| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | 3-thioketals of pregnadiene and method of preparation thereof | US35151564 | 1964-03-12 | US3192202A | 1965-06-29 | GEORGE KARMAS; IRVING SCHEER |
| 42 | Selective bromination of a-ring aromatic 17-ketalized steroids | US26340663 | 1963-03-07 | US3177206A | 1965-04-06 | SMITH LELAND L; TELLER DANIEL M |
| 43 | 3-oxo-16beta-mercapto-17beta-hydroxy-5alpha-androstane-16-17 acetonides and the process for the production thereof | US21605962 | 1962-08-10 | US3170920A | 1965-02-23 | TAICHIRO KOMENO |
| 44 | 3, 11-dioxygenated-17-desoxy-5beta-androstanes and processes therefor | US25610663 | 1963-02-04 | US3132160A | 1964-05-05 | WECHTER WILLIAM J |
| 45 | Preparation of 3-hydroxy-11-ketocholanic acid, derivatives and analogs thereof, and intermediates in said preparation | US41877954 | 1954-03-25 | US2745829A | 1956-05-15 | SYDNEY ARCHER |
| 46 | 3-ethylene mercaptole derivatives of progesterone | US42502354 | 1954-04-22 | US2744110A | 1956-05-01 | RALLS JACK W |
| 47 | 11β- aryl -17,17- Supirochioran substituted steroid | JP2001512545 | 2000-07-20 | JP4768181B2 | 2011-09-07 | クック、シー・エドガー; ケプラー、ジョン・エー; シェッティ、ルーパ・エス; リー、デビッド・ワイ−ダブリュ |
| 48 | 光解離性保護基 | JP2010502735 | 2009-01-08 | JPWO2009113322A1 | 2011-07-21 | 喜代三 垣内; 健 堤; 悟 木谷; 一起 菅原; 佳典 御所 |
| 本発明は、光照射下の穏和な条件下で脱保護できる光解離性保護基を提供することにある。具体的には、該光解離性保護基を用いて反応性官能基(例えば、水酸基、アミノ基、カルボキシル基、カルボニル基、リン酸ジエステル基等)を保護した後、中性条件下、光照射のみで該光解離性保護基を脱保護する方法を提供する。一般式(3):(式中、Ar1は置換基を有してもよい芳香環又はヘテロ芳香環、Ar1は置換基を有してもよいアリール基又はヘテロアリール基、Xは脱離基、nは1又は2の整数を示す。)で表される化合物、並びに該化合物を用いたアミノ基等の保護及び脱保護方法に関する。 | ||||||
| 49 | Reaction apparatus | JP2005260561 | 2005-09-08 | JP4631623B2 | 2011-02-23 | 雅治 塩谷; 直知 宮本; 忠夫 山本 |
| 50 | Heteroaromatic sulfonamides prodrugs | JP2008542679 | 2006-11-27 | JP2009517425A | 2009-04-30 | ヌベマイアー，ラインハルト; ビュルバ，ラルフ |
| 本発明は、複素芳香族リンカーを有する、下記一般式（I）：
で表されるスルホンアミドプロドラッグ類、それらの調製方法、それらの化合物を含んで成る医薬組成物、及び経口薬剤の製造のためへのそれらの使用に関する。 本発明の化合物は、カルボアンヒドラーゼに結合し、そしてそれらの酵素を阻害する。 |
||||||
| 51 | Organic compound | JP2004525343 | 2003-07-28 | JP2006501207A | 2006-01-12 | グイド・ヨルディネ; ミヒャエル・ムッツ |
| ３−メチルチオフェン−２−カルボン酸（６Ｓ,９Ｒ,１０Ｓ,１１Ｓ,１３Ｓ,１６Ｒ,１７Ｒ）−９−クロロ−６−フルオロ−１１−ヒドロキシ−１７−メトキシカルボニル−１０,１３,１６−トリメチル−３−オキソ−６,７,８,９,１０,１１,１２,１３,１４,１５,１６,１７−ドデカヒドロ−３Ｈ−シクロペンタ［ａ］フェナントレン−１７−イルエステルの多形結晶形。 これらの結晶形は、高い抗炎症活性を有し、そして非常に優れた安定性を有する。 これらの結晶形の製造方法も記載されている。 | ||||||
| 52 | 반응장치 | KR1020060086063 | 2006-09-07 | KR1020070029075A | 2007-03-13 | 미야모토나오토모; 야마모토다다오; 시오야마사하루 |
| Provided is a reacting device having advantages in that the reactor is downsized while the degree of vacuum in an insulating container is improved. The reacting device comprises a first reaction part(4) and a second reaction part(6), which are arranged to form a gap therebetween, to which a reactant is supplied, in which a reaction flow channel that the reactant flows therein is formed such that a reaction of the reactant is performed; a heat insulating container(200) for covering at least entirety of the first reaction part(4), the second reaction part(6) and the gap, in which an inner space(201) including the gap has a lower pressure than atmospheric pressure; and at least one getter material(188) which is disposed in a space including the gap in the inner space(201) of the heat insulating container(200). | ||||||
| 53 | POLYMORPH B OF A KNOWN THIOPHENECARBOXYLIC ACID DODECAHYDROCYCLOPENTA[A]PHENANTHRENYL ESTER | EP03766325.9 | 2003-07-28 | EP1554303B1 | 2006-12-27 | JORDINE, Guido; MUTZ, Michael |
| Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S,9R,10S,11S,13S,16R,17R)-9-chloro-6-fluoro-11-hydroxy-l7-methoxycarbonyl-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-l7-yl ester. The crystal forms possess anti-inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described. | ||||||
| 54 | KINETIC ASSAY | EP02738989 | 2002-05-14 | EP1404717A4 | 2006-03-08 | COOK CHRISTIAN JOHN; WU YINQIU; MITCHELL JOHN STANTON |
| A hapten-linker-large group conjugate for use in a rapid assay, wherein the assay is kinetic-based not approaching equilibrium, the hapten-linker-large group conjugate being of the general formula: X - W - Y - Zwherein:X is a hapten;W is an optional thioether or ether group;Y is a linker of 10 or more atoms in length; andZ is a large group of sufficient size to provide steric hindrance with respect to the binding of X to a ligand in the absence of Y.Also provided are processes for the production of the conjugates, assay methods and kits. The assays of the invention utilising conjugates of the invention [(5)-OVA] provide a better sensitivity than the same assays with conjugates with shorter linkers [(2)-OVA and 3-OVA]. | ||||||
| 55 | 11$g(b)-ARYL-17,17-SPIROTHIOLANE-SUBSTITUTED STEROIDS | EP00948741 | 2000-07-20 | EP1196428A4 | 2002-10-16 | COOK EDGAR C; SHETTY RUPA S; KEPLER JOHN A; LEE DAVID Y-W |
| 56 | 11$g(b)-ARYL-17,17-SPIROTHIOLANE-SUBSTITUTED STEROIDS | EP00948741.4 | 2000-07-20 | EP1196428A1 | 2002-04-17 | COOK, C., Edgar; SHETTY, Rupa, S.; KEPLER, John, A.; LEE, David, Y.-W. |
| The invention is directed to a novel class of 11β-aryl-17,17-spirothiolane-substituted steroid compounds exhibiting binding to the progestin receptor. | ||||||
| 57 | 반응장치 | KR1020060086063 | 2006-09-07 | KR100769393B1 | 2007-10-22 | 미야모토나오토모; 야마모토다다오; 시오야마사하루 |
| 반응장치에 있어서, 간극부를 갖고 설치되고, 반응물이 공급되며, 반응물이 흐르는 반응유로가 생성되어 반응물의 반응을 일으키는 제 1 반응부 및 제 2 반응부와, 적어도 제 1 반응부, 제 2 반응부 및 간극부의 전체를 덮고, 간극부를 포함하는 내부공간이 대기압보다 낮은 기압으로 된 단열용기와, 단열용기의 내부공간내의 간극부를 포함하는 공간내에 설치되어 있는 적어도 1개의 게터재를 구비하고, 게터재에 의해서 단열용기의 내부공간의 진공도를 높이는 동시에, 게터재를 제 1 반응부와 제 2 반응부의 사이의 간극에 설치하도록 해서, 반응장치의 크기가 증대하지 않도록 한다. 게터재, 단열용기, 절연선, 연결관, 고온/저온반응부 | ||||||
| 58 | 공지된 티오펜카르복실산 도데카히드로시클로펜타 (Ａ)페난트레닐 에스테르의 다형체 | KR1020057001581 | 2003-07-28 | KR1020050033632A | 2005-04-12 | 요르딘,구이도; 뮤츠,미카엘 |
| Polymorphic crystal forms of 3-methylthiophene-2-carboxylic acid (6S, 9R,10S,11S,13S,16R,17R)-9-chloro-6-fluoro-11-hydroxy-l7-methoxycarbonyl- 10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H- cyclopenta[a]phenanthren-l7-yl ester. The crystal forms possess anti- inflammatory activity and have very good stability. Methods for preparing the crystal forms are also described. | ||||||
| 59 | 헤테로방향족 술폰아미드 전구약물 | KR1020087015778 | 2006-11-27 | KR1020080074197A | 2008-08-12 | 비르바,랄프; 누베마이어,라인하르트 |
| The invention relates to the sulfonamide prodrugs of formula (I), comprising a heteroaromatic linker, to a method for producing the same, to pharmaceutical compositions containing said compounds and to their use for producing orally available drugs. The compounds according to the invention bind to carboanhydrases and inhibit these enzymes. | ||||||
| 60 | 공지된 티오펜카르복실산 도데카히드로시클로펜타 (Ａ)페난트레닐 에스테르의 다형체 | KR1020057001581 | 2003-07-28 | KR100688371B1 | 2007-03-02 | 요르딘,구이도; 뮤츠,미카엘 |
| 본 발명은 3-메틸티오펜-2-카르복실산 (6S,9R,10S,11S,13S,16R,17R)-9-클로로-6-플루오로-11-히드록시-17-메톡시카르보닐-10,13,16-트리메틸-3-옥소-6,7,8,9,10,11,12,13,14,15,16,17-도데카히드로-3H-시클로펜타[a]페난트렌-17-일 에스테르의 다형성 결정 형태에 관한 것이다. 상기 결정 형태는 소염 활성을 가지고 있으며, 안정성이 매우 양호하다. 이 결정 형태의 제조 방법 또한 기재되어 있다. 염증성 또는 폐색성 기도 질환, 호산구 관련 기도 장애, 티오펜카르복실산 도데카히드로시클로펜타 (A) 페난트레닐 에스테르, 다형성 결정 형태 | ||||||
QQ群二维码
意见反馈
意见反馈