| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | The use of electron-poor anilines to release hydrochloric acid present in the reaction mixture, and a method for removing the partial aniline at least from its hydrochloride | JP50391899 | 1998-06-24 | JP2002504923A | 2002-02-12 | ティレル，フィリップ−ジャン; ルスタン，アラン |
| (57)【要約】 アニリンをそのクロロハイドレートから少くとも部分的に外すための方法であって；前記アニリンが、６以下のｐＫａを示す共役酸を有するアニリンから選択され、且つ、約５０℃以上、好ましくは約７０℃以上の温度で、弱い極性溶媒に少なくとも部分的に溶解されたそのクロロハイドレートを含む反応媒体にそれを供する工程を含むことを特徴とする方法。 本発明は、有機合成に適用可能である。 | ||||||
| 82 | Substituted 3-phenyl uracil | JP50574593 | 1992-09-10 | JP3253299B2 | 2002-02-04 | ヴァルター，ヘルムート; ヴェストファレン，カール−オット; ヴォルフ，ハンス−ヨーゼフ; カルドルフ，ウヴェ; クリンツ，ラルフ; グロースマン，クラウス; ゲルバー，マティアス; シェファー，ペーター; ハイストラハー，エリーザベト; ハムプレヒト，ゲールハルト |
| 83 | N- (1- aryl-alkyl) -n- (2- fluoro-cyclopropyl) carbamate derivatives and their preparation | JP33487791 | 1991-12-18 | JP3040566B2 | 2000-05-15 | 和彦 中谷; 加藤 正; 孜郎 寺島; 祐子 小林; 勇夫 早川; 勝 橋本; 修 田村; 敏文 秋葉; 政宏 鎌田 |
| 84 | 2,2-dialkylpentane-1,5-diisocyanate,2,2-diaklylpentane-1,5-diurethane and 2,2-dialkylpentane 1,5-dicarbamic acid chloride, and preparation thereof | JP6302291 | 1991-03-27 | JPH04221357A | 1992-08-11 | FURANTSU MERUGAA; ANDOREASU OTAABATSUHA; TOMU BUITSUTSUERU; HANSU RENTSU |
| PURPOSE: To provide new pentane-diisocyanate in which the physical properties and the working properties thereof are alternatable by properly selecting substituents and which can effectively be used as a material for preparing polyisocyanate by the polyaddition process, and effectively used as an insect pest control agent. CONSTITUTION: This compound is represented by formula I (R 1 and R 2 are each alkyl, 2-12C alkenyl, or R 1 and R 2 form 4-7C alkylene together), e.g. 2,2- dialkylpentane-1,5-diisocyanate. The compound is prepared by thermally decomposing 2,2-dialkylpentane-1,5-diurethane of formula II (R 3 and R 4 are each 1-20C alkyl, 5-12C cycloalkyl), optionally in the presence of a catalyst (e.g. Lu), in a vapor phase at more than 300°C under reduced pressure. The compound of formula II is prepared by reacting 2,2-dialkylpentane-1,5-diamine with urea and alcohol. COPYRIGHT: (C)1992,JPO | ||||||
| 85 | Manufacture of carbamic acid chloride derived from secondaryamine | JP8440086 | 1986-04-14 | JPS61238771A | 1986-10-24 | GIYUNTERU ZEMURERU; GEORUKU SHIEEFUERU |
| 86 | JPS6129942B2 - | JP14911581 | 1981-09-21 | JPS6129942B2 | 1986-07-10 | YABUTANI KUNIHIRO; KODAMA HIROYOSHI; YAMAMOTO MORIHARU |
| 87 | JPS6121925B2 - | JP12770784 | 1984-06-22 | JPS6121925B2 | 1986-05-29 | MISHERU DEBOWA; KAMIIYU DEISUDEIE |
| 88 | JPS5735708B2 - | JP2582074 | 1974-03-07 | JPS5735708B2 | 1982-07-30 | |
| 89 | Anilide derivative and agricultural and horticultural germicide | JP6440680 | 1980-05-15 | JPS56161360A | 1981-12-11 | NAGAI SHIGEKI; HIROTA YOUJIROU; YORIE TAKASHI; SUGIURA HISAO; HIBI TOORU; SATOU KATSUMI; WADA TAKUO; MIYAHARA MASAHIKO |
| NEW MATERIAL:An anilide derivative of formula I (R 1 i H or lower alkyl; R 2 is thienyl, Cl, phenyl, etc.; X and Y are lower alkyl; m is an integer 0,1 or 2; n is an integer 0 or 1). EXAMPLE: N-Benzyl-2',6'-dimethyl-2-thiophenecarbox anilide. USE: An agricultural and horticultural germicide having a control activity against blast and helminthosporium leaf spot of rice plants. PROCESS: A compound of formula II is reacted with a compound of formula III to give the compound of formula I. COPYRIGHT: (C)1981,JPO&Japio | ||||||
| 90 | Manufacture of 1-monochloroethylcarbamic acid chloride | JP4950081 | 1981-04-03 | JPS56154448A | 1981-11-30 | KAARUUHAINTSU KEENITSUHI; KAARUUHAINTSU FUOIERUHERUTO |
| 91 | Preparation of carbamyl chloride | JP16004878 | 1978-12-27 | JPS5587754A | 1980-07-02 | ARISAWA YOSHIO; AMAMIYA HIDEYOSHI; TAKEUCHI TEI; SHIMOMURA KUNIKO; ISHIZUKA NAOYASU |
| PURPOSE: To obtain the title compound in simple procedures in high yield, by heating a homogeneous mixture of powdered cyanuric acid free from moisture and a heating medium solid granular material, and by reacting the mixture with hydrogen chloride in another reactor to coagulate and separate a by-product. CONSTITUTION: Powdered cyanuric acid, homogeneously mixed with a heating medium solid granular material, e.g. silica gel or sand, under substantially anhydrous conditions, is heated to 300°C or above. The isocyanic acid thus formed is reacted with hydrogen chloride in another reactor packed with a heat-resistant inert solid material, e.g. asbestos or glass wool, at 400°C or above, to give a gas reaction mixture, which is passed through a zone heated at 100W250°C. The ammonium chloride formed as a by-product is coagulated, separated, and then passed through the next cooling zone, to give corbamyl chloride. USE: Carbamyl group introducing agents for various organic compounds. COPYRIGHT: (C)1980,JPO&Japio | ||||||
