| 序号 | 专利名 | 申请号 | 申请日 | 公开（公告）号 | 公开（公告）日 | 发明人 |
|---|---|---|---|---|---|---|
| 161 | Method and apparatus for producing a discrete particle | US10399823 | 2003-10-23 | US20040063113A1 | 2004-04-01 | George Agnes; Xiao Feng; Michael Bogan |
| A method and apparatus for producing a discrete particle for subsequent analysis (such as mass spectrometry) or manipulation is disclosed. A discrete particle is generated by a particle generator. A net charge is induced onto the particle by an induction electrode. The particle is delivered to a levitation device where it is then electrodynamically levitated. If the particle is a droplet, desolvation will occur, leading to Coloumbic fissioning of the droplet into smaller droplets. The movement of the levitated droplet(s) can be manipulated by an electrode assembly. The droplet(s), and the charge thereon, can be delivered to a mass spectrometer in one aspect of the invention, providing an ion source for mass spectrometry without the detrimental space charge effects of electrospray ionization techniques. In another aspect of the invention, the levitated particle(s) may be controllably and precisely deposited onto a plate for subsequent analysis by matrix assisted laser desorption and ionization mass spectrometry. | ||||||
| 162 | Encoded random arrays matrices | US10365993 | 2003-02-13 | US20040018643A1 | 2004-01-29 | Michael Seul; Chiu Wo Chau |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (nulltime-varying patternsnull), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (nullgray scalesnull) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles. | ||||||
| 163 | Atomic beam control apparatus and method | US10014344 | 2001-12-14 | US06680473B2 | 2004-01-20 | Ryuzo Ohmukai; Masayoshi Watanabe |
| An atomic beam control apparatus controls a position of an atomic beam that passes through a multi-pole magnetic field by irradiating the atomic beam with a light beam. The apparatus includes a probe light generator to generate probe light to detect a position of the atomic beam, a light sensor to receive the probe light, and a current control section to control a current flowing in multi-pole magnetic field generating electrodes controlling the position of the atomic beam. The light beam irradiates the atomic beam so that the atomic beam interacts with both the light beam and the magnetic field, and the position of the atomic beam is controlled by controlling currents fed to the multiple-pole magnetic field generating electrodes based on output values of the light sensor receiving the probe light. | ||||||
| 164 | Method and apparatus for magnetically guiding neutral particles | US09640639 | 2000-08-17 | US06657188B1 | 2003-12-02 | Randall Gardner Hulet; Kevin Edwin Strecker; Jordan Mitchell Gerton; William Ian McAlexander; Curtis Charles Bradley; Jeffrey J Tollett; Charles Ackley Sackett; Bita Ghaffari; Stephen Calvin Moss |
| Neutral particles, such as atoms and molecules, transported along a path having at least one curved region are selectively conveyed or filtered according to each particle's velocity by generating an inhomogeneous magnetic field across a cross-section of the path. The neutral particles may be transported through a physical tube or simply through the region defined by the magnetic field. The path may have more than one curved region and may additionally have one or more straight regions. The magnetic field may be generated for example by homogeneously or inhomogeneously magnetized permanent magnets or by current carrying elements. The magnetic elements may additionally be used in conjunction with at least one piece of a high permeability magnetic material for focussing or containing the magnetic field. | ||||||
| 165 | Method for applying optical gradient forces and moving material | US09495064 | 2000-01-31 | US06624940B1 | 2003-09-23 | David G. Grier; Eric R. Dufresne |
| An apparatus and method for manipulating small dielectric particles. The apparatus and method involves use of a diffractive optical element which receives a laser beam and forms a plurality of light beams. These light beams are operated on by a telescope lens system and then an objective lens element to create an array of optical traps for manipulating small dielectric particles. | ||||||
| 166 | Electromagnetic energy driven separation methods | US09572763 | 2000-05-17 | US06573491B1 | 2003-06-03 | Kevin S. Marchitto; Stephen T. Flock |
| The present invention provides electromagnetic energy driven separation methods, including methods for separating molecules in a mixture, for increasing diffusion rate of a substance in a medium, and for moving fluids on a substrate. Such methods work with extremely small volumes of target and may be used for medical diagnosis and treatment. | ||||||
