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序号	专利名	申请号	申请日	公开（公告）号	公开（公告）日	发明人
41	回收和循环使用D－酒石酸的方法	CN00817998.0	2000-12-19	CN1414939A	2003-04-30	K·A·M·克雷默
提供一种通过形成和分离结晶酒石酸氢盐从拆分外消旋2－氨基－2，3－二甲基丁腈过程产生的含水有机废液流中回收基本上为对映体纯的D－酒石酸的方法。可将回收的光学纯的D－酒石酸有效地循环使用以维持对外消旋的2－氨基－2，3－二甲基丁腈拆分。
42	具有增强的照相感光度的卤化银光敏乳剂层	CN01130276.3	2001-12-28	CN1362640A	2002-08-07	J·R·伦哈德; A·A·穆恩特; S·A·戈德莱斯基; P·A·兹林斯基; D·舒克拉; D·R·迪尔
本发明提供了照相元件,它包含至少一个卤化银乳剂层,其中卤化银被下式(a)的化合物增感:Δ－(t)m－XY’(a);XY’－(t)m－Δ(b);Δ－(t)m－XY’－(t)m－Δ(c);其中Δ是在照相元件显影过程中消除的保护基团,t是定时基团,m是0－3的整数,XY’是可碎裂的电子给体部分,其中X是给电子基团而Y’是离去质子H或离去基团Y,前提是当Y’是质子时,则碱β－存在于乳剂中或与X直接或间接共价键合,其中1)X－Y’具有的氧化势为0－约1.4V;2)氧化形式的X－Y’进行键裂反应以得到自由基X·和离去片段Y’;3)自由基X·的氧化势≤－0.7V。
43	苯基烷烃酰胺衍生物及农业或园艺杀菌剂	CN96195928.2	1996-05-29	CN1078586C	2002-01-30	增田胜美; 漆畑育巳; 浅原豪; 古濑胜美; 小嶋芳幸; 阿部洋
本发明提供式(1)代表的苯基烷烃酰胺衍生物和包括该衍生物作活性成分的新的农业或园艺杀菌剂，其中R1代表氢原子、烷基或类似基团，R2、R3和R4代表烷基、氢原子或类似基团，Q代表氰基、羧基或类似基团，X代表烷基、烷氧基、卤原子、芳基、或类似基团，n代表0-3整数，Y和Z代表烷基、氢原子或类似基团。本发明的农业或园艺杀菌剂在稻谷损害，疥癣及类似物方面有优良预防效应，而对宿主植物没有副效应。另外，本发明的农业或园艺杀菌剂也显示优良系统作用，以及用于稻谷损害作灌溉处理剂上有优良的控制效应。
44	用作细胞拯救剂的脂族氨基羧酸和氨基膦酸、氨基腈和氨基四唑	CN99805638.3	1999-03-25	CN1299342A	2001-06-13	I·A·佩特森; L·E·戴克; B·A·戴维斯; Y-D·刘; D·A·德登; A·A·博尔顿
本发明提供了通式Ⅰ的化合或其可药用盐，其中：R1为(CH2)mCH3,其中，m为0或1—16的整数,或者为2—17个碳原子的链烯基、链炔基、烷氧基、烷硫基或烷基亚磺酰基，R2=H、CH3或CH2CH3,R3=H或CH3,R4=H或CH3,R5=1—5个碳原子的低级烷基，n为1—3的整数,X为羧基(COOH)、烷氧羰基(COOR5)、氰基(C≡N)、膦酸(PO3H2)、膦酸酯(PO3[R5]2)或5－四唑。优选地,该化合物为R－或S－构型的光学纯的对映异构体,其中,R3=R4=R5=H,R2=CH3,R1为具有1—5个碳原子的饱和脂族基团。该化合物可用作细胞拯救剂。
45	苯基烷烃酰胺衍生物及农业或园艺杀菌剂	CN96195928.2	1996-05-29	CN1192728A	1998-09-09	增田胜美; 漆畑育巳; 浅原豪; 古濑胜美; 小芳幸; 阿部洋
本发明提供式(1)代表的苯基烷烃酰胺衍生物和包括该衍生物作活性成分的新的农业或园艺杀菌剂,其中R1代表氢原子、烷基或类似基团,R2、R3和R4代表烷基、氢原子或类似基团,Q代表氰基、羧基或类似基团,X代表烷基、烷氧基、卤原子、芳基、或类似基团,n代表0—3整数,Y和Z代表烷基、氢原子或类似基团。本发明的农业或园艺杀菌剂在稻谷损害,疥癣及类似物方面有优良预防效应,而对宿主植物没有副效应。另外,本发明的农业或园艺杀菌剂也显示优良系统作用,以及用于稻谷损害作灌溉处理剂上有优良的控制效应。
46	具有邻位络合官能度的螯合剂及其复合物的制备方法	CN89108398.7	1989-10-30	CN1038929C	1998-07-01	戴维·A·威尔逊; 约瑟夫·R·加里希; 理查德·K·弗兰克; 肯尼思·麦米兰; 贾米·西蒙
本文公开了具有邻位络合官能度的官能化胺螯合剂的制备方法，该螯合剂与稀土金属离子形成复合物。该复合物可以以共价键与抗体或抗体片段连接，并用于治疗和/或诊断目的。另外，在组合中可使用某些螯合剂-放射性核素复合物用作钙化瘤和/或缓解骨痛的治疗剂和/或诊断剂。
47	用作IL-Iβ蛋白酶抑制剂的卤甲基酰胺	CN95192847.3	1995-04-28	CN1147201A	1997-04-09	R·E·多夫; J·M·林克
公开了用于抑制白细胞介素1-β蛋白酶活性的化合物、组合物和方法，该化合物具有式(A)结构。
48	具有邻位络合官能度的双官能配位体配合物及其共轭物的制备方法	CN93118881.4	1989-10-30	CN1090286A	1994-08-03	戴维·A·威尔逊; 约瑟夫·R·加里希; 理查德·K·弗兰克; 肯尼思·麦米兰; 贾米·西蒙
