| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 61 | (bis)urea and (bis)thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders | US13391247 | 2010-08-18 | US09708255B2 | 2017-07-18 | Robert A. Casero; Patrick M. Woster |
| The invention provides for novel (bis)urea and (bis)thiourea compounds which are inhibitors of lysine-specific demethylase 1 (LSD1). Such compounds may be used to treat disorders, including cancer. | ||||||
| 62 | 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease | US14301569 | 2014-06-11 | US09181181B2 | 2015-11-10 | Anders Broo; Johan Gottfries; Michael Kossenjans; Li Lanna; Eva-Lotte Lindstedt-Alstermark; Kristina A. Nilsson; Bengt Ohlsson; Maria Thorstensson; Maria Boije |
| The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them. | ||||||
| 63 | Use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas | US13678802 | 2012-11-16 | US08987262B2 | 2015-03-24 | Christine Leaute-Labreze; Eric Dumas De La Roque; Alain Taieb; Jean-Benoit Thambo |
| The present technology relates the use of a beta blocker for the manufacture of a medicament for the treatment of hemangiomas, for example of infantile hemangiomas. The beta blocker may be a non-selective beta-blocker, for example propranolol. The present technology provides an alternative to the known compounds, e.g. corticosteroïds, interferon or vincristine, generally used for the treatment of hemangiomas. | ||||||
| 64 | Compound reagents and method for synthesizing enantiomerically enriched amino acids | US13394693 | 2010-09-08 | US08859812B2 | 2014-10-14 | Eric N. Jacobsen; Stephan J. Zuend |
| Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile. | ||||||
| 65 | 2-substituted-3-phenylpropionic acid derivatives and their use in the treatment of inflammatory bowel disease | US13046288 | 2011-03-11 | US08785681B2 | 2014-07-22 | Anders Broo; Johan Gottfries; Michael Kossenjans; Li Lanna; Eva-Lotte Lindstedt-Alstermark; Kristina A. Nilsson; Bengt Ohlsson; Maria Thorstensson; Maria Boije |
| The present invention relates to 2-(substituted sulphur, sulphone or sulphoxide)-3-(substituted phenyl)propionic acid derivatives, 2-(substituted oxygen)-3-(substituted phenyl)propionic acid derivatives, benzoic acid derivatives, and derivatives of 2-methyl-2-(phenoxy or phenylthio)propanoic acid and 2-(methyl or ethyl)-2-(phenoxy or phenylthio)butanoic acid, to processes for preparing such compounds, to their use in the treatment of inflammatory conditions, and to pharmaceutical compositions containing them. | ||||||
| 66 | Method of treating sensorimotor disorders with alpha-2 adrenergic receptor agonists | US12680640 | 2008-10-14 | US08455548B2 | 2013-06-04 | Lauren M. B. Luhrs; Daniel W. Gil; John E. Donello |
| Disclosed herein is a method of treating sensorimotor disorders comprising administering to a subject in need of such treatment an alpha-2 receptor agonist lacking significant alpha-2A receptor activity. | ||||||
| 67 | Chiral thiourea compounds and process for enantioselective reduction of ketones | US12080634 | 2008-04-03 | US08334405B2 | 2012-12-18 | Derun Li; John R. Falck |
| Chiral thioureas are effective catalysts for the borane reduction of prochiral ketones to optically active alcohols. A prochiral ketone may be reduced to an optically active alcohol in the presence of a substantially sub-stoichiometric amount of chiral thiourea. The asymmetric thiourea compound of the present invention may be produced according to a production method described herein. | ||||||
| 68 | POLYMER COMPOSITES MECHANICALLY REINFORCED WITH ALKYL AND UREA FUNCTIONALIZED NANOTUBES | US12376901 | 2007-08-10 | US20100234503A1 | 2010-09-16 | Valery N. Khabashesku; Merlyn X. Pulikkathara |
| A polymer composite includes a polymer matrix and an alkyl-substituted carbon nanotube. A polymer composite also includes a polymer matrix and a fluorinated carbon nanotube reacted with urea, thiourea, or guanidine. A method of functionalizing a carbon nanotube includes heating a fluorinated carbon nanotube urea, thiourea, or guanidine. A substituted carbon nanotube includes a fluorinated carbon nanotube and amino silane compounds The amino silane compounds covalently link to the fluorinated nanotube through the amino functional group. Polymer composites, ceramics and surface coating materials may be constructed from these substituted carbon nanotubes. | ||||||
