| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 181 | Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity | US698674 | 1996-08-16 | US5714633A | 1998-02-03 | Sanjay R. Chemburkar; Hemantkumar H. Patel; David P. Sawick; Albert V. Thomas |
| The present invention provides a process for the preparation of a compound of formula ##STR1## wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation; and A is selected from optionally substituted carbocyclic phenyl. | ||||||
| 182 | Retroviral protease inhibitors | US476010 | 1995-06-07 | US5622949A | 1997-04-22 | John J. Talley; Daniel P. Getman; John N. Freskos; Ko-Chung Lin; Robert M. Heintz; Donald J. Rogier, Jr.; Deborah E. Bertenshaw |
| Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. | ||||||
| 183 | Retroviral protease inhibitors | US474569 | 1995-06-07 | US5620977A | 1997-04-15 | John J. Talley; Daniel P. Getman; John N. Freskos; Ko-Chung Lin; Robert M. Heintz; Donald J. Rogier, Jr.; Deborah E. Bertenshaw |
| Urea-containing hydroxyethylamine peptide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. | ||||||
| 184 | Retroviral protease inhibitors | US476009 | 1995-06-07 | US5610190A | 1997-03-11 | John J. Talley; Daniel P. Getman; Gary A. DeCrescenzo; Ko-Chung Lin; Michael L. Vazquez; Richard A. Mueller; Kathryn L. Reed; Robert M. Heintz; Michael Clare; John N. Freskos; Eric T. Sun |
| Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV Protease. | ||||||
| 185 | Retroviral protease inhibitors | US452603 | 1995-05-25 | US5510487A | 1996-04-23 | John J. Talley; Kathryn L. Reed |
| Hydroxyethylamine compounds are effective as retrovital protease inhibitors, and in particular as inhibitors of HIV protease. | ||||||
| 186 | Retroviral protease inhibitors | US471898 | 1995-06-07 | US5510349A | 1996-04-23 | John J. Talley; Daniel P. Getman; Gary A. DeCrescenzo; Ko-Chung Lin; Michael L. Vazquez; Richard A. Mueller; Kathryn L. Reed; Robert M. Heintz; Michael Clare; John N. Freskos; Eric T. Sun |
| Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. | ||||||
| 187 | Retroviral protease inhibitors | US148817 | 1993-11-08 | US5475027A | 1995-12-12 | John J. Talley; Daniel P. Getman; Ko-Chung Lin; Gary A. DeCrescenzo; Donald J. Rogier, Jr.; John N. Freskos |
| Urea-containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. | ||||||
| 188 | (Meth)-acrylic acid esters and the use thereof | US870610 | 1986-06-04 | US4744828A | 1988-05-17 | Jens Winkel; Bruno Bomer; Carlhans Suling; Jurgen Reiners; Wolfgang Podszun |
| The invention relates to novel (meth)-acrylic acid derivatives of tricyclodecanes of the formula ##STR1## in which R.sup.1 and R.sup.2 are identical or different and denote hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and R.sup.3 and R.sup.4 are identical or different and represent the groups. ##STR2## in which X is a divalent bridge member comprising the group ##STR3## and Y is a linear or branched hydrocarbon chain which has 2 to 10 carbon atoms and can optionally contain oxygen bridges and is optionally substituted by 1 to 4 acrylate or methacrylate radicals, andR.sup.5 represent hydrogen or methyl andR.sup.6 represents hydrogen, lower alkyl or phenyland to their use in dental compositions. | ||||||
| 189 | Diurethane diureas and the use thereof | US657869 | 1984-10-04 | US4562241A | 1985-12-31 | Alfred Renner |
| Diurethane diureas of the formula ##STR1## wherein each R is a radical derived from a diisocyanate and having at most 20 C atoms, R' is a radical derived from a diol and having a molecular weight of at most 1500, and the radicals R" are each methyl or ethyl, or both radicals R" bound to the same N atom form together with the N atom the piperidino, morpholino or pyrrolidino radical, are valuable curing agents for epoxide resins, and are also suitable as accelerators for the hot-curing of epoxide resins with dicyandiamide, cyanoacetyl compounds and polycarboxylic acid anhydrides. | ||||||
| 190 | Isocyanatomethyl group containing urea derivatives of 3(4), 8(9)-diisocyanatomethyltricyclo [5.2.1.0.sup.2,6 ] decane, method for their production as well as their use for producing polyurethane elastomers | US173619 | 1980-07-30 | US4317900A | 1982-03-02 | Horst Schnurbusch; Rainer Gras; Elmar Wolf |
