| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | N- substituted -n'- replacement - urea derivatives and pharmaceutical compositions containing the derivative | JP2005314773 | 2005-10-28 | JP4177841B2 | 2008-11-05 | 四郎 三田; 正和 伴; 正人 堀内; 寛 須原 |
| 42 | アミドカルボニル化反応方法 | JP2006510832 | 2005-03-10 | JPWO2005085180A1 | 2008-01-17 | 小林 修; 修 小林; 良 秋山 |
| アルデヒド化合物とアミド化合物、そして一酸化炭素とのアミドカルボニル化反応において、長径が20nm以下のパラジウムクラスターを含むパラジウム担持架橋高分子組成物を用い、N−アシル−α−アミノ酸合成を可能とするアミドカルボニル化反応をクリーンな反応系において、より効率的、選択的に行うことのできる、新しいアミドカルボニル化反応方法とそのための触媒を提供する。 | ||||||
| 43 | N-substituted-n'-substituted urea derivative and pharmaceutical composition comprising the same derivative | JP2005314773 | 2005-10-28 | JP2006117679A | 2006-05-11 | MITA SHIRO; HORIUCHI MASATO; BAN MASAKAZU; SUHARA HIROSHI |
| <P>PROBLEM TO BE SOLVED: To provide a new compound having a TNF-α production inhibitory activity. <P>SOLUTION: A TNF-α production inhibitor comprises an N-substituted-N'-substituted urea derivative represented by, e.g. the formula, an analog thereof or a pharmaceutically acceptable salt thereof. <P>COPYRIGHT: (C)2006,JPO&NCIPI | ||||||
| 44 | New urea derivative | JP7834699 | 1999-03-23 | JP3603177B2 | 2004-12-22 | 四郎 三田; 正和 伴; 正人 堀内; 寛 須原 |
| 45 | Inhibitors of integrin αvβ6 | JP2002581384 | 2002-03-13 | JP2004528325A | 2004-09-16 | ズィーモン グートマン、; オリヴァー シャット、; ヴォルフガンク シュタール、; アルフレット ヨンクツィク、 |
| 本発明は、Ｒ 1 、Ｒ 1' 、Ｒ 1" 、Ｒ 2およびnが請求項１のように定義される、一般式(I)で示される新規ビフェニル誘導体に関する。本発明は、特にα v β 6インテグリン受容体の新規インテグリン配位子を表す、立体異性体およびその生理学的に許容できる塩または溶媒和物にも関する。新規化合物は、薬剤としての使用に適している。 | ||||||
| 46 | N- alkanoyl phenylalanine derivative | JP2000507644 | 1998-08-13 | JP2001514163A | 2001-09-11 | ガスリー，ロバート・ウィリアム; シドゥリ，アキサラオ; チェン，リー; ティリー，ジェファソン・ライト; ハル，ケネス・ジー; ハン，タイ−ナン |
| (57)【要約】 ＶＣＡＭ−１と、ＶＬＡ−４を発現する細胞との結合の阻害剤としての活性を有する、式（１）の化合物、並びにその塩及びエステルが開示されている。 そのような化合物は、その症状及び／又は損傷が、ＶＬＡ−４を発現する細胞へのＶＣＡＭ−１の結合に関係する疾患を治療するのに有用である。 | ||||||
| 47 | Gelling agent for solidifying agent for liquid organic medium | JP6432899 | 1999-03-11 | JP2000256303A | 2000-09-19 | HANABUSA KENJI; NAKAYAMA HIROKO; KIMURA MUTSUMI; SHIRAI HIROYOSHI |
| PROBLEM TO BE SOLVED: To obtain a new compound capable of gelling or solidifying a wide variety of liquid organic media with a small amount thereof added and providing a gelled material excellent in long-term stability at about normal temperature and further producible by a simple method. SOLUTION: This compound is represented by the formula (R1 is a 7-21C alkyl or a 7-21C alkenyl; R2 is a 1-22C alkyl or a 1-22C alkenyl; R3 is an 8-22C alkyl or an 8-22C alkenyl; (n) is 2-4), e.g. Nα-octadecylcarbamoyl-Nω- lauroyllysine methyl ester. The above compound is obtained by using an Nω- acylamino acid such as Nε-acyllysine as a starting raw material, carrying out an esterification of the carboxyl group with an alcohol and an alkylcarbamoylation or an alkenylcarbomoylation by a reaction of an α-amino group with an alkyl isocyanate or an alkenyl isocyanate. | ||||||
| 48 | Urea-modified carbodiimide and production thereof | JP18675894 | 1994-07-15 | JPH0827092A | 1996-01-30 | IMASHIRO YASUO; TAKAHASHI IKUO; HORIE TADASHI; YAMANE TAKESHI |
| PURPOSE:To obtain a urea-modified carbodiimide which is prepared by introducing urea bonds into the carbodiimide main chain, thus shows high compatibility with thermoplastic resins and increases the heat resistance and hydrolysis resistance of thermoplastic resins. CONSTITUTION:This carbodiimide is represented by formula I [R is a 1-12C alkyl, a 3-10C cycloalkyl; Z is a 1-12C alkylene, a 3-10C cycloalkylene, a 4-16C alkylene having a (non)cyclic structure, an aromatic substituted 8-16C alkylene; m is 1, 2; n is 1-50]. This carbodiimide is obtained by reaction of a compound of formula II with a primary or secondary aliphatic amine to effect the introduction of the urea bond into the compound II followed by carbodiimidation reaction of the product in the presence of a catalyst such as 3-methyl-1-phenyl-2- phosphorene-1-oxide. | ||||||
| 49 | Urea moiety-containing acetylenic compound useful as environmental indicator substance | JP25395694 | 1994-10-19 | JPH07258198A | 1995-10-09 | ANSONII FURANKU PUREJIOSHI; TADEUSU PURASHITSUKU |
