| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 301 | ORGANIC COMPOUNDS | PCT/CH2008000332 | 2008-07-28 | WO2009015504A2 | 2009-02-05 | UNGUREANU IOANA MARIA; BRUNE NICOLE ERNA IRENE; SLACK JAY PATRICK; GRAY KIMBERLEY; SIMONS CHRISTOPHER TODD; EVANS PENNIMPEDE JENNY ELLEN |
| Disclosed are compounds that block off-notes in consumables and methods of blocking off-notes in consumables including off-notes provided by sweeteners shuch as stevioside, swingle extract, glyccerhizin, perillartine, naringin dihydrochalcone, neohesperidine dihydrochalcone, mogroside V, rubusoside, rubus extract, and rebaudioside A, and artificial sweeteners such as aspartame, saccharin, acesulfame K (Acesulfame potassium), sucralose and cyclamate. | ||||||
| 302 | PHENOLIC ACID SALTS OF GABAPENTIN IN LIQUID AND/OR SEMI-SOLID DOSAGE FORMS AND METHODS OF USE | PCT/US2004007872 | 2004-03-16 | WO2004093867A3 | 2004-12-02 | KIEL JEFFREY S; THOMAS H GREG; MANI NARASIMHAN |
| The present invention relates to pharmaceutical compositions of gabapentin tannate, processes for production of those compositions and methods of use of those compositions. The present invention provides a novel process for preparation of the tannate salt of gabapentin in liquid or semi-solid dosage form for human and veterinary pharmaceutical use. Tannate salts of active pharmaceutical ingredients are used in sustained release applications and to improve certain organoleptic properties such as taste. The process may utilize either natural or synthetic tannic acid. | ||||||
| 303 | CARBOCYCLIC AND OXACARBOCYCLIC FUMARIC ACID OLIGOMERS | PCT/EP0303498 | 2003-04-03 | WO03087174A2 | 2003-10-23 | JOSHI RAJENDRA KUMAR; STREBEL HANS-PETER |
| The invention relates to defined carbocyclic and oxacarbocyclic fumaric acid oligomers. The invention also relates to the use thereof for producing a drug and to drugs comprising the inventive compounds. | ||||||
| 304 | METHOD FOR PREPARING A CARBOXYLIC ACID | PCT/FR2000/002108 | 2000-07-21 | WO01005738A1 | 2001-01-25 | |
| The invention concerns a method for preparing a carboxylic acid comprising at least 3 carbon atoms. The invention concerns the preparation of such a carboxylic acid by a method using formic acid, as hydrocarboxylation reagent. The method for preparing a carboxylic acid comprising at least 3 carbon atoms, from a formic acid source is characterised in that it consists in reacting between 100 DEG C and 200 DEG C an unsaturated organic compound comprising at least 2 carbon atoms and formic acid, in the presence of an efficient amount of an iridium-based catalyst associated with an iodated promoter. | ||||||
| 305 | METHOD FOR PREPARING A CARBOXYLIC ACID | PCT/FR2000/002107 | 2000-07-21 | WO01005737A1 | 2001-01-25 | |
| The invention concerns a method for preparing a carboxylic acid comprising at least 3 carbon atoms. The invention concerns the preparation of such a carboxylic acid by a method using formic acid, as hydrocarboxylation reagent. The method for preparing a carboxylic acid comprising at least 3 carbon atoms, from a formic acid source is characterised in that it consists in reacting with formic acid, an organic compound comprising at least 2 carbon atoms and at least a reactive functional group selected among atoms or functions such as halogen, alcohol, thioalcohol, ester, thioester, carboxamide, thioamide, sulphonamide, sulphonic ester, amine or a diazonium salt, in the presence of an efficient amount of an iridium-based catalyst. | ||||||
| 306 | USE OF CYCLOHEXANE POLYCARBOXYLIC ACIDS AS PLASTICIZERS IN THE PRODUCTION OF PLASTICS WHICH ARE RATED TOXICOLOGICALLY FAVOURABLE | PCT/EP2000/005609 | 2000-06-16 | WO00078853A1 | 2000-12-28 | |
| The invention relates to the use of a cyclohexane polycarboxylic acid or of one of its derivatives, or of a mixture of one or more of said acids as plasticizers in the production of plastics which are rated toxicologically favourable. In animal experiments, using rodents, to which a daily oral dose of 1000 mg/kg body weight of the corresponding cyclohexane polycarboxylic acid, or a derivative thereof, or a mixture of two or more of said acids is administered by oesophageal tube over a period of at least 14 days, said dose, in comparison to untreated control animals, leads neither to a significant increase in the weight of the liver after treatment, nor to a doubling of the specific cyanide-insensitive palmitoyl-CoA oxidase activity, measured in the liver homogenisate. | ||||||
| 307 | CASPASE INHIBITORS AND THE USE THEREOF | PCT/US2000/009319 | 2000-04-07 | WO00061542A1 | 2000-10-19 | |
