| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 121 | Fluidic and electrical interface for microfluidic chips | US13677036 | 2012-11-14 | US09121824B2 | 2015-09-01 | James T. Palmer; Philippe M. Dekleva |
| A microfluidic chip interface for providing fluid communication with external fluid sources and external fluid waste containers, and for providing electrical contact with voltage sources and voltage and current measuring devices, is described. The microchip is first placed into electrical communication with at least one electrical source and at least one electronic measurement device, and reversibly secured in place. Chosen fluids are provided into the microchip and directed through the chip using a fluid manifold having dispensing tubes and fluid aspiration tubes, which is brought into the vicinity of the secured microchip. The distance between the fluid manifold and the microchip is chosen such that the injection tubes are located within wells in the microchip connected to microfluidic channels, and the aspiration tubes are located near the surface of the microchip in the vicinity of the wells such that fluid spillage onto the surface of the microchip during fluid transfer is avoided. The fluid manifold is removed from fluid communication with the microchip during electrical measurements. | ||||||
| 122 | MEMS anchors | US14090702 | 2013-11-26 | US09116344B2 | 2015-08-25 | Joyce H. Wu; Mark B. Andersson; Jasper Lodewyk Steyn |
| The invention relates to an improved apparatus and method for the design and manufacture of MEMS anchoring structures for light modulators in order to address the stresses of beams mounted on them. | ||||||
| 123 | Micro mixer | US13807009 | 2011-06-23 | US09073018B2 | 2015-07-07 | Fumihiko Ishiyama; Takeshi Hizawa; Kiyoo Kamei |
| Disclosed is a micro mixer which includes a mixing plate (14) with a first channel-forming section and a second channel-forming section. The first channel-forming section has a first channel formed for a first fluid to flow therethrough, while the second channel-forming section has a second channel formed for a second fluid to flow therethrough. Between the first channel-forming section and the second channel-forming section, there is provided a combined channel in which the first fluid and the second fluid merge with each other. The outlet of the first channel and the outlet of the second channel are opposed to each other with the combined channel disposed therebetween. The position of the outlet of the first channel facing the center axis of the combined channel is included in or the same as the position of the outlet of the second channel facing the center axis. | ||||||
| 124 | METHOD USING GLASS SUBSTRATE ANODIC BONDING | US14142712 | 2013-12-27 | US20150183200A1 | 2015-07-02 | Benedikt ZEYEN; Jeffery F. SUMMERS |
| A bonding technology is disclosed that can form an anodic, conductive bond between two optically transparent substrates. The anodic bond may be accompanied by a metal alloy, solder, eutectic and polymer bond. The first anodic bond may provide one attribute such as hermeticity, whereas the second bond may provide another attribute, such as electrical conductivity. | ||||||
| 125 | Applications for nanopillar structures | US13539070 | 2012-06-29 | US08951892B2 | 2015-02-10 | Mark D. Hall; Mehul D. Shroff |
| A disclosed method of fabricating a hybrid nanopillar device includes forming a mask on a substrate and a layer of nanoclusters on the hard mask. The hard mask is then etched to transfer a pattern formed by the first layer of nanoclusters into a first region of the hard mask. A second nanocluster layer is formed on the substrate. A second region of the hard mask overlying a second region of the substrate is etched to create a second pattern in the hard mask. The substrate is then etched through the hard mask to form a first set of nanopillars in the first region of the substrate and a second set of nanopillars in the second region of the substrate. By varying the nanocluster deposition steps between the first and second layers of nanoclusters, the first and second sets of nanopillars will exhibit different characteristics. | ||||||
| 126 | Flow passage structure | US13818884 | 2011-09-13 | US08920020B2 | 2014-12-30 | Koji Noishiki; Makoto Nishimura; Takeshi Yamashita; Tatsuo Yoshida |
