子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 用于合成软海绵素B类似物的中间体和方法 | CN200880119686.9 | 2008-10-03 | CN101883763B | 2016-04-20 | C·蔡斯; A·远藤; F·G·方; J·李 |
| 描述了用于合成软海绵素B类似物的中间体的合成方法。 | ||||||
| 2 | 用于合成软海绵素B类似物的中间体和方法 | CN200880119686.9 | 2008-10-03 | CN101883763A | 2010-11-10 | C·蔡斯; A·远藤; F·G·方; J·李 |
| 描述了用于合成软海绵素B类似物的中间体的合成方法。 | ||||||
| 3 | Intermediates and methods for the synthesis of halichondrin B analogs | US14624033 | 2015-02-17 | US09604993B2 | 2017-03-28 | Charles E. Chase; Atsushi Endo; Francis G. Fang; Jing Li |
| Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described. | ||||||
| 4 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | US13334516 | 2011-12-22 | US20120095242A1 | 2012-04-19 | Charles Chase; Atsushi Endo; Francis G. Fang; Jing Li |
| Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described. | ||||||
| 5 | Sulphonamide derivatives | US995009 | 1992-12-22 | US5258399A | 1993-11-02 | David Waterson |
| The invention concerns sulphonamide derivatives of the formula I ##STR1## wherein R.sup.1 includes (1-4C)alkyl; R.sup.2 and R.sup.3 together form --A.sup.2 --X.sup.2 --A.sup.3 --which defines a ring having 5 to 7 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl;A.sup.1 is a direct link to X.sup.1 or is (1-3C)alkylene;X.sup.1 is oxy, thio, sulphinyl, sulphonyl or imino;Ar is optionally substituted phenylene or Ar is pyridylene;Q is nitrogen or of the formula CR.sup.7, wherein R.sup.7 includes hydrogen, halogeno, (1-4C)alkyl and (1-4C)alkoxy;each of R.sup.4 and R.sup.5 is (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl or optionally substituted phenyl, benzyl or pyridyl, or R.sup.5 may be hydrogen; andR.sup.6 has any of the meanings defined for R.sup.7 ;or a pharmaceutically-acceptable salt thereof;processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors. | ||||||
| 6 | Sulphonamide derivatives | US818911 | 1992-01-10 | US5236948A | 1993-08-17 | David Waterson |
| The invention concerns sulphonamide derivatives of the formula I ##STR1## wherein R.sup.1 includes (1-4C)alkyl;R.sup.2 and R.sup.3 together form --A.sup.2 --X.sup.2 --A.sup.3 -- which defines a ring having 5 to 7 ring atoms, wherein A.sup.2 and A.sup.3 each is (1-3 C)alkylene and X.sup.2 is oxy, thio, sulphinyl or sulphonyl;A.sup.1 is a direct link to X.sup.1 or is (1-3 C)alkylene;X.sup.1 is oxy, thio, sulphinyl, sulphonyl or imino;Ar is optionally substituted phenylene or Ar is pyridylene;Q is nitrogen or of the formula CR.sup.7, wherein R.sup.7 includes hydrogen, halogeno, (1-4 C)alkyl and (1-4 C)alkoxy;each of R.sup.4 and R.sup.5 is (1-4 C)alkyl, (3-4 C)alkenyl, (3-4 C)alkynyl or optionally substituted phenyl, benzyl or pyridyl, or R.sup.5 may be hydrogen; andR.sup.6 has any of the meanings defined for R.sup.7 ;or a pharmaceutically-acceptable salt thereof; processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors. | ||||||
| 7 | 1-Nor-2-amino carbamates derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum | US765569 | 1977-02-04 | US4107429A | 1978-08-15 | David T. Connor; Samuel M. Ringel; Maximilian VON Strandtmann |
| The present invention relates to 1-nor-2-amino carbamates derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The 1-nor-2-amino carbamates of acid S of this invention are useful as antifungal agents. | ||||||
| 8 | Intermediates and methods for the synthesis of halichondrin B analogs | US15092850 | 2016-04-07 | US09802953B2 | 2017-10-31 | Charles E. Chase; Atsushi Endo; Francis G. Fang; Jing Li |
| Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described. | ||||||
| 9 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | US14624033 | 2015-02-17 | US20150225415A1 | 2015-08-13 | Charles E. CHASE; Atsushi ENDO; Francis G. FANG; Jing LI |
| Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described. | ||||||
| 10 | Intermediates and methods for the synthesis of halichondrin B analogs | US12245149 | 2008-10-03 | US08093410B2 | 2012-01-10 | Charles Chase; Atsushi Endo; Frances G. Fang; Jing Li |
| Methods of synthesizing intermediates useful for the synthesis of halichondrin B analogs are described. | ||||||
