| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 1 | 针状体及针状体制造方法 | CN201380025013.8 | 2013-06-10 | CN104321106B | 2017-05-24 | 田上英惠; 加藤洋行 |
| 课题在于提供容易剥离的针状体。针状体的制造方法中，针状体具备具有针状形状的突起部及对上述突起部进行支撑的支撑基板，其特征在于，具备：向具有与上述突起部对应的凹部的凹版供给突起部侧层形成材料的水溶液的工序；向上述凹版供给支撑基板侧层形成材料的水溶液的工序；使上述凹版内的水溶液干燥，形成针状体的工序；以及从上述凹版剥离针状体的工序；而且，上述突起部侧层形成材料的水溶液和支撑基板侧层形成材料的水溶液为液液分散体系。 | ||||||
| 2 | 模制套管与小深孔 | CN200980152063.6 | 2009-12-23 | CN102264524A | 2011-11-30 | A·埃施利曼 |
| 本发明提供用于注塑模制聚合物物品的装置与方法。该方法包括将加压的液态聚合物注入一个模具空腔之中，该空腔结合了一个芯针和一个压力分布装置。优选地该物品是一个套管。本发明提供了一种用于从聚合物材料注塑模制物品的模具，该模具包括限定一个空腔的至少两个部件，具有一个导管部分，该导管部分结合了一个针头部分；一个用于液态聚合物进入的通道；一个用于加压流体进入的通道；一个用于限定套管导管的芯针，以及一个用于控制该加压的液态聚合物的分布的压力分布装置。该压力分布装置的端表面限定该套管的尖端几何形状。该模具可以结合多个空腔。该方法包括以一种受控的方式来移动该压力分布装置从而限定该套管导管。 | ||||||
| 3 | 用来制造侧开口微型针的方法及模具 | CN200480043029.2 | 2004-03-12 | CN1993156A | 2007-07-04 | 徐源; 陈美马; 李忠莉; 林治远; 陈佩莹 |
| 一种侧开口的微型针，其由一形状合适的微型针模具(40)制成。一微型针模具基底(32)中有多个微型针模具凹口(30)。微型针模具基底(32)的一面镀有子层(34)。该微型针模具基底(32)包含两个微型针模片(24，26)，其分开后能接触到其中一个微型针模片(24，26)的内表面。该侧开口形成通道(38)形成于其中一个内表面上，并与相对应微型针模片(24)中的凹口(30)相交。这两个微型针模片(24，26)背对背靠在一起并结合形成一个整体式微型针模具(40)。在凹口中以及表面上沉积上子层(34)就在凹口(30)中形成微型针。该微型针层(44)不能沉积到侧开口形成孔(42)的地方，即侧开口形成通道(38)与凹口(30)相交的地方，由此就在模制的微型针(52)中形成了侧开口(46)。 | ||||||
| 4 | 针状体及针状体制造方法 | CN201380025013.8 | 2013-06-10 | CN104321106A | 2015-01-28 | 田上英惠; 加藤洋行 |
| 课题在于提供容易剥离的针状体。针状体的制造方法中，针状体具备具有针状形状的突起部及对上述突起部进行支撑的支撑基板，其特征在于，具备：向具有与上述突起部对应的凹部的凹版供给突起部侧层形成材料的水溶液的工序；向上述凹版供给支撑基板侧层形成材料的水溶液的工序；使上述凹版内的水溶液干燥，形成针状体的工序；以及从上述凹版剥离针状体的工序；而且，上述突起部侧层形成材料的水溶液和支撑基板侧层形成材料的水溶液为液液分散体系。 | ||||||
| 5 | 模制套管与小深孔 | CN200980152063.6 | 2009-12-23 | CN102264524B | 2014-11-26 | A·埃施利曼 |
| 本发明提供用于注塑模制聚合物物品的装置与方法。该方法包括将加压的液态聚合物注入一个模具空腔之中，该空腔结合了一个芯针和一个压力分布装置。优选地该物品是一个套管。本发明提供了一种用于从聚合物材料注塑模制物品的模具，该模具包括限定一个空腔的至少两个部件，具有一个导管部分，该导管部分结合了一个针头部分；一个用于液态聚合物进入的通道；一个用于加压流体进入的通道；一个用于限定套管导管的芯针，以及一个用于控制该加压的液态聚合物的分布的压力分布装置。该压力分布装置的端表面限定该套管的尖端几何形状。该模具可以结合多个空腔。该方法包括以一种受控的方式来移动该压力分布装置从而限定该套管导管。 | ||||||
| 6 | 生产热敏物质微针的方法 | CN200880003341.7 | 2008-01-29 | CN101594905A | 2009-12-02 | 浜本英利; 石桥贤树; 小林胜则 |
| 提供大规模低成本生产微针的新方法。加热钻模到高于表现出热塑性形变的温度敏感性材料变成粘塑性的水平的温度，使钻模接触温度敏感性材料，然后从温度敏感性材料拉出钻模，拉长接触钻模的温度敏感性材料部分，借此形成针状突起。本发明的微针生产的方法优选包括下面的步骤(i)至(iv)：(i)设定钻模温度高于表现出热塑性形变的温度敏感性材料变成粘塑性的温度，(ii)使钻模接触温度敏感性材料以使温度敏感性材料在接触部分呈粘塑性的步骤，(iii)从温度敏感性材料中拉出钻模并拉长粘塑态的温度敏感性材料成线形式的步骤，(iv)中断从温度敏感性材料中拉出钻模或减速拉出以切断线状温度敏感性材料并形成针状突起的步骤。 | ||||||
| 7 | 用来制造侧开口微型针的方法及模具 | CN200480043029.2 | 2004-03-12 | CN100540086C | 2009-09-16 | 徐源; 陈美马; 李忠莉; 林治远; 陈佩莹 |
| 一种侧开口的微型针，其由一形状合适的微型针模具(40)制成。一微型针模具基底(32)中有多个微型针模具凹口(30)。微型针模具基底(32)的一面镀有子层(34)。该微型针模具基底(32)包含两个微型针模片(24，26)，其分开后能接触到其中一个微型针模片(24，26)的内表面。该侧开口形成通道(38)形成于其中一个内表面上，并与相对应微型针模片(24)中的凹口(30)相交。这两个微型针模片(24，26)背对背靠在一起并结合形成一个整体式微型针模具(40)。在凹口中以及表面上沉积上子层(34)就在凹口(30)中形成微型针。该微型针层(44)不能沉积到侧开口形成孔(42)的地方，即侧开口形成通道(38)与凹口(30)相交的地方，由此就在模制的微型针(52)中形成了侧开口(46)。 | ||||||