| A flow passage structure having a plurality of flow passageways therein includes a first junction portion for joining a first fluid introduced into a first inlet path and a second fluid introduced into a second inlet path, a first joined fluid flow passage through which a fluid made by joining both the fluids flows, a branch portion for dividing the fluid flowing in the first joined fluid flow passage into two fluids, a first branch path through which one of the two divided fluids flows, and a second branch path through which the other flows, wherein a corresponding diameter of the first branch path and a corresponding diameter of the second branch path in each of the passageways are smaller than a corresponding diameter of the first joined fluid flow passage in the passageway. | ||||||
| 127 | DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM | US14361556 | 2014-01-06 | US20140353157A1 | 2014-12-04 | Daniel Hoffmeyer; Tiffany Lay; Travis Lee |
| A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. | ||||||
| 128 | SYSTEMS AND METHODS FOR FORMING A NANOPORE IN A LIPID BILAYER | US14150322 | 2014-01-08 | US20140203464A1 | 2014-07-24 | Roger J.A. Chen; Randy Davis |
| A method of forming a nanopore in a lipid bilayer is disclosed. A nanopore forming solution is deposited over a lipid bilayer. The nanopore forming solution has a concentration level and a corresponding activity level of pore molecules such that nanopores are substantially not formed un-stimulated in the lipid bilayer. Formation of a nanopore in the lipid bilayer is initiated by applying an agitation stimulus level to the lipid bilayer. In some embodiments, the concentration level and the corresponding activity level of pore molecules are at levels such that less than 30 percent of a plurality of available lipid bilayers have nanopores formed un-stimulated therein. | ||||||
| 129 | Registered structure formation via the application of directed thermal energy to diblock copolymer films | US13784353 | 2013-03-04 | US08753738B2 | 2014-06-17 | Dan B. Millward; Eugene P. Marsh |
| Methods for fabricating sub-lithographic, nanoscale linear microchannel arrays over surfaces without defined features utilizing self-assembling block copolymers, and films and devices formed from these methods are provided. Embodiments of the methods use a multi-layer induced ordering approach to align lamellar films to an underlying base film within trenches, and localized heating to anneal the lamellar-phase block copolymer film overlying the trenches and outwardly over the remaining surface. | ||||||
| 130 | ANODIC BONDING FOR A MEMS DEVICE | US14124946 | 2012-06-07 | US20140106095A1 | 2014-04-17 | Francois Bianchi |
| The invention relates to a device comprising a wafer comprising a silicon area and a wafer comprising a glass area fastened to each other, the fastening zone thus formed between the wafers defining a multilayer structure comprising a first layer protecting the silicon from physical changes caused by attack of the surface, which layer covers the silicon area, and a second layer protecting the glass from physical changes caused by attack of the surface, which layer covers the glass area; said multilayer structure furthermore comprising at least one additional layer enabling anodic bonding between the two protective layers; said device containing at least one fluid channel protected by said protective layers and able to contain a solution temporarily. | ||||||
| 131 | TWIST FLOW MICROFLUIDIC MIXER AND MODULE | US14119357 | 2012-05-30 | US20140104975A1 | 2014-04-17 | Mikhail Sergeevich Chivilikhin |
| A multilayer microfluidic module (10) contains a micromixer (12) comprising, in order along an internal fluid path (14), a first fluid channel (16) lying within a first layer (51) of the module (10) along a first direction (15) with the first layer having a lower boundary (21); at least one additional fluid channel (17) lying within the first layer (51) of the module (10) along an additional direction (19); a first injection passage (20) extending from a first injection passage inlet (22) in the lower boundary (21) of the first layer (51) of the module (10) through a second layer (52) of the module (10) to a first injection passage outlet (24), the first injection passage inlet (22) being fluidically connected to the first fluid channel (16) and to the additional fluid channel (17) either individually through the lower boundary (21) of the