| 11 | Diacyloxyacids derived from acid S, an antibiotic produced by Polyangium cellulosum var. fulvum | US948854 | 1978-10-05 | US4191825A | 1980-03-04 | David T. Connor; Samuel M. Ringel; Sidney Roemer; Maximillian von Strandtmann |
| The present invention relates to diacyloxyacids derived from the antibiotic substance, designated acid S, produced by Polyangium cellulosum var. fulvum (ATCC No. 25532), and to processes for their production. The diacyloxyacids derivatives of acid S of this invention are useful as antifungal and antibacterial agents. | ||||||
| 12 | Aldehyde, oxime and phenylhydrazone derivatives of acid S, an antibiotic produced by Polyangium cellulosum var. fulvum | US765567 | 1977-02-04 | US4098998A | 1978-07-04 | David T. Connor; Samuel M. Ringel; Maximillian Von Strandtmann |
| The present invention relates to aldehyde, oxime and phenylhydrazone derivatives of the novel antibiotic substance, acid S, produced by the organism Polyangium cellulosum var. fulvum (ATCC No. 25532) and to processes for their preparation. The aldehyde, oxime and phenylhydrazone derivatives of acid S of this invention are useful as antifungal agents. | ||||||
| 13 | Sulfonamide derivative, its manufacture and medicinal preparation containing the same used for leukotriene mediation disease or medical symptom | JP487092 | 1992-01-14 | JPH0551374A | 1993-03-02 | DEIBUITSUDO UOOTAASON |
| PURPOSE: To obtain a new sulfonamide deriv. as a 5-lipoxygenase inhibitor useful for a leukotriene mediation disease. CONSTITUTION: The sulfonamide deriv. is a compd. of formula I [where R 1 is a 1-4 C alkyl, 3-4 C alkenyl, etc.; R 2 and R 3 may bond to each other to form -A 2-X 2-A 3- (A 2 and A 3 are each a 1-3 C alkylene and X is oxy, etc.) giving a 5- to 7-membered ring in combination with C to which A 2 and A 3 bond; A 1 is a direct bond to X 1, etc.; X 1 is oxy, etc.; Ar is (substd.) phenylene, etc.; R 4 is a 1-4 C alkyl, etc.; R 5 is H, a 1-4 C alkyl, etc.; and R 6 is H, a halogen, etc.], e.g. N-{4-[3-(4-methoxytetrahydropyran-4-yl)phenylthio]phenyl}-N- methylmethanesulfonamide. The compd. of the formula I is obtd. by coupling a compd. of formula II (where Z is a substitutable group) with a compd. of formula III. COPYRIGHT: (C)1993,JPO | ||||||
| 14 | JPS5540587B2 - | JP6659377 | 1977-06-06 | JPS5540587B2 | 1980-10-18 | |
| 15 | INTERMEDIATES AND METHODS FOR THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EP08836425.2 | 2008-10-03 | EP2200992B1 | 2014-02-26 | CHASE, Charles; ENDO, Atsushi; FANG, Francis, G.; LI, Jing |
| The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula: | ||||||
| 16 | Bis-dihydropyran derivatives and their use in chiral transformations | EP94301628.7 | 1994-03-08 | EP0614895A1 | 1994-09-14 | Ley, Steven Victor; Woods, Martin |
A disubstituted bis-dihydropyran having C2 symmetry, in single enantiomer form can be used in an enantioselective reaction to form dispiroketal which are chiral templates. |
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| 17 | Intermediates for the synthesis of halichondrin B analogs | EP12191294.3 | 2008-10-03 | EP2578576B9 | 2016-09-14 | Chase, Charles; Endo, Atsushi; Fang, Francis, G.; Li, Jing |
| The following intermediates for the synthesis of halichondrin B analogs are described: Compound AU, Compound AR, or a composition comprising a compound having the formula: | ||||||
| 18 | DEOXYTHIOMARINOL DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MICROBICIDES AND HERBICIDES | EP94917614.0 | 1994-05-10 | EP0698027A1 | 1996-02-28 | BAGGALEY, Keith Howard; BEST, Desmond John; BROOM, Nigel John Perryman; O'HANLON, Peter John; OSBORNE, Neal Frederick |
| Ester derivatives of monic acid of formula (I) comprising a terminal pyrrothine moiety have useful anti-bacterial, anti-fungal and herbicibal properties. Intermediates have been claimed or well. | ||||||
| 19 | JPS5540589B2 - | JP764879 | 1979-01-25 | JPS5540589B2 | 1980-10-18 | |
| 20 | 11noll22aminocarbamate derived from antibiotic acid s | JP764779 | 1979-01-25 | JPS5522658A | 1980-02-18 | DEBITSUDO TEII KONAA; SAMUERU EMU RINGERU; MAKUSHIMIRIAN FUON SUTORANDOMA |
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