IMPROVED METHODS AND COMPOSITIONS FOR RNA INTERFERENCE |
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| 申请号 | PCT/US2004037475 | 申请日 | 2004-11-10 | 公开(公告)号 | WO2005047300A2 | 公开(公告)日 | 2005-05-26 |
| 申请人 | UNIV UTAH RES FOUND; ALVARADO A SANCHEZ; REDDIEN PETER WALTHOUR; BERMANGE ADAM LEWIS; | 发明人 | ALVARADO A SANCHEZ; REDDIEN PETER WALTHOUR; BERMANGE ADAM LEWIS; | ||||
| 摘要 | The invention relates to improved methods of attenuating expression of a target gene in a eukaryotic cell with dsRNA, identifying nucleic acid sequences responsible for conferring a particular phenotype to a cell, alleviating pest infestation in plants, and altering gene expression in an undifferentiated stem cell or the differentiated progeny thereof. Transcription of the RNA, which will form the dsRNA, is terminated by one or more terminators sequences, thereby increasing the efficiency of inhibition. | ||||||
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