| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | Substituted arylthiourea derivatives useful as inhibitors of viral replication | US10887227 | 2004-07-08 | US07718671B2 | 2010-05-18 | Avinash Phadke; Jesse Quinn; Junko Ohkanda; Andrew Thurkauf; Yiping Shen; Cuixian Liu; Dawei Chen; Shouming Li; Xiangzhu Wang |
| Substituted arylthiourea compounds of Formula I, and the pharmaceutically acceptable salts of such compounds, useful as antiviral agents, are provided herein. Certain substituted arylthioureas disclosed herein are potent and/or selective inhibitors of viral replication, particularly Hepatitis C virus replication. Pharmaceutical compositions containing one or more substituted arylthiourea compounds and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Such pharmaceutical compositions may contain a substituted arylthiourea as the only active agent or may contain a combination of a substituted arylthiourea derivative and one or more other pharmaceutically active agents. Methods of treating Hepatitis C viral infections in mammals are also provided herein. | ||||||
| 22 | CHEMICAL COMPOUNDS | US12374421 | 2007-06-29 | US20100048699A1 | 2010-02-25 | Juergen Harry Schaetzer; Christoph Luthy; William Lutz; Donn Warwick Moseley; Anthony Cornellius O'Sullivan |
| A compound of formula I where the substituents have the meanings assigned to them in claim 1, compositions comprising a compound of formula (I) and the use of such compounds and/or compositions controlling insects, acarines, nematodes or molluscs. | ||||||
| 23 | Derivatives of urea and related diamines, methods for their manufacture, and uses therefor | US11827407 | 2007-07-10 | US20080125424A1 | 2008-05-29 | Pierre DePrez; Sarah E. Lively; Taoues Temal |
| The present invention relates generally to compounds represented in Formula I, pharmaceutical compositions comprising them and methods of treating of diseases or disorders related to the function of the calcium sensing receptor. The invention also relates to processes for making such compounds and to intermediates useful in these processes. | ||||||
| 24 | Substituted thiourea complexing agent and a method for extracting a noble metal from a matrix using the complexing agent | US09890967 | 2000-02-08 | US06866833B1 | 2005-03-15 | Stephen John Harris |
| A substituted thiourea having the general formula characterized in that each of R1 and R2 independently comprises an alkyl, alkaryl or aryl group or a substituted derivative thereof, and contains at least one fluorine atom, and in that each of R3 and R4 is selected from the group which consists of H, alkyl, alkaryl and aryl and substituted derivatives thereof, including fluorine-containing derivatives. A method for producing the substituted thiourea is disclosed, and a method for extracting a noble metal such as gold from a matrix by treating the matrix with the substituted thiourea is also disclosed. | ||||||
| 25 | Coupler for use in oxidative hair dyeing | US10847428 | 2004-05-17 | US06861556B2 | 2005-03-01 | Mu-Ill Lim; Yuh-Guo Pan |
| Couplers for hair coloring compositions for oxidative dyeing of hair are compounds of formula (1): wherein X is selected from halogen; R3 is selected from the group consisting of C1 to C2 alkyl and hydroxyethyl; and R, R1 and R2 are each independently selected from C1 to C22 alkyl or C1 to C22 mono or dialkyl groups, or two of R, R1 and R2 together with the the nitrogen atom to which they are attached form a C3 to C6 cycloaliphatic or a C3 to C14 aromatic group, the cycloaliphatic or aromatic group optionally containing in their rings one or more hetero atoms selected from O, S and N atoms. | ||||||
| 26 | N,N, -Substituted s-Aryl-Isothioureas, N,N,N, -Substituted s-Aryl-Isothioureas and combinatorial libraries thereof | US10139646 | 2002-05-07 | US20040010036A1 | 2004-01-15 | Boris Rogovoy; Vladimir Vvedenskiy; Xiaohong Cai; Christophe Chassaing; Alan R. Katritzky; Behrouz Forood |
| The present invention relates to novel N,N,-Substituted S-Aryl-Isothioureas, and N,N,Nnull-Substituted S-Aryl-Isothioureas and combinatorial libraries thereof, as well as methods of preparing N,N,-Substituted S-Aryl-Isothioureas, and N,N,Nnull-Substituted S-Aryl-Isothiourea derivative compounds. | ||||||
| 27 | Compounds with growth hormone releasing properties | US09534135 | 2000-03-23 | US20030040483A1 | 2003-02-27 | Thomas Kruse Hansen; Bernd Peschke; Jesper Lau; Behrend Friedrich Lundt; Michael Ankersen; Brett Watson; Kjeld Madsen |
