| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 21 | 新規システイン化合物及びその塩 | JP2014506256 | 2013-03-19 | JPWO2013141264A1 | 2015-08-03 | 章良 浅井; 尚久 小郷; 潤一 澤田; 章弘 橋本 |
| 本発明は、Eg5阻害活性を有し、抗腫瘍剤として有用な新規化合物を提供することを目的とする。本発明は、下記一般式(I)[式(I)中、Aは、CH2、硫黄原子又は酸素原子、Rは、ハロゲン原子、C1−C6アルキル基、C1−C6アルコキシ基又はトリフルオロメチル基を示す。]で表される化合物又はその塩に関する。【化1】 | ||||||
| 22 | Polymerizable monomer and polymer | JP51936096 | 1995-12-18 | JP4153031B2 | 2008-09-17 | エバンス，リチャード・アレキサンダー; モード，グレアム; リザード，エジオ |
| 23 | Polycyclic alkaloid derivatives as Nmda receptor antagonist | JP50603297 | 1996-07-12 | JPH11509533A | 1999-08-24 | ディクシット，ディリップ，エム; ディマイオ，ジョン |
| (57)【要約】 次式（Ｉ） ［式中、Ｒ 1はＨ、炭素原子数１ないし６のアルキル基、または炭素原子数６ないし１２のアリール基であって所望により極性基で置換された基を表し、Ｒ 2およびＲ 3は独立してＨ、ＯＨ、炭素原子数１ないし６のアルキル基、−Ｃ（ＮＨ）−ＮＨ 2 、正帯電した基、または炭素原子数７ないし１３のアラルキル基であって所望によりＮＨ 2 、ＯＨ、炭素原子数１ないし６のアルキル基またはハロゲン原子で置換された基を表すか、またはＲ 2およびＲ 3は一緒になって所望によりヘテロ原子を組み入れる５ないし６員環を形成し、Ｒ 4はＨ、炭素原子数１ないし６のアルキル基、ＯＲ 6 、ＳＲ 6またはＮ（Ｒ 6 ） 2を表し、ここでそれぞれのＲ 6は独立してＨ、炭素原子数１ないし３のアルキル基を表し、ＸはＯ、Ｓ、ＳＯ、ＳＯ 2 、Ｎ−Ｒ 5またはＣ−（Ｒ 5 ） 2を表し、ここでそれぞれのＲ 5は独立してＨ、炭素原子数１ないし６のアルキル基、または炭素原子数７ないし１３のアラルキル基であって所望により１個またはそれ以上のヘテロ原子で中断された基を表し、ｎは０ないし２の整数を表し、ｍは０ないし３の整数を表し、但し、ＸがＣＨ 2を表すとき、Ｒ 1はＣＨ 3を表さず、Ｒ 2およびＲ 3は双方ともＨを表さず、Ｒ 4はＯＨを表さず、ｍは３を表さず、またｎは０を表さない。 ］で表される多環式アルカロイド。 それはイオノトロピックＮＭＤＡ（Ｎ−メチル−（Ｄ）−アスパラギン酸）受容体で拮抗薬として作用する。 | ||||||
| 24 | 新規システイン化合物及びその塩 | JP2014506256 | 2013-03-19 | JP5662618B2 | 2015-02-04 | 章良 浅井; 尚久 小郷; 潤一 澤田; 章弘 橋本 |
| 25 | New heterocyclic compounds for the treatment of pain and their applications | JP50610997 | 1996-07-12 | JPH11509211A | 1999-08-17 | ディクシット，ディリップ，エム．; ディマイオ，ジョン |
| (57)【要約】 次式（Ｉ）で表される多環式アルカロイド： （式中、Ｒ 1はＨ、炭素原子数１ないし６のアルキル基または場合により極性基で置換された炭素原子数６ないし１２のアリール基を表し、Ｒ 2およびＲ 3は独立してＨ、ＯＨ、炭素原子数１ないし６のアルキル基、−Ｃ（ＮＨ）−ＮＨ 2 、陽に荷電した基、または場合によりＮＨ 2 、ＯＨ、炭素原子数１ないし６のアルキル基またはハロゲン原子で置換された炭素原子数７ないし１３のアルアルキル基を表すか、またはＲ 2およびＲ 3は一緒になって場合により異原子を含む５ないし６員環を形成し、Ｒ 4はＨ、炭素原子数１ないし６のアルキル基、ＯＲ 6 、ＳＲ 6またはＮ（Ｒ 6 ） 2を表し、各々のＲ 6は独立してＨ、炭素原子数１ないし３のアルキル基またはハロゲン原子を表し、ＸはＯ、Ｓ、ＳＯ、ＳＯ 2 、Ｎ−Ｒ 5またはＣ−（Ｒ 5 ） 2を表し、各々のＲ 5は独立してＨ、炭素原子数１ないし６のアルキル基または１もしくはそれより多い異原子で場合により中断された炭素原子数７ないし１３のアルアルキル基を表し、ｎは０ないし２の整数を表し、ｍは０ないし３の整数を表すが、ただし、ＸがＣＨ 2である場合、Ｒ 1はＣＨ 3ではなく、Ｒ 2およびＲ 3は両方Ｈではなく、Ｒ 4はＯＨではなく、ｍは３ではなく、そしてｎは０ではない）。 痛みの処置のための上記化合物を含有する薬学的に許容され得る組成物。 本発明の化合物はアヘン剤受容体でアゴニストとして作用する。 | ||||||
| 26 | Substituted pyridazones and herbicides containing said compound | JP6615876 | 1976-06-08 | JPS52289A | 1977-01-05 | ADORUFU FUITSUSHIERU; HANSUPEETERU HANZEN; UORUFUGANGU ROORU |
| 27 | NOVEL HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF PAIN AND USE THEREOF | EP96921855.1 | 1996-07-12 | EP0850234B1 | 2001-11-28 | DIMAIO, John; DIXIT, Dilip M |
| Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 and R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl, or halogen; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. For the treatment of pain and pharmaceutically acceptable compositions comprising those compounds. The compounds of this invention act as agonists at the opiate receptor. | ||||||
| 28 | POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS | EP96922703.2 | 1996-07-12 | EP0840731B1 | 2001-10-10 | DIMAIO, John; DIXIT, Dilip, M. |
| Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 abd R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. That act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor. | ||||||
| 29 | Procédé de synthèse d'hétérocycles à partir de complexes palladocycliques | EP87111247.0 | 1987-08-04 | EP0255715B1 | 1991-07-31 | Pfeffer, Michel, Dr.; Maassarani, Figa; Dupont, Jairton |
| 30 | Tricyclic amine derivatives | EP89200473.0 | 1989-02-27 | EP0332246A1 | 1989-09-13 | Rae, Duncan Robertson; Cairns, James |
The present invention deals with dibenzo-oxocin-, dibenzo-thiocin-, dibenzo-azocin-and dibenzocyclo-octenamine derivatives suitable for use as antipsychotic compounds without extra-pyrimidal side-effects. |
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| 31 | POLYMERISABLE MONOMERS AND POLYMERS | EP95941979.7 | 1995-12-18 | EP0799220B1 | 2003-04-09 | EVANS, Richard, Alexander; RIZZARDO, Ezio; MOAD, Graeme |
| Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R?1 and R2 or R3 and R4¿ together form methylene; X is selected from sulfur, sulfoxide, sulfone and disulfide; Y is selected from sulfur, oxygen, N-H, N-alkyl, N-aryl, acyl and CR5R6 wherein R?5 and R6¿ are the same as R?1 to R4; and Z1 and Z2¿ are linking functionalites, with the proviso that when R1 to R4 are hydrogen and X and Y are sulfur in the compound of formula (1a), then Z1 is not -(CH¿2?)2- or -CH2-C(=CH2)-CH2-. Compounds of formula (1a) and (1b) are used to produce polymers, copolymers or block polymer to manufacture adhesives, dental compositions or optical lenses. | ||||||
| 32 | POLYCYCLIC ALCALOID-DERIVATIVES AS NMDA-RECEPTOR ANTAGONISTS | EP96922703.0 | 1996-07-12 | EP0840731A1 | 1998-05-13 | DIMAIO, John; DIXIT, Dilip, M. |
| Polycyclic alkaloids of formula (I), wherein R1 is H, C1-6 alkyl, or C6-12 aryl optionally substituted with polar groups; R2 abd R3 are independently H, OH, C1-6 alkyl, -C(NH)-NH2, a positively charged group, or C7-13 aralkyl optionally substituted with NH2, OH, C1-6 alkyl, or halogen; or R2 and R3 together form a 5 to 6 member ring optionally incorporating a heteroatom; R4 is H, C1-6 alkyl, OR6, SR6 or N(R6)2, wherein each R6 is independently H, C1-3 