| The present invention is directed to novel dipeptide thereof, represented by general formula (I): where R1-R3, X and Y are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are potent inhibitors of caspases and apoptotic cell death. Therefore, the inhibitors of this invention can retard or block cell death in a variety of clinical conditions in which the loss of cells, tissues or entire organs occurs. | ||||||
| 308 | METHOD FOR HYDROGENATING BENZENE POLYCARBOXYLIC ACIDS OR DERIVATIVES THEREOF BY USING A CATALYST CONTAINING MACROPORES | PCT/EP1998/008346 | 1998-12-18 | WO99032427A1 | 1999-07-01 | |
| The invention relates to a method for hydrogenating a benzene polycarboxylic acid or a derivative thereof or of a mixture comprised of two or more thereof with a gas containing hydrogen in the presence of a catalyst. Said catalyst comprises ruthenium as an active metal which is deposited alone or together with at least one metal of subgroups I, VII, or VIII of the periodic table on a support, whereby the support contains macropores. The invention also relates to novel hydrogenated products obtained by hydrogenating benzene polycarboxylic acid (derivatives) and to the use thereof as plasticizers in plastics. | ||||||
| 309 | EXCITATORY AMINO ACID RECEPTOR MODULATORS | PCT/US1998/009862 | 1998-05-14 | WO98051655A1 | 1998-11-19 | |
| Compounds of formula (I) in which R<1> and R<2> are as defined in the specification, and non-toxic metabolically labile ester and amides thereof are useful as modulators of metabotropic glutamate receptor function. | ||||||
| 310 | AN ANTICONVULSANT COMPOUND | EP15766568.8 | 2015-09-10 | EP3191088B1 | 2020-12-16 | WILLIAMS, Robin; WALKER, Matthew |
| 311 | METHOD FOR PRODUCING 1,2,4,5-CYCLOHEXANETETRACARBOXYLIC DIANHYDRIDE | EP18774234.1 | 2018-03-22 | EP3604313A1 | 2020-02-05 | SHIRAI, Shinyo; KUMANO, Tatsuyuki; SAITO, Shinya |
An object of the present invention is to provide a method for producing 1,2,4,5-cyclohexanetetracarboxylic dianhydride, which is capable of stably achieving a high dehydration rate. The method for producing 1,2,4,5-cyclohexanetetracarboxylic dianhydride of the present invention is a method for producing 1,2,4,5-cyclohexanetetracarboxylic dianhydride by subjecting 1,2,4,5-cyclohexanetetracarboxylic acid to a dehydration reaction in a slurry state in the presence of a dehydrating agent, wherein an average particle size of the 1,2,4,5-cyclohexanetetracarboxylic acid is 20 µm or more. |
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| 312 | AN ANTICONVULSANT COMPOUND | EP15766568.8 | 2015-09-10 | EP3191088A1 | 2017-07-19 | WILLIAMS, Robin; WALKER, Matthew |
| The invention relates to pharmaceutical uses of compounds of formula (II). Particular aspects of the invention relate to the use of those compounds in treating, preventing or ameliorating a seizure-related disorder, bipolar disorder, mania, migraine, Alzheimer's disease, Parkinson's disease or stroke. | ||||||
| 313 | 1-(2-ETHYL-BUTYL)-CYCLOHEXANECARBOXYLIC ACID ESTER AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE AMIDES | EP09765761.3 | 2009-06-08 | EP2297081B1 | 2017-03-08 | LOHRI, Bruno |
| 314 | NOVEL ALICYCLIC ALCOHOL | EP11852356.2 | 2011-12-27 | EP2660233B1 | 2016-11-16 | KITAMURA Mitsuharu; ATAKA Yoshiharu; FUKUDA Kazuyuki |
| 315 | NEW PROCESS FOR THE PREPARATIION OF CYCLOHEXANECARBOXYLIC ACID DERICATIVES | EP09728035.8 | 2009-03-26 | EP2274278B1 | 2016-08-17 | HARNETT, Gerard, John; HOFFMANN, Ursula; JANSEN, Michael; REENTS, Reinhard; SATTELKAU, Tim; SMITH, Dennis, A.; STAHR, Helmut |
| 316 | PROCESS FOR PREPARING A CYCLOHEXANECARBONITRILE DERIVATIVE | EP11758183.5 | 2011-09-13 | EP2616433B1 | 2015-12-09 | HARNETT, Gerard, John; HAYES, John; REENTS, Reinhard; SMITH, Dennis, A.; WALSH, Andrew |
| 317 | METHOD FOR PRODUCING ALICYCLIC CARBOXYLIC ACID AND CATALYST USED IN SAME | EP12752352.0 | 2012-02-24 | EP2682380A4 | 2014-07-30 | IIDA Akifumi; WATANABE Ryoko; TSUJIMOTO Tomoo |
| 318 | HYDROGENATION OF BENZENE POLYCARBOXYLIC ACIDS OR DERIVATIVES THEREOF | EP03767568.3 | 2003-11-18 | EP1567470B1 | 2013-06-05 | SCHLOSBERG, Richard Henry; SANTIESTEBAN, Jose, Guadalupe; SOLED, Stuart, L.; MALEK, Andrzej, Mariusz; BAUMGARTNER, Joseph, Ernest; LUO, Shifang; MISEO, Sabato; VARTULI, James, Clarke |
| 319 | PREPARATION METHOD OF PIMARIC ACID TYPE RESIN ACID | EP10753141.0 | 2010-03-18 | EP2410030A4 | 2012-12-26 | ZHAO, Zhendong; CHEN, Yuxiang; BI, Liangwu; GU, Yan; LI, Dongmei; WANG, Jing; LU, Yanju |
| 320 | PROCESS FOR PRODUCING HYDROGENATED AROMATIC POLYCARBOXYLIC ACID | EP09800383.3 | 2009-07-21 | EP2316811A4 | 2012-12-26 | SUGAWARA, Tomohiro |
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