| PURPOSE: To provide novel urea moiety-containing acetylenic substances useful as environmental indicator substances which incrementally and progressively change colors on exposure to environmental stimuli such as temperature, cumulative time-temperature and radiation. CONSTITUTION: Acetylenic organic compounds capable of incrementally varying reflectance on exposure to environmental stimuli are represented by the formula (wherein R is at least one group of a 3-7C cycloalkyl moiety, 3-18C alkenyl, 3-7C cycloalkenyl, 2-18C alkoxy, 1-8C alkyl, etc.; (y) is an integer of 1-8; and (x) is an integer of 1-6) and include, e.g. 2,4-hexadyne-1,6-bis(ethylurea). In the compounds of the formula it is preferred that R is 1-18C alkyl, 3-14C alkoxycarbonylmethyl or phenyl. The compounds of the formula can be obtained via the two-step reaction of, e.g. reacting monopropargylamine with a suitable isocyanate and subsequently subjecting the resulting alkyne intermediate to oxidation coupling. COPYRIGHT: (C)1995,JPO | ||||||
| 50 | Colorant composition | JP17181891 | 1991-06-18 | JPH0762120B2 | 1995-07-05 | クルト・ダマール・オルソン; モリー・イチン・バズビー |
| 51 | Amine derivative or an anti-ulcer agent containing a salt thereof | JP20592583 | 1983-11-04 | JPH0660096B2 | 1994-08-10 | 美奈子 四辻; 嗣郎 平井; 洋志 平野; 泰男 木羽; 久就 柴田; 貴久子 棚田; 和彦 橋場; 賀一 草柳; 博敏 荒井 |
| 52 | Inhibitor for biosynthesis of nitrogen oxide | JP5319991 | 1991-02-26 | JPH04270255A | 1992-09-25 | JIEFURII POORU HOITSUTEN; IAN AREKUSANDAA MAKUDONARUDO; ROORIE ERIZABESU RANBAATO; NEIRU SUTEFUAN DOUHAATEII |
| PURPOSE: To obtain a novel arginine deriv. which is useful for the treatment of symptom relating to hypotension, inflammatory diseases and apoplexy and is useful to inhibit biosynthesis of nitrogen oxide from L-arginine. CONSTITUTION: This inhibitor is a compd. expressed by formula I, formula II, formula III, or pharmaceutically acceptable salts of them. In the formulae, A is (CH 2) 2, (CH 2) 3, CH=CH, X is cyano, cyclopropyl, 2-propynyl, NHR 2 (R 2 is H, CF 3, an alkyl, etc.); R is an aminoacid, etc., Z is O, etc., W is CH 2NH, (CH 2) 2NH, NHNH, etc., and the compd. is, for example, O-[hydrazino- carbonyl]-5-hydroxynorvaline. A compd. expressed by formula I a as one compd. of formula I is obtd. by carrying out the reaction of a compd. expressed by formula IV (Pr' is t-butyl) and phosgene expressed by formula V to obtain a compd. expressed by formula VI, changing the obtd. compd. into an amide, and further removing protecting groups. The obtd. inhibitor is used for the treatment of neurotoxic and neuropathic diseases relating to hypotension symptom, inflammatory diseases, epilepsy, and ischemic, anoxic, traumatic or hypoglycemic symptoms. COPYRIGHT: (C)1992,JPO | ||||||
| 53 | JPH027946B2 - | JP13205081 | 1981-08-25 | JPH027946B2 | 1990-02-21 | HASHIMOTO YUTAKA |
| 54 | Isocyanateegrouppcontaining urea derivative of 3*4**8*9**diisocyanatemethylltricycloo *5*2*1*0*2*6**decane* its manufacture and its use | JP10843380 | 1980-08-08 | JPS5636446A | 1981-04-09 | HORUSUTO SHIYUNURUBUTSUSHIYU; RAINERU GURASU; ERUMAARU UORUFU |
| 55 | JPS5335949B2 - | JP465474 | 1973-12-24 | JPS5335949B2 | 1978-09-29 | |
| 56 | Preparation method of cyclopropylamine | JP11912477 | 1977-10-05 | JPS5359665A | 1978-05-29 | SHIYARURU MARAN; MONIKU DESUME; MISHIERU ROBIE; JIYAN KUROODO POWANIYAN |
| 57 | Preparation method of cyclopropylamine | JP11912577 | 1977-10-05 | JPS5356664A | 1978-05-23 | SHIYARURU MARAN; MONIKU DESUME; MISHIERU ROBIE; JIYAN KUROODO POWANIYAN |
| 58 | Surupponamidonoseizohoho | JP7281375 | 1975-06-17 | JPS5113781A | 1976-02-03 | HARII AREN ARUBUREHITO; JON TOMASU BURATSUTEI |
| 59 | JPS5064225A - | JP11875174 | 1974-10-17 | JPS5064225A | 1975-05-31 | |
| 60 | PSMA-BINDING AGENTS AND USES THEREOF | US17237850 | 2021-04-22 | US20220088229A1 | 2022-03-24 | Martin G. Pomper; Ronnie Charles Mease; Ying Chen |
| Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. | ||||||
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