| 167 | Apparatus for applying optical gradient forces | US10310704 | 2002-12-05 | US20030086175A1 | 2003-05-08 | David G. Grier; Eric R. Dufresne |
| A method and apparatus for control of optical trap arrays and formation of particle arrays. The method and apparatus provides a laser and a time variable diffractive optical element to allow dynamic control of optical trap arrays and consequent control of particle arrays and also the ability to manipulate singular objects using a plurality of optical traps. | ||||||
| 168 | Light-controlled electrokinetic assembly of particles near surfaces | US09690043 | 2000-10-17 | US06514771B1 | 2003-02-04 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 169 | Methods and apparatus for sorting of bioparticles based upon optical spectral signature | US09993376 | 2001-11-14 | US20020132316A1 | 2002-09-19 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a method is provided for analysis or separation of a plurality of particles by selecting a wavelength for illumination based upon an analysis of absorption spectra, illuminating the particles with the selected wavelength, considering response of particles to multiple wavelengths, selecting wavelengths based on one or more desired parameters, and illuminating the population to obtain optimized differential motion. | ||||||
| 170 | Array cytometry | US09995894 | 2001-11-28 | US20020123078A1 | 2002-09-05 | Michael Seul; Alice X. Li |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled elektrokinetic assembly of particles near surfaces relies on the combination of three functional elements. the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination. | ||||||
| 171 | Method for laser cooling of atoms and apparatus therefor as well as coherent light source used for laser cooling of atoms | US10058086 | 2002-01-29 | US20020117612A1 | 2002-08-29 | Hiroshi Kumagai; Katsumi Midorikawa |
| A method for laser cooling of atoms for laser-cooling atoms each involving a plurality of magnetic subsidiary levels as its cooling lower level being in a ground state in energy level wherein each coherent light of a predetermined wavelength containing a plurality of different polarized light is emitted sequentially to the atoms in response to the plurality of magnetic subsidiary levels being the cooling lower level in the ground level in an atom, which is an object to be laser-cooled, while keeping a predetermined time interval, whereby it becomes possible to laser-cool a variety of atoms including semiconductor atoms such as silicon and germanium. | ||||||
| 172 | Atomic beam control apparatus and method | US10014344 | 2001-12-14 | US20020113205A1 | 2002-08-22 | Ryuzo Ohmukai; Masayoshi Watanabe |
| An atomic beam control apparatus and method that controls the position of the atomic beam passing through a multiple-pole magnetic field by irradiating the atomic beam with a light beam. The atomic control apparatus comprises a probe light generator for generating probe light for detecting the position of the atomic beam, a light sensor for receiving the probe light, and a current control section for controlling currents flowing in multiple-pole magnetic field generating electrodes for controlling the position of the atomic beam on the basis of an output value of the light sensor. With this configuration, the position of the atomic beam is automatically controlled to two-dimensionally move the pattern forming position. | ||||||
| 173 | Apparatus for collection of sorted particles | US09993388 | 2001-11-14 | US20020113204A1 | 2002-08-22 | Mark M. Wang; Eugene Tu; James P. O'Connell; Kristie L. Lykstad; William F. Butler |
| Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, an apparatus is provided for collecting optically sorted particles by providing a first surface adapted to support a plurality of particles, an optical illumination system for subjecting the particles to a moving gradient force to cause the separation of the particles from the first surface, and a second adhesive surface for adhering the separated particles to the second surface. | ||||||
| 174 | Minute particle optical manipulation method and apparatus | US10117182 | 2002-04-08 | US20020109923A1 | 2002-08-15 | Kumiko Matsui; Hisashi Okugawa |
| A minute particle optical manipulation method and a minute particle optical manipulation apparatus are capable of simply strengthening a trapping force in an optical-axis direction and expanding a range where the trapping for acts in the optical-axis direction without requiring an optical element such as a special prism etc., and obtaining the trapping force enough to trap the particle even when the minute particle exists deep within a medium while keeping the trapping force when the minute particle is in a shallow position within the medium. | ||||||