本发明公开了具有邻位络合官能度的官能化胺配合剂的制备方法，该螯合剂与稀土金属离子形成复合物。该复合物可以以共价键与抗体或抗体片段连接，并用于治疗和/或诊断目的。另外，在组合中可使用某些螯合剂-放射性核素复合物用作钙化瘤和/或缓解骨痛的治疗剂和/或诊断剂。
49	Phenylalkane amide derivatives and agricultural or horticultural fungicides	US952665	1997-12-01	US6075055A	2000-06-13	Katsumi Masuda; Ikumi Urushibata; Tsuyoshi Asahara; Katsumi Furuse; Yoshiyuki Kojima; Hiroshi Abe
A phenylalkane amide compound having the formula (1): ##STR1## wherein R.sup.1 -R.sup.4, X, n, Y, Z and Q are as defined herein. The compound is useful as an agricultural or horticultural fungicide.
50	Amino nitrile intermediate for the preparation of 2-hydroxyethyl iminodiacetic acid	US955166	1997-10-21	US5817613A	1998-10-06	Phillip S. Athey; David A. Wilson; Druce K. Crump
A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylethyl iminodiacetic acid via hydrolysis.
51	N-formylanilines	US25503	1993-03-03	US5393913A	1995-02-28	Thierry Aubert
The present invention relates to N-carbonyl anilines which are intermediates for the preparation of pesticidal 1-aryl imidazoles and to processes for making them.
52	.alpha.-aminonitriles derived from fatty alkyl alkylene diamines	US10897	1993-01-29	US5319126A	1994-06-07	Alison A. Fleming; Robert F. Farmer; James F. Gadberry
.alpha.-aminonitrile compounds derived from a fatty alkyl alkylene diamine containing two reactible amino functionalities are disclosed.
53	Diastereoselective process for preparing n-substituted amino acids and derivatives	US934537	1992-10-06	US5292918A	1994-03-08	Jacques Gosteli; Ingrid Mergelsberg; Markus Tanner
A process for preparing an (S,S) or (R,R) diastereoisomer of the formula: ##STR1## or salts, esters or amides thereof, wherein R.sup.3 and R.sup.4 independently represent hydrogen, alkyl, aryl or aryl substituted with halogen, alkyl, nitro or alkoxy, and n and m independently represent integers from one to six, comprising combining a cyanide compound of the formula:M.sup.1 C.tbd.N (III)wherein M.sup.1 is hydrogen, trimethylsilyl or a metal, with an optional proton source, a solvent and a Lewis acid of the formula:M.sup.2 X.sub.4, AlCl.sub.3 or BF.sub.3 (IV)wherein M.sup.2 is Sn or Ti and X represents chloro, bromo, fluoro or iodo, with an .alpha.-amino acid compound or salts or esters thereof, followed by addition of an acyl or acetal compound to give the diastereoisomer of formula (X).