| 8 | Method of producing a microneedle or microimplant | US11660341 | 2005-08-16 | US08192787B2 | 2012-06-05 | Andrew James Kirby |
| A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles. | ||||||
| 9 | Apparatus for fabricating needles via conformal deposition in two-piece molds | US09454823 | 1999-12-06 | US06375148B1 | 2002-04-23 | Neil H. Talbot; Christopher G. Keller; Albert P. Pisano |
| A method of fabricating a needle via conformal deposition in a two-piece mold includes the step of attaching a top mold member to a bottom mold member such that the top mold member and the bottom mold member define an enclosed, elongated needle trench with a deposition aperture. A conformal substance, such as polysilicon, is then passed through the deposition aperture such that the conformal substance is deposited within the enclosed, elongated needle trench to form a needle. The method is used to form needles with prongs, multiple channels, multiple ports, barbs, strength enhancement features, and circuitry. | ||||||
| 10 | Knitting needle and methods of producing it | US38095553 | 1953-09-18 | US2817221A | 1957-12-24 | NEWTON PERHAM JOHN |
| 11 | SYSTEM AND METHOD FOR MANUFACTURING MICRONEEDLE DEVICES | US15982445 | 2018-05-17 | US20180333899A1 | 2018-11-22 | Raymond Joseph Francis; David Bardin; Gregory Lee Hunt; Antti Juhani Tauriainen; Markku Juha Kalervo Valkama; Ralph Liedert; Jarkko Tapani Tuominen |
| A method for manufacturing microneedle devices and systems and tools for implementing same. The method can include manufacturing a replica mold and forming a microneedle array via the replica mold. The replica mold can be manufactured by disposing replica mold material on a master mold and curing the replica mold material. To reduce manufacturing time, the replica mold material preferably is cured at a high temperature for a relatively short time and then cooled quickly before removal from the master mold. The microneedle array can be formed by disposing microneedle material on the replica mold under vacuum and drying the microneedle material in single or successive disposing and drying operations. One or more optional backing layers can be added to the microneedle array when forming the microneedle device. Advantageously, the disclosed methods, systems and tools can be used to manufacture skin-applied patches for delivering cosmetic and therapeutic agents. | ||||||
| 12 | Needle-shaped body and method for manufacturing needle-shaped body | US14579490 | 2014-12-22 | US09919141B2 | 2018-03-20 | Hanae Tagami; Hiroyuki Kato |
