2016571634 | 2015-01-30 | JPWO2016121095A1 | 2017-06-15 | 広斌 周; 政晴 木山; 由美子 五十嵐 |
| 培養しながら非破壊的に細胞シート厚さを計測する培養容器と計測装置を提供する。蓋4を有する培養容器は、その内部に設置される浮き具8を備え、浮き具は培養容器内の培地により浮上する構造を有する。また、この浮き具の高さ方向の位置変化を検出する発光素子10Aと受光素子10Bを有するセンサヘッド10と、センサヘッドの信号を処理するコントローラ11とを備える細胞シート厚さ計測装置を構成する。 | ||||||
| 12 | Apparatus for manufacturing an implantable prosthesis, kit and it | JP50390395 | 1994-07-05 | JP3493199B2 | 2004-02-03 | ウォロワッツ，ソレル，エリザベス; カーター，アンドルー，ジェームズ; キング，ジョン，ビー．; サール，リチャード，ジョン; キャロライン シェルトン，ジュリア; パーマー，デブラ; マシューズ，ジェーン，ブリジェット |
| An implantable prosthesis comprises a biocompatible, synthetic, substantially bioresorbable matrix material seeded with fibroblasts. | ||||||
| 13 | THREE-DIMENSIONAL PRINTED ORGANS, DEVICES, AND MATRICES | US16044413 | 2018-07-24 | US20190010463A1 | 2019-01-10 | Melanie P. MATHEU; Kathryn J. PARKINSON; Emma R. MOULTON |
| Provided herein are methods and systems for bio-printing of three-dimensional organs and organoids. Also provided herein are bio-printed three-dimensional organs and organoids for use in the generation and/or the assessment of immunological products and/or immune responses. Also provided herein are methods and system for bio-printing three-dimensional matrices. | ||||||
| 14 | OPEN-TOP MICROFLUIDIC DEVICES AND METHODS FOR SIMULATING A FUNCTION OF A TISSUE | US15781078 | 2016-12-02 | US20180346859A1 | 2018-12-06 | Antonio Varone; Norman Wen; Daniel Levner; Richard Novak; Lori McPartlin; Donald E. Ingber; Youngjae Choe; Lian Leng; Justin K. Nguyen |
| A device for simulating a function of a tissue includes a first structure, a second structure, and a membrane. The first structure defines a first chamber. The first chamber includes a matrix disposed therein and an opened region. The second structure defines a second chamber. The membrane is located at an interface region between the first chamber and the second chamber. The membrane includes a first side facing toward the first chamber and a second side facing toward the second chamber. The membrane separates the first chamber from the second chamber. | ||||||
| 15 | CELL CULTURE APPARATUS | US15521811 | 2015-03-20 | US20180282680A1 | 2018-10-04 | Seung Hwan CHANG; Ji Hun BAE |
| Techniques for providing in vivo environments to in vitro cells by periodically applying mechanical stimuli to in vitro cells are provided for effective studies on cell culture. A first embodiment of the present invention provides a cell culture apparatus including: a first layer including an electroactive polymer material and elongated in at least one direction by external force applied thereto; a first fixing part fixing both ends of the first layer in the direction in which the first layer is elongated, so as to maintain the elongation of the first layer; a second layer including the electroactive polymer material and spaced apart from a surface of the first layer, the second layer being elongated in at least one direction by external force applied thereto; a second fixing part fixing both ends of the second layer in the direction in which the second layer is elongated, so as to maintain the elongation of the second layer; a first electrode part applied to a region of the first layer; and a second electrode part applied to a region of the second layer, wherein the second layer is provided in such a manner that a cell to be cultured is sandwiched between the surface of the first layer and a surface of the second layer. | ||||||
| 16 | CELL CULTURE MODULE | US15909616 | 2018-03-01 | US20180251721A1 | 2018-09-06 | Shinya HASHIMOTO; Takafumi IMAIZUMI; Yukiko KIKUCHI; Kazunobu TSUNEMOTO; Takaaki ITOI; Misao OBASE |
| A cell culture module includes a cell culture substrate that has, on a surface thereof, a recessed portion that cultures a cell, in which at least a bottom surface of the recessed portion includes a porous body, a holding member that houses the cell culture substrate and that has an internal space partitioned into a first space and a second space by the cell culture substrate, and an oxygen sensor that is provided inside the first space of the holding member and that measures a concentration of dissolved oxygen in the culture medium. The oxygen sensor measures the concentration of dissolved oxygen in the vicinity of the cultured cell. | ||||||
