Process for the production of 2(4-alkylphenyl)propionic acid专利检索-丙酮酸酮酸酸，碱，盐，酸酐和碱专利检索查询-专利查询网

Process for the production of 2(4-alkylphenyl)propionic acid

阅读：487发布：2023-08-30

专利汇可以提供Process for the production of 2(4-alkylphenyl)propionic acid专利检索，专利查询，专利分析的服务。并且A new process for the production of a 2-(4-alkylphenyl)propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much more suitable for a commercial practice than the prior art methods.，下面是Process for the production of 2(4-alkylphenyl)propionic acid专利的具体信息内容。

权利要求

1. A PROCESS FOR PREPARING A 2-(4-ALKYLPHENYL-PROPIONIC ACID OF THE FORMULA

2. A process according to claim 1, wherein steps (a), (b) and (c) are conducted in the same reaction vessel without isolation of the intermediate products.

3. A process according to claim 1, wherein step (a) is effected at a temperature of 60*-90*C. for 30 minutes to 1 hour.

4. A process according to claim 1, wherein the alkaline hydrolysis conditions of step (b) are provided by an alkali metal hydroxide.

5. A process according to claim 4, wherein said alkali metal hydroxide is formed in situ by adding water to the reaction mixture obtained in step (a) to react with the alkali metal alcoholate therein and heating the resultant admixture under reflux for 10-30 minutes.

6. A process according to claim 1, wherein an alkali metal salt of said pyruvic acid is converted into the free acid by rendering the reaction mixture weakly acidic with a mineral acid prior to oxidation.

7. A process according to claim 1, wherein step (c) is effected at a temperature of 10*-25*C. for 10-20 hours.

8. A process according to claim 2, wherein: a. the reaction of said butenoic acid ester with said alkali metal alcoholate is effected at a temperature of 60*-90*C. for 30 minutes to 1 hour; b. the hydrolysis of said pyruvate is effected by adding water to the reaction mixture of step (a) and heating under reflux for 10-30 minutes; and c. the oxidation of the resultant pyruvic acid or salt thereof is effected at a temperature of 10*-25*C. for 10-20 hours.

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Process for the production of 2(4-alkylphenyl)propionic acid

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