Process for producing l-tryptophan
阅读：650发布：2023-10-30
专利汇可以提供Process for producing l-tryptophan专利检索，专利查询，专利分析的服务。并且L-tryptophan is produced by the fermentation of mutant strains of Corynebacterium glutamicum which require phenylalanine or tyrosine for growth and which are resistant to the inhibitory action of analogues of tryptophan and analogues of phenylalanine or tyrosine. The L-tryptophan is accumulated in the culture medium and is recovered therefrom.，下面是Process for producing l-tryptophan专利的具体信息内容。
1. A PROCESS FOR PRODUCING L-TYPTOPHAN BY FERMENTATION WHICH COMPRISES CULTURING A MUTANT STRAIN OF CORYNEBACTERIUM GLUTAMICUM WHICH REQUIRES PHENYLALANINE AND TYROSINE FOR GROWN AND WHICH IS RESISTANT TO AT LEAST ONE ANALOGUE OF TRYPTOPHAN AND AT LEAST ONE OF THE GROUP CONSISTING OF PHENYLALAMINE ANALOGUES AND TYROSINE ANALOGUES, IN AN AQUEOUS NUTRIENT MEDIUM CONTAINING SOURCES OF CARBON, NITROGEN, INORGANIC NUTRIENTS AND REQUIRED GROWTH FACTORS; ACCUMULATING LTRTRYPTOPHAN IN THE RESULTING CULTURE LIQUOR AND RECOVERING SAID L-TRYPTOPHAN THEREFROM.
2. A process according to claim 1 wherein said mutant strain is selected from the group consisting of Corynebacterium glutamicum ATCC 21842, ATCC 21843, ATCC 21844, ATCC 21845, ATCC 21846, ATCC 21847, ATCC 21848, ATCC 21849, ATCC 21850 and ATCC 21851.
3. A process according to claim 1, wherein culturing is carried out at a temperature of about 20* to 40*C and at a pH around neutrality.
4. A process according to claim 1 wherein said L-tryptophan is recovered by means of an ion exchange resin treatment.
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