Process for the manufacture of 3,4-disubstituted phenyl-l-alanines
阅读：415发布：2023-08-31
专利汇可以提供Process for the manufacture of 3,4-disubstituted phenyl-l-alanines专利检索，专利查询，专利分析的服务。并且3, 4-Disubstituted phenyl-L-alanines (including ''''L-dopa'''') prepared by transamination of corresponding 3, 4-disubstituted phenyl pyruvic acid and an amino radical donor. Selected bacteria, moulds and yeasts provide the transaminase.，下面是Process for the manufacture of 3,4-disubstituted phenyl-l-alanines专利的具体信息内容。
2. A process as claimed in claim 1 wherein the amino radical donor is L-glutamic acid, L-alanine, L-aspartic acid, glycine, peptones and protein hydrolysates and mixture thereof.
3. A process as claimed in claim 1 wherein the bacterium is Alcaligenes faecalis.
4. A process as claimed in claim 1 wherein the bacterium is PseUdomonas dachunhae.
5. A process as claimed in claim 1 wherein the bacterium is Pseudomonas melanogenum.
6. A process as claimed in claim 1 wherein the mould is Penicillium cyclopium.
7. A process as claimed in claim 1 wherein the yeast is Candida guilliermondii.
8. A process as claimed in claim 1 wherein the transamination is carried out under conditions that the temperature, pH value and reaction time are 25* to 45* C, 6.5 to 10.5 and 20 to 60 hours, respectively.
9. A process as claimed in claim 1 wherein said enzyme is produced by bacteria which is selected from the group consisting essentially of Alcaligones, Mycobacterium, Norcardia, Staphylococcus Arthrobacter, Gluconobacter and Achromobacter.
10. A process as claimed in claim 1 wherein said enzyme is produced by fungi taken from the group consisting essentially of Helicostylum and Trametes.
11. A process as claimed in claim 1 wherein said enzyme is produced by the yeast of Rhodotorula.
12. A process as claimed in claim 1 wherein said enzyme is produced by the fungal specie Heliscostylum piriforme.
13. A process as claimed in claim 11 wherein said enzyme is produced by the yeast specie Rhodotorula glutines.
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