first layer (51) or via a manifold (25) within the first layer (51); and a second fluid channel (26) lying within a third layer (53) of the module (10), the third layer (53) having an upper boundary (30), the second fluid channel having a width W26; wherein the first direction (15) and the additional direction (19) are non-collinear, and wherein the first injection passage outlet (24) is centered within the second fluid channel (26) in the direction of the width W26, and has a length L24 along the second fluid channel (26) and a width W24 in the direction of the width W26, and wherein the width W24 is narrower than the width W26, and wherein the first injection passage outlet (24) has a length-to-width ratio L24/W24 of greater than 1:1. | ||||||
| 132 | BIOFUNCTIONAL NANOFIBERS FOR ANALYTE SEPARATION IN MICROCHANNELS | US14007040 | 2012-03-23 | US20140083859A1 | 2014-03-27 | Antje J. Baeumner; Margaret W. Frey; Daehwan Cho |
| A method is provided for producing, in a substrate, an enclosed channel or enclosed cavity comprising at least one functional nanofiber, the method comprising the steps of providing a first substrate and a second substrate; forming a channel or cavity on the first substrate or the second substrate; electrospinning at least one functional nanofiber on the first substrate; assembling the first and second substrates, wherein the first substrate is placed over the second substrate, or the second substrate is placed over the first substrate; and bonding the first substrate and the second substrate to form the substrate, thereby forming an enclosed channel or enclosed cavity comprising the at least one functional nanofiber in the substrate. An enclosed channel or cavity comprising at least one functional electrospun nanofiber is also provided. A microfluidic device is also provided comprising an enclosed channel or cavity comprising at least one functional electrospun nanofiber. | ||||||
| 133 | MICROFLUIDIC EXTRACTION DEVICE HAVING A STABILIZED LIQUID/LIQUID INTERFACE | US14001425 | 2012-02-24 | US20140001116A1 | 2014-01-02 | Jean Berthier; Nicolas Sarrut-Rio |
| A microfluidic device for extraction of analytes of interest from a carrier liquid in a liquid solvent, the two liquids forming an interface between micro-pillars in an extraction chamber. The carrier liquid forms a wetting angle θ1 on the micro-pillars and a bottom wall of the extraction chamber, and a wetting angle θ2 on a top wall, the wetting angles satisfying equation 45°≦(θ1+θ2)/2≦135°. | ||||||
| 134 | FLUIDIC AND ELECTRICAL INTERFACE FOR MICROFLUIDIC CHIPS | US13677036 | 2012-11-14 | US20130313116A1 | 2013-11-28 | James T. Palmer; Philippe M. Dekleva |
| A microfluidic chip interface for providing fluid communication with external fluid sources and external fluid waste containers, and for providing electrical contact with voltage sources and voltage and current measuring devices, is described. The microchip is first placed into electrical communication with at least one electrical source and at least one electronic measurement device, and reversibly secured in place. Chosen fluids are provided into the microchip and directed through the chip using a fluid manifold having dispensing tubes and fluid aspiration tubes, which is brought into the vicinity of the secured microchip. The distance between the fluid manifold and the microchip is chosen such that the injection tubes are located within wells in the microchip connected to microfluidic channels, and the aspiration tubes are located near the surface of the microchip in the vicinity of the wells such that fluid spillage onto the surface of the microchip during fluid transfer is avoided. The fluid manifold is removed from fluid communication with the microchip during electrical measurements. | ||||||
| 135 | NANOWIRE DEVICE FOR MANIPULATING CHARGED MOLECULES | US13982892 | 2012-02-01 | US20130306476A1 | 2013-11-21 | Lars Samuelson; Jonas Tegenfeldt |
| The invention relates to a nanowire device for manipulation of charged molecules, comprising a tubular nanowire with a through-going channel; a plurality of individually addressable wrap gate electrodes arranged around said tubular nanowire with a spacing between each two adjacent wrap gate electrodes and means for connecting the wrap gate electrodes to a voltage source. The invention further relates to a nanowire system comprising at least one nanowire device, and to a method for manipulating of charged molecules within a through-going channel of a tubular nanowire. | ||||||