| 69 | DIVALENT HYDRAZIDE COMPOUND CONJUGATES FOR INHIBITING CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | US12418147 | 2009-04-03 | US20090253799A1 | 2009-10-08 | Alan S. Verkman; Nitin D. Sonawane |
| Provided herein are divalent hydrazide-polyethylene glycol conjugates that inhibit the ion transport activity of a cystic fibrosis transmembrane conductance regulator (CFTR). The conjugates described herein are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased CFTR activity, for example, secretory diarrhea. | ||||||
| 70 | Trifluoromethyl-thiophene carboxylic acid aniledes and use thereof as fungicides | US10548840 | 2004-03-20 | US07501530B2 | 2009-03-10 | Markus Gewehr; Bernd Müller; Thomas Grote; Wassilios Grammenos; Andreas Gypser; Jordi Tormo i Blasco; Anja Schwögler; Joachim Rheinheimer; Carsten Blettner; Frank Schieweck; Michael Rack; Ulrich Schöfl; Siegfried Strathmann; Reinhard Stierl; Jan Rether |
| The invention relates to novel biphenyl carboxamides of formula (I), wherein A, R, Z, X, Y, m and n have the meanings given in the description, to multiple methods for producing these substances, to their use for combating unwanted micro-organisms and to novel intermediate products and the production thereof. | ||||||
| 71 | Method for preparation of carborane anions | US10472329 | 2002-04-01 | US07161040B2 | 2007-01-09 | Andreas Franken; Benjamin T. King; Josef Michl |
| This invention relates to an improved method for making unsubstituted carborane anions and monosubstituted carborane anions of formula: (R—CBn—Hm′)− where n is an integer ranging from 5 to about 11 and m′ is an integer ranging from 5 to 16 where the relative values of n and m′ depend upon the exact structure of the carborane and the presence of a non-hydrogen substituent. m as used herein is an integer ranging from 5 to 16. When R is hydrogen the anion is unsubstituted. When R is a halogen, a phenyl, a substituted phenyl group, such as fluorophenyl group, or any other substituent, the carborane is substituted. The method is particularly useful for preparation of twelve-vertex carborane anions R—CB11H11−, where R is a defined above, and is specifically useful for preparation of the unsubstituted carborane CB11H12-??, where R is H. | ||||||
| 72 | Storage media for latent heat storage systems | US09835816 | 2001-04-17 | US20020016505A1 | 2002-02-07 | Joachim Gally; Ralf Glausch; Udo Heider; Natascha Lotz; Mark Neuschutz |
| The present invention generally relates to compositions for storing heat energy in the form of heat of phase transition, and to their use. The compositions of the invention for storing heat comprise at least one heat storage material and at least one auxiliary and are characterized in that the composition comprises at least one heat storage material which has at least one solid/solid phase transition and is solid throughout the application range. | ||||||
| 73 | Meta-guanidine, urea, thiourea or azacyclic amino benzoic acid compounds and derivatives thereof | US713555 | 1996-08-27 | US6028223A | 2000-02-22 | Peter Gerrard Ruminski; Michael Clare; Paul Waddell Collins; Bipinchandra Nanubhai Desai; Richard John Lindmark; Joseph Gerace Rico; Thomas Edward Rogers; Mark Andrew Russell |
| The present invention relates to a class of compounds represented by the Formula I ##STR1## or a pharmaceutically acceptable salt thereof, wherein A is ##STR2## pharmaceutical compositions thereof and methods of using such compounds and compositions as .alpha..sub.v .beta..sub.3 antagonists. | ||||||
| 74 | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them | US602018 | 1996-02-15 | US5880155A | 1999-03-09 | Heinrich Englert; Uwe Gerlach; Dieter Mania; Heinz Gogelein; Joachim Kaiser |
| This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system. | ||||||
