首页 / 国际专利分类库 / 化学;冶金 / C07有机化学 / 甾族化合物 / 具有与环戊烷并(a)氢化菲骨架螺稠合或不稠合的含氮杂环的正系甾族化合物
序号 专利名 申请号 申请日 公开(公告)号 公开(公告)日 发明人
81 JPS4857964A - JP11037972 1972-11-06 JPS4857964A 1973-08-14
82 17-CARBAMOYLOXY CORTISOL DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS PCT/US2004001191 2004-01-16 WO2004066920A3 2004-11-11 ALI AMJAD; BALKOVEC JAMES M; GRAHAM DONALD W; GREENLEE MARK L; TAYLOR GAYLE E
The present invention encompasses compounds of Formula (I) or ph armaceutically acceptable salts or hydrates thereof, which are useful as selective glucocorticoid receptor ligands for treating a variety of autoimmune and inflammatory diseases or conditions. Pharamaceutical compositions and methods of use are also included.
83 NITRATE ESTERS OF CORTICOID COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF PCT/EP9705426 1997-10-02 WO9815568A3 1998-06-18 DEL SOLDATO PIERO
Compounds of the general formula B-X1-NO2 or their esters or salts, where B has structure (1) where there may be substituents in place of the hydrogens H in the CH group or two hydrogens H2 in the CH2 group shown in the general formula; R and R' are equal or different one from the other and may be hydrogen or linear or branched alkyls having from 1 to 4 carbon atoms, preferably R = R' = CH3; B being a corticosteroid residue; R'' is -(CO-L)t-(X)t1- where t and t1 are integers equal or different one from the other and equal to 0 or 1; where L is a bivalent connecting group; X is equal to X0 where X0 = 0, NH, NR1C where R1C is a linear or branched alkyl having from 1 to 10 C atoms; or equal to X2 where X2 is equal to OH, CH3, Cl, N(-CH2-CH3)2, SCH2F, SH; X1 is a bivalent connecting bridge YO where Y is a C1-C20 alkylene. 00000
84 17-azolyl steroids useful as androgen synthesis inhibitors US953403 1997-10-17 US5994335A 1999-11-30 Angela Brodie; Vincent C. O. Njar
Androgen synthesis inhibitors, as well as methods for the use of the same to reduce plasma levels of testosterone and/or dyhydrotestosterone, and to treat prostate cancer and benign prostatic hypertrophy, are disclosed.
85 17-alpha-aminoalkynyl-3-chloro 19-norsteroidal 3,5-dienes US3553213D 1969-03-17 US3553213A 1971-01-05 OLIVER DONALD W; WENDT GERHARD R
13 - ALKYL - 17A - AMINOALKYNYL - 3 - CHLOROGONA - 3,5DIEN-17-OLS AND 17-ALKANOATES (1) AND THEIR SALTS ARE USEFUL AS TRICHOMONACIDES, FUNGICIDES, AMEBICIDES AND BACTERICIDES. COMPOUNDS (I) ARE PREPARED BY TREATING THE CORRESPONDING 13 - ALKYL - 3 - CHLORO - 17A - ETHYNLGONA-3,5DIEN-17-OL OR 17-ALKANOTE (II) WITH FORMALDEHYDE AND AN APPROPRIATELY-SUBSTITUTED SECONDARY AMINE.
86 2,2-ethylene-3-oxo-steroids and intermediates US3510477D 1967-10-04 US3510477A 1970-05-05 MANSON ANDREW JOHN
87 3-ketal,3-enol ether and 3-pyrrolidine derivatives of 17alpha-ethynyl and 17alpha-halo ethynyl - 17beta - tetrahydropyranyloxy-estra-5(10),9(11)-dien-3-ones US3452007D 1965-08-13 US3452007A 1969-06-24 SARETT LEWIS H; BRY THOMAS S; FRIED JOHN; OBERSTER ARTHUR E; BEYLER ROGER E
88 Steroid diazirines and diaziridines and a process for producing same US3445461D 1965-08-05 US3445461A 1969-05-20 BORREVANG POUL; FAARUP PETER
89 2,2- and 3,3-hydrazi-steroids of the androstane and pregnane series US3438973D 1964-08-25 US3438973A 1969-04-15 CHURCH ROBERT FITZ RANDOLPH; KENDE ANDREW STEVEN; WEISS MARTIN JOSEPH
90 Steroidal 21-pyrazoles and process therefor US3424746D 1966-02-04 US3424746A 1969-01-28 SCHNEIDER WILLIAM P
91 Pharmacologically active 10alpha-methyl, 9beta-steroids of the pregnane series US34323364 1964-02-07 US3373172A 1968-03-12 HARMEN REERINK ENGBERT; LOUIS SCHOLER HENDRIK FREDRIK
92 10alpha-methyl, 9beta-steroids of the androstane series US56129266 1966-06-28 US3362968A 1968-01-09 HARMEN REERINK ENGBERT; LOUIS SCHOLER HENDRIK FREDRIK
93 17-aminoalkyl ethers of 3-ketoestrenes US34483464 1964-02-14 US3351590A 1967-11-07 WENDT GERHARD R; LEDIG KURT W
94 Steroidal spiro-oxazolidinones US41230364 1964-11-19 US3272801A 1966-09-13 MARSHALL DAVID J; CLARA REVESZ
95 Mono and bis nu-(3alpha, 17alpha-dihydroxy-11, 20-dioxo-5beta-pregnan-21-yl) quaternary ammonium salts of triethylenediamine US33223663 1963-12-20 US3144446A 1964-08-11 MOFFETT ROBERT B
96 Fluorinated pyrazole steroid compounds US16223061 1961-12-26 US3096327A 1963-07-02 MARCEL HARNIK
97 3-(n-pyrrolidinyl)-derivatives of 4-hydroxy-17alpha-methyl testosterone US14549061 1961-10-16 US3083141A 1963-03-26 BRUNO CAMERINO; GIOVANNI SALA
98 2alpha-methyl-6-dehydro steroids, 21-esters thereof and intermediates US57461456 1956-03-29 US2985671A 1961-05-23 ALLAN CAMPBELL J; BABCOCK JOHN C; HOGG JOHN A
99 21-nitrogen derivatives of corticosteroids US66417157 1957-06-07 US2920999A 1960-01-12 AGNELLO EUGENE J; LAUBACH GERALD D
100 Cyclic derivatives of 3-hydroxy-delta-pregnene-20-carboxamide US48871355 1955-02-16 US2813094A 1957-11-12 NYSTED LEONARD N
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