| 175 | Array Cytometry | US09320274 | 1999-05-28 | US06387707B1 | 2002-05-14 | Michael Seul; Alice Xiang Li |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. This invention is also for a method and apparatus to direct the lateral motion and induce the assembly into planar arrays of cells on semiconductor surfaces in response to temporally and spatially varying electric fields and to projected patterns of illumination. | ||||||
| 176 | System and method for programmable illumination pattern generation | US09768414 | 2001-01-24 | US20010016361A1 | 2001-08-23 | Michael Seul; Chiu Wo Chau |
| A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. The invention is also for a system and method for programmable illumination pattern generation, including a novel method and apparatus to generate patterns of illumination and project them onto planar surfaces or onto planar interfaces such as the interface formed by an electrolyte-insulator-semiconductor (EIS), e.g., as described herein. This enables the creation of patterns or sequences of patterns using graphical design or drawing software on a personal computer and the projection of said patterns, or sequences of patterns (nulltime-varying patternsnull), onto the interface using a liquid crystal display (LCD) panel and an optical design which images the LCD panel onto the surface of interest. The use of the LCD technology provides flexibility and control over spatial layout, temporal sequences and intensities (nullgray scalesnull) of illumination patterns. The latter capability permits the creation of patterns with abruptly changing light intensities or patterns with gradually changing intensity profiles. | ||||||
| 177 | Light-controlled electrokinetic assembly of particles near surfaces | US09171550 | 1998-10-26 | US06251691B1 | 2001-06-26 | Michael Seul |
| A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components. | ||||||
| 178 | Method and apparatus for separating particles | US08734971 | 1996-11-19 | US06224732B1 | 2001-05-01 | Totaro Imasaka; Kazuo Isaka; Toshikazu Ohnishi; Takeshi Miyazaki |
| A dispersing medium containing plural types of particles is let to flow in a flow path formed in a flow cell. The flow cell is irradiated with interfering light to form interference fringes of a pattern of stripes. In another arrangement, light is two-dimensionally scanned at high speed so as to cross a flow in the flow path. The moving particles receive a braking force by the light gradient force whenever they pass through each irradiation light stripe. In that case, greater braking forces act on particles having larger sizes (or larger refractive indices) than on particles having smaller sizes (or smaller refractive indices). Accordingly, the particles receiving smaller braking forces pass through the irradiated position more rapidly, so that particles can be separated to flow in the order from the particles receiving smaller braking forces to the particles receiving greater braking forces. | ||||||
| 179 | Evanescent atom guiding in metal-coated hollow-core optical fibers | US184208 | 1998-11-01 | US6151435A | 2000-11-21 | Herschel S. Pilloff |
| A new type of atom guiding structure has been analyzed. It consists of a low-core optical fiber (step-index) which is not clad, but instead has a metal coating on its outer lateral surface. It will be shown that this structure produces the maximum evanescent field in the hollow region of the fiber and guiding can be accomplished with lower power lasers. Both the dipole and the vander Waals potentials have been combined and the resulting barrier height was maximized as a function of both .DELTA., the detuning, and r, the position. An optimized potential having a barrier height of 1 K has been determined by iteratively solving for the required laser intensity. The probability of atoms tunneling through this barrier to the inner wall has been calculated and is expected to be unimportant. Centripetal effects due to a bending of the fiber have also been estimated and are small for the barrier considered here. Compared to other structures, this new-type of guide provides bigger barriers for the same laser power, and therefore enhanced atom guiding. | ||||||
| 180 | Method for forming particulate reaction and measuring method thereof | US453776 | 1995-05-30 | US6086724A | 2000-07-11 | Kiyoharu Nakatani; Hiroaki Misawa; Noboru Kitamura; Tatsuya Uchida |
| Particulates are trapped by laser beam and brought into contact with electrodes to electrochemically and spectroscopically measure the reaction process thereof.Precise measurement of the process of chemical reactions such as electrochemical and photochemical ones of a single particulate is made possible. | ||||||
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