子分类：
| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 41 | SELF-POWERED MICROFLUIDIC CHIP WITH MICRO-PATTERNED REAGENTS | US15946615 | 2018-04-05 | US20180297028A1 | 2018-10-18 | Luke P. Lee; Erh-Chia Yeh |
| A microfluidic apparatus and methods for fabrication with a fluidic layer and a pattern layer of spots of concentrated reagents that are disposed in wells of a fluidic layer when the two layers are bonded together. Reagents are stored on the chip prior to use. Because reagents are confined to specific wells, contamination of the channels and other microfluidic structures of the fluidic layer are avoided. The fluidic layer also has a system of vacuum channels and at least one vacuum void to store vacuum potential for controlled micro-fluidic pumping. The top and bottom surfaces of the bonded layers are sealed. The chip can be used for point of care diagnostic assays such as quantitative testing, digital nucleic acid amplification, and biochemical testing such as immunoassays and chemistry testing. | ||||||
| 42 | Reconfigurable microfluidic device and method of manufacturing the same | US15277889 | 2016-09-27 | US10071375B2 | 2018-09-11 | Jaione Tirapu Azpiroz; Peter William Bryant; Rodrigo Neumann Barros Ferreira; Ronaldo Giro; Ricardo Luis Ohta |
| A microfluidic device, including a substrate including a microchannel, an activation setup disposed in the microchannel, and a matrix array of controllable shape-changing micropillars connected to the activation setup. A shape of the controllable shape-changing micropillars changes based on an activation of the activation setup. | ||||||
| 43 | PILLAR ARRAY STRUCTURE WITH UNIFORM AND HIGH ASPECT RATIO NANOMETER GAPS | US15474118 | 2017-03-30 | US20170205329A1 | 2017-07-20 | Yann A. Astier; Robert L. Bruce; Joshua T. Smith; Chao Wang; Benjamin H. Wunsch |
| A technique related to sorting entities is provided. An inlet is configured to receive a fluid, and an outlet is configured to exit the fluid. A nanopillar array, connected to the inlet and the outlet, is configured to allow the fluid to flow from the inlet to the outlet. The nanopillar array includes nanopillars arranged to separate entities by size. The nanopillars are arranged to have a gap separating one nanopillar from another nanopillar. The gap is constructed to be in a nanoscale range. | ||||||
| 44 | Pillar array structure with uniform and high aspect ratio nanometer gaps | US14697095 | 2015-04-27 | US09636675B2 | 2017-05-02 | Yann A. Astier; Robert L. Bruce; Joshua T. Smith; Chao Wang; Benjamin H. Wunsch |
| A technique related to sorting entities is provided. An inlet is configured to receive a fluid, and an outlet is configured to exit the fluid. A nanopillar array, connected to the inlet and the outlet, is configured to allow the fluid to flow from the inlet to the outlet. The nanopillar array includes nanopillars arranged to separate entities by size. The nanopillars are arranged to have a gap separating one nanopillar from another nanopillar. The gap is constructed to be in a nanoscale range. | ||||||
| 45 | Methods for fabricating high aspect ratio probes and deforming high aspect ratio nanopillars and micropillars | US14527039 | 2014-10-29 | US09390936B2 | 2016-07-12 | Michael D. Henry; Andrew P. Homyk; Axel Scherer; Thomas A. Tombrello; Sameer Walavalkar |
| Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described. | ||||||
| 46 | PILLAR ARRAY STRUCTURE WITH UNIFORM AND HIGH ASPECT RATIO NANOMETER GAPS | US14697095 | 2015-04-27 | US20160146717A1 | 2016-05-26 | Yann A. Astier; Robert L. Bruce; Joshua T. Smith; Chao Wang; Benjamin H. Wunsch |
| A technique related to sorting entities is provided. An inlet is configured to receive a fluid, and an outlet is configured to exit the fluid. A nanopillar array, connected to the inlet and the outlet, is configured to allow the fluid to flow from the inlet to the outlet. The nanopillar array includes nanopillars arranged to separate entities by size. The nanopillars are arranged to have a gap separating one nanopillar from another nanopillar. The gap is constructed to be in a nanoscale range. | ||||||
| 47 | METHODS FOR FABRICATING HIGH ASPECT RATIO PROBES AND DEFORMING HIGH ASPECT RATIO NANOPILLARS AND MICROPILLARS | US14527039 | 2014-10-29 | US20150050746A1 | 2015-02-19 | Michael D. HENRY; Andrew P. HOMYK; Axel SCHERER; Thomas A. TOMBRELLO; Sameer WALAVALKAR |
| Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described. | ||||||
| 48 | ELECTROKINETICS-ASSISTED SENSOR | US14133779 | 2013-12-19 | US20140166483A1 | 2014-06-19 | Jacky CHOW; Matthew R. TOMKINS; Yong Jun LAI; Aristides DOCOSLIS |
