METHOD TO GENERATE NON VIRULENT MICROORGANISMS FROM PATHOGENIC ONES TROUGH PERMANENT GENETIC MODIFICATION OF THEIR BIOLOGICAL MEMBRANE FOR VACCINE PRODUCTION
专利汇可以提供METHOD TO GENERATE NON VIRULENT MICROORGANISMS FROM PATHOGENIC ONES TROUGH PERMANENT GENETIC MODIFICATION OF THEIR BIOLOGICAL MEMBRANE FOR VACCINE PRODUCTION专利检索，专利查询，专利分析的服务。并且Here we describe a methodology to generate non virulent microorganisms from pathogenic ones through permanent genetic modification of the physical state of their membrane (MPS). Thus, at the onset of infection, in these transformed organisms, as they infect a host (e.g. a target cell of a higher eukaryote, particularly mammals, and more specifically human cells, or injecting them in a model of animal infection, the expression of heat shock (stress) genes and the accumulation of the coded proteins (stress proteins or HSPs) and that of other species-specific gene products, the regulation is altered as a consequence of the modification of MPS. Among others, we refer also to genes whose regulation is mediated by signaling transduction pathways. Therefore, as a result of this procedure, pathogens became non-virulent (attenuated, live microorganisms) that can be used for vaccine production.，下面是METHOD TO GENERATE NON VIRULENT MICROORGANISMS FROM PATHOGENIC ONES TROUGH PERMANENT GENETIC MODIFICATION OF THEIR BIOLOGICAL MEMBRANE FOR VACCINE PRODUCTION专利的具体信息内容。
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