alkyl; X is O, S, SO, SO2, N-R5, or C-(R5)2, wherein each R5 is independently H, C1-6 alkyl, or C7-13 aralkyl optionally interrupted with one or more heteroatom; n is an integer from 0 to 2; m is an integer from 0 to 3; with the proviso that when X is CH2 then R1 is not CH3, R2 and R3 are not both H, R4 is not OH, m is not 3 and n is not 0. That act as antagonists at the ionotropic NMDA (N-methyl-(D)-aspartic acid) receptor. | ||||||
| 33 | POLYMERISABLE MONOMERS AND POLYMERS | EP95941979 | 1995-12-18 | EP0799220A4 | 1998-04-15 | EVANS RICHARD ALEXANDER; RIZZARDO EZIO; MOAD GRAEME |
| Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R?1 and R2 or R3 and R4¿ together form methylene; X is selected from sulfur, sulfoxide, sulfone and disulfide; Y is selected from sulfur, oxygen, N-H, N-alkyl, N-aryl, acyl and CR5R6 wherein R?5 and R6¿ are the same as R?1 to R4; and Z1 and Z2¿ are linking functionalites, with the proviso that when R1 to R4 are hydrogen and X and Y are sulfur in the compound of formula (1a), then Z1 is not -(CH¿2?)2- or -CH2-C(=CH2)-CH2-. Compounds of formula (1a) and (1b) are used to produce polymers, copolymers or block polymer to manufacture adhesives, dental compositions or optical lenses. | ||||||
| 34 | POLYMERISABLE MONOMERS AND POLYMERS | EP95941979.0 | 1995-12-18 | EP0799220A1 | 1997-10-08 | EVANS, Richard, Alexander; RIZZARDO, Ezio; MOAD, Graeme |
| Compounds of formulae (1a) and (1b), wherein R1 to R4 may be the same or different and are selected from hydrogen, halogen, optionally substituted alkyl, optionally substituted aryl, nitrile, hydroxy, alkoxy acyloxy and ester; or R?1 and R2 or R3 and R4¿ together form methylene; X is selected from sulfur, sulfoxide, sulfone and disulfide; Y is selected from sulfur, oxygen, N-H, N-alkyl, N-aryl, acyl and CR5R6 wherein R?5 and R6¿ are the same as R?1 to R4; and Z1 and Z2¿ are linking functionalites, with the proviso that when R1 to R4 are hydrogen and X and Y are sulfur in the compound of formula (1a), then Z1 is not -(CH¿2?)2- or -CH2-C(=CH2)-CH2-. Compounds of formula (1a) and (1b) are used to produce polymers, copolymers or block polymer to manufacture adhesives, dental compositions or optical lenses. | ||||||
| 35 | ARTHROPODICIDAL CARBOXANILIDES | PCT/US9109172 | 1991-12-17 | WO9212133A3 | 1992-10-15 | HARRISON CHARLES RICHARD; KRANIS KEVIN THOMAS; STEVENSON THOMAS MARTIN |
| Compounds of formula (I), wherein Q, X, R?1, R2, R9¿ and Z are as defined in the text, including compositions containing said compounds and a method for using them to control arthropods. | ||||||
QQ群二维码
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