| An electrokinetics-assisted sensor for sensing a target material. The sensor may include a microstructure deflectable in response to added mass on its body. The sensor may also include one or more features on or near the microstructure designed to generate an electric field giving rise to one or more electrokinetic effects to drive material towards the microstructure, when an electrical signal is applied to the feature(s). Presence of the target material on the body of the microstructure may cause a response in the microstructure, including a detectable change in deflection of the microstructure. | ||||||
| 49 | NEGATIVE DIELECTROPHORESIS FOR SELECTIVE ELUTION OF IMMUMO-BOUND PARTICLES | US14042585 | 2013-09-30 | US20140102901A1 | 2014-04-17 | Mehdi Javanmard; Sam Emaminejad; Janine Mok; Michael N. Mindrinos |
| The procedure of dielectric electrophoresis (dielectrophoresis or DEP) utilizes field-polarized particles that move under the application of positive (attractive) and/or negative (repulsive) applied forces. This invention uses negative dielectric electrophoresis (negative dielectrophoresis or nDEP) within a microchannel separation apparatus to make particles move (detached) or remain stationary (attached). In an embodiment of the present invention, the nDEP force generated was strong enough to detach Ag-Ab (antigen-antibody) bonds, which are in the order of 400 pN (piconewtons) while maintaining the integrity of the system components. | ||||||
| 50 | NANOFABRICATION PROCESS AND NANODEVICE | US13871208 | 2013-04-26 | US20130236698A1 | 2013-09-12 | Samuel Martin Stavis; Elizabeth Arlene Strychalski; Michael Gaitan |
| A nanodevice includes a substrate that has an elongated channel with a plurality of nanoscale critical dimensions arranged as a stepped gradient across a width of the elongated channel. | ||||||
| 51 | METALIZED SEMICONDUCTOR SUBSTRATES FOR RAMAN SPECTROSCOPY | US12481973 | 2009-06-10 | US20100171948A1 | 2010-07-08 | Eric Mazur; Eric Diebold; Steven Ebstein |
| In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm. | ||||||
| 52 | Metalized semiconductor substrates for raman spectroscopy | US12017720 | 2008-01-22 | US07715003B2 | 2010-05-11 | Eric Mazur; Eric Diebold; Steven Ebstein |
| In one aspect, the present invention generally provides methods for fabricating substrates for use in a variety of analytical and/or diagnostic applications. Such a substrate can be generated by exposing a semiconductor surface (e.g., silicon surface) to a plurality of short laser pulses to generate micron-sized, and preferably submicron-sized, structures on the surface. The structured surface can then be coated with a thin metallic layer, e.g., one having a thickness in a range of about 10 nm to about 1000 nm. | ||||||
| 53 | Applications of laser-processed substrate for molecular diagnostics | US11452729 | 2006-06-14 | US07586601B2 | 2009-09-08 | Steven M. Ebstein |
| Surface enhanced Raman Scattering (SERS) and related modalities offer greatly enhanced sensitivity and selectivity for detection of molecular species through the excitation of plasmon modes and their coupling to molecular vibrational modes. One of the chief obstacles to widespread application is the availability of suitable nanostructured materials that exhibit strong enhancement of Raman scattering, are inexpensive to fabricate, and are reproducible. I describe nanostructured surfaces for SERS and other photonic sensing that use semiconductor and metal surfaces fabricated using femtosecond laser processing. A noble metal film (e.g., silver or gold) is evaporated onto the resulting nanostructured surfaces for use as a substrate for SERS. These surfaces are inexpensive to produce and can have their statistical properties precisely tailored by varying the laser processing. Surfaces can be readily micropatterned and both stochastic and self-organized structures can be fabricated. This material has application to a variety of genomic, proteomic, and biosensing applications including label free applications including binding detection. Using this material, monolithic or arrayed substrates can be designed. Substrates for cell culture and microlabs incorporating microfluidics and electrochemical processing can be fabricated as well. Laser processing can be used to form channels in the substrate or a material sandwiched onto it in order to introduce reagents and drive chemical reactions. The substrate can be fabricated so application of an electric potential enables separation of materials by electrophoresis or electro-osmosis. | ||||||
| 54 | Heating system and method for microfluidic and micromechanical applications | US12005862 | 2007-12-27 | US20090169190A1 | 2009-07-02 | Ming Fang; Fuchao Wang |