| A method for manufacturing a needle-shaped body, including supplying a first aqueous solution to an intaglio plate, supplying a second aqueous solution to the intaglio plate, drying the first and second aqueous solutions in the intaglio plate such that a dried body is formed on the intaglio plate, and separating the dried body from the intaglio plate such that a needle-shaped body including a needle-shaped projection and a support base which supports the needle-shaped projection is obtained. The intaglio plate includes a recess corresponding to the needle-shaped projection, the first aqueous solution is supplied to fill at least a portion of the recess, the first aqueous solution and the second aqueous solution are immiscible, the first aqueous solution forms a projection side layer in the needle-shaped body, and the second aqueous solution forms a support base side layer on the projection side layer in the needle-shaped body. | ||||||
| 13 | Methods and moulds for use in fabricating side-ported microneedles | US10592559 | 2004-03-12 | US08671544B2 | 2014-03-18 | Yuan Xu; Meí Ma Chen; Zhongli Li; Chee Yen Lim; Pei Ying Joyce Tan |
| A microneedle mold and a method of manufacturing a microneedle mold are provided for use in fabricating microneedles. The method includes providing a microneedle mold base with recesses therein, the recesses corresponding to the microneedles to be fabricated and extending from a first surface of the microneedle mold base; and forming side-port forming holes in the microneedle mold base, the side-port forming holes extend in side surfaces of the recesses within the microneedle mold base at side-port forming positions of the recesses. | ||||||
| 14 | MOULDING CANNULAE AND SMALL DEEP HOLES | US13142246 | 2009-12-23 | US20110254202A1 | 2011-10-20 | Andreas Aeschlimann |
| The present invention provides apparatus and methods for injection moulding polymeric articles. The method includes injecting pressurised liquid polymer into a mould cavity, the cavity incorporating a core pin and a pressure distribution means. Preferably the article is a cannula.The invention provides a mould for injection moulding articles from polymeric materials, the mould comprising at least two parts defining a cavity having a conduit portion incorporating a needle portion; a channel for liquid polymer ingress; a channel for pressurised fluid ingress; a core pin for defining the conduit of a cannula, and a pressure distribution means for controlling the distribution of the pressurised liquid polymer. The end surface of the pressure distribution means defines the tip geometry of the cannula. The mould may incorporate a plurality of cavities. The method includes moving the pressure distribution means in a controlled manner to define the conduit of the cannula. | ||||||