| Urea derivatives containing isocyanatomethyl groups of 3(4), 8(9)-diisocyanatomethyltricyclo [5.2.1.0.sup.2,6 ] decane of the formulaOCN--H.sub.2 C--[R--CH.sub.2 --NH--CO--NH--CH.sub.2 ].sub.n --R--CH.sub.2 --NCO, in which R is ##STR1## and n=1-5. | ||||||
| 191 | Ureidonitriles useful as antihypertensives | US840362 | 1977-10-07 | US4156738A | 1979-05-29 | Gregory W. Schwing; William A. Price, Jr.; Dewey H. Smith, Jr. |
| Ureidonitriles, such as N-(1-cyano-1-methylethyl)-N'-(1,1-dimethylethyl)urea with antihypertensive activity in warm-blooded animals. | ||||||
| 192 | 2-Amino oxazolines and process for making the same | US713381 | 1976-08-11 | US4102890A | 1978-07-25 | Charles Malen; Monique Desnos; Michel Laubie; Jean-Claude Poignant |
| Cyclopropylmethylamines which are substituted on the 2-position of nitrogen heterocycles so as to provide new compounds of the formula ##STR1## wherein A is oxygen, sulfur, or nitrogen; the other "R" variables in general are hydrogen, lower-alkyl, cyclopropyl, or lower-alkyl substituted cyclopropyl; and the n's are the numbers 0 to 3, inclusive, and acid addition salts thereof, are disclosed. The compounds are cardiovascular agents, which are depressive of the central nervous system. Their effects include hypnosis, analgesia, and neuro-modulation. They can be used as anti-hypertensive agents. | ||||||
| 193 | Sulfacytosine derivatives | US48078474 | 1974-06-19 | US3923792A | 1975-12-02 | ALBRECHT HARRY ALLEN; PLATI JOHN THOMAS |
| N1-(1,2-dihydro-2-oxo-4-pyrimidinyl)sulfanilamides, bearing a lower alkyl, cycloalkyl or cycloalkyl-lower alkyl substituent in the 1-position, prepared by reaction of the corresponding 1substituted-1,2-dihydro-2-oxo-4-aminopyrimidine and N-acylated sulfanilyl chloride with subsequent hydrolysis, are described. The end products are useful as antibacterial agents.
|
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| 194 | Epoxy curing agent | US3789071D | 1971-10-07 | US3789071A | 1974-01-29 | BABAYAN E |
| An improved curing agent for epoxy resin compositions containing a polyepoxide comprising a substituted diurea formed by the reaction of two mols of a secondary amine, preferably an aliphatic amine, such as dimethylamine with one mol of a diisocyanate containing one cycloaliphatic isocyanate group and one aliphatic isocyanate group such as isophorone diisocyanate. The curing temperature of the composition can be substantially increased to provide products having improved properties without the danger of undercuring or substantial shortening of the gel time.
|
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| 195 | Urea and thiourea compounds | US70578657 | 1957-12-30 | US3006954A | 1961-10-31 | RAMEY DAVID E; MILTON SILVERMAN |
| 196 | Novel polyhalogenopolycycloalkene derivatives as foliage fungicides | US70550457 | 1957-12-27 | US2994710A | 1961-08-01 | GABRIEL MORALES JUAN |
| 197 | PSMA-BINDING AGENTS AND USES THEREOF | US15864236 | 2018-01-08 | US20180236110A1 | 2018-08-23 | MARTIN G. POMPER; RONNIE CHARLES MEASE; YING CHEN |
| Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. | ||||||
| 198 | Inhibitors of human immunodeficiency virus replication | US15031352 | 2014-10-23 | US10035760B2 | 2018-07-31 | Annapurna Pendri; Guo Li; John A. Bender; Zhong Yang; Alan Xiangdong Wang; Brett R. Beno; Robert A. Fridell; Makonen Belema; Nicholas A. Meanwell; Robert G. Gentles |
| Compounds of Formula I with activity against HIV, including pharmaceutical compositions and methods for using these compounds in treating human immunodeficiency virus (HIV) infection, are set forth: | ||||||
| 199 | PSMA-binding agents and uses thereof | US14211683 | 2014-03-14 | US09226981B2 | 2016-01-05 | Martin G. Pomper; Ronnie Charles Mease; Ying Chen |
| Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis. | ||||||
| 200 | Oligomer-amino acid conjugates | US13203066 | 2010-02-24 | US09192681B2 | 2015-11-24 | Xuyuan Gu; Jennifer Riggs-Sauthier |
| The invention relates to (among other things) oligomer-amino acid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over un-conjugated amino acid compounds. | ||||||
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