54	Chiral quinolone intermediates	US943946	1992-09-11	US5252747A	1993-10-12	Daniel T. Chu; Qun Li
Chiral compounds having the formulae ##STR1## useful in the synthesis of quinolone intermediates.
55	Amine nitrile intermediate for the preparation of 2-hydroxyethyl iminodiacetic acid	US741592	1996-10-31	US5726341A	1998-03-10	Phillip S. Athey; Druce K. Crump; David A. Wilson
A novel intermediate useful in the synthesis of 2-hydroxyethyl iminodiacetic acid is disclosed. The intermediate can be formed by contacting 2-hydroxyethyl amine with glycolonitrile to form an aminonitrile which can be hydrolyzed and contacted with additional glycolonitrile to form the nitrile intermediate which can be converted to 2-hydroxylethyl iminodiacetic acid via hydrolysis.
56	Conjugates possessing ortho ligating functionality	US597335	1996-02-06	US5714631A	1998-02-03	David A. Wilson; Joseph R. Garlich; R. Keith Frank; Kenneth McMillan; Jaime Simon
A group of functionalized amine chelants having ortho ligating functionality that form complexes with rare-earth type metal ions are disclosed. The complexes can be covalently attached to an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes. In addition certain of the chelant-radionuclide complexes can be effectively employed in compositions useful as therapeutic and/or diagnostic agents for calcific tumors and/or relief of bone pain.
57	Benzothiazole compound, production thereof and use thereof	US343489	1994-11-25	US5532257A	1996-07-02	Takema Hase; Takahiro Kumonaka; Chikako Shimizu; Hiroshi Hosono; Tomoji Aotsuka; Yoshiyuki Nakamura; Tetsuo Matsui; Hiromichi Ishikawa
Production of a benzothiazole compound of the formula (I) ##STR1## wherein R.sup.1 is a halogen atom, R.sup.2 and R.sup.3 may be the same or different and each is a hydrogen atom or a halogen atom, R.sup.4 is a hydrogen atom, a halogen atom, a lower alkyl, an alkoxy or an alkyl mercapto and R.sup.5 is a hydrogen atom or a lower alkyl, or a pharmaceutically acceptable salt thereof.The compound of the formula (I) and a pharmaceutically acceptable salt thereof of the present invention have an aldose reductase inhibitory activity in mammals inclusive of human and have superior safety. Accordingly, they are useful as pharmaceutical compositions for the treatment of the complications of diabetes, such as faulty union of corneal injury, cataract, neurosis, retinopathy and nephropathy, particularly cataract and neurosis.
58	Intermediates for the production of diethanolamine	US748964	1991-08-23	US5210271A	1993-05-11	Yukio Mizuno; Miichiro Arita
A method of producing diethanolamine derivatives or acid salts thereof according to the reaction scheme: ##STR1## wherein X stands for a leaving group; and R.sup.1 stands for an alkylcarbamoyl group, which provides an industrially advantageous method of preparing the subject matter useful as an antiarrhythmic agent.
59	Process for the preparation of aminonitriles	US803923	1991-12-09	US5194657A	1993-03-16	Ronald J. McKinney; Robert N. McGill
A process for preparing an alpha aminonitrile comprises providing a cyclic or acyclic aliphatic ketone in a reactor, adding ammonia to the reactor, mixing the ketone and the ammonia, and adding hydrogen cyanide to the reactor to convert the hydrogen cyanide to an aminonitrile. Preferably, the reactor is purged with ammonia before the addition of hydrogen cyanide. The hydrogen cyanide may be added to the reactor at a constant rate, or it may be added to the reactor at a rate that decreases over time. A portion of the ketone may be added to the reactor during the addition of the hydrogen cyanide to the reactor.
60	N,N'-diacetic acid-N'-cyanomethyl, salts thereof, and their preparation	US922264	1992-07-30	US5191106A	1993-03-02	Brian A. Parker
A novel intermediate useful in the synthesis of ethylenediaminetriacetic acid (ED3A) or its salts. A salt of N,N'-ethylenediaminediacetic acid (ED2AH.sub.2) is condensed with formaldehyde to form a stable 5-membered ring intermediate. The addition of cyanide across this cyclic material forms ethylenediamine N,N'-diacetic acid-N'-cyanomethyl or salts thereof (mononitrile-diacid), which is a useful intermediate in the production of ED3A. The nitrile in aqueous solutions may be spontaneously cyclized to form 2-oxo-1,4-piperazinediacetic acid (3KP) or salts thereof. In the presence of excess base, salts of ED3A are formed in excellent yield and purity.

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