| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 101 | PROCESS FOR THE PURIFICATION OF 1,4-BENZOQUINONE GUANYLHYDRAZONE THIOSEMICARBAZONE (AMBAZONE) | UAA200604639 | 2004-09-15 | UA78470C2 | 2007-03-15 | |
| The invention is relates to a process for the purification of 1,4-benzoquinone guanylhydrazone thiosemicarbazone (ambazone) in two steps. At the first step, it takes place the removal of sulfur from ambazone by maceration of ambazone in a non-polar solvent (benzene, n-hexane, toluene or xylene). At the second step, it takes place the recrystallization of ambazone from a mixture N,N-dimethylformamide and lower aliphatic alcohols (C1-C4) at temperatures between 50-80 DEGREE C. | ||||||
| 102 | 2'-substituirani 1,1'-bifenil-2-karboksamidi, postopek za njihovo pripravo, njihova uporaba kot zdravilo, kot tudi farmacevtski pripravki, ki jih vsebujejo | SI200030883 | 2000-09-19 | SI1222163T1 | 2006-10-31 | BRENDEL JOACHIM; SCHMIDT WOLFGANG; BELOW PETER |
| 103 | ADESAO CELULAR MEDIADA POR INIBIDORES DE ALFA4 | PT99904115 | 1999-01-19 | PT1049662E | 2006-09-29 | ILA SIRCAR; GUDMUNDSSON KRISTJAN S; RICHARD MARTIN |
| 104 | MEJORA AL PROCESO DE LIXIVIACION DE PLATA Y ORO CON SOLUCIONES DE TIOUREA. | MXPA03002005 | 2003-03-07 | MXPA03002005A | 2004-09-09 | LAPIDUS LAVINE GRETCHEN TERRI; LOPEZ ESCUTIA MARIA CONCEPCION; OROPEZA GUZMAN MERCEDES TERESITA |
| La presente invencion esta relacionada con la industria minera y de tratamiento de minerales. Especificamente se relaciona con una composicion de disolucion que permite el uso de tiourea. Especificamente, la patente se refiere a una disolucion que mejore tanto la velocidad de extraccion de plata, a partir de minerales su otros materiales que la contengan, mejorando la estabilidad del tiourea en la disolucion lixiviante. El invento consiste en una disolucion del lixiviacion que anterior o simultaneamente ha y asido sujeto a una electro-oxidacion controlada para producir DSFA que actua como una agente oxidante para las fases minerales que contiene el oro y la plata. En su modalidad preferida el DSFA se encuentra en una proporcion de10 a 30% de la tiourea total contenido en la disolucion. | ||||||
| 105 | NO960411 | 1996-01-31 | NO315160B1 | 2003-07-21 | ENGLERT HEINRICH; HARTUNG JENS; CRAUSE PETER; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM | |
| 106 | Substituted benzenesulfonylureas and -thioureas, processes for their preparation and a medicament containing thereof | CZ43596 | 1996-02-14 | CZ291793B6 | 2003-05-14 | ENGLERT HEINRICH; GERLACH UWE; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM |
| In the present invention there are disclosed benzenesulfonylureas or ?thioureas of the general formula I in which: R(1) represents hydrogen, alkyl having 1 to 7 carbon atoms or cycloalkyl having 3 to 7 carbon atoms; R(2) denotes hydrogen, fluorine, chlorine, alkyl having 1 to 6 carbon atoms, cycloalkyl containing 3 to 6 carbon atoms, a carbon chain with 1 to 8 carbon atoms in which 1 to 4 carbon atoms are replaced oxygen, nitrogen or sulfur; R(3) and R(4) represent each hydrogen alkyl having 1 to 12 carbon atoms, cycloalkyl having 3 to 10 carbon atoms, fluoroalkyl having 1 to 6 carbon atoms, fluoro cycloalkyl having 3 to 6 carbon atoms, or a carbon chains with 1 to 10 carbon atoms in which 1 to 4 carbon atoms are replaced by oxygen, nitrogen or sulfur; or R(3) and R(4) together form a (CHi2)i2-8 ring, in which one of the -CHi2- groups can be replaced by oxygen, nitrogen or sulfur; E represents oxygen or sulfur; X denotes oxygen or sulfur; Y represents [CR(5)R(5')]im, wherein R(5) and R(5') independently of one another represent hydrogen or alkyl having 1 or 2 carbon atoms; whereby the members of the [CR(5)R(5')]im group are identical or different; and m is 1, 2, 3 or 4, as well as a pharmaceutically acceptable salt thereof. These compounds exhibit effects on the cardiovascular system. Further described is also a process for preparing such compounds as well a medicament in which they are comprised. | ||||||