| Compounds of peptide mimetic nature having the general formula I 1 wherein a and b are independently 1 or 2, R1 and R2 are independently H or C1-6alkyl, G and J are independently, inter alia, aromats, and D and E are independently several different groups are growth hormone secretagogous with improved bioavailability. | ||||||
| 28 | METHODS FOR SOLID-PHASE SYNTHESIS OF HYDROXYLAMINE COMPOUNDS AND DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | US08958638 | 1997-10-27 | US20010053555A1 | 2001-12-20 | DINESH V. PATEL; KHEHYONG NGU |
| A novel method for generating hydroxylamine, hydroxamic acid, hydroxyurea, and hydroxylsulfonamide compounds is disclosed. The method involves the nucleophilic attack of an alkoxyamine on a suitable solid phase support. Techniques of combinatorial chemistry can then be applied to the immobilized alkoxyamine to generate a diverse set of compounds. Cleavage of the compounds from the support yields a library of hydroxylamine or hydroxylamine derivative compounds, which can be screened for biological activity (e.g., inhibition of metalloproteases). | ||||||
| 29 | IL-8 receptor antagonists | US202569 | 1999-08-19 | US6133319A | 2000-10-17 | Katherine L. Widdowson |
| This invention relates to the use of phenyl ureas of formulas (I) and (II) in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). The variables of (I) and (II) are defined herein. ##STR1## | ||||||
| 30 | Butenoic acid derivatives | US169500 | 1993-12-20 | US5430059A | 1995-07-04 | Norio Minami; Fumihiro Ozaki; Keiji Ishibashi; Yasuhiro Kabasawa; Toshiaki Ogawa; Hideyuki Adachi; Takanori Kawamura |
| A butenoic acid compound of the following formula: ##STR1## in which Z is O, S, vinylene or azomethyne, A is an alkylene group and J is phenyl group, is a useful in treating heart disease. | ||||||
| 31 | Antioxidants and antiozonants | US2001560 | 1960-04-05 | US3138571A | 1964-06-23 | POPOFF IVAN C |
| 32 | Thiourea group IV transition metal catalysts and polymerization systems | US16333049 | 2017-09-13 | US10968297B2 | 2021-04-06 | Arkady L. Krasovskiy; Endre Szuromi |
| Catalyst compositions and polymerization systems include at least one thiourea complex according to Formula (I): MQaX4-a (I) in which M is Ti, Zr, or Hf; a is 1 or 2; each group Q of the thiourea complex is a bidentate thiourea ligand bound to the metal center and having Formula (Ia), Formula (Ib), or Formula (Ic): (Formulas should be inserted here). In Formulas (Ia), (Ib), and (Ic), each group R1, R2, and R3 is independently chosen from alkyl groups or aryl groups; each group Z1 or Z2 is independently chosen from alkylene groups. If a=2, groups R1 of the two groups Q are optionally linked, or groups R3 of the two groups Q are optionally linked. Each X is covalently bonded or coordinated to the metal center and is independently chosen from alkyl groups or halides. The polymerization systems may be configured to copolymerize ethylene and α-olefins. | ||||||
| 33 | Closthioamides, compositions, and methods for treating bacterial or fungal infections or cancer | US13504990 | 2010-11-02 | US08673980B2 | 2014-03-18 | Swantje Behnken; Hans-Martin Dahse; Christian Hertweck; Keishi Ishida; Thorger Lincke; Martin Roth; Florian Kloss |
| This invention relates to the field of biologically active compounds and specifically to closthioamides, pharmaceutical compositions comprising these compounds, and their use as antibiotic, antifungal, and/or cytotoxic agent. | ||||||
| 34 | Substituted biphenyl GPR40 modulators | US12082645 | 2008-04-10 | US07572934B2 | 2009-08-11 | Sean P. Brown; Paul Dransfield; Zice Fu; Jonathan Houze; Xian Yun Jiao; Todd J. Kohn; Vatee Pattaropong; Marc Vimolratana; Michael J. Schmitt |
| The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes. | ||||||
| 35 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv | US11911330 | 2006-04-11 | US20080207760A1 | 2008-08-28 | Mingjun Huang |
| The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers. | ||||||
| 36 | Zinc and zinc alloy electroplating additives and electroplating methods | US10333484 | 2001-07-11 | US07109375B2 | 2006-09-19 | Roderick Dennis Herdman; Trevor Pearson; Anthony Rowan |
| An additive for an alkaline zinc or zinc alloy electroplating bath medium, the additive comprising a random co-polymer comprising the reaction product of: (i) one or more di-tertiary amines including an amide or thioamide functional group, and (ii) optionally, one or more saturated second di-tertiary amines and/or one or more second di-tertiary amines including an unsaturated moiety, with (iii) one or more saturated or unsaturated linking agents capable of reacting with said di-tertiary amines (i) and (ii), provided that, where all the linking agents are saturated, an unsaturated di-tertiary amine must he present. Preferably, the polymer has the general formula n(2x+2y+zEp)j-. | ||||||