| 17 | CULTURE VESSEL, MEASUREMENT DEVICE, CULTURE METHOD, AND CULTURE DEVICE | US15536668 | 2015-01-30 | US20170355941A1 | 2017-12-14 | Guangbin ZHOU; Masaharu KIYAMA; Yumiko IGARASHI |
| The present invention provides a culture vessel and a measuring device for measuring a cell sheet thickness nondestructively during culturing. A culture vessel having a lid 4 has a float 8 installed in the interior and the float is structured so as to be uplifted by a culture medium in the culture vessel. Further, a cell sheet thickness measuring device having a sensor head 10 having a light-emitting element 10A and a light-receiving element 10B to detect a positional variation of the float in the vertical direction and a controller 11 to process a signal of the sensor head is configured. | ||||||
| 18 | PERFUSION BIOREACTOR PLATFORM | US15498062 | 2017-04-26 | US20170306281A1 | 2017-10-26 | Gregory Roger Martin; Allison Jean Tanner |
| A cell culture apparatus includes one or more plates having a first major surface and an opposing second major surface. The first major surface comprises a structured surface defining a plurality of wells. Each well has an interior surface defining an upper aperture and a nadir, wherein the upper aperture of each well has a diametric dimension in a range from 100 micrometers to 2000 micrometers. The apparatus also includes a plurality of spacers extending from the first major surface along a length of the bottom surface. A plurality of flow channels are defined between adjacent rails. | ||||||
| 19 | MICRODEVICE PLATFORM RECAPITULATING HYPOXIC TISSUE MICROENVIRONMENTS | US15941374 | 2018-03-30 | US20180291330A1 | 2018-10-11 | KEYUE SHEN; YUTA ANDO; DANIEL YEN; HOANG TA |
| Hypoxia plays a central role in cancer progression and resistance to therapy. A microdevice platform is engineered to recapitulate the intratumor oxygen gradients that drive the heterogeneous hypoxic landscapes in solid tumors. The microdevice design features a “tumor section”-like culture by incorporating a cell layer between two diffusion barriers, where an oxygen gradient is established by cellular metabolism and physical constraints. The oxygen gradient is confirmed by numerical simulation and imaging-based oxygen sensor measurement. Spatially-resolved hypoxic signaling in cancer cells is also demonstrated through immunostaining, gene expression assay, and hypoxia-targeted drug treatment. The microdevice platform can accurately generate and control oxygen gradients, eliminates complex microfluidic handling, allows for incorporation of additional tumor components, and is compatible with high-content imaging and high-throughput applications. It is well suited for understanding hypoxia-mediated mechanisms in cancer disease and other biological tissues and processes, and discovery of new therapeutics. | ||||||
| 20 | CULTURE DEVICE FOR TISSUE CELL SUSPENSION | US15752580 | 2016-08-09 | US20180237733A1 | 2018-08-23 | Lei Ye |
| The present invention relates to a culture device for tissue cell suspension. The culture device includes a tissue cell culture body. The tissue cell culture body is a porous material. The porous material is formed by cavities classified into different levels according to the pore size of material and cavity walls surrounding to form the cavities. A lower level of small cavities is provided to surround the cavity wall which forms the upper level of large cavity. Cavities of each level are in communication with each other, and cavities between respective levels are also in communication with each other. The culture device further includes a swirler device provided therein. Such culture device can particularly facilitate normal and unrestricted growth of the suspension of cells in three-dimensional space, obstructing the formation of over-dense cell region or nutrient-rich region during the cell culturing. | ||||||
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