| 107 | Novel anti-adhesive compounds and uses thereof | AU2002255704 | 2002-03-12 | AU2002255704A1 | 2002-09-24 | SMITH ROBERT D; ALBERTE RANDALL S |
| 108 | NOVEL SUBSTITUTED DERIVATIVES OF THIOPHENOSULPHONYL CARBAMIDE AND THIOPHENOSULPHONYL THIOCARBAMIDE, METHOD OF OBTAINING THEM, THEIR APPLICATION IN PRODUCTION OF PHARMACEUTICAL AGENTS AND PHARMACEUTICAL AGENT AS SUCH | PL31253296 | 1996-01-29 | PL183561B1 | 2002-06-28 | ENGLERT HEINRICH; HARTUNG JENS; CRAUSE PETER; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM |
| 109 | New 3,4-dihydroxybenzyl-substituted carbonic acid derivatives are antioxidants and radical scavengers useful e.g. for preventing skin aging or protecting cosmetic, dermatological or foodstuff compositions against oxidation | DE10030891 | 2000-06-23 | DE10030891A1 | 2002-01-03 | LEY JAKOB; JOHNCOCK WILLIAM; LANGNER ROLAND |
| The invention relates to 3,4-dihydroxybenzyl-substituted carbonic acid derivatives, to their production, and to their use as antioxidants or free-radical scavengers, especially in cosmetic and pharmaceutical preparations and in foodstuffs and stimulants, to protect cells and tissues from the harmful effects of radicals and reactive oxygen compounds that accelerate aging. The invention further relates to cosmetic and pharmaceutical preparations and to foodstuffs and stimulants that comprises the inventive 3,4-dihydroxybenzyl-substituted carbonic acid derivatives. | ||||||
| 110 | SUBSTITUTED BENZENESULFONYLUREAS AND -THIOUREAS, PROCESS FOR THEIR PREPARATION AND THE USE OF PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS, AS WELL AS MEDICAMENTS CONTAINING THEM | HRP960076 | 1996-02-15 | HRP960076B1 | 2001-12-31 | ENGLERT HEINRICH; GERLACH UWE; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM |
| 111 | BR9916041 | 1999-12-06 | BR9916041A | 2001-12-04 | BLOOM JONATHAN DAVID; DIGRANDI MARTIN JOSEPH; GEORGEDUSHIN RUSSELL; LANG STANLEY ALBERT; O'HARA BRYAN MARK | |
| 112 | SUBSTITUTED THIOPHENYLSULFONYLUREAS AND-THIOUREAS, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTICS AND MEDICAMENTS CONTAINING THEM | IL11698096 | 1996-01-31 | IL116980A | 2001-06-14 | |
| 113 | Benzenesulfonyl substituted ureas and -thioureas, process for their preparation and use of pharmaceutical preparations based on these compounds as well as medicaments containing them. | ES96101977 | 1996-02-12 | ES2155546T3 | 2001-05-16 | ENGLERT HEINRICH; GERLACH UWE; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM |
| BENZOLSULFONILUREAS Y -TIOUREAS DE FORMULA I, DONDE R(1) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5, 6 O 7 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6 O 7 ATOMOS DE C; R(2) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, ALCOXI CON CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, MERCAPTOALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5 O 6 ATOMOS DE C, Y OTRAS CADENAS DE C{SUB,1}-C{SUB,8}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, PE O, N, S (N=1-4), F, CL; R(3) H, ALQUILO CON 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 O 12 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6, 7, 8, 9 O 10 ATOMOS DE C, FLUOROALQUILO CON 3, 4, 5 O 6 ATOMOS, O CADENAS DE C{SUB,1}C{SUB,10}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, PE O, N, S (N=1, 2, 3 O 4); R(4) ES HIDROGENO, ALQUILO CON 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 O 12 ATOMOS DE C, CICLOALQUILO CON 3, 4, 5, 6, 7, 8, 9 O 10 ATOMOS DE C, FLUOROALQUILO CON 1, 2, 3, 4, 5 O 6 ATOMOS DE C, FLUOROCICLOALQUILO CON 3, 4, 5O 6 ATOMOS DE C, O CADENAS DE C{SUB,1}-C{SUB,10}, EN LAS CUALES N ATOMOS DE C ESTAN SUSTITUIDOS POR HETEROATOMOS, PE O, N, S (N=1, 2, 3 O 4); OR(3) YR(4) FORMAN JUNTOS UN ANILLO (CH{SUB,2}){SUB,2-8}, EN EL CUAL UNO O VARIOS GRUPOS CH{SUB,2} PUEDEN ESTAR SUSTITUIDOS POR HETEROATOMOS; E ES OXIGENO O AZUFRE; X ES OXIGENO O AZUFRE; Y ES [CR(5)R(5){SUP,''})]{SUB,M}; SIENDO R(5) YR(5{SUP,''}) INDEPENDIENTEMENTE UNO DE OTRO HIDROGENO O ALQUILO CON 1 O 2 ATOMOS DE C; DONDE LOS MIEMBROS DE [(CR(5)R(5{SUP,''})] PUEDEN SER IGUALES O DIFERENTES; YM ES 1, 2, 3 O 4. TAMBIEN SUS SALES FARMACEUTICAMENTE ACEPTABLES, TIENE EFECTOS MUY IMPORTANTES EN EL SISTEMA CARDIOVASCULAR. | ||||||
| 114 | SUBSTITUTED THIOPHENSULFONYLUREAS, METHOD OF THEIR SYNTHESIS AND DRUG | RU96101797 | 1996-01-31 | RU2164916C2 | 2001-04-10 | KHAJNRIKH EHNGLERT; JENS KHARTUNG; PETER KRAUZE; DITER MANIA; KHAJNTS GEGELAJN; JOAKHIM KAJZER |
| organic chemistry, pharmacy. SUBSTANCE: invention describes novel substituted thophensulfonylureas of the general formula (I) where R(1) means hydrogen atom or alkyl with one or two carbon atoms; R(2) means hydrogen atom or alkyl with one or two carbon atoms; Y and Z are similar or different and mean halogen atom or alkoxy-group with one or two carbon atoms; X means oxygen or sulfur atom, or their physiologically acceptable salts. Compounds show effect on cardiovascular system. Invention describes method of their synthesis and medicinal agent also. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 6 cl, 7 ex | ||||||
| 115 | SUBSTITUTED THIOPHENYL-SULFONYL-UREA- AND -THIOUREA DERIVATIVES PROCESS FOR PRODUCING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HU9600218 | 1996-01-31 | HU9600218A3 | 2000-03-28 | |
| 116 | Use of substituted thione compounds as nitric oxide synthase activators | DE19830081 | 1998-07-06 | DE19830081A1 | 2000-01-13 | CLEMENT BERND |
| Use of diaminothiones as nitric oxide (NO) synthase activators is new. Use of diaminothione derivatives of formula (I) and their tautomers and salts, as nitric oxide (NO) synthase activators is new: R1-R4 = H or alkyl, aryl or heterocyclyl (saturated or unsaturated, and each optionally substituted); or R2 + R4 or R1 + R2 and/or R3 + R4 = a saturated or unsaturated, optionally substituted 3-8 membered ring. An Independent claim is also included for the use of compounds (I) for the production of a medicament for increasing NO concentrations. | ||||||
| 117 | BR9709952 | 1997-06-24 | BR9709952A | 1999-08-10 | WIDDOWSON KATHERINE L | |
| 118 | NO960628 | 1996-02-16 | NO305795B1 | 1999-07-26 | ENGLERT HEINRICH; GERLACH UWE; MANIA DIETER; GOEGELEIN HEINZ; KAISER JOACHIM | |
| 119 | IL-8 RECEPTOR ANTAGONIST | CZ425698 | 1997-06-24 | CZ425698A3 | 1999-06-16 | WIDDOWSON KATHERINE L |
| 120 | ANTAGONISTS OF IL-8 RECEPTORS | PL33085097 | 1997-06-24 | PL330850A1 | 1999-06-07 | WIDDOWSON KATHERINE L |
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