| An integrated semiconductor heating assembly includes a semiconductor substrate, a chamber formed therein, and an exit port in fluid communication with the chamber, allowing fluid to exit the chamber in response to heating the chamber. The integrated heating assembly includes a first heating element adjacent the chamber, which can generate heat above a selected threshold and bias fluid in the chamber toward the exit port. A second heating element is positioned adjacent the exit port to generate heat above a selected threshold, facilitating movement of the fluid through the exit port away from the chamber. Addition of the second heating element reduces the amount of heat emitted per heating element and minimizes thickness of a heat absorption material toward an open end of the exit port. Since such material is expensive, this reduces the manufacturing cost and retail price of the assembly while improving efficiency and longevity thereof. | ||||||
| 55 | Photocurable perfluoropolyethers for use as novel materials in microfluidic devices | US11825482 | 2007-07-06 | US20090165320A1 | 2009-07-02 | Joseph M. DeSimone; Jason P. Rolland; Stephen R. Quake; Derek A. Schorzman; Jason Yarbrough; Michael Van Dam |
| A functionalized photocurable perfluoropolyether is used as a material for fabricating a solvent-resistant microfluidic device. Such solvent-resistant microfluidic devices can be used to control the flow of small amounts of a fluid, such as an organic solvent, and to perform microscale chemical reactions that are not amenable to other polymer-based microfluidic devices. | ||||||
| 56 | Photocurable Perfluoropolyethers for Use as Novel Materials in Microfluidic Devices | US10572764 | 2004-09-23 | US20070254278A1 | 2007-11-01 | Joseph DeSimone; Jason Rolland; Stephen Quake; Derek Schorzman; Jason Yarbrough; Michael Van Dam |
| A functionalized photocurable perfluoropolyether is used as a material for fabricating a solvent-resistant microfluidic device. Such solvent resistant microfluidic devices can be used to control the flow of small amounts of a fluid, such as an organic solvent, and to perform microscale chemical reactions that are not amenable to other polymer-based microfluidic devices. | ||||||
| 57 | Method of forming a mold and molding a micro-device | US10193317 | 2002-07-12 | US06899838B2 | 2005-05-31 | Alexander G. Lastovich |
| A method of forming a device including a plurality of micron or sub-micron sized features is provided. A master having a surface contour defining a plurality of features is provided. The surface contour of the master is coated with at least one layer of material to form a shell. The master is removed from the shell to form a negative image of the surface contour in the shell. The negative image in the shell is filled with material, for example, polycarbonate, polyacrylic, or polystyrene, to form a device having features substantially the same as the master. The negative image may be filled using injection molding, compression molding, embossing or any other compatible technique. | ||||||
| 58 | Micro mirror structure with flat reflective coating | US10254318 | 2002-09-25 | US20040057102A1 | 2004-03-25 | Shuwen Guo; Ross Hoffman |
| A micro mirror structure including a plurality of individually movable mirrors. Each mirror has a generally concave shape from a top perspective at a temperature of about 20 degrees Celsius and has a generally convex shape from a top perspective at a temperature of about 85 degrees Celsius. In one embodiment, the radius of curvature may be greater than about 500 mm at a temperature of about 20 degrees Celsius and may be less than about null600 mm at a temperature of about 85 degrees Celsius at a thickness of about 10 microns. In another embodiment, the invention is a micro mirror structure including a plurality of individually movable mirrors arranged in an array. Each mirror includes a substrate, a diffusion barrier layer located above the substrate, and a reflective layer located above the diffusion barrier layer. The diffusion barrier layer generally limits the diffusion of the top reflective layer through the diffusion barrier layer. | ||||||
| 59 | Micromachined rubber O-ring microfluidic couplers | US09835299 | 2001-04-12 | US06698798B2 | 2004-03-02 | Yu-Chong Tai; Tze-Jung Yao |
| A micromachined O-ring is described. The O-ring can be formed for use in micromachined microfluidic devices. | ||||||
| 60 | Method of forming a mold and molding a micro-device | US10193317 | 2002-07-12 | US20040007796A1 | 2004-01-15 | Alexander G. Lastovich |
| A method of forming a device including a plurality of micron or sub-micron sized features is provided. A master having a surface contour defining a plurality of features is provided. The surface contour of the master is coated with at least one layer of material to form a shell. The master is removed from the shell to form a negative image of the surface contour in the shell. The negative image in the shell is filled with material, for example, polycarbonate, polyacrylic, or polystyrene, to form a device having features substantially the same as the master. The negative image may be filled using injection molding, compression molding, embossing or any other compatible technique. | ||||||
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