| 37 | Thiols and disulphides and their use in producing substrates | US10493822 | 2002-11-06 | US20050043558A1 | 2005-02-24 | Luc Lebeau; Emmanuel Klein |
| The present invention concerns new methods for producing substrates with surfaces, that are covalently linked to at least one type of hapten or biological macromolecule, with reduced non-specific biological macromolecule adsorption. In another aspect, the invention concerns substrates with surfaces that are covalently linked to at least one type of hapten, showing circulating compounds and the use of these substrates for the quantitative detection of at least one type of hapten-specific biological macromolecule receptor, in particular a hapten-specific antibody, in a test probe. Further, the invention concerns substrates with surfaces that are covalently linked to at least one type of biological macromolecule, in particular one type of antibody, showing reduced non-specific interactions with circulating compounds and the use of these substrates for the quantitative detection of at least one type of hapten in a test probe. In another aspect, the invention is related to specific thiols of formula (A) and disulphides of formula (B), where the variables are as defined in the claims, which can be used for producing the above-mentioned substrate surfaces. The invention is further related to the use of these specific thiols and disulfides for producing substrates with surfaces that arc covalently linked to at least one type of hapten or to at least one type of biological macromolecule, showing reduced non-specific interactions with circulating compounds. | ||||||
| 38 | Process for the production of nitrogen compounds | US10296925 | 2002-11-29 | US20030158442A1 | 2003-08-21 | Takashi Emura; Tsuyoshi Haneishi |
| A synthesis method which comprises reacting NH group-containing compounds with thiocyanates, cyanamides, nitrites or esters in the presence of a silylating agent to synthesize the corresponding nitrogen-containing addition or substitution products. This method not only enables the direct and efficient synthesis of nitrogen-containing compounds including isothioureas, guanidines, amidines and amides, but it also has a wide range of applications and is suitable for large-scale synthesis. | ||||||
| 39 | PROCESS FOR THE PREPARATION OF THIOUREA | US09046740 | 1998-03-24 | US20030060662A1 | 2003-03-27 | BALAKRISHNAN SRINIVASA; MAHAJAN SHANKAR SHIVRAM; CHAPHEKAR GOPAL MORESHWAR; GUPTE MILIND YESHWANT; KULKARNI MOHAN PARSHURAM; BANDARUPALLI RADHA K MURTHY |
| The present invention relates to an improved process for the preparation of thiourea. The object of the present invention is to provide an improved process for the preparation of Thiourea using Calcium Cyanamide, carbon dioxide and hydrogen sulphide. The process of the present invention comprises passing a mixture of Carbon dioxide ad hydrogen sulphide into a slurry formed by addition of major part of calcium cyanamide charge into water using constant stirring, maintaining alkaline pH at a temperature ranging between ambient to 80null C., stopping the addition of hydrogen sulphide, continuing the slow passing of carbon dioxide and addition of remaining part of calcium cyanamide charge and retaining the reaction mass to complete the secondary reactions to form the product for a period ranging from 2-5 hours and continuing passing of carbon dioxide at an increased rate for effecting decomposition of Ca(SH)2 for a period of 1.6 to 6 hours, stopping the addition of carbon dioxide separating thiourea solution, treating the separated solution with activated carbon, removing the carbon by conventional methods, separating the product formed by conventional methods and drying the product at a temperature between 50-70null C. to obtain the product. | ||||||
| 40 | Substituted urea and isothiourea derivatives as no synthase inhibitors | US615291 | 1996-03-28 | US6090846A | 2000-07-18 | Jeffrey Alan Oplinger; Barry George Shearer; Eric Steven Furfine; Edward Patrick Garvey |
| The use of an N-substituted urea derivative for the manufacture of a medicament for the treatment of a condition where there is an advantage in inhibiting the NO synthase enzyme, in particular cerebral ischemia, and pharmaceutical formulations therefor are disclosed. Novel N-substituted urea derivatives and processes for the preparation thereof are also described. | ||||||
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