A composition comprising a compound having the general formula (I): F – [CF₂]_n – (O[CF₂]_n)_m –( L )_p – SH (Formula (I)) Each n is independently from 2 to 4, m is from 3 to 30, p is 0 or 1 and L represents a linker having the formula O_q(CF₂)_r(CH₂)_s, wherein q is 0 or 1, r is from 0 to 4 and s is from 0 to 4.

The present application provides chemical compounds useful, for example, in inhibiting gasdermin pore formation in a cell, inhibiting inflammasome-mediated death of a cell (pyroptosis); inhibiting cytokine secretion from a cell, inhibiting an inflammatory caspase in a cell, and/or covalently reacting with a cysteine of a gasdermin protein in a cell. These compounds are also useful in treating or preventing diseases or conditions in which inflammasome activation is implicated in pathogenesis. One example of such disease or condition is sepsis.

　炭素、水素、酸素及び硫黄を構成元素として含有し、ラマン分光法によって検出されたラマンスペクトルにおいて、482 cm^-1付近、846 cm^-1付近、1066 cm^-1付近、1279 cm^-1付近、及び1442 cm^-1付近にピークを有し、且つ、前記1442 cm^-1付近のピークが最強ピークである、有機硫黄材料は、液体有機原料を用いつつも、高容量且つ高耐熱性の有機硫黄材料である。

Described are covalent conjugates between lipoic acid (LA), or a derivative thereof, and resveratrol, or a derivative thereof. As an example, the covalent conjugate may be a compound of the formula: (I). Methods using the LA-resveratrol conjugates for the treatment of diseases, disorders, or conditions related to oxidative stress are also provided.

New methods for producing difluoromethylene-containing compounds with phenylsulfur trifluoride or a primary alkyl-substituted phenylsulfur trifluoride are disclosed. Also, new methods for producing trifluoromethyl-containing compounds with phenylsulfur trifluoride or primary alkyl-substituted phenylsulfur trifluoride are also disclosed.

Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are also provided.

Disclosed is a series of N-deacetylthiocolchicine derivatives of formula (I) in which: - the linker is a bivalent straight or branched C₁-C₈ alkyl residue, C₃-C₈ cycloalkyl, a phenylene or heterocyclic C₄-C₆ ring; - the G₁ and G₂ junctions, which can be the same or different, are - CO-, -COHN-, -CR₂- groups in which R₂ is hydrogen or a straight C₁-C₄ alkyl residue, or the G₁-linker-G₂ group is the -CO- group. The compounds of formula (I) have antiproliferative, antinflammatory, antiarthritic and antiviral activity.

Compounds of formula (I) are useful for increasing cGMP levels in a mammal.

The invention relates to compounds of formula (I) wherein R¹ represents benzyl; R² represents pyrazole; or a pharmaceutically acceptable derivative thereof. The invention also relates to pharmaceutical compositions containing compounds of formula (I) and to the use of compounds of formula (I) in medicine, particularly in the amelioration of a clinical condition for which a ACE and/or NEP inhibitor is indicated.

This invention relates to novel compounds characterized by the general Formula (I) any of its enantiomers or any mixture of its enantiomers, or a pharmaceutically acceptable salt thereof, or an N-oxide thereof, useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SK_Ca and/or IK_Ca channels.