| 75 | Dimerized thiourea derivatives near-infared absorbents comprising the same, and heat wave shielding materials comprising the same | US634126 | 1996-04-19 | US5723075A | 1998-03-03 | Hideki Hayasaka; Toshiyuki Takano; Toshimi Satake |
| A near-infrared absorbent is obtained by heating a dimerized thiourea derivative of Formula �1! or �2! and a copper compound: ##STR1## The near-infrared absorbent is used to obtain a near-infrared absorbent resin material having a wide absorption in the near-infrared region, and the absorbent does not substantially decompose at a molding temperature of the resin. Typical examples of the dimerized thiourea derivative are 4,4'-di(benzylthiocarbamoyl)-aminodiphenylmethane, 4,4'-di(benzylthiocarbamoyl)-aminodiphenylhexafluoropropane, and 1,4'-di(dibenzoylthiocarbamoylamino)-2,5-dimethylbenzene, and typical examples of the copper compound are copper stearate and copper .beta.-acryloyloxypropylhydrogenphthalate. | ||||||
| 76 | Mercapto-acylamino acid antihypertensives | US19243588 | 1988-05-11 | US4929641B1 | 1994-08-30 | HASLANGER MARTIN F; NEUSTADT BERNARD R; SMITH ELIZABETH M |
| 77 | Method for developing black diazotype photographic light-sensitive materials | US36272273 | 1973-05-22 | US3881931A | 1975-05-06 | TSUBOTA MOTOHIKO; NISHIMURA TAIICHI; OHKUBO KINJI |
| WHEREIN R7 represents a hydrogen atom, an alkyl group having 1-4 alkyl group or
(WHEREIN N REPRESENTS 1 OR 2), AS A COUPLER (Component B) capable of coupling with said light-sensitive diazonium compound (Component A) to form a blue dye; and, as a coupler (Component C1) capable of forming a yellow dye, at least one compound selected from the compounds represented by the general formula; (WHEREIN N REPRESENTS 1 OR 2) OR FROM THE COMPOUNDS REPRESENTED BY THE GENERAL FORMULA; (WHEREIN R4 and R5 each represents a hydrogen atom, a halogen atom or an alkyl group having 1-4 carbon atoms), -COR6 (wherein R6 represents an alkyl group having 1-4 carbon atoms, or a substituted or unsubstituted phenyl group or WHEREIN R3 represents WHEREIN R1 and R2 each represents an alkyl group having 1-6 carbon atoms or a cycloalkyl group having 5-6 carbon atoms, and X represents an anion, which comprises developing the lightsensitive material in the presence of: at least one compound selected from the compounds represented by the general formula; A method for developing a diazo-type photographic lightsensitive material containing at least one light-sensitive diazonium compound (Component A) selected from the compounds represented by the general formula; WHEREIN R8 and R10 each represents an alkyl group having 1-4 carbon atom, and R9 and R11 each represents a hydrogen atom or a halogen atom. D R A W I N G |
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| 78 | COMPOUNDS FOR INHIBITING CELL PROLIFERATION | PCT/US2009055509 | 2009-08-31 | WO2010025448A3 | 2010-07-15 | SEBTI SAID M; CHELLAPPAN SRIKUMAR; LAWRENCE NICHOLAS JAMES |
| Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided. | ||||||
| 79 | INHIBITION OF CELL PROLIFERATION | PCT/US2009/055509 | 2009-08-31 | WO2010025448A2 | 2010-03-04 | SEBTI, Said M.; CHELLAPPAN, Srikumar; LAWRENCE, Nicholas James |
Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided. |
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| 80 | LIPOPHILIC DIESTERS OF CHELATING AGENT FOR INHIBITION OF ENZYME ACTIVITY | PCT/IL0300225 | 2003-03-16 | WO2004028443A3 | 2004-05-27 | STRIEM SARINA; FRIEDMAN JONATHAN EDUARD; REZNITSKY-COHEN DALIA; KOZAK ALEXANDER |
| The present invention relates to the use of lipophilic diesters of the chelating agent 1,2-bis(2 aminophenoxy)ethane-N,N,N',N'-tetraacetic acid (BAPTA) for inhibition of proteolytic activities of certain metalloproteinases and of calpain. The invention further relates to methods for preventing, treating or managing MMP-related and calpain-related diseases or disorders in mammals comprising administering to a mammal in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of said lipophilic diesters of the chelating agent BAPTA. | ||||||
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