| 136 | Transparent material processing with an ultrashort pulse laser | US12571598 | 2009-10-01 | US08530786B2 | 2013-09-10 | James Bovatsek; Alan Y. Arai; Fumiyo Yoshino |
| Methods for ultrashort pulse laser processing of optically transparent materials. A method for scribing transparent materials uses ultrashort laser pulses to create multiple scribe features with a single pass of the laser beam across the material, with at least one of the scribe features being formed below the surface of the material. This enables clean breaking of transparent materials at a higher speed than conventional techniques. Slightly modifying the ultrashort pulse laser processing conditions produces sub-surface marks. When properly arranged, these marks are clearly visible with side-illumination and not clearly visible without side-illumination. In addition, a method for welding transparent materials uses ultrashort laser pulses to create a bond through localized heating. The ultrashort pulse duration causes nonlinear absorption of the laser radiation, and the high repetition rate of the laser causes pulse-to-pulse accumulation of heat within the materials. The laser is focused near the interface of the materials, generating a high energy fluence at the region to be welded. This minimizes damage to the rest of the material and enables fine weld lines. | ||||||
| 137 | MICROFLUIDIC MIXING USING CHANNEL WIDTH VARIATION FOR ENHANCED FLUID MIXING | US13853628 | 2013-03-29 | US20130223182A1 | 2013-08-29 | EHSAN YAKHSHI TAFTI; HYOUNG JIN CHO; RANGANATHAN KUMAR |
| A fluid mixing method using a micromixing apparatus which includes a mixing microchannel having a channel length and a continuously variable channel width defined by a first sidewall surface and an opposing second sidewall surface. The channel width varies from a minimum channel width h to a maximum channel width H in a ratio of H:h≧1.1:1.0. A first inlet injects a first fluid and a second inlet a second fluid into the mixing microchannel which both flow in a flow direction in the mixing microchannel along the channel length. The first sidewall surface includes first curved surface portions and the second sidewall surface includes second curved surface portions. The first and second curved surface portions are non-overlapping to provide the variable channel width. The flow velocity profile is passively varied and exclusively controlled by the continuously variable channel width. | ||||||
| 138 | THREE-DIMENSIONAL DIGITAL MICROFLUIDIC SYSTEM | US13781181 | 2013-02-28 | US20130220810A1 | 2013-08-29 | Gary Chorng-Jyh Wang |
| A three-dimensional digital microfluidic system comprises a first plate with a first electrode, a second plate with a second electrode, and a microfluidic drop in between the first and the second electrode. The electrodes are able to be actuated in sequence such that the microfluidic drop is able to be transported. A bridge plate is able to be included. | ||||||
| 139 | REGISTERED STRUCTURE FORMATION VIA THE APPLICATION OF DIRECTED THERMAL ENERGY TO DIBLOCK COPOLYMER FILMS | US13784353 | 2013-03-04 | US20130189492A1 | 2013-07-25 | Dan B. Millward; Eugene P. Marsh |
| Methods for fabricating sub-lithographic, nanoscale linear microchannel arrays over surfaces without defined features utilizing self-assembling block copolymers, and films and devices formed from these methods are provided. Embodiments of the methods use a multi-layer induced ordering approach to align lamellar films to an underlying base film within trenches, and localized heating to anneal the lamellar-phase block copolymer film overlying the trenches and outwardly over the remaining surface. | ||||||
| 140 | TRANSPARENT MATERIAL PROCESSING WITH AN ULTRASHORT PULSE LASER | US13766357 | 2013-02-13 | US20130183474A1 | 2013-07-18 | James Bovatsek; Alan Y. Arai; Fumiyo Yoshino |
| A method for scribing transparent materials uses ultrashort laser pulses to create multiple scribe features with a single pass of the laser beam across the material, with at least one of the scribe features being formed below the surface of the material. This enables clean breaking of transparent materials at a higher speed than conventional techniques. | ||||||
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