| 92 | N'-4-2-(methylphenyl) ethoxy phenyl-n-hydroxyurea and its preparation | JP1931378 | 1978-02-21 | JPS54112836A | 1979-09-04 | FUJITA FUMIO; KISHIDA HIROSHI; ITAYA NOBUSHIGE; TAKEMOTO KAZUKI |
| NEW MATERIAL:N'-4-[2-(4-Methylphenyl) ethoxy] phenyl-N-hydroxyurea of formula I. USE: An intermediate for N'-4-[2-(4-methylphenyl) ethoxyl] phenyl-N-methoxyl-N- methylurea which is a heribicide, having a killing action on a wide range of weeds particularly by foliar treatment, effective for rice plants and soybean. PROCESS: 4-[2-(4-Methylphenyl) ethoxyl]phenyl isocyanate of formula III or 4-[2- (4- methylphenyl) ethoxyl] phenyl-carbamyl chloride is reacted with hydroxylamine to give the desired compound of formula I. COPYRIGHT: (C)1979,JPO&Japio | ||||||
| 93 | JPS5246211B2 - | JP8046671 | 1971-10-12 | JPS5246211B2 | 1977-11-22 | |
| 94 | JPS5025467B1 - | JP11736670 | 1970-12-23 | JPS5025467B1 | 1975-08-23 | |
| 95 | JPS4875543A - | JP511672 | 1972-01-10 | JPS4875543A | 1973-10-11 | |
| 96 | EXTRACELLULAR VESICLES FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE | PCT/CA2023051585 | 2023-11-27 | WO2024108311A1 | 2024-05-30 | PASTERNAK STEPHEN; LEONG HON |
| A method of assessing a risk of developing Alzheimer's disease (AD) and of diagnosing AD in a subject comprising: comparing a level of extracellular vesicles (EVs) that are positive for at least one biomarker in a biofluid sample taken from the subject to a normal reference level of said EVs positive for the at least one biomarker, wherein a greater level of the EVs that are positive for at least one biomarker in the biofluid sample taken from subject as compared to the normal reference level is indicative of a risk of developing AD or a diagnosis of AD. The at least one biomarker includes at least one of pTau 231, pTau 181, LAMP1, pTau S235, Oligomeric Aβ, synuclein, ubiquitin, pTau 217, total Tau, pTau S203/T205 and Aβ42. | ||||||
| 97 | PROCESS FOR PRODUCING ISOCYANATES | PCT/EP2021073238 | 2021-08-23 | WO2022048930A1 | 2022-03-10 | JOSCH JAN PABLO; HINRICHS MATTHIAS; FERBITZ JENS; THIELE KAI; MATTKE TORSTEN; MAIXNER STEFAN |
| The invention relates to a process for producing isocyanates by reacting the corresponding amines with phosgene in the liquid phase, comprising: (a) mixing an amine comprising feed stream, a phosgene comprising feed stream and optionally an inert solvent; (b) reacting the amine with phosgene in a first reaction section to obtain an intermediate reaction mixture comprising isocyanate, carbamoyl chlorides, amine hydrochlorides and unreacted phosgene; (c) cleaving the carbamoyl chlorides and remove phosgene from the intermediate reaction mixture in a second reaction section to obtain an isocyanate comprising crude product, (d) optionally working-up the crude product; wherein reacting (b) is carried out such that the intermediate reaction mixture comprises 1.7 to 5 mol-% solid amine hydrochlorides based on the molar amount of amine fed into the process. | ||||||
| 98 | イソシアナート化合物の製造方法 | PCT/JP2009/060334 | 2009-06-05 | WO2009151005A1 | 2009-12-17 | 権 恒道; 田村 正則; 関屋 章 |
毒性の高いホスゲンを使うことなく、また、複雑なプロセス経由せず、低い反応温度、低い反応圧力でイソシアナート化合物を効率的に製造する方法を提供する。 フッ化カルボニルと有機アミンを反応させてイソシアナート化合物を製造する。フッ化カルボニルと有機アミンを反応させてフッ化カルバモイルを製造し、ついで該フッ化カルバモイルをイソシアナートに変換させる。フッ化カルバモイルを加熱することによりイソシアナートに変換させる。 |
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| 99 | NOVEL PROCESS | PCT/GB2007/050021 | 2007-01-16 | WO2007080430A1 | 2007-07-19 | VIJAYKAR, Priyesh, S.; GAITONDE, Abhay |
The present invention relates to a process for the preparation of a carbamoyl chloride RR’N-CO-Cl (I). |
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| 100 | PROCESS FOR PREPARING N, N-SUBSTITUTED CARBAMOYL HALIDES | PCT/EP2006/010437 | 2006-10-26 | WO2007048642A1 | 2007-05-03 | BIENTINESI, Ilaria; CIMAROSTI, Zadeo; GUERCIO, Giuseppe; LEROI, Corinne; PERBONI, Alcide |
The invention relates to a new and useful process for preparing N,N-substituted carbamoyl halides from secondary amines, carbon dioxide, trialkylsilyl chloride and a halogenating agent. |
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