| 15 | PROCESS FOR PRODUCING MICRONEEDLE OF THERMOSENSITIVE SUBSTANCE | US12524829 | 2008-01-29 | US20100004608A1 | 2010-01-07 | Hidetoshi Hamamoto; Masaki Ishibashi; Katsunori Kobayashi |
| The invention provides a method of producing a microneedle. A jig is heated to a temperature above the level at which a temperature-sensitive material that exhibits thermoplastic deformation becomes viscoplastic, the jig is brought into contact with the temperature-sensitive material, and then the jig is pulled part from the temperature-sensitive material to elongate the portion of the temperature-sensitive material in contact with the jig, whereby acicular projections are formed. | ||||||
| 16 | Method of Producing a Microneedle or Microimplant | US11660341 | 2005-08-16 | US20080299290A1 | 2008-12-04 | Andrew James Kirby |
| A method of manufacturing microneedles is provided, the method includes (i) depositing a substance onto a first surface and (ii) forming a solid needle-like shape from the substance. The substance may be deposited in non-solid form and subsequently solidified. A method provides an array of such microneedles. | ||||||
| 17 | 剣山型マイクロニードルの製造方法およびマイクロニードル | JP2014211784 | 2014-10-16 | JP2015016368A | 2015-01-29 | MIHARA YUTAKA; OHIRA FUMIKAZU; YOSHIMURA HIDENORI; OSUGA KENJI |
| 【課題】樹脂製のマイクロニードルの製造方法を提供する。【解決手段】液体吐出装置と微細な内径の多連ノズルを使用して、熔融樹脂を基板に1回以上吐出させ、密着した溶融樹脂を引き伸ばして微小針を形成することにより、所望のサイズの微小針を製造する方法であって、得られたマイクロニードルの微小針は、1段又は複数段の樹脂層を持ち、それが全体として一体となった伸展型の微小針を形成している。本発明は、熔融樹脂を基板に1回以上吐出させ、密着した溶融樹脂を引き伸ばして微小針を製造することを特徴とするマイクロニードルの製造方法とこの製造方法によって得られた特徴的な微小針を持つマイクロニードルに関するものである。【選択図】図5 | ||||||
| 18 | Method and mold for use in the manufacture of the lateral hole with microneedles | JP2007502767 | 2004-03-12 | JP4500851B2 | 2010-07-14 | ス、ユアン; イン、ジョイス タン、ペイ; マ チェン、メイ; リ、チョンリ; リム、チー、イェン |
| 19 | 温度感受性物質製のマイクロニードルの製造方法 | JP2008556112 | 2008-01-29 | JPWO2008093679A1 | 2010-05-20 | ▲浜▼本 英利; 英利 ▲浜▼本; 賢樹 石橋; 勝則 小林 |
| マイクロニードルを安価且つ量産規模で製造し得る、新規なマイクロニードルの製造方法を提供すること。治具の温度を熱塑性変形する温度感受性物質が粘塑性状態になる温度以上に加熱し、その治具を温度感受性物質に接触させ、その後、治具と温度感受性物質を引き離すことで、治具と接着した温度感受性物質が引き伸ばされて針状突起が形成される。好適には、以下の工程(i)〜(iv)を含む方法。(i)治具の温度を熱塑性変形する温度感受性物質が粘塑性状態になる温度以上に設定する。(ii)治具を上記温度感受性物質に接触させ、接触部位の温度感受性物質を粘塑性状態にする。(iii)治具と温度感受性物質を引き離し、粘塑性状態の温度感受性物質を糸状に引き伸ばす。(iv)治具と温度感受性物質の引き離しを停止又は引き離し速度を減速させることにより、糸状の温度感受性物質を切断して、針状突起を形成させる。 | ||||||
| 20 | Method of manufacturing a micro-needle or micro-implant | JP2007526569 | 2005-08-16 | JP2008509771A | 2008-04-03 | キルビー、アンドリュー、ジェイムズ |
| 【課題】マイクロ針の製造方法を提供する。
【解決手段】（ｉ）物質を第１の面上に付着させ、（ｉｉ）固体の針状構造体を物質から形成することを含む方法である。 この物質は、非固体形態で付着され、そして続いて固化される。 このようなマイクロ針のアレイを製造する方法も開示された。 【選択図】図１ |
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