| 序号 | 专利名 | 申请号 | 申请日 | 公开(公告)号 | 公开(公告)日 | 发明人 |
|---|---|---|---|---|---|---|
| 81 | JPS4857964A - | JP11037972 | 1972-11-06 | JPS4857964A | 1973-08-14 | |
| 82 | 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS | PCT/US2004001191 | 2004-01-16 | WO2004066920A3 | 2004-11-11 | ALI AMJAD; BALKOVEC JAMES M; GRAHAM DONALD W; GREENLEE MARK L; TAYLOR GAYLE E |
| The present invention encompasses compounds of Formula (I) or ph armaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharamaceutical compositions and methods of use are also included. | ||||||
| 83 | NITRATE ESTERS OF CORTICOID COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | PCT/EP9705426 | 1997-10-02 | WO9815568A3 | 1998-06-18 | DEL SOLDATO PIERO |
| Compounds of the general formula B-X1-NO2 or their esters or salts, where B has structure (1) where there may be substituents in place of the hydrogens H in the CH group or two hydrogens H2 in the CH2 group shown in the general formula; R and R' are equal or different one from the other and may be hydrogen or linear or branched alkyls having from 1 to 4 carbon atoms, preferably R = R' = CH3; B being a corticosteroid residue; R'' is -(CO-L)t-(X)t1- where t and t1 are integers equal or different one from the other and equal to 0 or 1; where L is a bivalent connecting group; X is equal to X0 where X0 = 0, NH, NR1C where R1C is a linear or branched alkyl having from 1 to 10 C atoms; or equal to X2 where X2 is equal to OH, CH3, Cl, N(-CH2-CH3)2, SCH2F, SH; X1 is a bivalent connecting bridge YO where Y is a C1-C20 alkylene. 00000 | ||||||
| 84 | 17-azolyl steroids useful as androgen synthesis inhibitors | US953403 | 1997-10-17 | US5994335A | 1999-11-30 | Angela Brodie; Vincent C. O. Njar |
| Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed. | ||||||
| 85 | 17-alpha-aminoalkynyl-3-chloro 19-norsteroidal 3,5-dienes | US3553213D | 1969-03-17 | US3553213A | 1971-01-05 | OLIVER DONALD W; WENDT GERHARD R |
| 13 - ALKYL - 17A - AMINOALKYNYL - 3 - CHLOROGONA - 3,5DIEN-17-OLS AND 17-ALKANOATES (1) AND THEIR SALTS ARE USEFUL AS TRICHOMONACIDES, FUNGICIDES, AMEBICIDES AND BACTERICIDES. COMPOUNDS (I) ARE PREPARED BY TREATING THE CORRESPONDING 13 - ALKYL - 3 - CHLORO - 17A - ETHYNLGONA-3,5DIEN-17-OL OR 17-ALKANOTE (II) WITH FORMALDEHYDE AND AN APPROPRIATELY-SUBSTITUTED SECONDARY AMINE.
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| 86 | 2,2-ethylene-3-oxo-steroids and intermediates | US3510477D | 1967-10-04 | US3510477A | 1970-05-05 | MANSON ANDREW JOHN |
| 87 | 3-ketal,3-enol ether and 3-pyrrolidine derivatives of 17alpha-ethynyl and 17alpha-halo ethynyl - 17beta - tetrahydropyranyloxy-estra-5(10),9(11)-dien-3-ones | US3452007D | 1965-08-13 | US3452007A | 1969-06-24 | SARETT LEWIS H; BRY THOMAS S; FRIED JOHN; OBERSTER ARTHUR E; BEYLER ROGER E |
| 88 | Steroid diazirines and diaziridines and a process for producing same | US3445461D | 1965-08-05 | US3445461A | 1969-05-20 | BORREVANG POUL; FAARUP PETER |
| 89 | 2,2- and 3,3-hydrazi-steroids of the androstane and pregnane series | US3438973D | 1964-08-25 | US3438973A | 1969-04-15 | CHURCH ROBERT FITZ RANDOLPH; KENDE ANDREW STEVEN; WEISS MARTIN JOSEPH |
| 90 | Steroidal 21-pyrazoles and process therefor | US3424746D | 1966-02-04 | US3424746A | 1969-01-28 | SCHNEIDER WILLIAM P |
| 91 | Pharmacologically active 10alpha-methyl, 9beta-steroids of the pregnane series | US34323364 | 1964-02-07 | US3373172A | 1968-03-12 | HARMEN REERINK ENGBERT; LOUIS SCHOLER HENDRIK FREDRIK |
| 92 | 10alpha-methyl, 9beta-steroids of the androstane series | US56129266 | 1966-06-28 | US3362968A | 1968-01-09 | HARMEN REERINK ENGBERT; LOUIS SCHOLER HENDRIK FREDRIK |
| 93 | 17-aminoalkyl ethers of 3-ketoestrenes | US34483464 | 1964-02-14 | US3351590A | 1967-11-07 | WENDT GERHARD R; LEDIG KURT W |
| 94 | Steroidal spiro-oxazolidinones | US41230364 | 1964-11-19 | US3272801A | 1966-09-13 | MARSHALL DAVID J; CLARA REVESZ |
| 95 | Mono and bis nu-(3alpha, 17alpha-dihydroxy-11, 20-dioxo-5beta-pregnan-21-yl) quaternary ammonium salts of triethylenediamine | US33223663 | 1963-12-20 | US3144446A | 1964-08-11 | MOFFETT ROBERT B |
| 96 | Fluorinated pyrazole steroid compounds | US16223061 | 1961-12-26 | US3096327A | 1963-07-02 | MARCEL HARNIK |
| 97 | 3-(n-pyrrolidinyl)-derivatives of 4-hydroxy-17alpha-methyl testosterone | US14549061 | 1961-10-16 | US3083141A | 1963-03-26 | BRUNO CAMERINO; GIOVANNI SALA |
| 98 | 2alpha-methyl-6-dehydro steroids, 21-esters thereof and intermediates | US57461456 | 1956-03-29 | US2985671A | 1961-05-23 | ALLAN CAMPBELL J; BABCOCK JOHN C; HOGG JOHN A |
| 99 | 21-nitrogen derivatives of corticosteroids | US66417157 | 1957-06-07 | US2920999A | 1960-01-12 | AGNELLO EUGENE J; LAUBACH GERALD D |
| 100 | Cyclic derivatives of 3-hydroxy-delta-pregnene-20-carboxamide | US48871355 | 1955-02-16 | US2813094A | 1957-11-12 | NYSTED LEONARD N |
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